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Chemistry

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Also known as: Larotaxel [inn], 156294-36-9, Xrp-9881, Xrp9881, Twq8k8a81y, Benzenepropanoic acid, beta-[[(1,1-dimethylethoxy)carbonyl]amino]-alpha-hydroxy-, (1s,2s,4s,7r,8ar,9as,10ar,12as,12br)-7,12a-bis(acetyloxy)-1-(benzoyloxy)-1,3,4,7,8,9,9a,10,10a,12,12a,12b-dodecahydro-2-hydroxy-5,13,13-trimethyl-8-oxo-2,6-methano-2h-cyclodeca[3,4]cyclopropa[4,5]benz[1,2-b]oxet-4-yl ester, (alphar,betas)-
Molecular Formula
C45H53NO14
Molecular Weight
831.9  g/mol
InChI Key
DXOJIXGRFSHVKA-BZVZGCBYSA-N
FDA UNII
TWQ8K8A81Y

Larotaxel
Larotaxel is a semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.
1 2D Structure

Larotaxel

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(1S,2S,3R,4S,7R,9S,11R,13R,16S)-4,13-diacetyloxy-1-hydroxy-16-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-15,18,18-trimethyl-12-oxo-6-oxapentacyclo[12.3.1.03,11.04,7.09,11]octadec-14-en-2-yl] benzoate
2.1.2 InChI
InChI=1S/C45H53NO14/c1-23-29(57-39(52)33(49)32(26-15-11-9-12-16-26)46-40(53)60-41(4,5)6)21-45(54)37(58-38(51)27-17-13-10-14-18-27)35-43(36(50)34(56-24(2)47)31(23)42(45,7)8)20-28(43)19-30-44(35,22-55-30)59-25(3)48/h9-18,28-30,32-35,37,49,54H,19-22H2,1-8H3,(H,46,53)/t28-,29+,30-,32+,33-,34-,35+,37+,43-,44+,45-/m1/s1
2.1.3 InChI Key
DXOJIXGRFSHVKA-BZVZGCBYSA-N
2.1.4 Canonical SMILES
CC1=C2C(C(=O)C34CC3CC5C(C4C(C(C2(C)C)(CC1OC(=O)C(C(C6=CC=CC=C6)NC(=O)OC(C)(C)C)O)O)OC(=O)C7=CC=CC=C7)(CO5)OC(=O)C)OC(=O)C
2.1.5 Isomeric SMILES
CC1=C2[C@H](C(=O)[C@]34C[C@H]3C[C@@H]5[C@]([C@H]4[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C6=CC=CC=C6)NC(=O)OC(C)(C)C)O)O)OC(=O)C7=CC=CC=C7)(CO5)OC(=O)C)OC(=O)C
2.2 Other Identifiers
2.2.1 UNII
TWQ8K8A81Y
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Xrp 9881

2. Xrp-9881

3. Xrp9881

2.3.2 Depositor-Supplied Synonyms

1. Larotaxel [inn]

2. 156294-36-9

3. Xrp-9881

4. Xrp9881

5. Twq8k8a81y

6. Benzenepropanoic Acid, Beta-[[(1,1-dimethylethoxy)carbonyl]amino]-alpha-hydroxy-, (1s,2s,4s,7r,8ar,9as,10ar,12as,12br)-7,12a-bis(acetyloxy)-1-(benzoyloxy)-1,3,4,7,8,9,9a,10,10a,12,12a,12b-dodecahydro-2-hydroxy-5,13,13-trimethyl-8-oxo-2,6-methano-2h-cyclodeca[3,4]cyclopropa[4,5]benz[1,2-b]oxet-4-yl Ester, (alphar,betas)-

7. (1s,2s,4s,7r,8ar,9as,10ar,12as,12br)-1-(benzoyloxy)-4-(((2r,3s)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-2-hydroxy-5,13,13-trimethyl-8-oxo-1,3,4,7,8,9,9a,10,10a,12b-decahydro-2h-2,6-methanocyclodeca[3,4]cyclopropa[4,5]benzo[1,2-b]oxete-7,12a(12h)-diyl Diacetate

8. Xrp 9881

9. Unii-twq8k8a81y

10. Pnu 100940

11. Benzenepropanoic Acid, Beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, (1s,2s,4s,7r,8ar,9as,10ar,12as,12br)-7,12a-bis(acetyloxy)-1-(benzoyloxy)-1,3,4,7,8,9,9a,10,10a,12,12a,12b-dodecahydro-2-hydroxy-5,13,13-trimethyl-8-oxo-2,6-methano-2h-cyclodeca(3,4)cyclopropa(4,5)benz(1,2-b)oxet-4-yl Ester, (alphar,betas)-

12. Larotaxel [who-dd]

13. Schembl125697

14. Chembl4279455

15. Zinc95627892

16. Db12984

17. Pnu-100940

18. Hy-125374

19. Cs-0091011

20. Q6489757

21. [(1s,2s,3r,4s,7r,9s,11r,13r,16s)-4,13-diacetyloxy-1-hydroxy-16-[(2r,3s)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-15,18,18-trimethyl-12-oxo-6-oxapentacyclo[12.3.1.03,11.04,7.09,11]octadec-14-en-2-yl] Benzoate

22. 1-hydroxy-9-oxo-5.beta.,20-epoxy-7.beta.,19-cyclotax-11-ene-2.alpha.,4,10.beta.,13.alpha.-tetrayl 4,10-diacetate 2-benzoate 13-((2r,3s)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoate)

2.4 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 831.9 g/mol
Molecular Formula C45H53NO14
XLogP32.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count14
Rotatable Bond Count15
Exact Mass831.34660536 g/mol
Monoisotopic Mass831.34660536 g/mol
Topological Polar Surface Area210 Ų
Heavy Atom Count60
Formal Charge0
Complexity1790
Isotope Atom Count0
Defined Atom Stereocenter Count11
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 156294-36-9 / Larotaxel API manufacturers, exporters & distributors?

Larotaxel manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Larotaxel API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Larotaxel manufacturer or Larotaxel supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Larotaxel manufacturer or Larotaxel supplier.

PharmaCompass also assists you with knowing the Larotaxel API Price utilized in the formulation of products. Larotaxel API Price is not always fixed or binding as the Larotaxel Price is obtained through a variety of data sources. The Larotaxel Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Larotaxel

Synonyms

Larotaxel [inn], 156294-36-9, Xrp-9881, Xrp9881, Twq8k8a81y, Benzenepropanoic acid, beta-[[(1,1-dimethylethoxy)carbonyl]amino]-alpha-hydroxy-, (1s,2s,4s,7r,8ar,9as,10ar,12as,12br)-7,12a-bis(acetyloxy)-1-(benzoyloxy)-1,3,4,7,8,9,9a,10,10a,12,12a,12b-dodecahydro-2-hydroxy-5,13,13-trimethyl-8-oxo-2,6-methano-2h-cyclodeca[3,4]cyclopropa[4,5]benz[1,2-b]oxet-4-yl ester, (alphar,betas)-

Cas Number

156294-36-9

Unique Ingredient Identifier (UNII)

TWQ8K8A81Y

About Larotaxel

Larotaxel is a semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.

Larotaxel Manufacturers

A Larotaxel manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Larotaxel, including repackagers and relabelers. The FDA regulates Larotaxel manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Larotaxel API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Larotaxel Suppliers

A Larotaxel supplier is an individual or a company that provides Larotaxel active pharmaceutical ingredient (API) or Larotaxel finished formulations upon request. The Larotaxel suppliers may include Larotaxel API manufacturers, exporters, distributors and traders.

Larotaxel GMP

Larotaxel Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Larotaxel GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Larotaxel GMP manufacturer or Larotaxel GMP API supplier for your needs.

Larotaxel CoA

A Larotaxel CoA (Certificate of Analysis) is a formal document that attests to Larotaxel's compliance with Larotaxel specifications and serves as a tool for batch-level quality control.

Larotaxel CoA mostly includes findings from lab analyses of a specific batch. For each Larotaxel CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Larotaxel may be tested according to a variety of international standards, such as European Pharmacopoeia (Larotaxel EP), Larotaxel JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Larotaxel USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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