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Chemistry

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Also known as: 202409-33-4, Arcoxia, Tauxib, Nucoxia, Algix, Mk-0663
Molecular Formula
C18H15ClN2O2S
Molecular Weight
358.8  g/mol
InChI Key
MNJVRJDLRVPLFE-UHFFFAOYSA-N
FDA UNII
WRX4NFY03R

Etoricoxib
A sulfone and pyridine derivative that acts as a cyclooxygenase-2 inhibitor. It is used as a NSAID for the treatment of pain associated with RHEUMATOID ARTHRITIS and ANKYLOSING SPONDYLITIS. It is also used for the short-term treatment of moderate postoperative dental pain.
1 2D Structure

Etoricoxib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
2.1.2 InChI
InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3
2.1.3 InChI Key
MNJVRJDLRVPLFE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=NC=C(C=C1)C2=C(C=C(C=N2)Cl)C3=CC=C(C=C3)S(=O)(=O)C
2.2 Other Identifiers
2.2.1 UNII
WRX4NFY03R
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Arcoxia

2. L 791456

3. L-791456

4. L791456

5. Mk 0663

6. Mk-0663

7. Mk0663

2.3.2 Depositor-Supplied Synonyms

1. 202409-33-4

2. Arcoxia

3. Tauxib

4. Nucoxia

5. Algix

6. Mk-0663

7. 5-chloro-6'-methyl-3-(4-(methylsulfonyl)phenyl)-2,3'-bipyridine

8. Mk-663

9. L-791456

10. Mk 0663

11. 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine

12. Mk 663

13. 2,3'-bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-

14. 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine

15. Wrx4nfy03r

16. L791456

17. 5-chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine

18. Chebi:6339

19. Chembl416146

20. 2,3'-bipyridine, 5-chloro-6'-methyl-3-(4-(methylsulfonyl)phenyl)-

21. 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine

22. Ncgc00164578-01

23. Etoricoxibe

24. Etropain

25. Torcoxia

26. Etoxib

27. 5-chloro-3-(4-methanesulfonyl-phenyl)-6'-methyl-[2,3']bipyridinyl

28. Mk-0663;l-791456

29. Dsstox_cid_26457

30. Dsstox_rid_81631

31. Dsstox_gsid_46457

32. Etoricoxib [usan:inn:ban]

33. Kingcox

34. 5-chloro-6'-methyl-3-(4-(methylsulfonyl)-phenyl)-2,3'-bipyridine

35. Etoricoxib [usan]

36. Cas-202409-33-4

37. Sr-05000001486

38. Etoricoxib (usan/inn)

39. Unii-wrx4nfy03r

40. Mk0663

41. Etoricoxibum

42. Etoricoxib- Bio-x

43. Etoricoxib [mi]

44. Etoricoxib [inn]

45. Etoricoxib [mart.]

46. Schembl4680

47. Etoricoxib [who-dd]

48. Gtpl2896

49. Dtxsid3046457

50. Hms2090a05

51. Hms3713p20

52. Hms3885h14

53. Zinc579472

54. Amy30994

55. Bcp06428

56. Ex-a2642

57. Tox21 112206

58. Tox21_112206

59. Bdbm50072064

60. Etoricoxib; Mk-663; Mk-0663

61. Mfcd06797512

62. S4651

63. Akos016010125

64. Tox21_112206_1

65. Ccg-220639

66. Cs-1047

67. Db01628

68. Sb18988

69. Ncgc00164578-02

70. 5ch

71. Ac-29052

72. As-17761

73. Bc164436

74. Etoricoxib 100 Microg/ml In Acetonitrile

75. Hy-15321

76. Db-045133

77. Ft-0602793

78. Ft-0668437

79. D03710

80. Etoricoxib, Vetranal(tm), Analytical Standard

81. Ab01275483-01

82. 409e334

83. A848896

84. L001141

85. Q631202

86. J-013140

87. Sr-05000001486-1

88. Sr-05000001486-2

89. Brd-k54770957-001-01-9

90. Brd-k54770957-001-02-7

91. L-791,456

92. F2173-0490

93. Etoricoxib, United States Pharmacopeia (usp) Reference Standard

94. 5-chloro-3-(4-methanesulfonyl-phenyl)-6''''-methyl-[2,3'''']bipyridinyl

95. 5-chloro-3-(4-methanesulfonyl-phenyl)-6''-methyl-[2,3'']bipyridinyl

96. 5-chloro-3-(4-methanesulfonylphenyl)-2-(6-methylpyridin-3-yl)pyridine

97. 5-chloro-3-[4-(methylsulfonyl)phenyl]-2-(2-methyl-5-pyridinyl)pyridine

98. 5-chloro-6''-methyl-3-[4-(methylsulfonyl)phenyl]-2,3''-bipyridine

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 358.8 g/mol
Molecular Formula C18H15ClN2O2S
XLogP33.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass358.0542766 g/mol
Monoisotopic Mass358.0542766 g/mol
Topological Polar Surface Area68.3 Ų
Heavy Atom Count24
Formal Charge0
Complexity514
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Etoricoxib is a COX-2 selective inhibitor (approximately 106 times more selective for COX-2 inhibition over COX-1).


5.2 MeSH Pharmacological Classification

Cyclooxygenase 2 Inhibitors

A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2. (See all compounds classified as Cyclooxygenase 2 Inhibitors.)


Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


5.3 ATC Code

M01AH05

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


M - Musculo-skeletal system

M01 - Antiinflammatory and antirheumatic products

M01A - Antiinflammatory and antirheumatic products, non-steroids

M01AH - Coxibs

M01AH05 - Etoricoxib


5.4 Absorption, Distribution and Excretion

Absorption

Bioavailability is 100% following oral administration.


5.5 Metabolism/Metabolites

Hepatic, primarily via CYP3A4.


Etoricoxib has known human metabolites that include 6-Hydroxymethyletoricoxib and Etoricoxib 1'-N'-oxide.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


5.6 Biological Half-Life

22 hours


5.7 Mechanism of Action

Like any other COX-2 selective inhibitor Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2), preventing production of prostaglandins (PGs) from arachidonic acid.


API Reference Price

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03-Jan-2022
31-Aug-2025
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Looking for 202409-33-4 / Etoricoxib API manufacturers, exporters & distributors?

Etoricoxib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Etoricoxib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Etoricoxib manufacturer or Etoricoxib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Etoricoxib manufacturer or Etoricoxib supplier.

PharmaCompass also assists you with knowing the Etoricoxib API Price utilized in the formulation of products. Etoricoxib API Price is not always fixed or binding as the Etoricoxib Price is obtained through a variety of data sources. The Etoricoxib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Etoricoxib

Synonyms

202409-33-4, Arcoxia, Tauxib, Nucoxia, Algix, Mk-0663

Cas Number

202409-33-4

Unique Ingredient Identifier (UNII)

WRX4NFY03R

About Etoricoxib

A sulfone and pyridine derivative that acts as a cyclooxygenase-2 inhibitor. It is used as a NSAID for the treatment of pain associated with RHEUMATOID ARTHRITIS and ANKYLOSING SPONDYLITIS. It is also used for the short-term treatment of moderate postoperative dental pain.

Etoricoxib Manufacturers

A Etoricoxib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Etoricoxib, including repackagers and relabelers. The FDA regulates Etoricoxib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Etoricoxib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Etoricoxib manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Etoricoxib Suppliers

A Etoricoxib supplier is an individual or a company that provides Etoricoxib active pharmaceutical ingredient (API) or Etoricoxib finished formulations upon request. The Etoricoxib suppliers may include Etoricoxib API manufacturers, exporters, distributors and traders.

click here to find a list of Etoricoxib suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Etoricoxib USDMF

A Etoricoxib DMF (Drug Master File) is a document detailing the whole manufacturing process of Etoricoxib active pharmaceutical ingredient (API) in detail. Different forms of Etoricoxib DMFs exist exist since differing nations have different regulations, such as Etoricoxib USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Etoricoxib DMF submitted to regulatory agencies in the US is known as a USDMF. Etoricoxib USDMF includes data on Etoricoxib's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Etoricoxib USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Etoricoxib suppliers with USDMF on PharmaCompass.

Etoricoxib KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Etoricoxib Drug Master File in Korea (Etoricoxib KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Etoricoxib. The MFDS reviews the Etoricoxib KDMF as part of the drug registration process and uses the information provided in the Etoricoxib KDMF to evaluate the safety and efficacy of the drug.

After submitting a Etoricoxib KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Etoricoxib API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Etoricoxib suppliers with KDMF on PharmaCompass.

Etoricoxib WC

A Etoricoxib written confirmation (Etoricoxib WC) is an official document issued by a regulatory agency to a Etoricoxib manufacturer, verifying that the manufacturing facility of a Etoricoxib active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Etoricoxib APIs or Etoricoxib finished pharmaceutical products to another nation, regulatory agencies frequently require a Etoricoxib WC (written confirmation) as part of the regulatory process.

click here to find a list of Etoricoxib suppliers with Written Confirmation (WC) on PharmaCompass.

Etoricoxib NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Etoricoxib as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Etoricoxib API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Etoricoxib as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Etoricoxib and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Etoricoxib NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Etoricoxib suppliers with NDC on PharmaCompass.

Etoricoxib GMP

Etoricoxib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Etoricoxib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Etoricoxib GMP manufacturer or Etoricoxib GMP API supplier for your needs.

Etoricoxib CoA

A Etoricoxib CoA (Certificate of Analysis) is a formal document that attests to Etoricoxib's compliance with Etoricoxib specifications and serves as a tool for batch-level quality control.

Etoricoxib CoA mostly includes findings from lab analyses of a specific batch. For each Etoricoxib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Etoricoxib may be tested according to a variety of international standards, such as European Pharmacopoeia (Etoricoxib EP), Etoricoxib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Etoricoxib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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