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Chemistry

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Also known as: Ncgc00167966-01, Dsstox_cid_26750, Dsstox_rid_81875, Dsstox_gsid_46750, Chembl1874250, Dtxsid20858848
Molecular Formula
C28H44N2O23
Molecular Weight
776.6  g/mol
InChI Key
KIUKXJAPPMFGSW-YXBJCWEESA-N

Hyaluronic Acid
1 2D Structure

Hyaluronic Acid

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S,4S,5R,6S)-6-[(2S,3R,5S,6R)-3-acetamido-2-[(3S,4R,5R,6R)-6-[(3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
2.1.2 InChI
InChI=1S/C28H44N2O23/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45)/t7-,8-,9-,10-,11-,12-,13+,14?,15-,16-,17-,18-,19?,20+,21+,22?,25?,26+,27+,28-/m1/s1
2.1.3 InChI Key
KIUKXJAPPMFGSW-YXBJCWEESA-N
2.1.4 Canonical SMILES
CC(=O)NC1C(C(C(OC1O)CO)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)C(=O)O)O)O)O)NC(=O)C)O)O
2.1.5 Isomeric SMILES
CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](OC1O)CO)O)O[C@H]2[C@@H]([C@H]([C@@H](C(O2)C(=O)O)O[C@H]3[C@@H](C([C@@H]([C@H](O3)CO)O)O[C@@H]4[C@@H]([C@H](C([C@H](O4)C(=O)O)O)O)O)NC(=O)C)O)O
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. Ncgc00167966-01

2. Dsstox_cid_26750

3. Dsstox_rid_81875

4. Dsstox_gsid_46750

5. Chembl1874250

6. Dtxsid20858848

7. Tox21_112595

8. Akos015960603

9. Ac-11740

10. Ac-31947

11. Cas-9004-61-9

12. (4xi)-alpha-d-xylo-hexopyranuronosyl-(1->3)-(3xi)-2-(acetylamino)-2-deoxy-beta-d-ribo-hexopyranosyl-(1->4)-(5xi)-beta-d-xylo-hexopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-d-glucopyranose

2.2.2 Other Synonyms

1. Hyaluronan

2.3 Create Date
2008-02-29
3 Chemical and Physical Properties
Molecular Weight 776.6 g/mol
Molecular Formula C28H44N2O23
XLogP3-7.4
Hydrogen Bond Donor Count14
Hydrogen Bond Acceptor Count23
Rotatable Bond Count12
Exact Mass776.23348565 g/mol
Monoisotopic Mass776.23348565 g/mol
Topological Polar Surface Area400 Ų
Heavy Atom Count53
Formal Charge0
Complexity1300
Isotope Atom Count0
Defined Atom Stereocenter Count16
Undefined Atom Stereocenter Count4
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

USDMF

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Bayer Corp

Germany

USDMF

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Pharmex
Not Confirmed

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02

Pharmex
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Nv Organon

U.S.A

USDMF

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Pharmex
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Nv Organon

U.S.A
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Pharmex
Not Confirmed

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 11593

Submission : 1995-07-20

Status : Inactive

Type : II

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Listed Suppliers

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01

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Virtual BoothBloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

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Digital Content Digital Content

Hyaluronic Acid

About the Company : Bloomage Biotechnology Corporation Limited, formerly Bloomage Freda Biopharm, was established by Bloomage International Investment Group. It is a global leader in bioactive materia...

Bloomage Biotechnology Corporation Limited, formerly Bloomage Freda Biopharm, was established by Bloomage International Investment Group. It is a global leader in bioactive materials like mucopolysaccharides, proteins, peptides, amino acids, & natural compounds. In the 1990s, it became the first company in China to develop fermentation-based sodium hyaluronate. With around 200 specifications of hyaluronic acid, it caters to the pharmaceutical, medical devices, cosmetics, & functional food sectors. For pharma raw materials, Bloomage offers innovative solutions in aesthetics, dermatology, ophthalmology, orthopedics, & regenerative medicines.
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02

  • fda
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  • WHO-GMP

Virtual BoothKewpie is your partner for Sodium Hyaluronate & Hyaluronic Acid// CEP, USDMF, KDMF & JDMF registered.

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Hyaluronic Acid

About the Company : Kewpie first developed Sodium hyaluronate in 1983 and is currently the leading Japanese manufacturer of pharmaceutical grade Sodium hyaluronate used as an API and pharmaceutical ex...

Kewpie first developed Sodium hyaluronate in 1983 and is currently the leading Japanese manufacturer of pharmaceutical grade Sodium hyaluronate used as an API and pharmaceutical excipients. Its Sodium hyaluronate is suitable for injections, eye drops and external preparations. Its pharmaceutical grade Sodium hyaluronate (Hyaluronic acid) is manufactured at its factory near Tokyo under strict regulations. Since 2016, Kewpie has developed and manufactured medical devices using Sodium hyaluronate. Its R&D team can also provide Sodium hyaluronate derivatives as per clients’ needs. Kewpie exports Sodium hyaluronate to over 30 countries.
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03

  • fda
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Virtual BoothHTL Biotechnology is a French biotech & a global leader in the responsible development & production of pharma-grade biopolymers.

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Hyaluronic Acid

About the Company : HTL is a biotechnology company pioneering the development and production of pharmaceutical-grade Hyaluronic Acid (Sodium Hyaluronate) and other functional biopolymers such as PDRN ...

HTL is a biotechnology company pioneering the development and production of pharmaceutical-grade Hyaluronic Acid (Sodium Hyaluronate) and other functional biopolymers such as PDRN and PN, designed to improve people's lives. HTL is the only Hyaluronic Acid producer exclusively producing injectable grade. Our premium quality biopolymers are used by healthcare companies for the development of treatments in various cutting-edge therapeutic areas such as ophthalmology, dermatology, medical aesthetics and rheumatology.
HTL Biotechnology Biopolymer

04

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Virtual BoothTopscience Biotech specializes in R&D, production, sales of Sodium Hyaluronate, focusing on Cosmetics, Medical, Pharmaceutical Grade HA

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Hyaluronic Acid

About the Company : Established in 2005, Topscience located in Lanshan, Rizhao of PRC and covers an area of 100,000m². Products include Sodium Hyaluronate, Chondroitin Sulfate, Alpha-Arbutin, L-Ascor...

Established in 2005, Topscience located in Lanshan, Rizhao of PRC and covers an area of 100,000m². Products include Sodium Hyaluronate, Chondroitin Sulfate, Alpha-Arbutin, L-Ascorbic Acid 2-Glucoside, Sulglycotide etc. We have GMP certificate, Drug manufacturing Certificate, CEP of Sodium Hyaluronate, Written Confirmation, Certificate of DMF Registration, Halal, Kosher etc. Sodium Hyaluronate API includes Injection grade, Eye-Drop grade and Excipients grade. The bacterial endotoxin of Sodium Hyaluronate(Injection Grade) is less than 0.001 IU/mg, which is much lower than European Pharmacopoeia current edition 50 times.
Shandong Topscience Biotech

05

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Virtual BoothKikkoman Biochemifa Company advances global health and safety through precision-driven innovation in biotech and food testing.

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Hyaluronic Acid

About the Company : Kikkoman Biochemifa Company, a core division of Kikkoman Corporation, is dedicated to the production and sale of pharmaceuticals, enzymes, specialty chemicals, and advanced food sa...

Kikkoman Biochemifa Company, a core division of Kikkoman Corporation, is dedicated to the production and sale of pharmaceuticals, enzymes, specialty chemicals, and advanced food safety and hygiene monitoring systems. ISO certified, we offer a broad range of fast, effective, and user-friendly technologies that enhance food testing and quality assurance. With a strong legacy of scientific innovation, we are committed to improving public health, ensuring product safety, and supporting industries worldwide with high-performance, reliable, and sustainable solutions.
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06

LGM Pharma

U.S.A
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Virtual BoothLGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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Hyaluronic Acid

About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.
LGM Pharma CB

07

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Virtual BoothPharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

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Hyaluronic Acid

About the Company : Pharm-Rx has earned an outstanding reputation since its establishment in 1991, serving as a reputable importer and distributor of active ingredients to the pharmaceutical, nutritio...

Pharm-Rx has earned an outstanding reputation since its establishment in 1991, serving as a reputable importer and distributor of active ingredients to the pharmaceutical, nutritional supplement, and food industries. The company maintains an exceptionally selective approach to its suppliers, personally visiting manufacturers overseas to ensure the highest standards. The sustained growth of Pharm-Rx can be attributed to its steadfast commitment to three core values: quality ingredients, competitive pricing, and unparalleled customer service.
Pharm RX

08

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Virtual BoothBasic Nutrition, your expert for sourcing from China, India and Europe.

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Hyaluronic Acid

About the Company : As an ISO9001, ISO22000 certificated supplier, Basic Nutrition supply high-quality ingredients for nutraceuticals. We can offer a range of products from small to large quantites: h...

As an ISO9001, ISO22000 certificated supplier, Basic Nutrition supply high-quality ingredients for nutraceuticals. We can offer a range of products from small to large quantites: herbal extract, amino acid, vitamin, etc. Featured products: cranberry extract, rhidiola extract, Q10, hyaluronic acid, cysteine (non-animals), glutathoninr, orgaic products like organic spirulina, organic red yeast rice powder, etc.
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09

Aroma-Zone

France
Pharmex
Not Confirmed
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Aroma-Zone

France
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Pharmex
Not Confirmed

Hyaluronic Acid

About the Company : Aroma-Zone project was conceived with a simple aim to share our expertise and enthusiasm for essential oils, the potent essences of plant life. We are dedicated to providing transp...

Aroma-Zone project was conceived with a simple aim to share our expertise and enthusiasm for essential oils, the potent essences of plant life. We are dedicated to providing transparent information about our products, including their origins, production methods, and benefits. Our detailed technical guides empower you to make informed choices that align with your preferences. Aroma-Zone has been committed to making 100% natural skincare accessible to as many people as possible, ensuring our presence both in physical stores and online for your convenience.
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Sibbiotech

Russia
Pharmex
Not Confirmed
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Sibbiotech

Russia
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Pharmex
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Hyaluronic Acid

About the Company : The technology of production of artemisinin and its derivatives is based on the use of cultivation of annual wormwood cells and extraction of artemisinin and artemisinic acid. Qual...

The technology of production of artemisinin and its derivatives is based on the use of cultivation of annual wormwood cells and extraction of artemisinin and artemisinic acid. Quality control is carried out by an independent accredited laboratory of the Koltsovo Biotechnopark, which complies with the norms and rules of the international standard of good manufacturing practice GMP.SIBBIOTECH Industrial Park occupies 3 hectares. The electric capacities of the green electricity of the Novosibirsk hydroelectric power station, centralized gas and water supply and centralized wastewater disposal are available.
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API Reference Price

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INCHEON INT\\'","customer":"METEORIC BIOPHARMACEUTICALS PRIVATE LTD","customerCountry":"INDIA","quantity":"240.00","actualQuantity":"240","unit":"KGS","unitRateFc":"150","totalValueFC":"36056.3","currency":"USD","unitRateINR":"13065","date":"05-Feb-2025","totalValueINR":"3135600","totalValueInUsd":"36056.3","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"8187900","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"SEOUL - INCHEON INT\\'","supplierAddress":"2ND FLOOR , 15-13 IRWOLCHEON-RO 4 BEON-GIL, GWONSEON-GU SUWON-SI , GYEONGGI-DO, KOREA,REPUBLIC OF","customerAddress":"408,409 SHAIL COMPLEX,OP-MADHUSUDAN"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1746556200,"product":"HYALURONIC ACID-BT HYALURONIC ACID-BT","address":"1601 16TH FLR G WING,LOTUS CORPOR","city":"MUMBAI,MAHARASHTRA","supplier":"DSM NUTRITIONAL PRODUCTS ASIA PACIF","supplierCountry":"CZECH REPUBLIC","foreign_port":"SCHIPOL AIRPORT","customer":"S KUSHALCHAND INTERNATIONAL PRIVATE LTD","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"1200","totalValueFC":"1204.9","currency":"USD","unitRateINR":"102660","date":"07-May-2025","totalValueINR":"102660","totalValueInUsd":"1204.9","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"9913772","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"SCHIPOL AIRPORT","supplierAddress":"IC30 PASIR PANJANG ROAD,# 13-31, , MAPLETREE BUSINESS CITY,117440 SDNF SINGAPORE","customerAddress":"1601 16TH FLR G WING,LOTUS CORPOR"}]
20-Jan-2022
07-May-2025
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ABOUT THIS PAGE

Looking for / Hyaluronic Acid API manufacturers, exporters & distributors?

Hyaluronic Acid manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Hyaluronic Acid API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Hyaluronic Acid manufacturer or Hyaluronic Acid supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Hyaluronic Acid manufacturer or Hyaluronic Acid supplier.

PharmaCompass also assists you with knowing the Hyaluronic Acid API Price utilized in the formulation of products. Hyaluronic Acid API Price is not always fixed or binding as the Hyaluronic Acid Price is obtained through a variety of data sources. The Hyaluronic Acid Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Hyaluronic Acid

Synonyms

Ncgc00167966-01, Dsstox_cid_26750, Dsstox_rid_81875, Dsstox_gsid_46750, Chembl1874250, Dtxsid20858848

Hyaluronic Acid Manufacturers

A Hyaluronic Acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hyaluronic Acid, including repackagers and relabelers. The FDA regulates Hyaluronic Acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hyaluronic Acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Hyaluronic Acid manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Hyaluronic Acid Suppliers

A Hyaluronic Acid supplier is an individual or a company that provides Hyaluronic Acid active pharmaceutical ingredient (API) or Hyaluronic Acid finished formulations upon request. The Hyaluronic Acid suppliers may include Hyaluronic Acid API manufacturers, exporters, distributors and traders.

click here to find a list of Hyaluronic Acid suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Hyaluronic Acid USDMF

A Hyaluronic Acid DMF (Drug Master File) is a document detailing the whole manufacturing process of Hyaluronic Acid active pharmaceutical ingredient (API) in detail. Different forms of Hyaluronic Acid DMFs exist exist since differing nations have different regulations, such as Hyaluronic Acid USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Hyaluronic Acid DMF submitted to regulatory agencies in the US is known as a USDMF. Hyaluronic Acid USDMF includes data on Hyaluronic Acid's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Hyaluronic Acid USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Hyaluronic Acid suppliers with USDMF on PharmaCompass.

Hyaluronic Acid JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Hyaluronic Acid Drug Master File in Japan (Hyaluronic Acid JDMF) empowers Hyaluronic Acid API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Hyaluronic Acid JDMF during the approval evaluation for pharmaceutical products. At the time of Hyaluronic Acid JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Hyaluronic Acid suppliers with JDMF on PharmaCompass.

Hyaluronic Acid GMP

Hyaluronic Acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Hyaluronic Acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hyaluronic Acid GMP manufacturer or Hyaluronic Acid GMP API supplier for your needs.

Hyaluronic Acid CoA

A Hyaluronic Acid CoA (Certificate of Analysis) is a formal document that attests to Hyaluronic Acid's compliance with Hyaluronic Acid specifications and serves as a tool for batch-level quality control.

Hyaluronic Acid CoA mostly includes findings from lab analyses of a specific batch. For each Hyaluronic Acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Hyaluronic Acid may be tested according to a variety of international standards, such as European Pharmacopoeia (Hyaluronic Acid EP), Hyaluronic Acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hyaluronic Acid USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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