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1. 3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetic Acid, Alpha, Alpha', Alpha''-tris(3-((2,3-dihydroxypropyl)amino)-3-oxopropyl)-, Gadolinium Salt (1:1)
2. Gadolinium 2,2',2''-(3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triyl)tris(5-((2,3-dihydroxypropyl)amino)-5-oxopentanoate)
1. Unii-s276568koy
2. Gadopiclenol [usan]
3. S276568koy
4. Elucirem
5. P03277
6. Who 10744
7. 933983-75-6
8. P-03277
9. (alpha3,alpha6,alpha9-tris(3-((2,3-dihydroxypropyl)amino)-3-oxopropyl)-3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetato(3-)-kappan3,kappan6,kappan9,kappan15,kappao3,kappao6,kappao9)gadolinium
10. 2-[3,9-bis[1-carboxylato-4-(2,3-dihydroxypropylamino)-4-oxobutyl]-3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-trien-6-yl]-5-(2,3-dihydroxypropylamino)-5-oxopentanoate;gadolinium(3+)
11. Gadopiclenolum
12. Vueway
13. Gadopiclenol [inn]
14. Schembl21682611
15. Gbca P03277
16. P 03277
17. Gadolinium-based Magnetic Resonance Contrast Agent P03277
18. (.alpha.3,.alpha.6,.alpha.9-tris(3-((2,3-dihydroxypropyl)amino)-3-oxopropyl)-3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetato(3-)-.kappa.n3,.kappa.n6,.kappa.n9,.kappa.n15,.kappa.o3,.kappa.o6,.kappa.o9)gadolinium
19. Gadolinium, (.alpha.3, .alpha.6, .alpha.9-tris(3-((2-hydroxy-1-(hydroxymethyl)ethyl)amino)-3-oxopropyl)-3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetato(3-)-.kappa.n3, .kappa.n6, .kappa.n9, .kappa.n15, .kappa.o3, .kappa.o6, .kappa.o9)
20. Gadolinium, (alpha3, Alpha6, Alpha9-tris(3-((2-hydroxy-1-(hydroxymethyl)ethyl)amino)-3-oxopropyl)-3,6,9,15-tetraazabicyclo(9.3.1)pentadeca-1(15),11,13-triene-3,6,9-triacetato(3-)-kappan3, Kappan6, Kappan9, Kappan15, Kappao3, Kappao6, Kappao9)
Molecular Weight | 970.1 g/mol |
---|---|
Molecular Formula | C35H54GdN7O15 |
Hydrogen Bond Donor Count | 9 |
Hydrogen Bond Acceptor Count | 19 |
Rotatable Bond Count | 21 |
Exact Mass | g/mol |
Monoisotopic Mass | g/mol |
Topological Polar Surface Area | 352 |
Heavy Atom Count | 58 |
Formal Charge | 0 |
Complexity | 1200 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 6 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 2 |
Gadopiclenol is indicated in adult and pediatric patients aged 2 years and older for use with magnetic resonance imaging (MRI) to detect and visualize lesions with abnormal vascularity in the central nervous system (brain, spine, and associated tissues) and the body (head and neck, thorax, abdomen, pelvis, and musculoskeletal system).
Detection and visualization of disorders or lesions with suspected abnormal vascularity in various body regions for diagnostic purposes
Detection and visualisation of areas with disruption of the blood brain barrier and/or abnormal vascularity for diagnostic purposes
V - Various
V08 - Contrast media
V08C - Magnetic resonance imaging contrast media
V08CA - Paramagnetic contrast media
V08CA12 - Gadopiclenol
Absorption
At a dose range between 0.025 mmol/kg and 0.3 mmol/kg (0.5 times to 6 times the recommended dosage), the Cmax and AUCinf of gadopiclenol increases in a dose-proportional manner. At the recommended dose, gadopiclenol has a Cmax of 525 g/mL and an AUCinf of 569 gh/mL. A study that evaluated the pharmacokinetic parameters of gadopiclenol in healthy subjects and patients with brain lesions did not detect significant differences between the two groups.
Route of Elimination
Gadopiclenol is mainly excreted in urine by glomerular filtration. Within 48 hours after administration, approximately 98% of the gadopiclenol dose was recovered in urine.
Volume of Distribution
At steady state, the mean volume of distribution of gadopiclenol is 13 L.
Clearance
Gadopiclenol has a total body clearance of 100 mL/min and a renal clearance of 81 mL/min.
Gadopiclenol is not metabolized and is eliminated unchanged.
Gadopiclenol has a mean elimination half-life of is 1.5 hours.
Gadopiclenol is a macrocyclic non-ionic complex of gadolinium and a paramagnetic molecule that develops a magnetic moment when placed in a magnetic field. The magnetic moment alters the relaxation rates of water protons in its vicinity in the body. Its use in magnetic resonance imaging (MRI) allows to selectively increase contrast in tissues where gadopiclenol accumulates.
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PharmaCompass offers a list of Gadopiclenol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Gadopiclenol manufacturer or Gadopiclenol supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Gadopiclenol manufacturer or Gadopiclenol supplier.
PharmaCompass also assists you with knowing the Gadopiclenol API Price utilized in the formulation of products. Gadopiclenol API Price is not always fixed or binding as the Gadopiclenol Price is obtained through a variety of data sources. The Gadopiclenol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Gadopiclenol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Gadopiclenol, including repackagers and relabelers. The FDA regulates Gadopiclenol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Gadopiclenol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Gadopiclenol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Gadopiclenol supplier is an individual or a company that provides Gadopiclenol active pharmaceutical ingredient (API) or Gadopiclenol finished formulations upon request. The Gadopiclenol suppliers may include Gadopiclenol API manufacturers, exporters, distributors and traders.
click here to find a list of Gadopiclenol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
Gadopiclenol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Gadopiclenol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Gadopiclenol GMP manufacturer or Gadopiclenol GMP API supplier for your needs.
A Gadopiclenol CoA (Certificate of Analysis) is a formal document that attests to Gadopiclenol's compliance with Gadopiclenol specifications and serves as a tool for batch-level quality control.
Gadopiclenol CoA mostly includes findings from lab analyses of a specific batch. For each Gadopiclenol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Gadopiclenol may be tested according to a variety of international standards, such as European Pharmacopoeia (Gadopiclenol EP), Gadopiclenol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Gadopiclenol USP).