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Chemistry

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Also known as: Methylcobalamin, 13422-55-4
Molecular Formula
C63H91CoN13O14P
Molecular Weight
1344.4  g/mol
InChI Key
ZFLASALABLFSNM-UHFFFAOYSA-L

Methylcobalamin
1 2D Structure

Methylcobalamin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
carbanide;cobalt(3+);[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(4Z,9Z,14Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl phosphate
2.1.2 InChI
InChI=1S/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3;/q;-1;+3/p-2
2.1.3 InChI Key
ZFLASALABLFSNM-UHFFFAOYSA-L
2.1.4 Canonical SMILES
[CH3-].CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=N6)C(=C7C(C(C(=N7)C=C8C(C(C(=N8)C(=C4[N-]5)C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[Co+3]
2.1.5 Isomeric SMILES
[CH3-].CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC\4(C(C5C6(C(C(C(=N6)/C(=C\7/C(C(C(=N7)/C=C\8/C(C(C(=N8)/C(=C4\[N-]5)/C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)/C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[Co+3]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Ch3-b12

2. Mecobalamin

3. Mecobalamin Monohydrate

4. Mecobalamin, (13beta)-isomer

5. Mecobalamin, 3h-labeled

6. Mecobalamin, 57co-labeled

7. Mecobalamin, Co-methyl-13c-labeled

8. Mecobalamin, Co-methyl-14c-labeled

9. Methylcobalamin

10. Methylcobalamine

11. Methylvitamin B12

2.2.2 Depositor-Supplied Synonyms

1. Methylcobalamin

2. 13422-55-4

2.3 Create Date
2006-04-28
3 Chemical and Physical Properties
Molecular Weight 1344.4 g/mol
Molecular Formula C63H91CoN13O14P
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count20
Rotatable Bond Count26
Exact Mass1343.587800 g/mol
Monoisotopic Mass1343.587800 g/mol
Topological Polar Surface Area452 Ų
Heavy Atom Count92
Formal Charge0
Complexity3140
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count14
Defined Bond Stereocenter Count3
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3

API SUPPLIERS

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01

HealthTech BioActives

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothHealthTech BioActives, leading globally in Flavonoids and Vitamin B12 Derivatives.

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Interquim SA

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothInterquim comes from an international group of 50 companies active in the pharma, hospital, diagnostics, fine chemicals & feed sectors.

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Gonane Pharma

India

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Virtual BoothGonane has API manufacturing expertise in new-age Corticosteroids, Hormones and other pharma raw materials.

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Deccan Nutraceuticals Pvt. Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothDeccan Nutraceuticals: A global leader in the integrated development, manufacturing, and marketing of pharmaceutical products.

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Supriya Lifescience

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothSupriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

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Supriya Lifescience

India

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Virtual BoothSupriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

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Supriya Lifescience

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothSupriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

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CSPC Pharmaceutical Group

China

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CSPC Pharmaceutical Group

China

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Mahima Life Sciences

India

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Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1742581800,"product":"VITAMIN B12-CYANOCOBALAMIN IP(RAW MATERIAL FOR PHARMACEUTICAL-NOT FOR FOOD&MEDICINAL USE MFG.BLUK DRUG METHYLCOBALAMIN)VITAMIN B12","address":"VENKATESH,MAHANT ROAD EXTN,","city":"VILE PARLE[E],MUMBAI, MAHARASHTRA.","supplier":"SINOBRIGHT PHARMACEUTICAL COMPANY LTD","supplierCountry":"CHINA","foreign_port":"NANNING","customer":"VITAL LABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"95.76","actualQuantity":"95.76","unit":"KGS","unitRateFc":"1230","totalValueFC":"118712.8","currency":"USD","unitRateINR":"107379","date":"22-Mar-2025","totalValueINR":"10282613.04","totalValueInUsd":"118712.8","indian_port":"Bombay Air","hs_no":"29362610","bill_no":"9040699","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NANNING","supplierAddress":"OFFICE F,32\/F,PLAZA 88 NO.88 YEUNG UK ROAD TSUEN WAN, NT, HONG KONG, CHINA","customerAddress":"VENKATESH,MAHANT ROAD EXTN,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1743705000,"product":"VITAMIN B12-CYANOCOBALAMIN IP(RAW MATERIAL FOR PHARMACEUTICAL-NOT FOR FOOD&MEDICINAL USE MFG.BLUK DRUG METHYLCOBALAMIN)VITAMIN B12","address":"VENKATESH,MAHANT ROAD EXTN,","city":"VILE PARLE[E],MUMBAI, MAHARASHTRA.","supplier":"SINOBRIGHT PHARMACEUTICAL COMPANY LTD","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"VITAL LABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"29.27","actualQuantity":"29.27","unit":"KGS","unitRateFc":"1230","totalValueFC":"36421.9","currency":"USD","unitRateINR":"106518","date":"04-Apr-2025","totalValueINR":"3117781.86","totalValueInUsd":"36421.9","indian_port":"Bombay Air","hs_no":"29362610","bill_no":"9295217","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"OFFICE F,32\/F,PLAZA 88 NO.88 YEUNG UK ROAD TSUEN WAN, NT, HONG KONG, CHINA","customerAddress":"VENKATESH,MAHANT ROAD EXTN,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1744828200,"product":"METHYLCOBALAMIN (MECOBALAMIN) IP METHYLCOBALAMIN (MECOBALAMIN) IP","address":"42,MAHANT ROAD,3,VILE PARLE","city":"MUMBAI,MAHARASHTRA","supplier":"SINOBRIGHT PHARMACEUTICAL COMPANY LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"PRATISTHA PHARMA","customerCountry":"INDIA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"1240","totalValueFC":"37633.8","currency":"USD","unitRateINR":"107384","date":"17-Apr-2025","totalValueINR":"3221520","totalValueInUsd":"37633.8","indian_port":"Bombay Air","hs_no":"29362690","bill_no":"9533598","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"OFFICE F,32\/F,PLAZA 88 NO.88 YEUNG UK ROAD,TSUEN WAN,NT,HONG KONG,CHIN A ., , CHINA CHINA","customerAddress":"42,MAHANT ROAD,3,VILE PARLE"}]
02-Jan-2021
24-Apr-2025
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ABOUT THIS PAGE

Looking for 13422-55-4 / Methylcobalamin API manufacturers, exporters & distributors?

Methylcobalamin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Methylcobalamin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Methylcobalamin manufacturer or Methylcobalamin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Methylcobalamin manufacturer or Methylcobalamin supplier.

PharmaCompass also assists you with knowing the Methylcobalamin API Price utilized in the formulation of products. Methylcobalamin API Price is not always fixed or binding as the Methylcobalamin Price is obtained through a variety of data sources. The Methylcobalamin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Methylcobalamin

Synonyms

13422-55-4

Cas Number

13422-55-4

Methylcobalamin Manufacturers

A Methylcobalamin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Methylcobalamin, including repackagers and relabelers. The FDA regulates Methylcobalamin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Methylcobalamin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Methylcobalamin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Methylcobalamin Suppliers

A Methylcobalamin supplier is an individual or a company that provides Methylcobalamin active pharmaceutical ingredient (API) or Methylcobalamin finished formulations upon request. The Methylcobalamin suppliers may include Methylcobalamin API manufacturers, exporters, distributors and traders.

click here to find a list of Methylcobalamin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Methylcobalamin USDMF

A Methylcobalamin DMF (Drug Master File) is a document detailing the whole manufacturing process of Methylcobalamin active pharmaceutical ingredient (API) in detail. Different forms of Methylcobalamin DMFs exist exist since differing nations have different regulations, such as Methylcobalamin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Methylcobalamin DMF submitted to regulatory agencies in the US is known as a USDMF. Methylcobalamin USDMF includes data on Methylcobalamin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Methylcobalamin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Methylcobalamin suppliers with USDMF on PharmaCompass.

Methylcobalamin JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Methylcobalamin Drug Master File in Japan (Methylcobalamin JDMF) empowers Methylcobalamin API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Methylcobalamin JDMF during the approval evaluation for pharmaceutical products. At the time of Methylcobalamin JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Methylcobalamin suppliers with JDMF on PharmaCompass.

Methylcobalamin KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Methylcobalamin Drug Master File in Korea (Methylcobalamin KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Methylcobalamin. The MFDS reviews the Methylcobalamin KDMF as part of the drug registration process and uses the information provided in the Methylcobalamin KDMF to evaluate the safety and efficacy of the drug.

After submitting a Methylcobalamin KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Methylcobalamin API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Methylcobalamin suppliers with KDMF on PharmaCompass.

Methylcobalamin WC

A Methylcobalamin written confirmation (Methylcobalamin WC) is an official document issued by a regulatory agency to a Methylcobalamin manufacturer, verifying that the manufacturing facility of a Methylcobalamin active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Methylcobalamin APIs or Methylcobalamin finished pharmaceutical products to another nation, regulatory agencies frequently require a Methylcobalamin WC (written confirmation) as part of the regulatory process.

click here to find a list of Methylcobalamin suppliers with Written Confirmation (WC) on PharmaCompass.

Methylcobalamin NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Methylcobalamin as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Methylcobalamin API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Methylcobalamin as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Methylcobalamin and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Methylcobalamin NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Methylcobalamin suppliers with NDC on PharmaCompass.

Methylcobalamin GMP

Methylcobalamin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Methylcobalamin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Methylcobalamin GMP manufacturer or Methylcobalamin GMP API supplier for your needs.

Methylcobalamin CoA

A Methylcobalamin CoA (Certificate of Analysis) is a formal document that attests to Methylcobalamin's compliance with Methylcobalamin specifications and serves as a tool for batch-level quality control.

Methylcobalamin CoA mostly includes findings from lab analyses of a specific batch. For each Methylcobalamin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Methylcobalamin may be tested according to a variety of international standards, such as European Pharmacopoeia (Methylcobalamin EP), Methylcobalamin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Methylcobalamin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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