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Chemistry

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Also known as: Ncgc00167966-01, Dsstox_cid_26750, Dsstox_rid_81875, Dsstox_gsid_46750, Chembl1874250, Dtxsid20858848
Molecular Formula
C28H44N2O23
Molecular Weight
776.6  g/mol
InChI Key
KIUKXJAPPMFGSW-YXBJCWEESA-N

Hyaluronic Acid
1 2D Structure

Hyaluronic Acid

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S,4S,5R,6S)-6-[(2S,3R,5S,6R)-3-acetamido-2-[(3S,4R,5R,6R)-6-[(3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
2.1.2 InChI
InChI=1S/C28H44N2O23/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45)/t7-,8-,9-,10-,11-,12-,13+,14?,15-,16-,17-,18-,19?,20+,21+,22?,25?,26+,27+,28-/m1/s1
2.1.3 InChI Key
KIUKXJAPPMFGSW-YXBJCWEESA-N
2.1.4 Canonical SMILES
CC(=O)NC1C(C(C(OC1O)CO)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)C(=O)O)O)O)O)NC(=O)C)O)O
2.1.5 Isomeric SMILES
CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](OC1O)CO)O)O[C@H]2[C@@H]([C@H]([C@@H](C(O2)C(=O)O)O[C@H]3[C@@H](C([C@@H]([C@H](O3)CO)O)O[C@@H]4[C@@H]([C@H](C([C@H](O4)C(=O)O)O)O)O)NC(=O)C)O)O
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. Ncgc00167966-01

2. Dsstox_cid_26750

3. Dsstox_rid_81875

4. Dsstox_gsid_46750

5. Chembl1874250

6. Dtxsid20858848

7. Tox21_112595

8. Akos015960603

9. Ac-11740

10. Ac-31947

11. Cas-9004-61-9

12. (4xi)-alpha-d-xylo-hexopyranuronosyl-(1->3)-(3xi)-2-(acetylamino)-2-deoxy-beta-d-ribo-hexopyranosyl-(1->4)-(5xi)-beta-d-xylo-hexopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-d-glucopyranose

2.2.2 Other Synonyms

1. Hyaluronan

2.3 Create Date
2008-02-29
3 Chemical and Physical Properties
Molecular Weight 776.6 g/mol
Molecular Formula C28H44N2O23
XLogP3-7.4
Hydrogen Bond Donor Count14
Hydrogen Bond Acceptor Count23
Rotatable Bond Count12
Exact Mass776.23348565 g/mol
Monoisotopic Mass776.23348565 g/mol
Topological Polar Surface Area400 Ų
Heavy Atom Count53
Formal Charge0
Complexity1300
Isotope Atom Count0
Defined Atom Stereocenter Count16
Undefined Atom Stereocenter Count4
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

API SUPPLIERS

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Bloomage Biotechnology Corp., Ltd

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothBloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

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Kewpie Corporation

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
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  • WHO-GMP

Virtual BoothKewpie is your partner for Sodium Hyaluronate & Hyaluronic Acid// CEP, USDMF, KDMF & JDMF registered.

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HTL Biotechnology

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothHTL Biotechnology is a French biotech & a global leader in the responsible development & production of pharma-grade biopolymers.

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Shandong Topscience Biotech Co., L...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothTopscience Biotech specializes in R&D, production, sales of Sodium Hyaluronate, focusing on Cosmetics, Medical, Pharmaceutical Grade HA

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Shandong Topscience Biotech

05

Kikkoman Biochemifa Company

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothKikkoman Biochemifa Company advances global health and safety through precision-driven innovation in biotech and food testing.

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LGM Pharma

U.S.A

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Virtual BoothLGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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Pharm-RX Chemical

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothPharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

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Pharm RX

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Basic Nutrition

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothBasic Nutrition, your expert for sourcing from China, India and Europe.

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Merck & Co

U.S.A

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Merck & Co

U.S.A

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Bayer AG

Germany

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Bayer AG

Germany

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USDMF

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Bayer Corp

Germany

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Bayer Corp

Germany
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 15901

Submission : 2002-03-15

Status : Inactive

Type : II

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Nv Organon

U.S.A

USDMF

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Nv Organon

U.S.A
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GDUFA

DMF Review : N/A

Rev. Date :

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DMF Number : 11593

Submission : 1995-07-20

Status : Inactive

Type : II

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JDMF

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Virtual BoothKewpie is your partner for Sodium Hyaluronate & Hyaluronic Acid// CEP, USDMF, KDMF & JDMF registered.

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Hyaluronic Acid HA-AM (S)

Registration Number : 302MF10032

Registrant's Address : Shibuya 1-4-13, Shibuya-ku, Tokyo

Initial Date of Registration : 2020-02-27

Latest Date of Registration : 2020-02-27

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Virtual BoothKikkoman Biochemifa Company advances global health and safety through precision-driven innovation in biotech and food testing.

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Hyaluronic acid FCH-80LE

Registration Number : 217MF10551

Registrant's Address : 250 Noda, Noda City, Chiba Prefecture

Initial Date of Registration : 2005-09-09

Latest Date of Registration : 2009-09-24

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Denka Hyaluronic Acid

Registration Number : 218MF10489

Registrant's Address : 2-1-1 Muromachi, Nihonbashi, Chuo-ku, Tokyo

Initial Date of Registration : 2006-05-15

Latest Date of Registration : 2016-12-05

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API Reference Price

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C.O.O. - CZECH REPUBLIC","address":"1601 16TH FLR G WING,LOTUS CORPOR","city":"MUMBAI,MAHARASHTRA","supplier":"DSM NUTRITIONAL PRODUCTS ASIA PACIF","supplierCountry":"CZECH REPUBLIC","foreign_port":"SCHIPOL AIRPORT","customer":"S KUSHALCHAND INTERNATIONAL PRIVATE LTD","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"1200","totalValueFC":"6068.4","currency":"USD","unitRateINR":"102420","date":"22-Nov-2024","totalValueINR":"512100","totalValueInUsd":"6068.4","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"6807544","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"SCHIPOL AIRPORT","supplierAddress":"IC30 PASIR PANJANG ROAD,# 13-31, , MAPLETREE BUSINESS CITY,117440 SDNF SINGAPORE","customerAddress":"1601 16TH FLR G WING,LOTUS CORPOR"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1738693800,"product":"HYALURONIC ACID RETURN MATERIAL S\/B NO .6612489 DT 20.12.2024.HYALURONIC ACID","address":"408,409 SHAIL COMPLEX,OP-MADHUSUDAN","city":"EXCHANGE,ELLISBRIDGE,AHMEDABAD","supplier":"DAMWON INTERNATIONAL CO LTD","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"METEORIC BIOPHARMACEUTICALS PRIVATE LTD","customerCountry":"INDIA","quantity":"240.00","actualQuantity":"240","unit":"KGS","unitRateFc":"150","totalValueFC":"36056.3","currency":"USD","unitRateINR":"13065","date":"05-Feb-2025","totalValueINR":"3135600","totalValueInUsd":"36056.3","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"8187900","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"SEOUL - INCHEON INT\\'","supplierAddress":"2ND FLOOR , 15-13 IRWOLCHEON-RO 4 BEON-GIL, GWONSEON-GU SUWON-SI , GYEONGGI-DO, KOREA,REPUBLIC OF","customerAddress":"408,409 SHAIL COMPLEX,OP-MADHUSUDAN"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1748975400,"product":"4D HYALURONIC ACID (COSMETIC INGREDIENT FOR MANUFACTURING OF ANTI AGEING CREAM APPLICATION)4D HYALURONIC ACID (COSMETIC INGREDIENT FOR MANUFACTURING OF","address":"Flat No. C\/UH-527 In Tower-C Urban Homes Shahpur Bamheta","city":"GHAZIABAD","supplier":"BAODING FAITHFUL INDUSTRY CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SG GREEN TECH HEALTH BEAUTY","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"162.1","totalValueFC":"8152.1","currency":"USD","unitRateINR":"14009.5","date":"04-Jun-2025","totalValueINR":"700475.5","totalValueInUsd":"8152.1","indian_port":"Delhi Air","hs_no":"29420090","bill_no":"2457264","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"7A 401-01 HEBEI UNIVERSITY SCIENCE PARK 5699 NORTH SECOND RING ROAD BAODING HEBEI 071051 CHINA CHINA","customerAddress":"Flat No. C\/UH-527 In Tower-C Urban Homes Shahpur Bamheta"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1748975400,"product":"HYALURONIC ACID (COSMETIC INGREDIENT FOR MANUFACTURING OF ANTI-AGEING CREAM APPLICATION)HYALURONIC ACID","address":"Flat No. C\/UH-527 In Tower-C Urban Homes Shahpur Bamheta","city":"GHAZIABAD","supplier":"BAODING FAITHFUL INDUSTRY CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SG GREEN TECH HEALTH BEAUTY","customerCountry":"INDIA","quantity":"40.00","actualQuantity":"40","unit":"KGS","unitRateFc":"177.9","totalValueFC":"7156.7","currency":"USD","unitRateINR":"15373.5","date":"04-Jun-2025","totalValueINR":"614941.5","totalValueInUsd":"7156.7","indian_port":"Delhi Air","hs_no":"29420090","bill_no":"2458247","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"7A 401-01 HEBEI UNIVERSITY SCIENCE PARK 5699 NORTH SECOND RING ROAD BAODING HEBEI 071051 CHINA CHINA","customerAddress":"Flat No. C\/UH-527 In Tower-C Urban Homes Shahpur Bamheta"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1749580200,"product":"HYALURONIC ACID HYALURONIC ACID","address":"184, HARIOM AVAS","city":"SURAT","supplier":"EFFEPHARM LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"CENTENARIANS LIFE SCIENCES PRIVATE LTD","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"308.7","totalValueFC":"3116.9","currency":"USD","unitRateINR":"26782.1","date":"11-Jun-2025","totalValueINR":"267820.91","totalValueInUsd":"3116.9","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"2594494","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"Bld 4, No.1, Mid Wangzhong Rd, Shan ghai, China SDNF China","customerAddress":"184, HARIOM AVAS"}]
20-Jan-2022
11-Jun-2025
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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Drugs in Development

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Details:

Undisclosed


Lead Product(s): Hyaluronic Acid,Inapplicable

Therapeutic Area: Musculoskeletal Brand Name: Synvisc-One

Study Phase: Phase IVProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable March 17, 2015

Sanofi Company Banner

01

Sanofi

France
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Lead Product(s) : Hyaluronic Acid,Inapplicable

Therapeutic Area : Musculoskeletal

Highest Development Status : Phase IV

Partner/Sponsor/Collaborator : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : Undisclosed

Product Name : Synvisc-One

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

March 17, 2015

Sanofi Company Banner

Details:

Skinvive™ by Juvéderm® is a smooth, injectable HA gel that contains a small amount of local anesthetic (lidocaine). It improves skin quality in the cheeks by smoothing the skin and increasing hydration.


Lead Product(s): Hyaluronic Acid,Inapplicable

Therapeutic Area: Dermatology Brand Name: Skinvive

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable May 15, 2023

Abbvie Company Banner

02

AbbVie Inc

U.S.A
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Details : Skinvive™ by Juvéderm® is a smooth, injectable HA gel that contains a small amount of local anesthetic (lidocaine). It improves skin quality in the cheeks by smoothing the skin and increasing hydration.

Product Name : Skinvive

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

May 15, 2023

Abbvie Company Banner

Details:

Juvederm Voluma™ XC (hyaluronic acid) is indicated for deep (subcutaneous and/or supraperiosteal) injection for cheek augmentation to correct age-related volume deficit in the mid-face in adults over the age of 21.


Lead Product(s): Hyaluronic Acid,Inapplicable

Therapeutic Area: Dermatology Brand Name: Juvederm Volux XC

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable January 18, 2023

Abbvie CB

03

Details : Juvederm Voluma™ XC (hyaluronic acid) is indicated for deep (subcutaneous and/or supraperiosteal) injection for cheek augmentation to correct age-related volume deficit in the mid-face in adults over the age of 21.

Product Name : Juvederm Volux XC

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 18, 2023

Abbvie CB

Details:

JUVÉDERM® VOLBELLA® XC was first FDA–approved in 2016 for use in the lips and perioral rhytids.2 As the category leader, the JUVÉDERM® Collection of Fillers offers the broadest portfolio, and this latest approval marks the sixth approved indication in the U.S.


Lead Product(s): Hyaluronic Acid,Lidocaine

Therapeutic Area: Dermatology Brand Name: Juvederm Volux XC

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable August 02, 2022

Abbvie CB

04

Details : JUVÉDERM® VOLBELLA® XC was first FDA–approved in 2016 for use in the lips and perioral rhytids.2 As the category leader, the JUVÉDERM® Collection of Fillers offers the broadest portfolio, and this latest approval marks the sixth approved indicatio...

Product Name : Juvederm Volux XC

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

August 02, 2022

Abbvie CB

Details:

Allergan Aesthetics looks to further develop the Hybrid Injectables category by introducing its first dual-effect product, which combines the two active ingredients - hyaluronic acid, a well-known ingredient found in facial fillers and calcium hydroxyapatite in one injection.


Lead Product(s): Hyaluronic Acid,HYDROXYPROPYLMETHYLCELLULOSE

Therapeutic Area: Dermatology Brand Name: Juvederm Volux XC

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable March 29, 2022

Abbvie CB

05

Details : Allergan Aesthetics looks to further develop the Hybrid Injectables category by introducing its first dual-effect product, which combines the two active ingredients - hyaluronic acid, a well-known ingredient found in facial fillers and calcium hydroxyapa...

Product Name : Juvederm Volux XC

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

March 29, 2022

Abbvie CB

Details:

JUVÉDERM® VOLUMA® XC injectable gel is for deep injection in the cheek area to correct age-related volume loss and for augmentation of the chin region to improve the chin profile in adults over 21.


Lead Product(s): Hyaluronic Acid,Inapplicable

Therapeutic Area: Dermatology Brand Name: Juvederm Volux XC

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable March 08, 2022

Abbvie CB

06

Details : JUVÉDERM® VOLUMA® XC injectable gel is for deep injection in the cheek area to correct age-related volume loss and for augmentation of the chin region to improve the chin profile in adults over 21.

Product Name : Juvederm Volux XC

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

March 08, 2022

Abbvie CB

Details:

JUVÉDERM (Hyaluronic Acid) is indicated for deep (subcutaneous and/or supraperiosteal) injection for cheek augmentation to correct age-related volume deficit in mid-face and for augmentation of chin region to improve chin profile in adults over age of 21.


Lead Product(s): Hyaluronic Acid,Inapplicable

Therapeutic Area: Dermatology Brand Name: Juvederm Volux XC

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable June 15, 2020

Abbvie CB

07

Details : JUVÉDERM (Hyaluronic Acid) is indicated for deep (subcutaneous and/or supraperiosteal) injection for cheek augmentation to correct age-related volume deficit in mid-face and for augmentation of chin region to improve chin profile in adults over age of 2...

Product Name : Juvederm Volux XC

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

June 15, 2020

Abbvie CB

Details:

New pre-clinical study showed that Dermial® hyaluronic acid matrix ingredient increased type I collagen production by almost half – an observation not seen with standard hyaluronic acid from fermentation or extraction origin.


Lead Product(s): Hyaluronic Acid,Collagen,Dermatan Sulfate

Therapeutic Area: Dermatology Brand Name: Dermial

Study Phase: PreclinicalProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable May 25, 2022

Bioiberica Company Banner

08

Bioiberica

Spain
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Lead Product(s) : Hyaluronic Acid,Collagen,Dermatan Sulfate

Therapeutic Area : Dermatology

Highest Development Status : Preclinical

Partner/Sponsor/Collaborator : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : New pre-clinical study showed that Dermial® hyaluronic acid matrix ingredient increased type I collagen production by almost half – an observation not seen with standard hyaluronic acid from fermentation or extraction origin.

Product Name : Dermial

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

May 25, 2022

Bioiberica Company Banner

Details:

Apsen’s Motilex HA combines two leading ingredients, b-2Cool native type II collagen and Mobilee, patented ingredient that synergistically combines a high concentration of hyaluronic acid with polysaccharides and collagen, to effectively maintain joint function.


Lead Product(s): Hyaluronic Acid,Type II Collagen

Therapeutic Area: Musculoskeletal Brand Name: Motilex HA

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Apsen

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Partnership April 26, 2021

Bioiberica Company Banner

09

Bioiberica

Spain
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Lead Product(s) : Hyaluronic Acid,Type II Collagen

Therapeutic Area : Musculoskeletal

Highest Development Status : Approved FDF

Partner/Sponsor/Collaborator : Apsen

Deal Size : Undisclosed

Deal Type : Partnership

Details : Apsen’s Motilex HA combines two leading ingredients, b-2Cool native type II collagen and Mobilee, patented ingredient that synergistically combines a high concentration of hyaluronic acid with polysaccharides and collagen, to effectively maintain joint...

Product Name : Motilex HA

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

April 26, 2021

Bioiberica Company Banner

Details:

B-2Cool (Bioiberica’s native type II collagen) is an innovative ingredient, has been shown in four scientific studies to help maintain good joint health at a very low daily dose.


Lead Product(s): Undenatured Type II Collagen,Harpagophytum Procumbens Extract,Hyaluronic Acid

Therapeutic Area: Musculoskeletal Brand Name: Undisclosed

Study Phase: Approved FDFProduct Type: Other Large Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable July 15, 2020

Bioiberica Company Banner

10

Bioiberica

Spain
arrow

Lead Product(s) : Undenatured Type II Collagen,Harpagophytum Procumbens Extract,Hyaluronic Acid

Therapeutic Area : Musculoskeletal

Highest Development Status : Approved FDF

Partner/Sponsor/Collaborator : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : B-2Cool (Bioiberica’s native type II collagen) is an innovative ingredient, has been shown in four scientific studies to help maintain good joint health at a very low daily dose.

Product Name : Undisclosed

Product Type : Other Large Molecule

Upfront Cash : Inapplicable

July 15, 2020

Bioiberica Company Banner
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FDF Dossiers

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01

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothEgis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

Flag Hungary
Digital Content Digital Content

Regulatory Info :

Registration Country : Hungary

Hyaluronic Acid; Lactic Acid

Brand Name : Hyaluronic acid ; Lactic acid (MD)

Dosage Form : Vaginal Gel

Dosage Strength : 75G

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Hungary

Egis Pharmaceuticals

02

Coatings Trends
Not Confirmed
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Coatings Trends
Not Confirmed

Hyaluronic Acid; Collagen

Brand Name : JONEXA TROPHIC

Dosage Form : Pre-Filled Syringe

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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03

Bitop AG

Germany
Coatings Trends
Not Confirmed
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Bitop AG

Germany
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Coatings Trends
Not Confirmed

Ectoine; Niacinamide; Hyaluronic Acid

Brand Name :

Dosage Form : Serum

Dosage Strength : 2%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Germany

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04

Farmigea

Italy
Coatings Trends
Not Confirmed
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Farmigea

Italy
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Coatings Trends
Not Confirmed

Hyaluronic Acid

Brand Name :

Dosage Form : Eye Drop Solution

Dosage Strength : 0.4%

Packaging : 20 x 0.5 ml Single Dose Unit, 10 ml Bottle

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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05

Coatings Trends
Not Confirmed
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Coatings Trends
Not Confirmed

Hyaluronic Acid

Brand Name : Hyalgan

Dosage Form :

Dosage Strength : 5 Bottles 2 Ml 20 Mg/2 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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06

Coatings Trends
Not Confirmed
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Coatings Trends
Not Confirmed

Hyaluronic Acid

Brand Name : Hyalgan

Dosage Form :

Dosage Strength : 1 Vial 2 Ml 20 Mg/2 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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07

Laboratorios Poen

Argentina
Coatings Trends
Not Confirmed
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Laboratorios Poen

Argentina
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Coatings Trends
Not Confirmed

Hyaluronic Acid

Brand Name : Dropstar

Dosage Form : Ophthalmic Solution

Dosage Strength : 0.4%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Argentina

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08

Coatings Trends
Not Confirmed
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Coatings Trends
Not Confirmed

Vitamin C; Niacinamide; Ginkgo Biloba Extract; Hyaluronic Acid

Brand Name : Vitamin C Revitalizing Serum

Dosage Form : Serum

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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09

Thea Pharma

U.S.A
Coatings Trends
Not Confirmed
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Thea Pharma

U.S.A
arrow
Coatings Trends
Not Confirmed

Hyaluronic Acid

Brand Name : Lacrycon

Dosage Form : Eye Gel

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

blank

10

Wellcopharma

Guatemala
Coatings Trends
Not Confirmed
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Wellcopharma

Guatemala
arrow
Coatings Trends
Not Confirmed

Hyaluronic Acid; D-Panthenol

Brand Name : Hidraplus

Dosage Form : Emulgel

Dosage Strength : 0.5%; 2%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Guatemala

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Europe

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01

Coatings Trends
Not Confirmed
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Coatings Trends
Not Confirmed

Hyaluronic Acid

Brand Name : Hypotonic Ialurex

Dosage Form :

Dosage Strength : 30 Monod Coll 0.4 %  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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02

Coatings Trends
Not Confirmed
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Coatings Trends
Not Confirmed

Hyaluronic Acid

Brand Name : Dropyal

Dosage Form :

Dosage Strength : 20 Monod Coll 0.65 Ml 0.015 G/100 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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03

Coatings Trends
Not Confirmed
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Coatings Trends
Not Confirmed

Hyaluronic Acid

Brand Name : Hyalgan

Dosage Form :

Dosage Strength : 5 Bottles 2 Ml 20 Mg/2 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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04

Coatings Trends
Not Confirmed
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Coatings Trends
Not Confirmed

Hyaluronic Acid

Brand Name : Hyalgan

Dosage Form :

Dosage Strength : 1 Syringe 2 Ml 20 Mg/2 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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05

Pannon

Hungary
Coatings Trends
Not Confirmed
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Pannon

Hungary
arrow
Coatings Trends
Not Confirmed

Hyaluronic Acid; Glycerine

Brand Name : Conheal

Dosage Form : Eye Drops, Solution

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Hungary

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06

Coatings Trends
Not Confirmed
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Coatings Trends
Not Confirmed

Hyaluronic Acid

Brand Name : Lacrycon

Dosage Form : Eye Gel

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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07

Vefa Ilac

Turkey
Coatings Trends
Not Confirmed
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Vefa Ilac

Turkey
arrow
Coatings Trends
Not Confirmed

Glucosamine Sulphate Potassium Chloride; Chondroitin Sulfate A; Boswellia serrata; Hyaluronic Acid; Cucurmin; Magnesium Sulfate; Ascorbic Acid

Brand Name : Arteasy

Dosage Form : TABLET

Dosage Strength :

Packaging : 30 Tablets

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : Turkey

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08

Coatings Trends
Not Confirmed
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Coatings Trends
Not Confirmed

Citicoline Sodium; Hyaluronic Acid

Brand Name :

Dosage Form : EYE DROPS

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : Turkey

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09

MDM SpA

Country
Coatings Trends
Not Confirmed
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MDM SpA

Country
arrow
Coatings Trends
Not Confirmed

Hyaluronic Acid

Brand Name : Artz

Dosage Form :

Dosage Strength : 1 Ampoule Ia 2.5 Ml 25 Mg/2.5 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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10

SPA (SOC.PRO.ANTIBIOTICI)SpA

Country
Coatings Trends
Not Confirmed
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SPA (SOC.PRO.ANTIBIOTICI)SpA

Country
arrow
Coatings Trends
Not Confirmed

Hyaluronic Acid

Brand Name : Hyalart

Dosage Form :

Dosage Strength : 1 Vial 2 Ml 20 Mg/2 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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Looking for / Hyaluronic Acid API manufacturers, exporters & distributors?

Hyaluronic Acid manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Hyaluronic Acid API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Hyaluronic Acid manufacturer or Hyaluronic Acid supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Hyaluronic Acid manufacturer or Hyaluronic Acid supplier.

PharmaCompass also assists you with knowing the Hyaluronic Acid API Price utilized in the formulation of products. Hyaluronic Acid API Price is not always fixed or binding as the Hyaluronic Acid Price is obtained through a variety of data sources. The Hyaluronic Acid Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Hyaluronic Acid

Synonyms

Ncgc00167966-01, Dsstox_cid_26750, Dsstox_rid_81875, Dsstox_gsid_46750, Chembl1874250, Dtxsid20858848

Hyaluronic Acid Manufacturers

A Hyaluronic Acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hyaluronic Acid, including repackagers and relabelers. The FDA regulates Hyaluronic Acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hyaluronic Acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Hyaluronic Acid manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Hyaluronic Acid Suppliers

A Hyaluronic Acid supplier is an individual or a company that provides Hyaluronic Acid active pharmaceutical ingredient (API) or Hyaluronic Acid finished formulations upon request. The Hyaluronic Acid suppliers may include Hyaluronic Acid API manufacturers, exporters, distributors and traders.

click here to find a list of Hyaluronic Acid suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Hyaluronic Acid USDMF

A Hyaluronic Acid DMF (Drug Master File) is a document detailing the whole manufacturing process of Hyaluronic Acid active pharmaceutical ingredient (API) in detail. Different forms of Hyaluronic Acid DMFs exist exist since differing nations have different regulations, such as Hyaluronic Acid USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Hyaluronic Acid DMF submitted to regulatory agencies in the US is known as a USDMF. Hyaluronic Acid USDMF includes data on Hyaluronic Acid's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Hyaluronic Acid USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Hyaluronic Acid suppliers with USDMF on PharmaCompass.

Hyaluronic Acid JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Hyaluronic Acid Drug Master File in Japan (Hyaluronic Acid JDMF) empowers Hyaluronic Acid API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Hyaluronic Acid JDMF during the approval evaluation for pharmaceutical products. At the time of Hyaluronic Acid JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Hyaluronic Acid suppliers with JDMF on PharmaCompass.

Hyaluronic Acid GMP

Hyaluronic Acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Hyaluronic Acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hyaluronic Acid GMP manufacturer or Hyaluronic Acid GMP API supplier for your needs.

Hyaluronic Acid CoA

A Hyaluronic Acid CoA (Certificate of Analysis) is a formal document that attests to Hyaluronic Acid's compliance with Hyaluronic Acid specifications and serves as a tool for batch-level quality control.

Hyaluronic Acid CoA mostly includes findings from lab analyses of a specific batch. For each Hyaluronic Acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Hyaluronic Acid may be tested according to a variety of international standards, such as European Pharmacopoeia (Hyaluronic Acid EP), Hyaluronic Acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hyaluronic Acid USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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