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    Chemistry

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    Also known as: 54-31-9, Frusemide, Lasix, Furosemid, Furanthril, Errolon
    Molecular Formula
    C12H11ClN2O5S
    Molecular Weight
    330.74  g/mol
    InChI Key
    ZZUFCTLCJUWOSV-UHFFFAOYSA-N
    FDA UNII
    7LXU5N7ZO5
    Furosemide
    A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
    Furosemide is a Loop Diuretic. The physiologic effect of furosemide is by means of Increased Diuresis at Loop of Henle.
    1 2D Structure

    Furosemide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
    2.1.2 InChI
    InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
    2.1.3 InChI Key
    ZZUFCTLCJUWOSV-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl
    2.2 Other Identifiers
    2.2.1 UNII
    7LXU5N7ZO5
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Errolon

    2. Frusemid

    3. Frusemide

    4. Furanthril

    5. Furantral

    6. Furosemide Monohydrochloride

    7. Furosemide Monosodium Salt

    8. Fursemide

    9. Fusid

    10. Lasix

    2.3.2 Depositor-Supplied Synonyms

    1. 54-31-9

    2. Frusemide

    3. Lasix

    4. Furosemid

    5. Furanthril

    6. Errolon

    7. Fusid

    8. Aisemide

    9. Beronald

    10. Desdemin

    11. Frusemin

    12. Fuluvamide

    13. Furanthryl

    14. Furantril

    15. Fursemide

    16. Lowpstron

    17. Macasirool

    18. Prefemin

    19. Rosemide

    20. Trofurit

    21. Fulsix

    22. Furesis

    23. Katlex

    24. Lasilix

    25. Radonna

    26. Seguril

    27. Transit

    28. Lasex

    29. Salix

    30. Urex

    31. Marsemide

    32. Eutensin

    33. Frusetic

    34. Fursemid

    35. Logirene

    36. Oedemex

    37. Promedes

    38. Frusid

    39. Lazix

    40. Mirfat

    41. Frusemid

    42. Frusenex

    43. Furanturil

    44. Furosedon

    45. Profemin

    46. Urosemide

    47. Aluzine

    48. Diural

    49. Dryptal

    50. Impugan

    51. Nicorol

    52. Rusyde

    53. Uremide

    54. Uresix

    55. Yidoli

    56. Disal

    57. Laxur

    58. Urian

    59. Apo-frusemide

    60. Hydro-rapid

    61. Anfuramaide

    62. Arasemide

    63. Bioretic

    64. Disemide

    65. Diurapid

    66. Diurolasa

    67. Diusemide

    68. Durafurid

    69. Fluidrol

    70. Frusedan

    71. Fuluvamine

    72. Furobeta

    73. Furodiurol

    74. Furodrix

    75. Furorese

    76. Furosemidum

    77. Furosemix

    78. Furoside

    79. Furosifar

    80. Furovite

    81. Fursemida

    82. Hissuflux

    83. Hydroled

    84. Jenafusid

    85. Lasiletten

    86. Lowpston

    87. Moilarorin

    88. Novosemide

    89. Protargen

    90. Radisemide

    91. Selectofur

    92. Sigasalur

    93. Spirofur

    94. Synephron

    95. Zafimida

    96. Aldalix

    97. Aquarid

    98. Aquasin

    99. Cetasix

    100. Dirine

    101. Discoid

    102. Diurin

    103. Diusil

    104. Diuzol

    105. Dranex

    106. Edemid

    107. Edenol

    108. Endural

    109. Farsix

    110. Franyl

    111. Frumex

    112. Frumide

    113. Frusema

    114. Furetic

    115. Furfan

    116. Furmid

    117. Furocot

    118. Furomen

    119. Furomex

    120. Furosan

    121. Furose

    122. Furosix

    123. Furoter

    124. Fursol

    125. Hydrex

    126. Kofuzon

    127. Kolkin

    128. Kutrix

    129. Lasemid

    130. Liside

    131. Luscek

    132. Nelsix

    133. Odemase

    134. Odemex

    135. Promide

    136. Puresis

    137. Radouna

    138. Salinex

    139. Salurex

    140. Salurid

    141. Uridon

    142. Uritol

    143. Aldic

    144. Depix

    145. Desal

    146. Eliur

    147. Fluss

    148. Furex

    149. Furix

    150. Golan

    151. Hydro

    152. Nadis

    153. Retep

    154. Rosis

    155. Vesix

    156. Mita

    157. Apo-furosemide

    158. Furo-puren

    159. Lasix Retard

    160. Polysquall A

    161. 4-chloro-n-furfuryl-5-sulfamoylanthranilic Acid

    162. Less Diur

    163. Neo-renal

    164. Furo-basan

    165. Furosemidu

    166. Urex-m

    167. Nephron

    168. Furomide M.d.

    169. Furosemida

    170. 4-chloro-n-(2-furylmethyl)-5-sulfamoylanthranilic Acid

    171. Lb 502

    172. 5-(aminosulfonyl)-4-chloro-2-[(2-furylmethyl)amino]benzoic Acid

    173. 2-furfurylamino-4-chloro-5-sulfamoylbenzoic Acid

    174. Lb-502

    175. Nci-c55936

    176. Lasix (tn)

    177. Benzoic Acid, 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]-

    178. 4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic Acid

    179. Diumide-k

    180. 4-chloro-5-sulfamoyl-n-furfuryl-anthranilic Acid

    181. 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic Acid

    182. Chlor-n-(2-furylmethyl)-5-sulfamylanthranilsaeure

    183. Anthranilic Acid, 4-chloro-n-furfuryl-5-sulfamoyl-

    184. Chembl35

    185. 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic Acid

    186. Nsc-269420

    187. Benzoic Acid, 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)-

    188. 7lxu5n7zo5

    189. Chebi:47426

    190. Furosemidu [polish]

    191. 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)benzoic Acid

    192. 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic Acid

    193. Cas-54-31-9

    194. Furosemidum [inn-latin]

    195. Furosemida [inn-spanish]

    196. Ncgc00016241-06

    197. Sal Diureticum

    198. 4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic Acid

    199. Dsstox_cid_648

    200. Dsstox_rid_75710

    201. Dsstox_gsid_20648

    202. Furosemide "mita"

    203. Fun

    204. Furosemide Mita

    205. Furosemide Oral

    206. 5-(aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic Acid

    207. 5-(aminosulfonyl)-4-chloro-2-[(furan-2-ylmethyl)amino]benzoic Acid

    208. Smr000058202

    209. Ccris 1951

    210. Furosemide ''mita''

    211. Hsdb 3086

    212. Sr-01000765380

    213. Einecs 200-203-6

    214. Hoe-058a

    215. Unii-7lxu5n7zo5

    216. Nsc 269420

    217. Brn 0840915

    218. Neosemid

    219. Zafurida

    220. Chlor-n-(2-furylmethyl)-5-sulfamylanthranilsaeure [german]

    221. 5-(aminosulfonyl)-4-chloro-2-((2-furylmethyl)amino)benzoic Acid

    222. Furosemide, 4

    223. Urex M

    224. Furosemide (lasix)

    225. Prestwick_752

    226. Frumil (salt/mix)

    227. Mfcd00010549

    228. Furosemide [usan:usp:inn:ban:jan]

    229. Spectrum_001100

    230. 1z9y

    231. 4-chloro-2-[(2-furylmethyl)amino]-5-sulfamoylbenzoic Acid

    232. Furosemide [mi]

    233. Furosemide [inn]

    234. Furosemide [jan]

    235. Prestwick0_000341

    236. Prestwick1_000341

    237. Prestwick2_000341

    238. Prestwick3_000341

    239. Spectrum2_001005

    240. Spectrum3_000437

    241. Spectrum4_000560

    242. Spectrum5_000744

    243. Furosemide [hsdb]

    244. Furosemide [iarc]

    245. Furosemide [usan]

    246. F0182

    247. Furosemide [vandf]

    248. Upcmld-dp022

    249. Furosemide [mart.]

    250. Schembl9811

    251. Furosemide [usp-rs]

    252. Furosemide [who-dd]

    253. Furosemide [who-ip]

    254. Oprea1_667724

    255. Bspbio_000401

    256. Bspbio_002054

    257. Kbiogr_001259

    258. Kbioss_001580

    259. 5-18-09-00555 (beilstein Handbook Reference)

    260. Mls001066374

    261. Mls001306403

    262. Mls002548896

    263. Bidd:gt0139

    264. Divk1c_000575

    265. Spectrum1500310

    266. Spbio_001129

    267. Spbio_002322

    268. Bpbio1_000443

    269. Furosemide (jp17/usp/inn)

    270. Gtpl4839

    271. Furosemide [green Book]

    272. Dtxsid6020648

    273. Furosemide [orange Book]

    274. Upcmld-dp022:001

    275. Bdbm25902

    276. Hms501m17

    277. Kbio1_000575

    278. Kbio2_001580

    279. Kbio2_004148

    280. Kbio2_006716

    281. Kbio3_001274

    282. Zinc35804

    283. 4-chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic Acid

    284. Furosemide [ep Monograph]

    285. Ninds_000575

    286. Furosemide [usp Monograph]

    287. Hms1569e03

    288. Hms1920b03

    289. Hms2090k06

    290. Hms2091h05

    291. Hms2096e03

    292. Hms2233h03

    293. Hms3259m03

    294. Hms3370j22

    295. Hms3655e09

    296. Hms3713e03

    297. Hms3874g03

    298. Pharmakon1600-01500310

    299. Furosemide 1.0 Mg/ml In Methanol

    300. Furosemidum [who-ip Latin]

    301. Albb-019200

    302. Hy-b0135

    303. Tox21_110322

    304. Tox21_202213

    305. Tox21_302971

    306. Bbl027780

    307. Ccg-40223

    308. Nsc269420

    309. Nsc757039

    310. Stk177334

    311. Wln: T5oj B1mr Cg Fvq Dszw

    312. Akos000266625

    313. Furosemide 100 Microg/ml In Methanol

    314. Tox21_110322_1

    315. Bcp9000708

    316. Cs-1915

    317. Db00695

    318. Ks-1226

    319. Nc00453

    320. Nsc-757039

    321. Idi1_000575

    322. Smp1_000129

    323. Ncgc00016241-01

    324. Ncgc00016241-02

    325. Ncgc00016241-03

    326. Ncgc00016241-04

    327. Ncgc00016241-05

    328. Ncgc00016241-07

    329. Ncgc00016241-08

    330. Ncgc00016241-10

    331. Ncgc00016241-11

    332. Ncgc00090893-01

    333. Ncgc00090893-02

    334. Ncgc00090893-03

    335. Ncgc00090893-05

    336. Ncgc00090893-06

    337. Ncgc00256523-01

    338. Ncgc00259762-01

    339. Ac-11067

    340. Bf166384

    341. Bp-13261

    342. Sbi-0051389.p003

    343. Db-052536

    344. Ab00052001

    345. Sw196894-3

    346. 54f319

    347. C07017

    348. D00331

    349. D87719

    350. Ab00052001-10

    351. Ab00052001-11

    352. Ab00052001_12

    353. Ab00052001_13

    354. A830094

    355. Q388801

    356. Sr-01000765380-2

    357. Sr-01000765380-3

    358. Sr-01000765380-7

    359. Brd-k78010432-001-05-8

    360. Brd-k78010432-001-10-8

    361. Z275128584

    362. 4-chloro-2-(2-furanylmethylamino)-5-sulfamoylbenzoic Acid

    363. Furosemide, British Pharmacopoeia (bp) Reference Standard

    364. Furosemide, European Pharmacopoeia (ep) Reference Standard

    365. 4-chloranyl-2-(furan-2-ylmethylamino)-5-sulfamoyl-benzoic Acid

    366. Furosemide, United States Pharmacopeia (usp) Reference Standard

    367. 4-chloro-n-furfuryl-5-sulfamoylanthranilic Acid Furosemide

    368. 4-chloro-n-furfuryl-5-sulfamoylanthranilic Acid??furosemide

    369. 5-(aminosulfamyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic Acid

    370. 5-(aminosulfonyl)-4-chloro-2-[(2-furylmethyl)amino]benzoic Acid #

    371. 4-chloro-n-furfuryl-5-sulfamoylanthranilic Acid Pound>>furosemide

    372. Furosemide, Pharmaceutical Secondary Standard; Certified Reference Material

    373. Furosemide For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    374. Furosemide Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 330.74 g/mol
    Molecular Formula C12H11ClN2O5S
    XLogP32
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count5
    Exact Mass330.0077203 g/mol
    Monoisotopic Mass330.0077203 g/mol
    Topological Polar Surface Area131 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity481
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameFurosemide
    PubMed HealthFurosemide
    Drug ClassesCardiovascular Agent
    Drug LabelThe CAS Registry Number is 54-31-9.It has a molecular formula of C12H11ClN2O5S and a molecular weight of 330.75.The molecular structure is as follows:...
    Active IngredientFurosemide
    Dosage FormTablet; Injectable; Solution
    RouteInjection; Oral
    Strength40mg/5ml; 10mg/ml; 80mg; 40mg; 20mg
    Market StatusPrescription
    CompanyVintage Pharms; Wockhardt; Excellium; Hospira; Sun Pharm Inds; Sandoz; Roxane; Ivax Sub Teva Pharms; Emcure Pharms; Fresenius Kabi Usa; Ipca Labs; Claris Lifesciences; Luitpold; Mylan

    2 of 6  
    Drug NameLasix
    PubMed HealthFurosemide
    Drug ClassesCardiovascular Agent
    Drug LabelLASIX is a diuretic which is an anthranilic acid derivative. LASIX tablets for oral administration contain furosemide as the active ingredient and the following inactive ingredients: lactose monohydrate NF, magnesium stearate NF, starch NF, talc US...
    Active IngredientFurosemide
    Dosage FormTablet
    RouteOral
    Strength80mg; 40mg; 20mg
    Market StatusPrescription
    CompanySanofi Aventis Us

    3 of 6  
    Drug NameUrex
    Active IngredientMethenamine hippurate
    Dosage FormTablet
    RouteOral
    Strength1gm
    Market StatusPrescription
    CompanyCnty Line Pharms

    4 of 6  
    Drug NameFurosemide
    PubMed HealthFurosemide
    Drug ClassesCardiovascular Agent
    Drug LabelThe CAS Registry Number is 54-31-9.It has a molecular formula of C12H11ClN2O5S and a molecular weight of 330.75.The molecular structure is as follows:...
    Active IngredientFurosemide
    Dosage FormTablet; Injectable; Solution
    RouteInjection; Oral
    Strength40mg/5ml; 10mg/ml; 80mg; 40mg; 20mg
    Market StatusPrescription
    CompanyVintage Pharms; Wockhardt; Excellium; Hospira; Sun Pharm Inds; Sandoz; Roxane; Ivax Sub Teva Pharms; Emcure Pharms; Fresenius Kabi Usa; Ipca Labs; Claris Lifesciences; Luitpold; Mylan

    5 of 6  
    Drug NameLasix
    PubMed HealthFurosemide
    Drug ClassesCardiovascular Agent
    Drug LabelLASIX is a diuretic which is an anthranilic acid derivative. LASIX tablets for oral administration contain furosemide as the active ingredient and the following inactive ingredients: lactose monohydrate NF, magnesium stearate NF, starch NF, talc US...
    Active IngredientFurosemide
    Dosage FormTablet
    RouteOral
    Strength80mg; 40mg; 20mg
    Market StatusPrescription
    CompanySanofi Aventis Us

    6 of 6  
    Drug NameUrex
    Active IngredientMethenamine hippurate
    Dosage FormTablet
    RouteOral
    Strength1gm
    Market StatusPrescription
    CompanyCnty Line Pharms

    4.2 Therapeutic Uses

    Diuretics; Sodium Potassium Chloride Symporter Inhibitors

    National Library of Medicine's Medical Subject Headings. Furosemide. Online file (MeSH, 2017). Available from, as of April 10, 2017: https://www.nlm.nih.gov/mesh/2017/mesh_browser/MBrowser.html

    Oral Lasix may be used in adults for the treatment of hypertension alone or in combination with other antihypertensive agents. Hypertensive patients who cannot be adequately controlled with thiazides will probably also not be adequately controlled with Lasix alone. /Included in US product labeling/

    NIH; DailyMed. Current Medication Information for Lasix (Furosemide Tablet) (Updated: April 2016). Available from, as of April 19, 2017: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2c9b4d8f-0770-482d-a9e6-9c616a440b1a

    Lasix is indicated in adults and pediatric patients for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Lasix is particularly useful when an agent with greater diuretic potential is desired. /Included in US product labeling/

    NIH; DailyMed. Current Medication Information for Lasix (Furosemide Tablet) (Updated: April 2016). Available from, as of April 19, 2017: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2c9b4d8f-0770-482d-a9e6-9c616a440b1a

    IV furosemide has been found useful as an adjunct to hypotensive agents in the treatment of hypertensive crises, especially when associated with acute pulmonary edema or renal failure. In addition to producing a rapid diuresis, furosemide enhances the effects of other hypotensive drugs and counteracts the sodium retention caused by some of these agents. /NOT included in US product labeling/

    American Society of Health-System Pharmacists 2016; Drug Information 2016. Bethesda, MD. 2016, p. 2828

    For more Therapeutic Uses (Complete) data for Furosemide (11 to