Find LS301-IT manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: M48hcf27ze, Cronexitide lanocianine [inn], Ls301-it, Ls-301, Cronexitide lanocianine [usan], Cypate-cyclo(cys-gly-arg-asp-ser-pro-cys)-lys-oh (ls301)
Molecular Formula
C73H92N14O15S2
Molecular Weight
1469.7  g/mol
InChI Key
FFEZUEIKRUQWTE-MYFKLRRKSA-N
FDA UNII
M48HCF27ZE

LS301-IT
Cronexitide Lanocianine is a hydrophobic near-infrared (NIR) fluorescent probe composed of a NIR fluorescent dye cypate linked to an unnatural D-cysteine-containing cyclic octapeptide (D-Cys-Gly-Arg--Asp-Ser-Pro-Cys)-Lys-OH, with potential cancer imaging activity. Upon administration of cronexitide lanocianine during tumor resection, the peptide component specifically targets and binds integrin receptors expressed on tumor cells, which are not expressed on normal, healthy cells. Upon receptor-mediated endocytosis and fluorescence imaging using infrared light that is visualized by the surgeon with special Cancer Vision Goggles (CVG), tumor cells can be detected, identified, and removed accordingly. This enhances the accuracy of cancer cell removal during surgery. The D-cysteine on the peptide prevents degradation by endogenous proteases.
1 2D Structure

LS301-IT

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[2-[7-[3-[3-[[(3S,6S,9S,15S,20R,23S)-20-[[(1S)-5-amino-1-carboxypentyl]carbamoyl]-6-(carboxymethyl)-9-[3-(diaminomethylideneamino)propyl]-3-(hydroxymethyl)-2,5,8,11,14,22-hexaoxo-17,18-dithia-1,4,7,10,13,21-hexazabicyclo[21.3.0]hexacosan-15-yl]amino]-3-oxopropyl]-1,1-dimethylbenzo[e]indol-2-ylidene]hepta-1,3,5-trienyl]-1,1-dimethylbenzo[e]indol-3-ium-3-yl]propanoate
2.1.2 InChI
InChI=1S/C73H92N14O15S2/c1-72(2)56(25-8-6-5-7-9-26-57-73(3,4)63-46-21-13-11-19-44(46)28-30-54(63)86(57)37-32-60(91)92)85(53-29-27-43-18-10-12-20-45(43)62(53)72)36-31-58(89)80-51-41-103-104-42-52(67(98)81-48(70(101)102)22-14-15-33-74)84-68(99)55-24-17-35-87(55)69(100)50(40-88)83-66(97)49(38-61(93)94)82-65(96)47(23-16-34-77-71(75)76)79-59(90)39-78-64(51)95/h5-13,18-21,25-30,47-52,55,88H,14-17,22-24,31-42,74H2,1-4H3,(H13-,75,76,77,78,79,80,81,82,83,84,89,90,91,92,93,94,95,96,97,98,99,101,102)/t47-,48-,49-,50-,51+,52-,55-/m0/s1
2.1.3 InChI Key
FFEZUEIKRUQWTE-MYFKLRRKSA-N
2.2 Other Identifiers
2.2.1 UNII
M48HCF27ZE
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. M48hcf27ze

2. Cronexitide Lanocianine [inn]

3. Ls301-it

4. Ls-301

5. Cronexitide Lanocianine [usan]

6. Cypate-cyclo(cys-gly-arg-asp-ser-pro-cys)-lys-oh (ls301)

7. 2041574-23-4

8. Cypate-d-cysteyl-l-glycyl-l-arginyl-l-aspartyl-l-seryl-l-prolyl-l-cysteyl-l-lysine Cyclic (2->8)-disulfide

2.4 Create Date
2023-04-17
3 Chemical and Physical Properties
Molecular Weight 1469.7 g/mol
Molecular Formula C73H92N14O15S2
XLogP31.5
Hydrogen Bond Donor Count13
Hydrogen Bond Acceptor Count20
Rotatable Bond Count24
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area506
Heavy Atom Count104
Formal Charge0
Complexity3300
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count4
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 2041574-23-4 / LS301-IT API manufacturers, exporters & distributors?

LS301-IT manufacturers, exporters & distributors 1

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PharmaCompass offers a list of LS301-IT API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right LS301-IT manufacturer or LS301-IT supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred LS301-IT manufacturer or LS301-IT supplier.

API | Excipient name

LS301-IT

Synonyms

M48hcf27ze, Cronexitide lanocianine [inn], Ls-301, Cronexitide lanocianine [usan], Cypate-cyclo(cys-gly-arg-asp-ser-pro-cys)-lys-oh (ls301), 2041574-23-4

Cas Number

2041574-23-4

Unique Ingredient Identifier (UNII)

M48HCF27ZE

About LS301-IT

Cronexitide Lanocianine is a hydrophobic near-infrared (NIR) fluorescent probe composed of a NIR fluorescent dye cypate linked to an unnatural D-cysteine-containing cyclic octapeptide (D-Cys-Gly-Arg--Asp-Ser-Pro-Cys)-Lys-OH, with potential cancer imaging activity. Upon administration of cronexitide lanocianine during tumor resection, the peptide component specifically targets and binds integrin receptors expressed on tumor cells, which are not expressed on normal, healthy cells. Upon receptor-mediated endocytosis and fluorescence imaging using infrared light that is visualized by the surgeon with special Cancer Vision Goggles (CVG), tumor cells can be detected, identified, and removed accordingly. This enhances the accuracy of cancer cell removal during surgery. The D-cysteine on the peptide prevents degradation by endogenous proteases.

LS301-IT Manufacturers

A LS301-IT manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of LS301-IT, including repackagers and relabelers. The FDA regulates LS301-IT manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. LS301-IT API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

LS301-IT Suppliers

A LS301-IT supplier is an individual or a company that provides LS301-IT active pharmaceutical ingredient (API) or LS301-IT finished formulations upon request. The LS301-IT suppliers may include LS301-IT API manufacturers, exporters, distributors and traders.

LS301-IT GMP

LS301-IT Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of LS301-IT GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right LS301-IT GMP manufacturer or LS301-IT GMP API supplier for your needs.

LS301-IT CoA

A LS301-IT CoA (Certificate of Analysis) is a formal document that attests to LS301-IT's compliance with LS301-IT specifications and serves as a tool for batch-level quality control.

LS301-IT CoA mostly includes findings from lab analyses of a specific batch. For each LS301-IT CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

LS301-IT may be tested according to a variety of international standards, such as European Pharmacopoeia (LS301-IT EP), LS301-IT JP (Japanese Pharmacopeia) and the US Pharmacopoeia (LS301-IT USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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