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Chemistry

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Also known as: 133107-64-9, Insulin lispro (5.97 mg), Insulin-lispro, Dtxsid90157956
Molecular Formula
C257H389N65O77S6
Molecular Weight
5814  g/mol
InChI Key
WNRQPCUGRUFHED-DETKDSODSA-N

Insulin Lispro
Insulin that has been modified so that the B-chain contains a LYSINE at position 28 instead of a PROLINE and a PROLINE at position 29 instead of a LYSINE. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES.
1 2D Structure

Insulin Lispro

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4S)-4-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[(2-aminoacetyl)amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-5-[[(2S)-4-amino-1-[[(2S)-1-[[(2R)-1-[[(1S)-3-amino-1-carboxy-3-oxopropyl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-5-oxopentanoic acid;(4S)-4-[[2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-5-oxopentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-sulfanylpropanoyl]amino]acetyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-6-amino-1-[(2S)-2-[[(1S,2R)-1-carboxy-2-hydroxypropyl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
2.1.2 InChI
InChI=1S/C158H234N40O42S2.C99H155N25O35S4/c1-79(2)57-104(181-131(213)86(15)173-136(218)102(50-53-125(211)212)179-152(234)127(84(11)12)194-148(230)107(60-82(7)8)184-145(227)113(67-95-70-166-78-172-95)189-150(232)115(74-199)176-123(208)73-170-134(216)116(75-241)191-140(222)105(58-80(3)4)182-144(226)112(66-94-69-165-77-171-94)188-138(220)101(48-51-119(161)204)178-146(228)114(68-120(162)205)190-153(235)126(83(9)10)193-132(214)98(160)61-89-31-21-18-22-32-89)139(221)185-110(64-92-40-44-96(202)45-41-92)142(224)183-106(59-81(5)6)147(229)195-128(85(13)14)154(236)192-117(76-242)135(217)169-71-121(206)174-100(49-52-124(209)210)137(219)177-99(38-29-55-167-158(163)164)133(215)168-72-122(207)175-108(62-90-33-23-19-24-34-90)141(223)186-109(63-91-35-25-20-26-36-91)143(225)187-111(65-93-42-46-97(203)47-43-93)149(231)196-129(87(16)200)155(237)180-103(37-27-28-54-159)156(238)198-56-30-39-118(198)151(233)197-130(88(17)201)157(239)240;1-12-46(9)77(121-73(134)36-100)97(156)122-76(45(7)8)95(154)108-56(25-29-75(137)138)80(139)105-54(23-27-70(102)131)83(142)117-66(40-161)93(152)119-68(42-163)94(153)124-79(48(11)127)98(157)116-64(38-126)90(149)123-78(47(10)13-2)96(155)120-67(41-162)92(151)115-63(37-125)89(148)110-58(31-44(5)6)85(144)111-59(32-49-14-18-51(128)19-15-49)86(145)106-53(22-26-69(101)130)81(140)109-57(30-43(3)4)84(143)107-55(24-28-74(135)136)82(141)113-61(34-71(103)132)88(147)112-60(33-50-16-20-52(129)21-17-50)87(146)118-65(39-160)91(150)114-62(99(158)159)35-72(104)133/h18-26,31-36,40-47,69-70,77-88,98-118,126-130,199-203,241-242H,27-30,37-39,48-68,71-76,159-160H2,1-17H3,(H2,161,204)(H2,162,205)(H,165,171)(H,166,172)(H,168,215)(H,169,217)(H,170,216)(H,173,218)(H,174,206)(H,175,207)(H,176,208)(H,177,219)(H,178,228)(H,179,234)(H,180,237)(H,181,213)(H,182,226)(H,183,224)(H,184,227)(H,185,221)(H,186,223)(H,187,225)(H,188,220)(H,189,232)(H,190,235)(H,191,222)(H,192,236)(H,193,214)(H,194,230)(H,195,229)(H,196,231)(H,197,233)(H,209,210)(H,211,212)(H,239,240)(H4,163,164,167);14-21,43-48,53-68,76-79,125-129,160-163H,12-13,22-42,100H2,1-11H3,(H2,101,130)(H2,102,131)(H2,103,132)(H2,104,133)(H,105,139)(H,106,145)(H,107,143)(H,108,154)(H,109,140)(H,110,148)(H,111,144)(H,112,147)(H,113,141)(H,114,150)(H,115,151)(H,116,157)(H,117,142)(H,118,146)(H,119,152)(H,120,155)(H,121,134)(H,122,156)(H,123,149)(H,124,153)(H,135,136)(H,137,138)(H,158,159)/t86-,87+,88+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,126-,127-,128-,129-,130-;46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-,77-,78-,79-/m00/s1
2.1.3 InChI Key
WNRQPCUGRUFHED-DETKDSODSA-N
2.1.4 Canonical SMILES
CCC(C)C(C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CS)C(=O)NC(CS)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)NC(C(C)CC)C(=O)NC(CS)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)O)NC(=O)CN.CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CS)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)O)C(=O)O)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC6=CN=CN6)NC(=O)C(CO)NC(=O)CNC(=O)C(CS)NC(=O)C(CC(C)C)NC(=O)C(CC7=CN=CN7)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC8=CC=CC=C8)N
2.1.5 Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)CN.C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC6=CN=CN6)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC8=CC=CC=C8)N)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 28(b)-lys-29(b)-pro-insulin

2. 28(b)-lysine-29(b)-prolineinsulin

3. Humalog

4. Humalog Kwikpen

5. Insulin, Lys(28b)-pro(29b)-

6. Insulin, Lysyl(28b)-prolyl(28b)-

7. Kwikpen, Humalog

8. Lispro

9. Lispro, Insulin

10. Lyspro

2.2.2 Depositor-Supplied Synonyms

1. 133107-64-9

2. Insulin Lispro (5.97 Mg)

3. Insulin-lispro

4. Dtxsid90157956

2.3 Create Date
2007-07-03
3 Chemical and Physical Properties
Molecular Weight 5814 g/mol
Molecular Formula C257H389N65O77S6
Hydrogen Bond Donor Count84
Hydrogen Bond Acceptor Count89
Rotatable Bond Count185
Exact Mass5811.6913101 g/mol
Monoisotopic Mass5809.6846004 g/mol
Topological Polar Surface Area2310 Ų
Heavy Atom Count405
Formal Charge0
Complexity13000
Isotope Atom Count0
Defined Atom Stereocenter Count52
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameHumalog
PubMed HealthInsulin Lispro
Drug ClassesAntidiabetic
Drug LabelHumalog Mix50/50 [50% insulin lispro protamine suspension and 50% insulin lispro injection, (rDNA origin)] is a mixture of insulin lispro solution, a rapid-acting blood glucose-lowering agent and insulin lispro protamine suspension, an intermedi...
Active IngredientInsulin lispro recombinant
Dosage FormInjectable
RouteInjection
Strength100 units/ml
Market StatusPrescription
CompanyLilly

2 of 2  
Drug NameHumalog
PubMed HealthInsulin Lispro
Drug ClassesAntidiabetic
Drug LabelHumalog Mix50/50 [50% insulin lispro protamine suspension and 50% insulin lispro injection, (rDNA origin)] is a mixture of insulin lispro solution, a rapid-acting blood glucose-lowering agent and insulin lispro protamine suspension, an intermedi...
Active IngredientInsulin lispro recombinant
Dosage FormInjectable
RouteInjection
Strength100 units/ml
Market StatusPrescription
CompanyLilly

4.2 Drug Indication

Insulin lispro is indicated to improve glycemic control in adults and children with diabetes mellitus.


FDA Label


Treatment of diabetes mellitus in adults.


For the treatment of adults and children with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis. Insulin lispro Sanofi is also indicated for the initial stabilisation of diabetes mellitus.


For the treatment of adults and children with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis. Liprolog is also indicated for the initial stabilisation of diabetes mellitus.


For the treatment of adults and children with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis. Humalog is also indicated for the initial stabilisation of diabetes mellitus.


For the treatment of patients with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis. Liprolog is also indicated for the initial stabilization of diabetes mellitus. Liprolog is a short acting insulin and may be used in conjunction with a longer acting human insulin. Liprolog is indicated for preprandial administration.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Insulin is a natural hormone produced by beta cells of the pancreas. In non-diabetic individuals, a basal level of insulin is supplemented with insulin spikes following meals. Increased insulin secretion following meals is responsible for the metabolic changes that occur as the body transitions from a postabsorptive to absorptive state. Insulin promotes cellular uptake of glucose, particularly in muscle and adipose tissues, promotes energy storage via glycogenesis, opposes catabolism of energy stores, increases DNA replication and protein synthesis by stimulating amino acid uptake by liver, muscle and adipose tissue, and modifies the activity of numerous enzymes involved in glycogen synthesis and glycolysis. Insulin also promotes growth and is required for the actions of growth hormone (e.g. protein synthesis, cell division, DNA synthesis). Insulin lispro is a rapid-acting insulin analogue used to mimic postprandial insulin spikes in diabetic individuals. The onset of action of insulin lispro is 10-15 minutes. Its activity peaks 60 minutes following subcutaneous injection and its duration of action is 4-5 hours. Compared to regular human insulin, insulin lispro has a more rapid onset of action and a shorter duration of action. Insulin lispro is also shown to be equipotent to human insulin on a molar basis.


5.2 MeSH Pharmacological Classification

Hypoglycemic Agents

Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Pharmacological Classes
Insulin [Chemical/Ingredient]; Insulin Analog [EPC]
5.4 ATC Code

A10AB04


A10AB04


A10AB04, A10AD04


A10AB04, A10AD04


A10AB04


A - Alimentary tract and metabolism

A10 - Drugs used in diabetes

A10A - Insulins and analogues

A10AB - Insulins and analogues for injection, fast-acting

A10AB04 - Insulin lispro


A - Alimentary tract and metabolism

A10 - Drugs used in diabetes

A10A - Insulins and analogues

A10AC - Insulins and analogues for injection, intermediate-acting

A10AC04 - Insulin lispro


A - Alimentary tract and metabolism

A10 - Drugs used in diabetes

A10A - Insulins and analogues

A10AD - Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting

A10AD04 - Insulin lispro


5.5 Absorption, Distribution and Excretion

Absorption

Insulin lispro is rapidly absorbed following subcutaneous administration. It is also absorbed more quickly than regular human insulin. Peak serum levels occur 30-90 minutes after injection in healthy subjects. Absorption also differs depending on the site of injection. After insulin lispro was administered in the abdomen, serum drug levels were higher and the duration of action was slightly shorter than after deltoid or thigh administration. The absolute bioavailability after subcutaneous injection ranges from 55% to 77% with doses between 0.1 to 0.2 unit/kg, inclusive. The mean observed area under the serum insulin concentration-time curve from time zero to infinity was 2360 pmol hr/L and 2390 pmol hr/L for HUMALOG U-200 and HUMALOG U-100, respectively. The corresponding mean peak serum insulin concentration was 795 pmol/L and 909 pmol/L for HUMALOG U-200 and HUMALOG U-100, respectively. The median time to maximum concentration was 1.0 hour for both formulations.


Volume of Distribution

When administered intravenously as bolus injections of 0.1 and 0.2 U/kg dose in two separate groups of healthy subjects, the mean volume of distribution of insulin lispro appeared to decrease with increase in dose (1.55 and 0.72 L/kg, respectively).


Clearance

Clearance is dose dependent. When a dose of 0.1 unit/kg and 0.2 unit/kg were administered intravenously, the mean clearance was 21.0 mL/min/kg and 9.6 mL/min/kg respectively.


5.6 Metabolism/Metabolites

Insulin is predominantly cleared by metabolic degradation via a receptor-mediated process.


5.7 Biological Half-Life

After subcutaneous administration of insulin lispro, the t1/2 is shorter than that of regular human insulin (1 versus 1.5 hours, respectively).


5.8 Mechanism of Action

Insulin lispro binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor autophosphorylates and phosphorylates numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. Activation of these proteins leads to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC), both of which play critical roles in metabolism and catabolism. In humans, insulin is stored in the form of hexamers; however, only insulin monomers are able to interact with IR. Reversal of the proline and lysine residues at positions B28 and B29 of native insulin eliminates hydrophobic interactions and weakens some of the hydrogen bonds that contribute to the stability of the insulin dimers that comprise insulin hexamers. Hexamers of insulin lispro are produced in the presence of zinc and m-cresol. These weakly associated hexamers quickly dissociate upon subcutaneous injection and are absorbed as monomers through vascular endothelial cells. These properties give insulin lispro its fast-acting properties.


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USDMF

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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 4846

Submission : 1983-03-11

Status : Inactive

Type : II

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02

World Dairy Expo
Not Confirmed

03

World Dairy Expo
Not Confirmed

03

04

Biocon Sdn Bhd

India

USDMF

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Not Confirmed

04

World Dairy Expo
Not Confirmed

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 32125

Submission : 2017-12-01

Status : Inactive

Type : II

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05

Biocon Ltd

India

USDMF

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Not Confirmed

05

Biocon Ltd

India
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Not Confirmed

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 27702

Submission : 2013-11-28

Status : Inactive

Type : II

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06

Novo Nordisk As

Denmark

USDMF

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Not Confirmed

06

Novo Nordisk As

Denmark
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Not Confirmed

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 5533

Submission : 1984-09-14

Status : Inactive

Type : II

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07

Novo Nordisk As

Denmark

USDMF

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07

Novo Nordisk As

Denmark
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World Dairy Expo
Not Confirmed

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 5527

Submission : 1984-09-14

Status : Inactive

Type : II

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JDMF

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01

World Dairy Expo
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Insulin lispro (genetical recombination)

Registration Number : 303MF10175

Registrant's Address : 65th Infantry Road, Km. 12.6, Carolina, Puerto Rico 00985

Initial Date of Registration : 2021-12-09

Latest Date of Registration : 2021-12-09

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02

World Dairy Expo
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Insulin lispro (genetical recombination)

Registration Number : 226MF10225

Registrant's Address : Lilly Corporate Center, Indianapolis, Indiana 46285, USA

Initial Date of Registration : 2014-12-08

Latest Date of Registration : 2017-12-25

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03

World Dairy Expo
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Insulin lispro (genetical recombination)

Registration Number : 217MF10534

Registrant's Address : Lilly Corporate Center, Indianapolis, Indiana 46285, USA

Initial Date of Registration : 2005-09-09

Latest Date of Registration : 2017-12-25

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04

World Dairy Expo
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Insulin lispro (genetical recombination)

Registration Number : 229MF10064

Registrant's Address : 65th Infantry Road, Km. 12.6, Carolina, Puerto Rico 00985

Initial Date of Registration : 2017-03-13

Latest Date of Registration : 2017-12-25

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05

World Dairy Expo
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Insulin lispro (genetical recombination)

Registration Number : 219MF10053

Registrant's Address : 65th Infantry Road, Km. 12.6, Carolina, Puerto Rico 00985

Initial Date of Registration : 2007-03-05

Latest Date of Registration : 2017-12-25

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Listed Suppliers

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01

World Dairy Expo
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Insulin Lispro

About the Company : Wanbang Biopharmaceuticals is a leading anti-diabetic pharmaceutical company in China and a core member of Fosun Group (SH600196; HK02196). Wanbang Biopharma has been focusing at t...

Wanbang Biopharmaceuticals is a leading anti-diabetic pharmaceutical company in China and a core member of Fosun Group (SH600196; HK02196). Wanbang Biopharma has been focusing at the development, manufacture and sale of pharmaceuticals to address the unmet medical needs in the area of diabetic disease since its establishment in 1981.As the pioneer insulin producer in China, Wanbang has been developed into the largest anti-diabetic pharmaceutical provider of China with a comprehensive product portfolio that covers a wide range of anti-diabetic drugs, serving for more than eight million diabetic patients.
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Drugs in Development

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Details:

Insulin Lispro is a Peptide drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Diabetes Mellitus, Type 1.


Lead Product(s): Insulin Lispro,Inapplicable

Therapeutic Area: Endocrinology Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Peptide, Unconjugated

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable April 04, 2019

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Sanofi

France
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Lead Product(s) : Insulin Lispro,Inapplicable

Therapeutic Area : Endocrinology

Highest Development Status : Phase I

Partner/Sponsor/Collaborator : Undisclosed

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : Insulin Lispro is a Peptide drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Diabetes Mellitus, Type 1.

Product Name : Undisclosed

Product Type : Peptide, Unconjugated

Upfront Cash : Inapplicable

April 04, 2019

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Details:

Insulin Glargine is a Peptide drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Diabetes Mellitus, Type 1.


Lead Product(s): Insulin Glargine,Insulin Lispro,Insulin aspart,Insulin Glulisine

Therapeutic Area: Endocrinology Brand Name: Undisclosed

Study Phase: Phase IVProduct Type: Peptide, Unconjugated

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable August 24, 2017

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02

Sanofi

France
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Lead Product(s) : Insulin Glargine,Insulin Lispro,Insulin aspart,Insulin Glulisine

Therapeutic Area : Endocrinology

Highest Development Status : Phase IV

Partner/Sponsor/Collaborator : Undisclosed

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : Insulin Glargine is a Peptide drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Diabetes Mellitus, Type 1.

Product Name : Undisclosed

Product Type : Peptide, Unconjugated

Upfront Cash : Inapplicable

August 24, 2017

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Details:

SAR342434 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Diabetes Mellitus, Type 1.


Lead Product(s): SAR342434,Insulin Lispro

Therapeutic Area: Endocrinology Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Undisclosed

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable November 11, 2015

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03

Sanofi

France
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Lead Product(s) : SAR342434,Insulin Lispro

Therapeutic Area : Endocrinology

Highest Development Status : Phase I

Partner/Sponsor/Collaborator : Undisclosed

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : SAR342434 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Diabetes Mellitus, Type 1.

Product Name : Undisclosed

Product Type : Undisclosed

Upfront Cash : Inapplicable

November 11, 2015

Sanofi Company Banner

Details:

Human Insulin is a Protein drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Diabetes Mellitus, Type 2.


Lead Product(s): Insulin Lispro,Inapplicable

Therapeutic Area: Endocrinology Brand Name: Undisclosed

Study Phase: Phase IVProduct Type: Protein

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable June 28, 2012

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04

Sanofi

France
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Lead Product(s) : Insulin Lispro,Inapplicable

Therapeutic Area : Endocrinology

Highest Development Status : Phase IV

Partner/Sponsor/Collaborator : Undisclosed

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : Human Insulin is a Protein drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Diabetes Mellitus, Type 2.

Product Name : Undisclosed

Product Type : Protein

Upfront Cash : Inapplicable

June 28, 2012

Sanofi Company Banner

Details:

Human Insulin is a Protein drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Diabetes Mellitus, Type 2.


Lead Product(s): Insulin Lispro,Inapplicable

Therapeutic Area: Endocrinology Brand Name: Undisclosed

Study Phase: Phase IIIProduct Type: Protein

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable May 13, 2011

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05

Sanofi

France
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Lead Product(s) : Insulin Lispro,Inapplicable

Therapeutic Area : Endocrinology

Highest Development Status : Phase III

Partner/Sponsor/Collaborator : Undisclosed

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : Human Insulin is a Protein drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Diabetes Mellitus, Type 2.

Product Name : Undisclosed

Product Type : Protein

Upfront Cash : Inapplicable

May 13, 2011

Sanofi Company Banner

Details:

Human Insulin is a Protein drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Diabetes Mellitus, Type 1.


Lead Product(s): Insulin Lispro,Inapplicable

Therapeutic Area: Endocrinology Brand Name: Undisclosed

Study Phase: Phase IIIProduct Type: Protein

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable September 03, 2010

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06

Sanofi

France
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Lead Product(s) : Insulin Lispro,Inapplicable

Therapeutic Area : Endocrinology

Highest Development Status : Phase III

Partner/Sponsor/Collaborator : Undisclosed

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : Human Insulin is a Protein drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Diabetes Mellitus, Type 1.

Product Name : Undisclosed

Product Type : Protein

Upfront Cash : Inapplicable

September 03, 2010

Sanofi Company Banner
  • Development Update

Details:

Haloperidol is a Other Small Molecule drug candidate, which is currently being evaluated in Phase IV clinical studies for the treatment of unspecified medical condition.


Lead Product(s): Haloperidol,Insulin Lispro,Sodium Chloride

Therapeutic Area: Undisclosed Brand Name: Undisclosed

Study Phase: Phase IVProduct Type: Miscellaneous

Sponsor: Physician Services Incorporated

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable August 07, 2025

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07

Centre for Addiction and Mental Health

Country
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Centre for Addiction and Mental Health

Country
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Not Confirmed

Details : Haloperidol is a Other Small Molecule drug candidate, which is currently being evaluated in Phase IV clinical studies for the treatment of unspecified medical condition.

Product Name : Undisclosed

Product Type : Miscellaneous

Upfront Cash : Inapplicable

August 07, 2025

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Details:

Through the acquisition, Lupin will enhance its portfolio and gain the right to commercialize Humulin N (human insulin) in India. It is indicated for the treatment of diabetes mellitus.


Lead Product(s): Insulin Lispro,Inapplicable

Therapeutic Area: Endocrinology Brand Name: Humulin N

Study Phase: Approved FDFProduct Type: Peptide, Unconjugated

Sponsor: Lupin Ltd

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Acquisition December 30, 2024

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08

Eli Lilly

U.S.A
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Not Confirmed

Eli Lilly

U.S.A
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Not Confirmed

Details : Through the acquisition, Lupin will enhance its portfolio and gain the right to commercialize Humulin N (human insulin) in India. It is indicated for the treatment of diabetes mellitus.

Product Name : Humulin N

Product Type : Peptide, Unconjugated

Upfront Cash : Undisclosed

December 30, 2024

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Details:

Humalog (insulin) is a peptide based drug, works by showing agonistic action for GLP-1R, mainly indicated for the treatment of patients with type 1 and 2 diabetes.


Lead Product(s): Insulin Lispro,Inapplicable

Therapeutic Area: Endocrinology Brand Name: Humalog

Study Phase: Approved FDFProduct Type: Peptide, Unconjugated

Sponsor: Eli Lilly

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable December 17, 2024

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09

Eva Pharma

Egypt
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World Dairy Expo
Not Confirmed

Eva Pharma

Egypt
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World Dairy Expo
Not Confirmed

Details : Humalog (insulin) is a peptide based drug, works by showing agonistic action for GLP-1R, mainly indicated for the treatment of patients with type 1 and 2 diabetes.

Product Name : Humalog

Product Type : Peptide, Unconjugated

Upfront Cash : Inapplicable

December 17, 2024

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Details:

Insulin Lispro is a Peptide drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Diabetes Mellitus, Type 2.


Lead Product(s): Insulin Lispro,Insulin Glargine

Therapeutic Area: Endocrinology Brand Name: Undisclosed

Study Phase: Phase IVProduct Type: Peptide, Unconjugated

Sponsor: Cipla

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable April 17, 2024

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10

Eli Lilly

U.S.A
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Not Confirmed

Eli Lilly

U.S.A
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World Dairy Expo
Not Confirmed

Details : Insulin Lispro is a Peptide drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Diabetes Mellitus, Type 2.

Product Name : Undisclosed

Product Type : Peptide, Unconjugated

Upfront Cash : Inapplicable

April 17, 2024

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FDA Orange Book

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Digital Content Digital Content

RLD :

TE Code :

INSULIN LISPRO

Brand Name : ADMELOG

Dosage Form : SOLUTION;INTRAVENOUS, SUBCUTANEOUS

Dosage Strength : 1000 UNITS/10ML (100 UNITS/ML)

Approval Date :

Application Number : 209196

RX/OTC/DISCN :

RLD :

TE Code :

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Digital Content Digital Content

RLD :

TE Code :

INSULIN LISPRO

Brand Name : ADMELOG SOLOSTAR

Dosage Form : SOLUTION;INTRAVENOUS, SUBCUTANEOUS

Dosage Strength : 300 UNITS/3ML (100 UNITS/ML)

Approval Date :

Application Number : 209196

RX/OTC/DISCN :

RLD :

TE Code :

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Digital Content Digital Content

RLD :

TE Code :

INSULIN LISPRO

Brand Name : ADMELOG

Dosage Form : SOLUTION;INTRAVENOUS, SUBCUTANEOUS

Dosage Strength : 300 UNITS/3ML (100 UNITS/ML)

Approval Date :

Application Number : 209196

RX/OTC/DISCN :

RLD :

TE Code :

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Europe

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Regulatory Info :

Registration Country : Norway

Insulin Lispro

Brand Name : Insuman Basal

Dosage Form : Injection fluid, suspension

Dosage Strength : 100 IE/ml

Packaging : Hood glass

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Digital Content Digital Content

Regulatory Info :

Registration Country : Norway

Insulin Lispro

Brand Name : Insuman Comb 25

Dosage Form : Injection fluid, suspension

Dosage Strength : 100 IE/ml

Packaging : Sylinderampulle

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Regulatory Info :

Registration Country : Norway

Insulin Lispro

Brand Name : Insuman Rapid

Dosage Form : Injection fluid, resolution

Dosage Strength : 100 IE/ml

Packaging : Sylinderampulle

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Regulatory Info : Approved

Registration Country : Sweden

Human Insulin (Soluble)

Brand Name : Insuman Infusat

Dosage Form : Injectable Solution

Dosage Strength : 100IU/ml

Packaging :

Approval Date : 11/11/1998

Application Number : 19970221000111

Regulatory Info : Approved

Registration Country : Sweden

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Regulatory Info : Approved

Registration Country : Sweden

Human Insulin (Soluble); Human Insulin Isophane (NPH)

Brand Name : Insuman Comb 25 Solostar

Dosage Form : Suspension For Injection

Dosage Strength : 100IU/ml

Packaging :

Approval Date : 31/10/2008

Application Number : 20081016000103

Regulatory Info : Approved

Registration Country : Sweden

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Regulatory Info : Approved

Registration Country : Sweden

Human Insulin (Soluble); Human Insulin Isophane (NPH)

Brand Name : Insuman Comb 50

Dosage Form : Injectable Solution

Dosage Strength : 100IU/ml

Packaging :

Approval Date : 11/11/1998

Application Number : 19970221000098

Regulatory Info : Approved

Registration Country : Sweden

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Regulatory Info : Deregistered

Registration Country : Sweden

Human Insulin (Soluble); Human Insulin Isophane (NPH)

Brand Name : Insulin Human Winthrop Comb 15

Dosage Form : Injectable Solution

Dosage Strength : 100IU/ml

Packaging :

Approval Date : 17/01/2007

Application Number : 20060824000116

Regulatory Info : Deregistered

Registration Country : Sweden

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Digital Content Digital Content

Regulatory Info : Deregistered

Registration Country : Sweden

Human Insulin (Soluble); Human Insulin Isophane (NPH)

Brand Name : Insulin Human Winthrop Comb 25

Dosage Form : Injectable Solution

Dosage Strength : 100IU/ml

Packaging :

Approval Date : 17/01/2007

Application Number : 20060824000147

Regulatory Info : Deregistered

Registration Country : Sweden

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Flag France
Digital Content Digital Content

Regulatory Info : Deregistered

Registration Country : Sweden

Human Insulin (Soluble); Human Insulin Isophane (NPH)

Brand Name : Insulin Human Winthrop Comb 25

Dosage Form : Injectable Solution

Dosage Strength : 100IU/ml

Packaging :

Approval Date : 17/01/2007

Application Number : 20060824000154

Regulatory Info : Deregistered

Registration Country : Sweden

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  • fda
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  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Flag France
Digital Content Digital Content

Regulatory Info : Deregistered

Registration Country : Sweden

Human Insulin (Soluble); Human Insulin Isophane (NPH)

Brand Name : Insulin Human Winthrop Comb 30

Dosage Form : Injectable Solution

Dosage Strength : 100IU/ml

Packaging :

Approval Date : 19/02/2009

Application Number : 20080112000109

Regulatory Info : Deregistered

Registration Country : Sweden

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Canada

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Regulatory Info : Schedule D

Registration Country : Canada

INSULIN LISPRO

Brand Name : ADMELOG

Dosage Form : SOLUTION

Dosage Strength : 100UNIT/ML

Packaging : 3ML CARTRIDGE

Approval Date :

Application Number : 2469898

Regulatory Info : Schedule D

Registration Country : Canada

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Regulatory Info : Schedule D

Registration Country : Canada

INSULIN LISPRO

Brand Name : ADMELOG SOLOSTAR

Dosage Form : SOLUTION

Dosage Strength : 100UNIT/ML

Packaging : 3ML PREFILLED PEN

Approval Date :

Application Number : 2469871

Regulatory Info : Schedule D

Registration Country : Canada

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Regulatory Info : Schedule D

Registration Country : Canada

INSULIN LISPRO

Brand Name : ADMELOG

Dosage Form : SOLUTION

Dosage Strength : 100UNIT/ML

Packaging : 10ML VIAL

Approval Date :

Application Number : 2469901

Regulatory Info : Schedule D

Registration Country : Canada

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World Dairy Expo
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INSULIN LISPRO

Brand Name : HUMALOG

Dosage Form : SOLUTION

Dosage Strength : 100UNIT/ML

Packaging : 3/10ML

Approval Date :

Application Number : 2229704

Regulatory Info : Schedule D

Registration Country : Canada

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World Dairy Expo
Not Confirmed
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INSULIN LISPRO

Brand Name : HUMALOG (CARTRIDGE)

Dosage Form : SOLUTION

Dosage Strength : 100UNIT/ML

Packaging : 1.5/3ML

Approval Date :

Application Number : 2229705

Regulatory Info : Schedule D

Registration Country : Canada

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INSULIN LISPRO PROTAMINE SUSPENSION

Brand Name : HUMALOG MIX 50 (CARTRIDGE)

Dosage Form : SUSPENSION

Dosage Strength : 50UNIT/ML

Packaging : 3.0ML

Approval Date :

Application Number : 2240297

Regulatory Info : Schedule D

Registration Country : Canada

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World Dairy Expo
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World Dairy Expo
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INSULIN LISPRO

Brand Name : HUMALOG MIX 50 (CARTRIDGE)

Dosage Form : SUSPENSION

Dosage Strength : 50UNIT/ML

Packaging : 3.0ML

Approval Date :

Application Number : 2240297

Regulatory Info : Schedule D

Registration Country : Canada

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World Dairy Expo
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World Dairy Expo
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INSULIN LISPRO PROTAMINE SUSPENSION

Brand Name : HUMALOG MIX 25 (KWIKPEN)

Dosage Form : SUSPENSION

Dosage Strength : 75UNIT/ML

Packaging :

Approval Date :

Application Number : 2403420

Regulatory Info : Schedule D

Registration Country : Canada

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World Dairy Expo
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INSULIN LISPRO PROTAMINE SUSPENSION

Brand Name : HUMALOG MIX 50 (KWIKPEN)

Dosage Form : SUSPENSION

Dosage Strength : 50UNIT/ML

Packaging : 3ML/PEN

Approval Date :

Application Number : 2403439

Regulatory Info : Schedule D

Registration Country : Canada

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World Dairy Expo
Not Confirmed
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INSULIN LISPRO

Brand Name : HUMALOG 200 UNITS/ML KWIKPEN

Dosage Form : SOLUTION

Dosage Strength : 200UNIT/ML

Packaging : 3ML

Approval Date :

Application Number : 2439611

Regulatory Info : Schedule D

Registration Country : Canada

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Australia

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World Dairy Expo
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Insulin lispro

Brand Name : Humalog U200 Kwikpen

Dosage Form :

Dosage Strength :

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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World Dairy Expo
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Insulin lispro

Brand Name : Humalog KwikPen

Dosage Form :

Dosage Strength :

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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World Dairy Expo
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World Dairy Expo
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Insulin lispro

Brand Name : Humalog

Dosage Form :

Dosage Strength :

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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World Dairy Expo
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World Dairy Expo
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Insulin lispro

Brand Name : Humalog

Dosage Form :

Dosage Strength :

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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Company : Sanofi-Aventis

Insulin Lispro

Drug Cost (USD) : 1,393,724

Year : 2023

Prescribers : 4971

Prescriptions : 10933

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Company : Sanofi-Aventis

Insulin Lispro

Drug Cost (USD) : 4,074,927

Year : 2023

Prescribers : 11113

Prescriptions : 24807

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Company : Eli Lilly & Co.

Insulin Lispro

Drug Cost (USD) : 458,058,582

Year : 2023

Prescribers : 156031

Prescriptions : 572082

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Company : Eli Lilly & Co.

Insulin Lispro

Drug Cost (USD) : 9,905,950

Year : 2023

Prescribers : 5648

Prescriptions : 15111

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Company : Eli Lilly & Co.

Insulin Lispro

Drug Cost (USD) : 1,208,385,334

Year : 2023

Prescribers : 418431

Prescriptions : 1363952

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World Dairy Expo
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Company : Eli Lilly & Co.

Insulin Lispro

Drug Cost (USD) : 224,440,404

Year : 2023

Prescribers : 40611

Prescriptions : 143978

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Company : Eli Lilly & Co.

Insulin Lispro Protamin/Lispro

Drug Cost (USD) : 6,085,553

Year : 2023

Prescribers : 1297

Prescriptions : 6483

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Company : Eli Lilly & Co.

Insulin Lispro Protamin/Lispro

Drug Cost (USD) : 20,294,452

Year : 2023

Prescribers : 3890

Prescriptions : 16268

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Company : Eli Lilly & Co.

Insulin Lispro Protamin/Lispro

Drug Cost (USD) : 59,917,382

Year : 2023

Prescribers : 12749

Prescriptions : 62177

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Company : Eli Lilly & Co.

Insulin Lispro Protamin/Lispro

Drug Cost (USD) : 213,875,690

Year : 2023

Prescribers : 40527

Prescriptions : 171187

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01

Brand Name : Admelog/Insulin Lispro

France
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Insulin Lispro

Main Therapeutic Indication : Diabetes

Currency : USD

2019 Revenue in Millions : 273

2018 Revenue in Millions : 101

Growth (%) : 169

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02

Brand Name : Admelog/Insulin Lispro

France
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Insulin Lispro

Main Therapeutic Indication : Diabetes

Currency : USD

2018 Revenue in Millions : 105

2017 Revenue in Millions : 0

Growth (%) : NA

Sanofi Company Banner

03

Brand Name : Humalog

Insulin Lispro

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World Dairy Expo
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Brand Name : Humalog

U.S.A
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Insulin Lispro

Main Therapeutic Indication : Diabetes

Currency : USD

2020 Revenue in Millions : 2,626

2019 Revenue in Millions : 2,821

Growth (%) : -7

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Brand Name : Humalog

Insulin Lispro

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World Dairy Expo
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Brand Name : Humalog

U.S.A
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World Dairy Expo
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Insulin Lispro

Main Therapeutic Indication : Diabetes

Currency : USD

2021 Revenue in Millions : 2,453

2020 Revenue in Millions : 2,626

Growth (%) : -7

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Brand Name : Humalog

Insulin Lispro

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World Dairy Expo
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Brand Name : Humalog

U.S.A
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World Dairy Expo
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Insulin Lispro

Main Therapeutic Indication : Diabetes

Currency : USD

2022 Revenue in Millions : 2,061

2021 Revenue in Millions : 2,453

Growth (%) : -16

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Brand Name : Humalog

Insulin Lispro

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World Dairy Expo
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Brand Name : Humalog

U.S.A
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World Dairy Expo
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Insulin Lispro

Main Therapeutic Indication : Diabetes

Currency : USD

2023 Revenue in Millions : 1,663

2022 Revenue in Millions : 2,061

Growth (%) : -19

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Brand Name : Humalog

Insulin Lispro

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World Dairy Expo
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Brand Name : Humalog

U.S.A
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World Dairy Expo
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Insulin Lispro

Main Therapeutic Indication : Diabetes

Currency : USD

2024 Revenue in Millions : 2,325

2023 Revenue in Millions : 1,663

Growth (%) : 40

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Brand Name : Humalog

Insulin Lispro

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Brand Name : Humalog

U.S.A
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Insulin Lispro

Main Therapeutic Indication : Diabetes

Currency : USD

2015 Revenue in Millions : 2,785

2014 Revenue in Millions : 2,842

Growth (%) : 2%

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Brand Name : Humalog

Insulin Lispro

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Brand Name : Humalog

U.S.A
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Insulin Lispro

Main Therapeutic Indication : Diabetes

Currency : USD

2014 Revenue in Millions : 6.70%

2013 Revenue in Millions :

Growth (%) :

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Brand Name : Humalog

Insulin Lispro

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Brand Name : Humalog

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Insulin Lispro

Main Therapeutic Indication : Diabetes

Currency : USD

2016 Revenue in Millions : 2,769

2015 Revenue in Millions : 2,842

Growth (%) : -3

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ABOUT THIS PAGE

Looking for 133107-64-9 / Insulin Lispro API manufacturers, exporters & distributors?

Insulin Lispro manufacturers, exporters & distributors 1

41

PharmaCompass offers a list of Insulin Lispro API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Insulin Lispro manufacturer or Insulin Lispro supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Insulin Lispro manufacturer or Insulin Lispro supplier.

PharmaCompass also assists you with knowing the Insulin Lispro API Price utilized in the formulation of products. Insulin Lispro API Price is not always fixed or binding as the Insulin Lispro Price is obtained through a variety of data sources. The Insulin Lispro Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Insulin Lispro

Synonyms

133107-64-9, Insulin lispro (5.97 mg), Insulin-lispro, Dtxsid90157956

Cas Number

133107-64-9

About Insulin Lispro

Insulin that has been modified so that the B-chain contains a LYSINE at position 28 instead of a PROLINE and a PROLINE at position 29 instead of a LYSINE. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES.

Insulin Lispro Manufacturers

A Insulin Lispro manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Insulin Lispro, including repackagers and relabelers. The FDA regulates Insulin Lispro manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Insulin Lispro API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Insulin Lispro manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Insulin Lispro Suppliers

A Insulin Lispro supplier is an individual or a company that provides Insulin Lispro active pharmaceutical ingredient (API) or Insulin Lispro finished formulations upon request. The Insulin Lispro suppliers may include Insulin Lispro API manufacturers, exporters, distributors and traders.

click here to find a list of Insulin Lispro suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Insulin Lispro USDMF

A Insulin Lispro DMF (Drug Master File) is a document detailing the whole manufacturing process of Insulin Lispro active pharmaceutical ingredient (API) in detail. Different forms of Insulin Lispro DMFs exist exist since differing nations have different regulations, such as Insulin Lispro USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Insulin Lispro DMF submitted to regulatory agencies in the US is known as a USDMF. Insulin Lispro USDMF includes data on Insulin Lispro's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Insulin Lispro USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Insulin Lispro suppliers with USDMF on PharmaCompass.

Insulin Lispro JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Insulin Lispro Drug Master File in Japan (Insulin Lispro JDMF) empowers Insulin Lispro API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Insulin Lispro JDMF during the approval evaluation for pharmaceutical products. At the time of Insulin Lispro JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Insulin Lispro suppliers with JDMF on PharmaCompass.

Insulin Lispro GMP

Insulin Lispro Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Insulin Lispro GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Insulin Lispro GMP manufacturer or Insulin Lispro GMP API supplier for your needs.

Insulin Lispro CoA

A Insulin Lispro CoA (Certificate of Analysis) is a formal document that attests to Insulin Lispro's compliance with Insulin Lispro specifications and serves as a tool for batch-level quality control.

Insulin Lispro CoA mostly includes findings from lab analyses of a specific batch. For each Insulin Lispro CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Insulin Lispro may be tested according to a variety of international standards, such as European Pharmacopoeia (Insulin Lispro EP), Insulin Lispro JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Insulin Lispro USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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