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Chemistry

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Also known as: 5714-73-8, Hiprex, Hexamine hippurate, Hexamethylenetetramine monohippurate, Hexamethylenetetramine hippurate, 1,3,5,7-tetraazaadamantane benzoylglycinate
Molecular Formula
C15H21N5O3
Molecular Weight
319.36  g/mol
InChI Key
ROAIXOJGRFKICW-UHFFFAOYSA-N
FDA UNII
M329791L57

Methenamine Hippurate
Methenamine Hippurate is the hippurate salt form of methenamine, a prodrug and inactive weak base that slowly hydrolyzes in acidic urine to ammonia and the effective, urinary tract antiseptic formaldehyde. Formaldehyde probably exerts its antibacterial effect by denaturation of protein. Depending on the urinary concentrations, formaldehyde is either bactericidal or bacteriostatic. Formaldehyde urinary concentrations are dependent on urine pH, volume, and flow rate. Formaldehyde acts as an antibacterial agent against gram-positive and gram-negative organisms.
1 2D Structure

Methenamine Hippurate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-benzamidoacetic acid;1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane
2.1.2 InChI
InChI=1S/C9H9NO3.C6H12N4/c11-8(12)6-10-9(13)7-4-2-1-3-5-7;1-7-2-9-4-8(1)5-10(3-7)6-9/h1-5H,6H2,(H,10,13)(H,11,12);1-6H2
2.1.3 InChI Key
ROAIXOJGRFKICW-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1N2CN3CN1CN(C2)C3.C1=CC=C(C=C1)C(=O)NCC(=O)O
2.2 Other Identifiers
2.2.1 UNII
M329791L57
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Hexamine Hippurate

2. Hip-rex

3. Hiprex

4. Urex

5. Urotractan

2.3.2 Depositor-Supplied Synonyms

1. 5714-73-8

2. Hiprex

3. Hexamine Hippurate

4. Hexamethylenetetramine Monohippurate

5. Hexamethylenetetramine Hippurate

6. 1,3,5,7-tetraazaadamantane Benzoylglycinate

7. Methenamine (hippurate)

8. Hippramine

9. Haiprex

10. Viapta

11. 2-benzamidoacetic Acid;1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane

12. M329791l57

13. Glycine, N-benzoyl, Compd. With 1,3,5,7-tetraazatricyclo(3.3.1.1(sup 3,7))decane (1:1)

14. Hexamethylenetetramine Monohippurate;hexamethylenetetramine Monohippurate

15. Methenamine Hippurate [usan]

16. R-657

17. Einecs 227-206-5

18. Hexamethylene Tetramine Hippurate

19. Unii-m329791l57

20. Hiprex (tn)

21. Urex (tn)

22. Hippuric Acid, Compd. With Hexamethylenetetramine (1:1)

23. Methenamine Hippurate [usan:usp:inn:ban]

24. Schembl3029

25. Chebi:6825

26. Chembl1201104

27. Dtxsid10972603

28. Methenamine Hippurate (jan/usp)

29. Methenamine Hippurate [jan]

30. Hy-b1691

31. Methenamine Hippurate [vandf]

32. Mfcd00072147

33. S9466

34. Methenamine Hippurate [mart.]

35. Akos037645132

36. Methenamine Hippurate [usp-rs]

37. Methenamine Hippurate [who-dd]

38. N-benzoylglycine, Compound With 1,3,5,7-tetraazatricyclo(3.3.1.13,7)decane (1:1)

39. Methenamine Hippurate (200 Mg)

40. As-57463

41. Methenamine Hippurate [orange Book]

42. Methenamine Hippurate [usp Impurity]

43. Cs-0013675

44. Ft-0671059

45. Methenamine Hippurate [usp Monograph]

46. D00855

47. D81437

48. 714m738

49. Q27283414

50. 1,3,5,7-tetraazatricyclo[3.3.1.1(3),?]decane; 2-(phenylformamido)acetic Acid

51. N-[hydroxy(phenyl)methylidene]glycine--1,3,5,7-tetraazatricyclo[3.3.1.1~3,7~]decane (1/1)

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 319.36 g/mol
Molecular Formula C15H21N5O3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass319.16443955 g/mol
Monoisotopic Mass319.16443955 g/mol
Topological Polar Surface Area79.4 Ų
Heavy Atom Count23
Formal Charge0
Complexity282
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameHiprex
Drug LabelEach yellow capsule-shaped tablet contains 1 g Methenamine Hippurate which is the Hippuric Acid Salt of Methenamine (hexamethylene tetramine). The tablet also contains inactive ingredients. FD&C Yellow No. 5 (tartrazine, see PRECAUTIONS), Magnesium S.
Active IngredientMethenamine hippurate
Dosage FormTablet
RouteOral
Strength1gm
Market StatusPrescription
CompanySanofi Aventis Us

2 of 4  
Drug NameMethenamine hippurate
PubMed HealthMethenamine (By mouth)
Drug ClassesAntiseptic
Drug LabelMethenamine Hippurate Tablets are a urinary tract antiseptic drug. Each white, scored tablet contains methenamine hippurate 1g (see HOW SUPPLIED). Methenamine Hippurate Tablets also contain: magnesium stearate, povidone and saccharin sodium. Chemical...
Active IngredientMethenamine hippurate
Dosage FormTablet
RouteOral
Strength1gm
Market StatusPrescription
CompanyCorepharma

3 of 4  
Drug NameHiprex
Drug LabelEach yellow capsule-shaped tablet contains 1 g Methenamine Hippurate which is the Hippuric Acid Salt of Methenamine (hexamethylene tetramine). The tablet also contains inactive ingredients. FD&C Yellow No. 5 (tartrazine, see PRECAUTIONS), Magnesium S.
Active IngredientMethenamine hippurate
Dosage FormTablet
RouteOral
Strength1gm
Market StatusPrescription
CompanySanofi Aventis Us

4 of 4  
Drug NameMethenamine hippurate
PubMed HealthMethenamine (By mouth)
Drug ClassesAntiseptic
Drug LabelMethenamine Hippurate Tablets are a urinary tract antiseptic drug. Each white, scored tablet contains methenamine hippurate 1g (see HOW SUPPLIED). Methenamine Hippurate Tablets also contain: magnesium stearate, povidone and saccharin sodium. Chemical...
Active IngredientMethenamine hippurate
Dosage FormTablet
RouteOral
Strength1gm
Market StatusPrescription
CompanyCorepharma

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


Anti-Infective Agents, Urinary

Substances capable of killing agents causing urinary tract infections or of preventing them from spreading. (See all compounds classified as Anti-Infective Agents, Urinary.)


API SUPPLIERS

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Laboratorium Ofichem B.V

Netherlands

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Nuray Chemicals Private Limited

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Micro Labs Limited

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Micro Labs Ltd

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Jame Fine Chemicals Inc

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Virtual BoothLaboratorium Ofichem, offering a flexible, high-tech environment to produce broad range of APIs for Human & Vet pharmaceutical markets.

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Methenamine Hippurate

About the Company : Laboratorium Ofichem is a GMP-certified and FDA-approved API manufacturer with state-of-the-art development and production facilities in the Netherlands. We develop and manufacture...

Laboratorium Ofichem is a GMP-certified and FDA-approved API manufacturer with state-of-the-art development and production facilities in the Netherlands. We develop and manufacture small molecule APIs in a cost-effective, robust, and compliant way. We have our own portfolio of generic APIs, but we also operate as a CDMO for a wide range of customers. We are a stable family-owned business and with nearly 50 years of experience we have a long history of regulatory compliance and a strong reputation for reliability and quality.
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About the Company : Established in 2012, Nuray Chemicals Pvt Ltd is an API manufacturer for highly regulated markets. Its manufacturing facility with state-of-the-art R&D is located near Chennai in th...

Established in 2012, Nuray Chemicals Pvt Ltd is an API manufacturer for highly regulated markets. Its manufacturing facility with state-of-the-art R&D is located near Chennai in the Indian state of Tamil Nadu. Nuray’s expertise and experience lie in developing the chemistry requirements of the pharmaceutical industry, including the synthesis of NCEs, impurities, metabolites, method development, advanced intermediates and APIs for commercial launch. With its focus on maintaining the highest levels of quality, reliability and transparency, Nuray has emerged as a trusted partner in the global generic market.
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Virtual BoothMoehs Group, a reference company in the production of pharmaceutical active ingredients.

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Methenamine Hippurate

About the Company : Since its founding in 1962, MOEHS has produced Active Pharmaceutical Ingredients (APIs) for the international pharmaceutical industry. Thanks to a business history of more than 50 ...

Since its founding in 1962, MOEHS has produced Active Pharmaceutical Ingredients (APIs) for the international pharmaceutical industry. Thanks to a business history of more than 50 years, MOEHS has considerable technical experience in the production of these substances. At Moehs Group we have a large tradition and experience in the area of manufacturing of active pharmaceutical and veterinary ingredients, agrochemicals, nutraceutical, cosmetic, as well as fine chemistry in general, with high levels of quality and safety standards-GMP´s, ICH, approved by the FDA and TGA.
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Methenamine Hippurate

About the Company : Kreative Organics Private Limited is a manufacturer of Active Pharmaceutical Ingredients (APIs) for the world market. Kreative started operations in 1990. Kreative was established ...

Kreative Organics Private Limited is a manufacturer of Active Pharmaceutical Ingredients (APIs) for the world market. Kreative started operations in 1990. Kreative was established by Dr. S. Krishnamohan. Dr. Krishnamohan was formerly with TIFR, BARC, Caltech and NASA. He is a scientist of international repute and runs Kreative with professionalism and a focus on innovation. Kreative maintains strict quality standards and has developed a robust quality system around which all of our products are manufactured. Kreative invested in a state of the art cGMP facility in 2005 and expanded it to a US FDA class facility in 2013.
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Methenamine Hippurate

About the Company : Micro Labs Limited is a diversified healthcare company with cutting-edge R&D, advanced manufacturing facilities, and a strong distribution network. It ranks among India's top pharm...

Micro Labs Limited is a diversified healthcare company with cutting-edge R&D, advanced manufacturing facilities, and a strong distribution network. It ranks among India's top pharmaceutical companies, with a leading presence in cardiology, diabetology, anti-infectives, ophthalmology, and pain management. The company is known for its high-quality medicines, including the popular fever management brand, Dolo. Micro Labs continues to grow through innovation, research, and global expansion, delivering healthcare solutions that meet international standards.
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Recordati

Italy
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Recordati

Italy
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Methenamine Hippurate

About the Company : Recordati, established in 1926, is an international pharmaceutical group, listed on the Italian Stock Exchange (Reuters RECI.MI, Bloomberg REC IM, ISIN IT 0003828271), with a total...

Recordati, established in 1926, is an international pharmaceutical group, listed on the Italian Stock Exchange (Reuters RECI.MI, Bloomberg REC IM, ISIN IT 0003828271), with a total staff of around 4,000, dedicated to the research, development, manufacturing and marketing of pharmaceuticals. Headquartered in Milan, Italy, Recordati has operations in the main European countries, in Russia, in other Central and Eastern European countries, in Turkey, in North Africa and in the United States of America.
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Siegfried AG

Switzerland
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Siegfried AG

Switzerland
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Methenamine Hippurate

About the Company : As an internationally renowned outsourcing partner, we offer products and tailor-made service packages that are seamlessly embedded in the value chain of our customers. Our pharmac...

As an internationally renowned outsourcing partner, we offer products and tailor-made service packages that are seamlessly embedded in the value chain of our customers. Our pharmaceutical industry partners benefit from a wide range of offers - from the development of active ingredients to development services for ready-made drugs, their approval and production to packaging and logistics. As a former fully integrated pharmaceutical company, Siegfried is now one of the few suppliers who can develop both active ingredients and ready-made drugs under one roof. This combination of experience and know-how is unique in the CDMO market.
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API Reference Price

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Contact No: 78313"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1688063400,"product":"METHENAMINE HIPPURATE BATCH NO. 23100335","address":"CADILA CORPORATE CAMPUS SARKHEJ-DHOLKA ROAD, BHAT","city":"AHMEDABAD","supplier":"RECORDATI","supplierCountry":"ITALY","foreign_port":"NA","customer":"CADILA PHARMACEUTICALS","customerCountry":"INDIA","quantity":"1095.00","actualQuantity":"1095","unit":"KGS","unitRateFc":"81","totalValueFC":"89616.2","currency":"USD","unitRateINR":"6727.3","date":"30-Jun-2023","totalValueINR":"7366119.873","totalValueInUsd":"89616.2","indian_port":"AHMEDABAD AIR","hs_no":"29420090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"CADILA CORPORATE CAMPUS SARKHEJ-DHOLKA ROAD, BHAT"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693506600,"product":"METHENAMINE HIPPURATE USP BTACH NO 103516P0015","address":"NO.49D, BOMMASANDRA INDUSTRIAL","city":"BANGALORE","supplier":"ORGAPHARM S.A.S","supplierCountry":"FRANCE","foreign_port":"PARIS","customer":"ADCOCK INGRAM","customerCountry":"INDIA","quantity":"962.54","actualQuantity":"962.54","unit":"KGS","unitRateFc":"49.2","totalValueFC":"56242.6","currency":"EUR","unitRateINR":"4850.3","date":"01-Sep-2023","totalValueINR":"4668599.63","totalValueInUsd":"56242.6","indian_port":"Bangalore Air","hs_no":"29212990","bill_no":"7630306","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS","supplierAddress":"RUE DU MOULIN DE LA CANNE45300 PYTHIVIERSSDNF FRANCE","customerAddress":"NO.49D, BOMMASANDRA INDUSTRIAL"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1697826600,"product":"METHENAMINE HIPPURATE USP BATCH NO 103516P0019,10351690020,103516P0021 103516","address":"NO.49D, BOMMASANDRA INDUSTRIAL","city":"BANGALORE","supplier":"ORGAPHARM S.A.S","supplierCountry":"FRANCE","foreign_port":"PARIS","customer":"ADCOCK INGRAM","customerCountry":"INDIA","quantity":"2758.32","actualQuantity":"2758.32","unit":"KGS","unitRateFc":"49.2","totalValueFC":"154673","currency":"EUR","unitRateINR":"4667.1","date":"21-Oct-2023","totalValueINR":"12873321.94","totalValueInUsd":"154673","indian_port":"Bangalore Air","hs_no":"29212990","bill_no":"8407362","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS","supplierAddress":"RUE DU MOULIN DE LA CANNE45300 PYTHIVIERSSDNF FRANCE","customerAddress":"NO.49D, BOMMASANDRA INDUSTRIAL"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1705429800,"product":"METHENAMINE HIPPURATE USP BATCH NO 103516P0023,103516P0022","address":"NO.49D, BOMMASANDRA INDUSTRIAL","city":"BANGALORE","supplier":"ORGAPHARM S.A.S","supplierCountry":"FRANCE","foreign_port":"PARIS","customer":"ADCOCK INGRAM","customerCountry":"INDIA","quantity":"1757.70","actualQuantity":"1757.7","unit":"KGS","unitRateFc":"49.2","totalValueFC":"102355.4","currency":"EUR","unitRateINR":"4839.8","date":"17-Jan-2024","totalValueINR":"8506927.8","totalValueInUsd":"102355.4","indian_port":"Bangalore Air","hs_no":"29212990","bill_no":"9696529","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS","supplierAddress":"RUE DU MOULIN DE LA CANNE45300 PYTHIVIERSSDNF FRANCE","customerAddress":"NO.49D, BOMMASANDRA INDUSTRIAL"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1712255400,"product":"METHENAMINE HIPPURATE USP 103516 BATCH NO 103516P0027,103516P0028","address":"NO.49D, BOMMASANDRA INDUSTRIAL","city":"BANGALORE","supplier":"ORGAPHARM S.A.S","supplierCountry":"FRANCE","foreign_port":"PARIS","customer":"ADCOCK INGRAM","customerCountry":"INDIA","quantity":"1520.28","actualQuantity":"1520.28","unit":"KGS","unitRateFc":"49.2","totalValueFC":"87658.3","currency":"EUR","unitRateINR":"4815","date":"05-Apr-2024","totalValueINR":"7320106.78","totalValueInUsd":"87658.3","indian_port":"Bangalore Air","hs_no":"29212990","bill_no":"2886524","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS","supplierAddress":"RUE DU MOULIN DE LA CANNE45300 PITHIVIERSSDNF FRANCE","customerAddress":"NO.49D, BOMMASANDRA INDUSTRIAL"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1713205800,"product":"RELEVANT BULK DRUG\/S - METHENAMINE USP","address":"EI-362-363-364 SITAPURA INDL. AREA,","city":"JAIPUR","supplier":"JIANGSU GUOTAI GUOMIAN TRADING CO., LTD,","supplierCountry":"CHINA","foreign_port":"NANSHA","customer":"AMOL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"6600.00","actualQuantity":"6600","unit":"KGS","unitRateFc":"15","totalValueFC":"99999","currency":"USD","unitRateINR":"1265.3","date":"16-Apr-2024","totalValueINR":"8350650","totalValueInUsd":"99999","indian_port":"JNPT","hs_no":"29336990","bill_no":"3054482","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NANSHA","supplierAddress":"19-21\/F., GUOTAI BLDG., RENMIN ROAD(M), ZHANGJIAGANG CITY,JIANGSU CHINA","customerAddress":"EI-362-363-364 SITAPURA INDL. AREA,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715711400,"product":"METHENAMINE HIPPURATE USP BATCH NO 103516P0029,10351690031 103516","address":"NO.49D, BOMMASANDRA INDUSTRIAL","city":"BANGALORE","supplier":"ORGAPHARM S.A.S","supplierCountry":"FRANCE","foreign_port":"PARIS","customer":"ADCOCK INGRAM","customerCountry":"INDIA","quantity":"1673.44","actualQuantity":"1673.44","unit":"KGS","unitRateFc":"49.2","totalValueFC":"95047","currency":"EUR","unitRateINR":"4734.3","date":"15-May-2024","totalValueINR":"7922562.73","totalValueInUsd":"95047","indian_port":"Bangalore Air","hs_no":"29212990","bill_no":"3495240","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS","supplierAddress":"RUE DU MOULIN DE LA CANNE45300 PITHIVIERSSDNF FRANCE","customerAddress":"NO.49D, BOMMASANDRA INDUSTRIAL"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717439400,"product":"METHENAMINE HIPPURATE","address":"N\/A","city":"","supplier":"RECORDATI","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"CONCRESCO PHARMA TECHNOLOGIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"16.00","actualQuantity":"16","unit":"KGS","unitRateFc":"155","totalValueFC":"2505.9","currency":"USD","unitRateINR":"13074.3","date":"04-Jun-2024","totalValueINR":"209188","totalValueInUsd":"2505.9","indian_port":"Hyderabad Air","hs_no":"29336990","bill_no":"3812898","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"SEDE LEGALE VIA MATTEO CIVITALI, 120148 MILANO, ITALIA , ITALYSDNF Italy","customerAddress":"N\/A"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725301800,"product":"METHENAMINE HIPPURATE USP 103516 BATCH NO 103516P0037","address":"NO.49D, BOMMASANDRA INDUSTRIAL","city":"BANGALORE","supplier":"ORGAPHARM S.A.S","supplierCountry":"FRANCE","foreign_port":"PARIS - CHARLES DE G","customer":"ADCOCK INGRAM","customerCountry":"INDIA","quantity":"400.00","actualQuantity":"400","unit":"KGS","unitRateFc":"50.6","totalValueFC":"23502.9","currency":"EUR","unitRateINR":"4923.9","date":"03-Sep-2024","totalValueINR":"1969571.3","totalValueInUsd":"23502.9","indian_port":"Bangalore Air","hs_no":"29212990","bill_no":"5395400","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"PARIS - CHARLES DE G","supplierAddress":"RUE DU MOULIN DE LA CANNE 45300 PITHIVIERS SDNF FRANCE FRANCE","customerAddress":"NO.49D, BOMMASANDRA INDUSTRIAL"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725474600,"product":"METHENAMINE HIPPURATE BATCH 24100383 MNF.DT 08.07.2024 EXP.DT 07.07.2029 , BATCH 24100384 MNF.DT 08.07.2024 EXP.DT 07.07","address":"CADILA CORPORATE CAMPUS","city":"AHMEDABAD, GUJARAT","supplier":"RECORDATI","supplierCountry":"ITALY","foreign_port":"ROME","customer":"CADILA PHARMACEUTICALS","customerCountry":"INDIA","quantity":"1800.00","actualQuantity":"1800","unit":"KGS","unitRateFc":"75","totalValueFC":"136689.5","currency":"USD","unitRateINR":"6363.8","date":"05-Sep-2024","totalValueINR":"11454750","totalValueInUsd":"136689.5","indian_port":"Ahmedabad Air","hs_no":"29420090","bill_no":"5432742","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROME","supplierAddress":"SEDE LEGALE VIA M. CIVITALI, 1 2014 8 MILANO ITALIA, , Italy SDNF Italy Italy","customerAddress":"CADILA CORPORATE CAMPUS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727289000,"product":"METHENAMINE HIPPURATE BATCH NO. 24100388 MFG DTD. 25.07.2024EXP. DTD. 24.07.2029","address":"CADILA CORPORATE CAMPUS","city":"AHMEDABAD, GUJARAT","supplier":"RECORDATI","supplierCountry":"ITALY","foreign_port":"ROME","customer":"CADILA PHARMACEUTICALS","customerCountry":"INDIA","quantity":"427.00","actualQuantity":"427","unit":"KGS","unitRateFc":"75","totalValueFC":"32330.3","currency":"USD","unitRateINR":"6345","date":"26-Sep-2024","totalValueINR":"2709315","totalValueInUsd":"32330.3","indian_port":"Ahmedabad Air","hs_no":"29420090","bill_no":"5807535","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROME","supplierAddress":"SEDE LEGALE VIA M. CIVITALI, 1 2014 8 MILANO ITALIA, , Italy SDNF Italy","customerAddress":"CADILA CORPORATE CAMPUS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730745000,"product":"METHENAMINE HIPPURATE BATCH 24100498 \/ 24100500 , MNF.DT 14.10.2024 EXP.DT 13.10.2029 , MNF.DT 17.10.2024 EXP.DT 16.10.2","address":"CADILA CORPORATE CAMPUS","city":"AHMEDABAD, GUJARAT","supplier":"RECORDATI","supplierCountry":"ITALY","foreign_port":"ROME","customer":"CADILA PHARMACEUTICALS","customerCountry":"INDIA","quantity":"1844.00","actualQuantity":"1844","unit":"KGS","unitRateFc":"75","totalValueFC":"139220.7","currency":"USD","unitRateINR":"6371.3","date":"05-Nov-2024","totalValueINR":"11748585","totalValueInUsd":"139220.7","indian_port":"Ahmedabad Air","hs_no":"29420090","bill_no":"6507270","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROME","supplierAddress":"SEDE LEGALE VIA M. CIVITALI, 1 2014 8 MILANO ITALIA, , Italy SDNF Italy","customerAddress":"CADILA CORPORATE CAMPUS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733077800,"product":"METHENAMINE HIPPURATE BATCH 24100552 \/ BATCH 24100553 MNF.DT 11.11.2024 EXP.DT 10.11.2029METHENAMINE HYPPURATE BATCH 24100552 \/ BATCH 24100553 MNF.DT","address":"CADILA CORPORATE CAMPUS","city":"AHMEDABAD, GUJARAT","supplier":"RECORDATI","supplierCountry":"ITALY","foreign_port":"ROME","customer":"CADILA PHARMACEUTICALS","customerCountry":"INDIA","quantity":"700.00","actualQuantity":"700","unit":"KGS","unitRateFc":"75","totalValueFC":"52735.4","currency":"USD","unitRateINR":"6401.3","date":"02-Dec-2024","totalValueINR":"4480875","totalValueInUsd":"52735.4","indian_port":"Ahmedabad Air","hs_no":"29420090","bill_no":"6995974","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROME","supplierAddress":"SEDE LEGALE VIA M. CIVITALI, 1 2014 8 MILANO ITALIA, , Italy SDNF Italy","customerAddress":"CADILA CORPORATE CAMPUS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733077800,"product":"METHENAMINE HIPPURATE BATCH 24100552 \/ BATCH 24100553 MNF.DT11.11.2024 EXP.DT 10.11.2029METHENAMINE HYPPURATE BATCH 24100552 \/ BATCH 24100553 MNF.DT","address":"CADILA CORPORATE CAMPUS","city":"AHMEDABAD, GUJARAT","supplier":"RECORDATI","supplierCountry":"ITALY","foreign_port":"ROME","customer":"CADILA PHARMACEUTICALS","customerCountry":"INDIA","quantity":"450.00","actualQuantity":"450","unit":"KGS","unitRateFc":"75","totalValueFC":"33901.3","currency":"USD","unitRateINR":"6401.3","date":"02-Dec-2024","totalValueINR":"2880562.5","totalValueInUsd":"33901.3","indian_port":"Ahmedabad Air","hs_no":"29420090","bill_no":"6995974","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROME","supplierAddress":"SEDE LEGALE VIA M. CIVITALI, 1 2014 8 MILANO ITALIA, , Italy SDNF Italy","customerAddress":"CADILA CORPORATE CAMPUS"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1743445800,"product":"METHENAMINE HIPPURATE METHENAMINE HIPPURATE","address":"NO.49D, BOMMASANDRA INDUSTRIAL","city":"BANGALORE","supplier":"AXYNTIS GROUP","supplierCountry":"FRANCE","foreign_port":"LE HAVRE","customer":"ADCOCK INGRAM","customerCountry":"INDIA","quantity":"1894.80","actualQuantity":"1894.8","unit":"KGS","unitRateFc":"57.7","totalValueFC":"111534.9","currency":"EUR","unitRateINR":"5038.8","date":"01-Apr-2025","totalValueINR":"9547588.03","totalValueInUsd":"111534.9","indian_port":"Madras Sea","hs_no":"29212990","bill_no":"9226530","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"LE HAVRE","supplierAddress":"ZI-RUE DU MOULIN DE LA CANNE-F-45300 PITHIVIERS FRANCE SDNF","customerAddress":"NO.49D, BOMMASANDRA INDUSTRIAL"}]
11-Feb-2021
05-Apr-2025
KGS
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Drugs in Development

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Details:

Methenamine Hippurate tablets works by releasing formaldehyde in acidic urine, which denatures bacterial proteins and DNA, it is indicated for recurring urinary tract infections.


Lead Product(s): Methenamine Hippurate

Therapeutic Area: Infections and Infectious Diseases Brand Name: Hiprex-Generic

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable March 13, 2025

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01

American Thoracic Society
Not Confirmed
American Thoracic Society
Not Confirmed

Details : Methenamine Hippurate tablets works by releasing formaldehyde in acidic urine, which denatures bacterial proteins and DNA, it is indicated for recurring urinary tract infections.

Product Name : Hiprex-Generic

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

March 13, 2025

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FDF Dossiers

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01

methenamine hippurate

Brand Name : Uramet

Dosage Form :

Dosage Strength :

Packaging : 100

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

Aspen API Comapny Banner

02

methenamine hippurate

Brand Name : Uramet

Dosage Form :

Dosage Strength :

Packaging : 100

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

Aspen API Comapny Banner

03

STLE Annual Meeting
Not Confirmed
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STLE Annual Meeting
Not Confirmed

METHENAMINE HIPPURATE

Brand Name : METHENAMINE HIPPURATE

Dosage Form : TABLET;ORAL

Dosage Strength : 1GM

Packaging :

Approval Date : 2016-07-05

Application Number : 205661

Regulatory Info : RX

Registration Country : USA

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04

Esjay Pharma

India
STLE Annual Meeting
Not Confirmed
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Esjay Pharma

India
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STLE Annual Meeting
Not Confirmed

METHENAMINE HIPPURATE

Brand Name : HIPREX

Dosage Form : TABLET;ORAL

Dosage Strength : 1GM

Packaging :

Approval Date : 1982-01-01

Application Number : 17681

Regulatory Info : RX

Registration Country : USA

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05

STLE Annual Meeting
Not Confirmed
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STLE Annual Meeting
Not Confirmed

methenamine hippurate

Brand Name : Hiprex

Dosage Form :

Dosage Strength :

Packaging : 100

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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06

STLE Annual Meeting
Not Confirmed
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STLE Annual Meeting
Not Confirmed

methenamine hippurate

Brand Name : Hiprex

Dosage Form :

Dosage Strength :

Packaging : 100

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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07

STLE Annual Meeting
Not Confirmed
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STLE Annual Meeting
Not Confirmed

METHENAMINE HIPPURATE

Brand Name : METHENAMINE HIPPURATE

Dosage Form : TABLET;ORAL

Dosage Strength : 1GM

Packaging :

Approval Date : 2023-12-01

Application Number : 217675

Regulatory Info : RX

Registration Country : USA

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08

STLE Annual Meeting
Not Confirmed
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STLE Annual Meeting
Not Confirmed

METHENAMINE HIPPURATE

Brand Name : METHENAMINE HIPPURATE

Dosage Form : TABLET;ORAL

Dosage Strength : 1GM

Packaging :

Approval Date : 2019-08-01

Application Number : 212172

Regulatory Info : RX

Registration Country : USA

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09

Country
STLE Annual Meeting
Not Confirmed
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Country
arrow
STLE Annual Meeting
Not Confirmed

methenamine hippurate

Brand Name : Hiprex

Dosage Form : ORAL POWDER IN SACHET

Dosage Strength : 1 G

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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10

Country
STLE Annual Meeting
Not Confirmed
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Country
arrow
STLE Annual Meeting
Not Confirmed

Methenamine Hippurate

Brand Name : Hiprex

Dosage Form : Antic-calc Tablet

Dosage Strength : 1 g

Packaging : Box

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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FDA Orange Book

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01

ALVOGEN

U.S.A
STLE Annual Meeting
Not Confirmed
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ALVOGEN

U.S.A
arrow
STLE Annual Meeting
Not Confirmed

METHENAMINE HIPPURATE

Brand Name : UREX

Dosage Form : TABLET;ORAL

Dosage Strength : 1GM

Approval Date : 1982-01-01

Application Number : 16151

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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02

STLE Annual Meeting
Not Confirmed
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arrow
STLE Annual Meeting
Not Confirmed

METHENAMINE HIPPURATE

Brand Name : METHENAMINE HIPPURATE

Dosage Form : TABLET;ORAL

Dosage Strength : 1GM

Approval Date : 2016-07-05

Application Number : 205661

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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03

ESJAY PHARMA

India
STLE Annual Meeting
Not Confirmed
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ESJAY PHARMA

India
arrow
STLE Annual Meeting
Not Confirmed

METHENAMINE HIPPURATE

Brand Name : HIPREX

Dosage Form : TABLET;ORAL

Dosage Strength : 1GM

Approval Date : 1982-01-01

Application Number : 17681

RX/OTC/DISCN : RX

RLD : Yes

TE Code : AB

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04

STLE Annual Meeting
Not Confirmed
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STLE Annual Meeting
Not Confirmed

METHENAMINE HIPPURATE

Brand Name : METHENAMINE HIPPURATE

Dosage Form : TABLET;ORAL

Dosage Strength : 1GM

Approval Date : 2003-06-20

Application Number : 76411

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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05

STLE Annual Meeting
Not Confirmed
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arrow
STLE Annual Meeting
Not Confirmed

METHENAMINE HIPPURATE

Brand Name : METHENAMINE HIPPURATE

Dosage Form : TABLET;ORAL

Dosage Strength : 1GM

Approval Date : 2023-12-01

Application Number : 217675

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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06

MICRO LABS

India
STLE Annual Meeting
Not Confirmed
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MICRO LABS

India
arrow
STLE Annual Meeting
Not Confirmed

METHENAMINE HIPPURATE

Brand Name : METHENAMINE HIPPURATE

Dosage Form : TABLET;ORAL

Dosage Strength : 1GM

Approval Date : 2019-08-01

Application Number : 212172

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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07

NOVAST LABS

China
STLE Annual Meeting
Not Confirmed
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NOVAST LABS

China
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METHENAMINE HIPPURATE

Brand Name : METHENAMINE HIPPURATE

Dosage Form : TABLET;ORAL

Dosage Strength : 1GM

Approval Date : 2020-11-27

Application Number : 210068

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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METHENAMINE HIPPURATE

Brand Name : METHENAMINE HIPPURATE

Dosage Form : TABLET;ORAL

Dosage Strength : 1GM

Approval Date : 2025-03-10

Application Number : 219661

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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methenamine hippurate

Brand Name : Hiprex

Dosage Form : ORAL POWDER IN SACHET

Dosage Strength : 1 G

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Registration Country : Sweden

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methenamine hippurate

Brand Name : Hiprex

Dosage Form : TABLET

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Methenamine Hippurate

Brand Name : Hiprex

Dosage Form : Antic-calc Tablet

Dosage Strength : 1 g

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Registration Country : Norway

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Methenamine Hippurate

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Methenamine Hippurate

Brand Name : Hiprex

Dosage Form : Powder in dose bag

Dosage Strength : 1 g

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Registration Country : Norway

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Registration Country : Australia

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ABOUT THIS PAGE

Looking for 5714-73-8 / Methenamine Hippurate API manufacturers, exporters & distributors?

Methenamine Hippurate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Methenamine Hippurate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Methenamine Hippurate manufacturer or Methenamine Hippurate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Methenamine Hippurate manufacturer or Methenamine Hippurate supplier.

PharmaCompass also assists you with knowing the Methenamine Hippurate API Price utilized in the formulation of products. Methenamine Hippurate API Price is not always fixed or binding as the Methenamine Hippurate Price is obtained through a variety of data sources. The Methenamine Hippurate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Methenamine Hippurate

Synonyms

5714-73-8, Hiprex, Hexamine hippurate, Hexamethylenetetramine monohippurate, Hexamethylenetetramine hippurate, 1,3,5,7-tetraazaadamantane benzoylglycinate

Cas Number

5714-73-8

Unique Ingredient Identifier (UNII)

M329791L57

About Methenamine Hippurate

Methenamine Hippurate is the hippurate salt form of methenamine, a prodrug and inactive weak base that slowly hydrolyzes in acidic urine to ammonia and the effective, urinary tract antiseptic formaldehyde. Formaldehyde probably exerts its antibacterial effect by denaturation of protein. Depending on the urinary concentrations, formaldehyde is either bactericidal or bacteriostatic. Formaldehyde urinary concentrations are dependent on urine pH, volume, and flow rate. Formaldehyde acts as an antibacterial agent against gram-positive and gram-negative organisms.

Methenamine Manufacturers

A Methenamine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Methenamine, including repackagers and relabelers. The FDA regulates Methenamine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Methenamine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Methenamine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Methenamine Suppliers

A Methenamine supplier is an individual or a company that provides Methenamine active pharmaceutical ingredient (API) or Methenamine finished formulations upon request. The Methenamine suppliers may include Methenamine API manufacturers, exporters, distributors and traders.

click here to find a list of Methenamine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Methenamine USDMF

A Methenamine DMF (Drug Master File) is a document detailing the whole manufacturing process of Methenamine active pharmaceutical ingredient (API) in detail. Different forms of Methenamine DMFs exist exist since differing nations have different regulations, such as Methenamine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Methenamine DMF submitted to regulatory agencies in the US is known as a USDMF. Methenamine USDMF includes data on Methenamine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Methenamine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Methenamine suppliers with USDMF on PharmaCompass.

Methenamine WC

A Methenamine written confirmation (Methenamine WC) is an official document issued by a regulatory agency to a Methenamine manufacturer, verifying that the manufacturing facility of a Methenamine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Methenamine APIs or Methenamine finished pharmaceutical products to another nation, regulatory agencies frequently require a Methenamine WC (written confirmation) as part of the regulatory process.

click here to find a list of Methenamine suppliers with Written Confirmation (WC) on PharmaCompass.

Methenamine NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Methenamine as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Methenamine API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Methenamine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Methenamine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Methenamine NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Methenamine suppliers with NDC on PharmaCompass.

Methenamine GMP

Methenamine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Methenamine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Methenamine GMP manufacturer or Methenamine GMP API supplier for your needs.

Methenamine CoA

A Methenamine CoA (Certificate of Analysis) is a formal document that attests to Methenamine's compliance with Methenamine specifications and serves as a tool for batch-level quality control.

Methenamine CoA mostly includes findings from lab analyses of a specific batch. For each Methenamine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Methenamine may be tested according to a variety of international standards, such as European Pharmacopoeia (Methenamine EP), Methenamine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Methenamine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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