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Chemistry

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Also known as: Scy-078 citrate, M4nu2sdx3e, Ibrexafungerp citrate [usan], 1965291-08-0, Ibrexafungerp citrate (usan), Brexafemme
Molecular Formula
C50H75N5O11
Molecular Weight
922.2  g/mol
InChI Key
WKIRTJACGBEXBZ-FQGZCCSZSA-N
FDA UNII
M4NU2SDX3E

Ibrexafungerp Citrate
1 2D Structure

Ibrexafungerp Citrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1R,5S,6R,7R,10R,11R,14R,15S,20R,21R)-21-[(2R)-2-amino-2,3,3-trimethylbutoxy]-5,7,10,15-tetramethyl-7-[(2R)-3-methylbutan-2-yl]-20-(5-pyridin-4-yl-1,2,4-triazol-1-yl)-17-oxapentacyclo[13.3.3.01,14.02,11.05,10]henicos-2-ene-6-carboxylic acid;2-hydroxypropane-1,2,3-tricarboxylic acid
2.1.2 InChI
InChI=1S/C44H67N5O4.C6H8O7/c1-27(2)28(3)39(7)18-19-41(9)30-12-13-33-40(8)23-52-25-44(33,31(30)14-17-42(41,10)34(39)37(50)51)22-32(35(40)53-24-43(11,45)38(4,5)6)49-36(47-26-48-49)29-15-20-46-21-16-29;7-3(8)1-6(13,5(11)12)2-4(9)10/h14-16,20-21,26-28,30,32-35H,12-13,17-19,22-25,45H2,1-11H3,(H,50,51);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t28-,30+,32-,33+,34-,35+,39-,40-,41-,42+,43+,44+;/m1./s1
2.1.3 InChI Key
WKIRTJACGBEXBZ-FQGZCCSZSA-N
2.1.4 Canonical SMILES
CC(C)C(C)C1(CCC2(C3CCC4C5(COCC4(C3=CCC2(C1C(=O)O)C)CC(C5OCC(C)(C(C)(C)C)N)N6C(=NC=N6)C7=CC=NC=C7)C)C)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
2.1.5 Isomeric SMILES
C[C@H](C(C)C)[C@]1(CC[C@@]2([C@H]3CC[C@H]4[C@]5(COC[C@]4(C3=CC[C@]2([C@@H]1C(=O)O)C)C[C@H]([C@@H]5OC[C@@](C)(C(C)(C)C)N)N6C(=NC=N6)C7=CC=NC=C7)C)C)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
2.2 Other Identifiers
2.2.1 UNII
M4NU2SDX3E
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Brexafemme

2. Ibrexafungerp

3. Mk-3118

4. Scy-078

2.3.2 Depositor-Supplied Synonyms

1. Scy-078 Citrate

2. M4nu2sdx3e

3. Ibrexafungerp Citrate [usan]

4. 1965291-08-0

5. Ibrexafungerp Citrate (usan)

6. Brexafemme

7. Unii-m4nu2sdx3e

8. Chembl4298168

9. Glxc-26020

10. Ibrexafungerp Citrate [who-dd]

11. Ibrexafungerp Citrate [orange Book]

12. D11545

13. (1s,4ar,6as,7r,8r,10ar,10br,12ar,14r,15r)-15-((2r)- 2-amino-2,3,3-trimethylbutoxy)-1,6a,8,10a-tetramethyl-8- ((2r)-3-methylbutan-2-yl)-14-(5-(pyridin-4-yl)-1h-1,2,4- Triazol-1-yl)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-2h,4h-1,4a-propanophenanthro(1,2-c)pyran-7-carboxylic Acid Compound With 2-hydroxypropane-1,2,3-tricarboxylic Acid (1:1)

14. 4h-1,4a-propano-2h-phenanthro(1,2-c)pyran-7-carboxylic Acid, 15-((2r)-2-amino-2,3,3-trimethylbutoxy)-8-((1r)-1,2-dimethylpropyl)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-14-(5-(4-pyridinyl)-1h-1,2,4-triazol-1-yl)-, (1s,4ar,6as

15. 4h-1,4a-propano-2h-phenanthro(1,2-c)pyran-7-carboxylic Acid, 15-((2r)-2-amino-2,3,3-trimethylbutoxy)-8-((1r)-1,2-dimethylpropyl)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-14-(5-(4-pyridinyl)-1h-1,2,4-triazol-1-yl)-, (1s,4ar,6as,7r,8r,10ar,10br,12ar,14r,15r)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

2.4 Create Date
2019-03-24
3 Chemical and Physical Properties
Molecular Weight 922.2 g/mol
Molecular Formula C50H75N5O11
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count15
Rotatable Bond Count14
Exact Mass921.54630823 g/mol
Monoisotopic Mass921.54630823 g/mol
Topological Polar Surface Area258 Ų
Heavy Atom Count66
Formal Charge0
Complexity1650
Isotope Atom Count0
Defined Atom Stereocenter Count12
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


API SUPPLIERS

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01

Metrochem API Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
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  • WHO-GMP

Virtual BoothMetrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
Metrochem

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Omgene Life Sciences Pvt. Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothOmgene: R&D-based biopharmaceutical company with GMP facilities, focused on innovation and high-quality, affordable medicines.

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Omgene Company Banner

03

BrightGene Bio-Medical Technology ...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIOHK2025
Not Confirmed
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API Reference Price

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[{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1655058600,"product":"IBREXAFUNGERP CITRATE","address":"SANALI INFO PARK, 8-2-120\/113,ROAD NO.2, BANJARA HILLS","city":"HYDERABAD,TELANGANA","supplier":"NEULAND LABORATORIES LTD","supplierCountry":"INDIA","foreign_port":"SHANGHAI","customer":"UNDISCLOSED","customerCountry":"CHINA","quantity":"0.01","actualQuantity":"10.1","unit":"GMS","unitRateFc":"2","totalValueFC":"25.6","currency":"USD","unitRateINR":198.01980198019803,"date":"13-Jun-2022","totalValueINR":"2000","totalValueInUsd":"25.6","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"2089903","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"SANALI INFO PARK, 8-2-120\/113,ROAD NO.2, BANJARA HILLS, HYDERABAD,TELANGANA","customerAddress":""}]
13-Jun-2022
13-Jun-2022
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Drugs in Development

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Details:

Undisclosed


Lead Product(s): Ibrexafungerp Citrate,Inapplicable

Therapeutic Area: Infections and Infectious Diseases Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable May 01, 2025

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01

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Details : Undisclosed

Product Name : Undisclosed

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

May 01, 2025

blank

Details:

Under the agreement, GSK has the rights to develop GSK5458448/SCY-078 (ibrexafungerp), a novel oral glucan synthase inhibitor and commercialize Brexafemme in all countries except the greater China.


Lead Product(s): Ibrexafungerp Citrate,Inapplicable

Therapeutic Area: Infections and Infectious Diseases Brand Name: Brexafemme

Study Phase: Phase II/ Phase IIIProduct Type: Other Small Molecule

Sponsor: GSK

Deal Size: $593.0 million Upfront Cash: $90.0 million

Deal Type: Licensing Agreement July 23, 2024

blank

02

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Details : Under the agreement, GSK has the rights to develop GSK5458448/SCY-078 (ibrexafungerp), a novel oral glucan synthase inhibitor and commercialize Brexafemme in all countries except the greater China.

Product Name : Brexafemme

Product Type : Other Small Molecule

Upfront Cash : $90.0 million

July 23, 2024

blank

Details:

GSK acquired the rights to develop and commercialize GSK5458448 (ibrexafungerp), a glucan synthase inhibitor, and market Brexafemme for antifungal indications outside China.


Lead Product(s): Ibrexafungerp Citrate,Caspofungin

Therapeutic Area: Infections and Infectious Diseases Brand Name: Brexafemme

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: GSK

Deal Size: $401.0 million Upfront Cash: $90.0 million

Deal Type: Licensing Agreement March 01, 2024

blank

03

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Details : GSK acquired the rights to develop and commercialize GSK5458448 (ibrexafungerp), a glucan synthase inhibitor, and market Brexafemme for antifungal indications outside China.

Product Name : Brexafemme

Product Type : Other Small Molecule

Upfront Cash : $90.0 million

March 01, 2024

blank

Details:

Under the agreement, GSK has the rights to develop ibrexafungerp, a novel oral glucan synthase inhibitor with a broad spectrum of activity and commercialize Brexafemme (ibrexafungerp tablets) in all countries except the greater China region.


Lead Product(s): Ibrexafungerp Citrate,Inapplicable

Therapeutic Area: Infections and Infectious Diseases Brand Name: Brexafemme

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: GSK

Deal Size: $593.0 million Upfront Cash: $90.0 million

Deal Type: Licensing Agreement December 05, 2023

blank

04

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Details : Under the agreement, GSK has the rights to develop ibrexafungerp, a novel oral glucan synthase inhibitor with a broad spectrum of activity and commercialize Brexafemme (ibrexafungerp tablets) in all countries except the greater China region.

Product Name : Brexafemme

Product Type : Other Small Molecule

Upfront Cash : $90.0 million

December 05, 2023

blank

Details:

Brexafemme (ibrexafungerp), a novel glucan synthase inhibitor, approved for vulvovaginal candidiasis and RVVC, is being develop in phase 3 trials for the potential treatment of invasive candidiasis.


Lead Product(s): Ibrexafungerp Citrate,Inapplicable

Therapeutic Area: Infections and Infectious Diseases Brand Name: Brexafemme

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Hansoh Pharma

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable July 20, 2023

blank

05

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Details : Brexafemme (ibrexafungerp), a novel glucan synthase inhibitor, approved for vulvovaginal candidiasis and RVVC, is being develop in phase 3 trials for the potential treatment of invasive candidiasis.

Product Name : Brexafemme

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

July 20, 2023

blank

Details:

Under the agreement GSK gains right to commercialize Brexafemme (ibrexafungerp), a novel glucan synthase inhibitor, for vulvovaginal candidiasis and RVVC while continuing to develop ibrexafungerp, in phase 3 trials for the potential treatment of invasive candidiasis.


Lead Product(s): Ibrexafungerp Citrate,Caspofungin

Therapeutic Area: Infections and Infectious Diseases Brand Name: Brexafemme

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: GSK

Deal Size: $593.0 million Upfront Cash: $90.0 million

Deal Type: Licensing Agreement June 21, 2023

blank

06

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Details : Under the agreement GSK gains right to commercialize Brexafemme (ibrexafungerp), a novel glucan synthase inhibitor, for vulvovaginal candidiasis and RVVC while continuing to develop ibrexafungerp, in phase 3 trials for the potential treatment of invasive...

Product Name : Brexafemme

Product Type : Other Small Molecule

Upfront Cash : $90.0 million

June 21, 2023

blank

Details:

Under the agreement, GSK gains rights to commercialise Brexafemme, a first-in-class antifungal for the treatment of VVC and for reduction in the incidence of RVVC while continuing to develop ibrexafungerp, which is in phase III trials for the potential treatment of IC.


Lead Product(s): Ibrexafungerp Citrate,Inapplicable

Therapeutic Area: Infections and Infectious Diseases Brand Name: Brexafemme

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: GSK

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement March 30, 2023

blank

07

Scynexis

U.S.A
arrow
ECRM CMO & Packaging
Not Confirmed

Scynexis

U.S.A
arrow
ECRM CMO & Packaging
Not Confirmed

Details : Under the agreement, GSK gains rights to commercialise Brexafemme, a first-in-class antifungal for the treatment of VVC and for reduction in the incidence of RVVC while continuing to develop ibrexafungerp, which is in phase III trials for the potential t...

Product Name : Brexafemme

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

March 30, 2023

blank

Details:

Undisclosed


Lead Product(s): Ibrexafungerp Citrate,Inapplicable

Therapeutic Area: Infections and Infectious Diseases Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable December 29, 2022

blank

08

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Details : Undisclosed

Product Name : Undisclosed

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

December 29, 2022

blank

Details:

Brexafemme (Ibrexafungerp) is an antifungal agent and the first representative of a novel class of structurally-distinct glucan synthase inhibitors, triterpenoids.


Lead Product(s): Ibrexafungerp Citrate,Inapplicable

Therapeutic Area: Infections and Infectious Diseases Brand Name: Brexafemme

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable November 17, 2022

blank

09

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Details : Brexafemme (Ibrexafungerp) is an antifungal agent and the first representative of a novel class of structurally-distinct glucan synthase inhibitors, triterpenoids.

Product Name : Brexafemme

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

November 17, 2022

blank

Details:

Brexafemme (ibrexafungerp) is in late-stage development for multiple indications, including life-threatening fungal infections caused primarily by Candida (including C. auris) and Aspergillus species in hospitalized patients.


Lead Product(s): Ibrexafungerp Citrate,Inapplicable

Therapeutic Area: Infections and Infectious Diseases Brand Name: Brexafemme

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable November 10, 2022

blank

10

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Scynexis

U.S.A
arrow
BIOHK2025
Not Confirmed

Details : Brexafemme (ibrexafungerp) is in late-stage development for multiple indications, including life-threatening fungal infections caused primarily by Candida (including C. auris) and Aspergillus species in hospitalized patients.

Product Name : Brexafemme

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

November 10, 2022

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Ibrexafungerp Citrate manufacturers, exporters & distributors 1

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API | Excipient name

Ibrexafungerp Citrate

Synonyms

Scy-078 citrate, M4nu2sdx3e, Ibrexafungerp citrate [usan], 1965291-08-0, Ibrexafungerp citrate (usan), Brexafemme

Cas Number

1965291-08-0

Unique Ingredient Identifier (UNII)

M4NU2SDX3E

Ibrexafungerp citrate (USAN) Manufacturers

A Ibrexafungerp citrate (USAN) manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ibrexafungerp citrate (USAN), including repackagers and relabelers. The FDA regulates Ibrexafungerp citrate (USAN) manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ibrexafungerp citrate (USAN) API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ibrexafungerp citrate (USAN) manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ibrexafungerp citrate (USAN) Suppliers

A Ibrexafungerp citrate (USAN) supplier is an individual or a company that provides Ibrexafungerp citrate (USAN) active pharmaceutical ingredient (API) or Ibrexafungerp citrate (USAN) finished formulations upon request. The Ibrexafungerp citrate (USAN) suppliers may include Ibrexafungerp citrate (USAN) API manufacturers, exporters, distributors and traders.

click here to find a list of Ibrexafungerp citrate (USAN) suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ibrexafungerp citrate (USAN) GMP

Ibrexafungerp citrate (USAN) Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ibrexafungerp citrate (USAN) GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ibrexafungerp citrate (USAN) GMP manufacturer or Ibrexafungerp citrate (USAN) GMP API supplier for your needs.

Ibrexafungerp citrate (USAN) CoA

A Ibrexafungerp citrate (USAN) CoA (Certificate of Analysis) is a formal document that attests to Ibrexafungerp citrate (USAN)'s compliance with Ibrexafungerp citrate (USAN) specifications and serves as a tool for batch-level quality control.

Ibrexafungerp citrate (USAN) CoA mostly includes findings from lab analyses of a specific batch. For each Ibrexafungerp citrate (USAN) CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ibrexafungerp citrate (USAN) may be tested according to a variety of international standards, such as European Pharmacopoeia (Ibrexafungerp citrate (USAN) EP), Ibrexafungerp citrate (USAN) JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ibrexafungerp citrate (USAN) USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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