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Lorcainide

Lorcainide

Synopsis, Chemistry

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Also known as: Lopantrol, Socainide hydrochloride, Isocainide hydrochloride, Lorcainide hydrochloride [usan], Einecs 261-504-6, N-(4-chlorophenyl)-2-phenyl-n-(1-propan-2-ylpiperidin-1-ium-4-yl)acetamide;chloride

Molecular Formula

C₂₂H₂₈Cl₂N₂O

Molecular Weight

407.4 g/mol

InChI Key

FSFSWNBDCJVFGI-UHFFFAOYSA-N

1 2D Structure

Lorcainide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-1-ium-4-yl)acetamide;chloride

2.1.2 InChI

InChI=1S/C22H27ClN2O.ClH/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-20)22(26)16-18-6-4-3-5-7-18;/h3-11,17,21H,12-16H2,1-2H3;1H

2.1.3 InChI Key

FSFSWNBDCJVFGI-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)[NH+]1CCC(CC1)N(C2=CC=C(C=C2)Cl)C(=O)CC3=CC=CC=C3.[Cl-]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 4'-chloro-n-(1-isopropyl-4-piperidyl)-2-phenylacetanilide

2. Lorcainid

3. Lorcainide

4. Lorcainide Monohydrochloride

5. R 15889

6. R15889

7. Ro 13-1042

2.2.2 Depositor-Supplied Synonyms

1. Lopantrol

2. Socainide Hydrochloride

3. Isocainide Hydrochloride

4. Lorcainide Hydrochloride [usan]

5. Einecs 261-504-6

6. N-(4-chlorophenyl)-2-phenyl-n-(1-propan-2-ylpiperidin-1-ium-4-yl)acetamide;chloride

7. Ro 13-1042

8. Lorivox

9. R 15889

10. 1t1s98onm1

11. 1313498-17-7

12. Benzeneacetamide, N-(4-chlorophenyl)-n-(1-(1-methylethyl)-4-piperidinyl)-, Monohydrochloride

13. Lorcainida Clorhidrato [spanish]

14. Lorcainida Clorhidrato

15. Unii-1t1s98onm1

16. N-(p-chlorophenyl)-n-(1-isopropylpiperidin-4-yl)phenylacetamide Hydrochloride

17. Nsc 310411

2.3 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₈Cl₂N₂O
Molecular Weight	407.4 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	406.1578689 g/mol
Monoisotopic Mass	406.1578689 g/mol
Topological Polar Surface Area	24.8 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	433
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)