Find LYC-55716 manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

0

USDMF

0

CEP/COS

0

JDMF

0

EU WC

0

KDMF

0

NDC API

0

VMF

0

Listed Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

0

FDA Orange Book

0

Europe

0

Canada

0

Australia

0

South Africa

0

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

API/FDF Prices: Book a Demo

API REF. PRICE (USD/KG)

$
$ 0

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Regulatory FDF Prices

NA

MARKET PLACE

0

API

0

FDF

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 2055536-64-4, Lyc-55716, Cintirorgon [inn], Lpn433p0ea, 3-[(2s)-6-[3-(difluoromethoxy)-5-fluorophenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid, Chembl4472508
Molecular Formula
C27H23F6NO6S
Molecular Weight
603.5  g/mol
InChI Key
GULSIMHVQYBADX-FQEVSTJZSA-N
FDA UNII
LPN433P0EA

LYC-55716
Cintirorgon is an orally bioavailable agonist of retinoic acid-related orphan receptor gamma (RORg), with potential immunomodulatory and antineoplastic activities. Upon oral administration of cintirorgon, this agent selectively binds to the nuclear receptor transcription factor RORg, forming a receptor complex that translocates to the nucleus, and binds to ROR response elements (ROREs), enhancing the function, proliferation and survival of type 17 T-cells, including Th17 (helper T-cells) and Tc17 (cytotoxic T-cells). This may increase the expression of co-stimulatory molecules and decrease the expression of co-inhibitory molecules on T-cells leading to increased production of cytokines and chemokines by T-cells, decreased proliferation of regulatory T-cells (Tregs), and abrogation of tumor-induced immunosuppression. This ultimately induces a T-cell-mediated immune response against cancer cells and leads to a reduction in tumor cell growth. RORg, the nuclear receptor transcription factor that is involved in Th17/Tc17 differentiation, plays a key role in immune activation.
1 2D Structure

LYC-55716

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[(2S)-6-[3-(difluoromethoxy)-5-fluorophenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid
2.1.2 InChI
InChI=1S/C27H23F6NO6S/c1-26(2,24(35)36)13-20-14-34(41(37,38)21-5-3-4-17(11-21)27(31,32)33)22-10-15(6-7-23(22)39-20)16-8-18(28)12-19(9-16)40-25(29)30/h3-12,20,25H,13-14H2,1-2H3,(H,35,36)/t20-/m0/s1
2.1.3 InChI Key
GULSIMHVQYBADX-FQEVSTJZSA-N
2.1.4 Canonical SMILES
CC(C)(CC1CN(C2=C(O1)C=CC(=C2)C3=CC(=CC(=C3)F)OC(F)F)S(=O)(=O)C4=CC=CC(=C4)C(F)(F)F)C(=O)O
2.1.5 Isomeric SMILES
CC(C)(C[C@H]1CN(C2=C(O1)C=CC(=C2)C3=CC(=CC(=C3)F)OC(F)F)S(=O)(=O)C4=CC=CC(=C4)C(F)(F)F)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
LPN433P0EA
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2h-1,4-benzoxazine-2-propanoic Acid, 6-(3-(difluoromethoxy)-5-fluorophenyl)-3,4-dihydro-alpha,alpha-dimethyl-4-((3-(trifluoromethyl)phenyl)sulfonyl)-, (2s)-

2. 3-((2s)-6-(3-(difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2h-1,4-benzoxazin-2-yl)-2,2-dimethylpropanoic Acid

3. Lyc-55716

2.3.2 Depositor-Supplied Synonyms

1. 2055536-64-4

2. Lyc-55716

3. Cintirorgon [inn]

4. Lpn433p0ea

5. 3-[(2s)-6-[3-(difluoromethoxy)-5-fluorophenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic Acid

6. Chembl4472508

7. Lyc55716

8. Unii-lpn433p0ea

9. Cintirorgon [who-dd]

10. Cintirorgon (lyc-55716)

11. Schembl18302870

12. Gtpl10045

13. Bcp28882

14. Ex-a2635

15. Bdbm50515653

16. Nsc803601

17. S8860

18. Cs-7496

19. Nsc-803601

20. Lyc-55716lyc-55716

21. Ac-36326

22. Compound 32j [wo2016201225a1]

23. Hy-104037

24. A16863

25. F78355

26. Lyc 55716;lyc55716; Lyc-55716

27. (s)-3-(6-(3-(difluoromethoxy)-5-fluorophenyl)-4-(3-(trifluoromethyl)phenylsulfonyl)-3,4-dihydro-2h-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic Acid

28. 2h-1,4-benzoxazine-2-propanoic Acid, 6-(3-(difluoromethoxy)-5-fluorophenyl)-3,4-dihydro-alpha,alpha-dimethyl-4-((3-(trifluoromethyl)phenyl)sulfonyl)-, (2s)-

29. 3-((2s)-6-(3-(difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2h-1,4-benzoxazin-2-yl)-2,2-dimethylpropanoic Acid

2.4 Create Date
2017-02-18
3 Chemical and Physical Properties
Molecular Weight 603.5 g/mol
Molecular Formula C27H23F6NO6S
XLogP36.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count13
Rotatable Bond Count8
Exact Mass603.11502760 g/mol
Monoisotopic Mass603.11502760 g/mol
Topological Polar Surface Area102 Ų
Heavy Atom Count41
Formal Charge0
Complexity1020
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 2055536-64-4 / LYC-55716 API manufacturers, exporters & distributors?

LYC-55716 manufacturers, exporters & distributors 1

65

PharmaCompass offers a list of LYC-55716 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right LYC-55716 manufacturer or LYC-55716 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred LYC-55716 manufacturer or LYC-55716 supplier.

PharmaCompass also assists you with knowing the LYC-55716 API Price utilized in the formulation of products. LYC-55716 API Price is not always fixed or binding as the LYC-55716 Price is obtained through a variety of data sources. The LYC-55716 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

LYC-55716

Synonyms

2055536-64-4, Cintirorgon [inn], Lpn433p0ea, 3-[(2s)-6-[3-(difluoromethoxy)-5-fluorophenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid, Chembl4472508, Lyc55716

Cas Number

2055536-64-4

Unique Ingredient Identifier (UNII)

LPN433P0EA

About LYC-55716

Cintirorgon is an orally bioavailable agonist of retinoic acid-related orphan receptor gamma (RORg), with potential immunomodulatory and antineoplastic activities. Upon oral administration of cintirorgon, this agent selectively binds to the nuclear receptor transcription factor RORg, forming a receptor complex that translocates to the nucleus, and binds to ROR response elements (ROREs), enhancing the function, proliferation and survival of type 17 T-cells, including Th17 (helper T-cells) and Tc17 (cytotoxic T-cells). This may increase the expression of co-stimulatory molecules and decrease the expression of co-inhibitory molecules on T-cells leading to increased production of cytokines and chemokines by T-cells, decreased proliferation of regulatory T-cells (Tregs), and abrogation of tumor-induced immunosuppression. This ultimately induces a T-cell-mediated immune response against cancer cells and leads to a reduction in tumor cell growth. RORg, the nuclear receptor transcription factor that is involved in Th17/Tc17 differentiation, plays a key role in immune activation.

LYC-55716 Manufacturers

A LYC-55716 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of LYC-55716, including repackagers and relabelers. The FDA regulates LYC-55716 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. LYC-55716 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

LYC-55716 Suppliers

A LYC-55716 supplier is an individual or a company that provides LYC-55716 active pharmaceutical ingredient (API) or LYC-55716 finished formulations upon request. The LYC-55716 suppliers may include LYC-55716 API manufacturers, exporters, distributors and traders.

LYC-55716 GMP

LYC-55716 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of LYC-55716 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right LYC-55716 GMP manufacturer or LYC-55716 GMP API supplier for your needs.

LYC-55716 CoA

A LYC-55716 CoA (Certificate of Analysis) is a formal document that attests to LYC-55716's compliance with LYC-55716 specifications and serves as a tool for batch-level quality control.

LYC-55716 CoA mostly includes findings from lab analyses of a specific batch. For each LYC-55716 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

LYC-55716 may be tested according to a variety of international standards, such as European Pharmacopoeia (LYC-55716 EP), LYC-55716 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (LYC-55716 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty