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    Chemistry

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    Also known as: Ivermectin, Dihydroavermectin b1a, 70288-86-7, 22,23-dihydroavermectin b1a, 70161-11-4, Ivermectin component b1a
    Molecular Formula
    C48H74O14
    Molecular Weight
    875.1  g/mol
    InChI Key
    AZSNMRSAGSSBNP-XPNPUAGNSA-N
    FDA UNII
    91Y2202OUW
    Ivermectin
    A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
    1 2D Structure

    Ivermectin

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-6'-[(2S)-butan-2-yl]-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
    2.1.2 InChI
    InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
    2.1.3 InChI Key
    AZSNMRSAGSSBNP-XPNPUAGNSA-N
    2.1.4 Canonical SMILES
    CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C
    2.1.5 Isomeric SMILES
    CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C
    2.2 Other Identifiers
    2.2.1 UNII
    91Y2202OUW
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Eqvalan

    2. Ivermectin

    3. Ivomec

    4. Mectizan

    5. Mk 933

    6. Mk-933

    7. Mk933

    8. Stromectol

    2.3.2 Depositor-Supplied Synonyms

    1. Ivermectin

    2. Dihydroavermectin B1a

    3. 70288-86-7

    4. 22,23-dihydroavermectin B1a

    5. 70161-11-4

    6. Ivermectin Component B1a

    7. 71827-03-7

    8. Avermectin H2b1a

    9. 5-o-demethyl-22,23-dihydroavermectin A1a

    10. Chebi:63941

    11. 91y2202ouw

    12. (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2h,7h-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-l-arabino-hexopyranosyl)-3-o-methyl-alpha-l-arabino-hexopyranoside

    13. Mk-933

    14. (1r,4s,5's,6r,6'r,8r,10e,12s,13s,14e,16e,20r,21r,24s)-6'-[(2s)-butan-2-yl]-21,24-dihydroxy-12-[(2r,4s,5s,6s)-5-[(2s,4s,5s,6s)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one

    15. Ivermectin B1a-d2

    16. C48h74o14

    17. Unii-91y2202ouw

    18. 22,23-dihydroavermectin B(1)a

    19. Ncgc00163233-01

    20. Ivermectin (ivm)

    21. Ivm

    22. Einecs 276-046-2

    23. Dihydro Avermectin Bla

    24. Brn 4643153

    25. 22,23-dihydro-5-o-demethylavermectin A1a

    26. H2b1a

    27. Prestwick3_000156

    28. Dsstox_cid_3181

    29. Ivermectin (mk-0933)

    30. Dsstox_rid_76909

    31. Dsstox_gsid_23181

    32. Bspbio_000292

    33. Schembl312795

    34. Bpbio1_000322

    35. Chembl263291

    36. Dtxsid8023181

    37. Chebi:94551

    38. Hms2089m09

    39. Hms2095o14

    40. Hms3712o14

    41. Wca82703

    42. Tox21_112034

    43. Bdbm50409816

    44. Mfcd30496678

    45. S1351

    46. Akos027470116

    47. Ivermectin Component B1a [mi]

    48. Zinc238808778

    49. Zinc252286706

    50. Ac-6014

    51. Ccg-220156

    52. Ncgc00186639-01

    53. Ncgc00186639-03

    54. As-14167

    55. Bi166167

    56. Cas-71827-03-7

    57. Hy-126937

    58. Ab00513813

    59. Cs-0108408

    60. 22,23-dihydroavermectin B1a; Ivermectin

    61. Ab00513813-02

    62. Ab00513813-03

    63. Ab00513813_04

    64. Avermectin A1a, 22,23-dihydro-5-o-demethyl-

    65. 288i867

    66. Ivermectin, Antibiotic For Culture Media Use Only

    67. Q-201262

    68. Brd-k24652731-001-02-7

    69. Brd-k85554912-001-08-9

    70. Q27132923

    71. Ivermectin, British Pharmacopoeia (bp) Reference Standard

    72. Ivermectin, European Pharmacopoeia (ep) Reference Standard

    73. Ivermectin, United States Pharmacopeia (usp) Reference Standard

    74. Ivermectin, Pharmaceutical Secondary Standard; Certified Reference Material

    75. (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17

    76. Clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-l-arabino-hexopyranosyl)-3-o-methyl-alpha-l-arabino-hexopyranoside

    2.4 Create Date
    2005-11-20
    3 Chemical and Physical Properties
    Molecular Weight 875.1 g/mol
    Molecular Formula C48H74O14
    XLogP34.1
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count8
    Exact Mass874.50785703 g/mol
    Monoisotopic Mass874.50785703 g/mol
    Topological Polar Surface Area170 Ų
    Heavy Atom Count62
    Formal Charge0
    Complexity1680
    Isotope Atom Count0
    Defined Atom Stereocenter Count20
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count3
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of rosacea

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antiparasitic Agents

    Drugs used to treat or prevent parasitic infections. (See all compounds classified as Antiparasitic Agents.)

    Insecticides

    Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Pediculicide [EPC]; Antiparasitic [EPC]
    5.3 ATC Code

    D - Dermatologicals

    D11 - Other dermatological preparations

    D11A - Other dermatological preparations

    D11AX - Other dermatologicals

    D11AX22 - Ivermectin

    P - Antiparasitic products, insecticides and repellents

    P02 - Anthelmintics

    P02C - Antinematodal agents

    P02CF - Avermectines

    P02CF01 - Ivermectin

    API Reference Price

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    01-Jan-2021
    28-Mar-2025
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    DOSAGE - LOTION;TOPICAL - 0.5%

    USFDA APPLICATION NUMBER - 202736

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    DOSAGE - CREAM;TOPICAL - 1%

    USFDA APPLICATION NUMBER - 206255

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    ABOUT THIS PAGE

    Looking for 71827-03-7 / Ivermectin API manufacturers, exporters & distributors?

    Ivermectin manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Ivermectin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ivermectin manufacturer or Ivermectin supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ivermectin manufacturer or Ivermectin supplier.

    PharmaCompass also assists you with knowing the Ivermectin API Price utilized in the formulation of products. Ivermectin API Price is not always fixed or binding as the Ivermectin Price is obtained through a variety of data sources. The Ivermectin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Ivermectin

    Synonyms

    Dihydroavermectin b1a, 70288-86-7, 22,23-dihydroavermectin b1a, 70161-11-4, Ivermectin component b1a, 71827-03-7

    Cas Number

    71827-03-7

    Unique Ingredient Identifier (UNII)

    91Y2202OUW

    About Ivermectin

    A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.

    Ivermectin B1a Manufacturers

    A Ivermectin B1a manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ivermectin B1a, including repackagers and relabelers. The FDA regulates Ivermectin B1a manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ivermectin B1a API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Ivermectin B1a manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Ivermectin B1a Suppliers

    A Ivermectin B1a supplier is an individual or a company that provides Ivermectin B1a active pharmaceutical ingredient (API) or Ivermectin B1a finished formulations upon request. The Ivermectin B1a suppliers may include Ivermectin B1a API manufacturers, exporters, distributors and traders.

    click here to find a list of Ivermectin B1a suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Ivermectin B1a USDMF

    A Ivermectin B1a DMF (Drug Master File) is a document detailing the whole manufacturing process of Ivermectin B1a active pharmaceutical ingredient (API) in detail. Different forms of Ivermectin B1a DMFs exist exist since differing nations have different regulations, such as Ivermectin B1a USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Ivermectin B1a DMF submitted to regulatory agencies in the US is known as a USDMF. Ivermectin B1a USDMF includes data on Ivermectin B1a's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ivermectin B1a USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Ivermectin B1a suppliers with USDMF on PharmaCompass.

    Ivermectin B1a JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Ivermectin B1a Drug Master File in Japan (Ivermectin B1a JDMF) empowers Ivermectin B1a API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Ivermectin B1a JDMF during the approval evaluation for pharmaceutical products. At the time of Ivermectin B1a JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Ivermectin B1a suppliers with JDMF on PharmaCompass.

    Ivermectin B1a KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Ivermectin B1a Drug Master File in Korea (Ivermectin B1a KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Ivermectin B1a. The MFDS reviews the Ivermectin B1a KDMF as part of the drug registration process and uses the information provided in the Ivermectin B1a KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Ivermectin B1a KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Ivermectin B1a API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Ivermectin B1a suppliers with KDMF on PharmaCompass.

    Ivermectin B1a CEP

    A Ivermectin B1a CEP of the European Pharmacopoeia monograph is often referred to as a Ivermectin B1a Certificate of Suitability (COS). The purpose of a Ivermectin B1a CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Ivermectin B1a EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Ivermectin B1a to their clients by showing that a Ivermectin B1a CEP has been issued for it. The manufacturer submits a Ivermectin B1a CEP (COS) as part of the market authorization procedure, and it takes on the role of a Ivermectin B1a CEP holder for the record. Additionally, the data presented in the Ivermectin B1a CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Ivermectin B1a DMF.

    A Ivermectin B1a CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Ivermectin B1a CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Ivermectin B1a suppliers with CEP (COS) on PharmaCompass.

    Ivermectin B1a NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Ivermectin B1a as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Ivermectin B1a API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Ivermectin B1a as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Ivermectin B1a and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Ivermectin B1a NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Ivermectin B1a suppliers with NDC on PharmaCompass.

    Ivermectin B1a GMP

    Ivermectin B1a Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Ivermectin B1a GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ivermectin B1a GMP manufacturer or Ivermectin B1a GMP API supplier for your needs.

    Ivermectin B1a CoA

    A Ivermectin B1a CoA (Certificate of Analysis) is a formal document that attests to Ivermectin B1a's compliance with Ivermectin B1a specifications and serves as a tool for batch-level quality control.

    Ivermectin B1a CoA mostly includes findings from lab analyses of a specific batch. For each Ivermectin B1a CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Ivermectin B1a may be tested according to a variety of international standards, such as European Pharmacopoeia (Ivermectin B1a EP), Ivermectin B1a JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ivermectin B1a USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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