Find Imofinostat manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

0

USDMF

0

CEP/COS

0

JDMF

0

EU WC

0

KDMF

0

NDC API

0

VMF

0

Listed Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

0

FDA Orange Book

0

Europe

0

Canada

0

Australia

0

South Africa

0

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Regulatory FDF Prices

NA

MARKET PLACE

0

API

0

FDF

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Mpt0e028, 1338320-94-7, T65l58fi65, (e)-3-[1-(benzenesulfonyl)-2,3-dihydroindol-5-yl]-n-hydroxyprop-2-enamide, 2-propenamide, 3-(2,3-dihydro-1-(phenylsulfonyl)-1h-indol-5-yl)-n-hydroxy-, Imofinostat
Molecular Formula
C17H16N2O4S
Molecular Weight
344.4  g/mol
InChI Key
MGTIFSBCGGAZDB-VQHVLOKHSA-N
FDA UNII
T65L58FI65

Imofinostat
Imofinostat is an orally bioavailable N-hydroxyacrylamide-derived inhibitor of both human pan-histone deacetylase (HDAC) enzymes and the serine/threonine protein kinase Akt (protein kinase B), with potential antineoplastic activity. Upon administration, imofinostat selectively binds to and inhibits HDACs, which inhibits deacetylation of histone proteins and leads to the accumulation of highly acetylated histones. This may result in both an induction of chromatin remodeling, and the selective transcription of tumor suppressor genes. This prevents cell division and induces both cell cycle arrest and apoptosis, which may inhibit the proliferation of susceptible tumor cells. In addition, imofinostat inhibits the phosphorylation and activation of Akt, which prevents the activation of downstream signaling pathways, independent of its HDAC inhibitory activity. HDACs, upregulated in many tumor cell types, are a family of enzymes that deacetylate histone proteins. Akt, overexpressed in many tumor cell types, plays a key role in tumor cell proliferation and survival.
1 2D Structure

Imofinostat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(E)-3-[1-(benzenesulfonyl)-2,3-dihydroindol-5-yl]-N-hydroxyprop-2-enamide
2.1.2 InChI
InChI=1S/C17H16N2O4S/c20-17(18-21)9-7-13-6-8-16-14(12-13)10-11-19(16)24(22,23)15-4-2-1-3-5-15/h1-9,12,21H,10-11H2,(H,18,20)/b9-7+
2.1.3 InChI Key
MGTIFSBCGGAZDB-VQHVLOKHSA-N
2.2 Other Identifiers
2.2.1 UNII
T65L58FI65
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Mpt0e028

2. 1338320-94-7

3. T65l58fi65

4. (e)-3-[1-(benzenesulfonyl)-2,3-dihydroindol-5-yl]-n-hydroxyprop-2-enamide

5. 2-propenamide, 3-(2,3-dihydro-1-(phenylsulfonyl)-1h-indol-5-yl)-n-hydroxy-

6. Imofinostat

7. Unii-t65l58fi65

8. Imofinostat [inn]

9. Orb1706952

10. Schembl2511433

11. Mgtifsbcggazdb-vqhvlokhsa-n

12. Glxc-04031

13. Akos040742169

14. Ms-25283

15. Sy461501

16. Hy-124295

17. Cs-0086144

18. G16985

19. Q27289720

20. (e)-n-hydroxy-3-[1-(phenylsulfonyl)indolin-5-yl]acrylamide

21. (2e)-3-[1-(benzenesulfonyl)-2,3-dihydro-1h-indol-5-yl]-n-hydroxyprop-2-enamide

2.4 Create Date
2011-10-31
3 Chemical and Physical Properties
Molecular Weight 344.4 g/mol
Molecular Formula C17H16N2O4S
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area95.1
Heavy Atom Count24
Formal Charge0
Complexity578
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Looking for 1338320-94-7 / Imofinostat API manufacturers, exporters & distributors?

Imofinostat manufacturers, exporters & distributors 1

70

PharmaCompass offers a list of Imofinostat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Imofinostat manufacturer or Imofinostat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Imofinostat manufacturer or Imofinostat supplier.

API | Excipient name

Imofinostat

Synonyms

Mpt0e028, 1338320-94-7, T65l58fi65, (e)-3-[1-(benzenesulfonyl)-2,3-dihydroindol-5-yl]-n-hydroxyprop-2-enamide, 2-propenamide, 3-(2,3-dihydro-1-(phenylsulfonyl)-1h-indol-5-yl)-n-hydroxy-, Unii-t65l58fi65

Cas Number

1338320-94-7

Unique Ingredient Identifier (UNII)

T65L58FI65

About Imofinostat

Imofinostat is an orally bioavailable N-hydroxyacrylamide-derived inhibitor of both human pan-histone deacetylase (HDAC) enzymes and the serine/threonine protein kinase Akt (protein kinase B), with potential antineoplastic activity. Upon administration, imofinostat selectively binds to and inhibits HDACs, which inhibits deacetylation of histone proteins and leads to the accumulation of highly acetylated histones. This may result in both an induction of chromatin remodeling, and the selective transcription of tumor suppressor genes. This prevents cell division and induces both cell cycle arrest and apoptosis, which may inhibit the proliferation of susceptible tumor cells. In addition, imofinostat inhibits the phosphorylation and activation of Akt, which prevents the activation of downstream signaling pathways, independent of its HDAC inhibitory activity. HDACs, upregulated in many tumor cell types, are a family of enzymes that deacetylate histone proteins. Akt, overexpressed in many tumor cell types, plays a key role in tumor cell proliferation and survival.

Imofinostat Manufacturers

A Imofinostat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Imofinostat, including repackagers and relabelers. The FDA regulates Imofinostat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Imofinostat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Imofinostat Suppliers

A Imofinostat supplier is an individual or a company that provides Imofinostat active pharmaceutical ingredient (API) or Imofinostat finished formulations upon request. The Imofinostat suppliers may include Imofinostat API manufacturers, exporters, distributors and traders.

Imofinostat GMP

Imofinostat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Imofinostat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Imofinostat GMP manufacturer or Imofinostat GMP API supplier for your needs.

Imofinostat CoA

A Imofinostat CoA (Certificate of Analysis) is a formal document that attests to Imofinostat's compliance with Imofinostat specifications and serves as a tool for batch-level quality control.

Imofinostat CoA mostly includes findings from lab analyses of a specific batch. For each Imofinostat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Imofinostat may be tested according to a variety of international standards, such as European Pharmacopoeia (Imofinostat EP), Imofinostat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Imofinostat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty