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Chemistry

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Also known as: 87-28-5, Glycol salicylate, 2-hydroxyethyl 2-hydroxybenzoate, Ethylene glycol monosalicylate, Espirosal, Glycol monosalicylate
Molecular Formula
C9H10O4
Molecular Weight
182.17  g/mol
InChI Key
LVYLCBNXHHHPSB-UHFFFAOYSA-N
FDA UNII
3I1VBB7AXH

Hydroxyethyl Salicylate
Glycol salicylate, also known as 2-hydroxyethyl salicylate, is a benzoate ester formed from the condensation of the carboxy group of salicylic acid with one of the hydroxy groups of ethylene glycol. It is found as an active ingredient and topical analgesic in patches used to provide relief for mild to moderate muscle and joint pain. This drug belongs to the salicylate group of drugs, which are used as analgesic agents for the treatment of mild to moderate pain. Glycol salicylate (GS), composed of salicylic acid (SA) and ethylene glycol, is a non-steroidal anti-inflammatory drug. This ingredient is an important component of many topical creams and sprays for the relief of aches, pains, and stiffness of the muscles, joints, and tendons.
1 2D Structure

Hydroxyethyl Salicylate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-hydroxyethyl 2-hydroxybenzoate
2.1.2 InChI
InChI=1S/C9H10O4/c10-5-6-13-9(12)7-3-1-2-4-8(7)11/h1-4,10-11H,5-6H2
2.1.3 InChI Key
LVYLCBNXHHHPSB-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C(=C1)C(=O)OCCO)O
2.2 Other Identifiers
2.2.1 UNII
3I1VBB7AXH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ethyleneglycolmonosalicylic Acid Ester

2. Glycol Monosalicylate

3. Glycol Salicylate

4. Hydroxyethyl Salicylate

5. Menthoneurin

2.3.2 Depositor-Supplied Synonyms

1. 87-28-5

2. Glycol Salicylate

3. 2-hydroxyethyl 2-hydroxybenzoate

4. Ethylene Glycol Monosalicylate

5. Espirosal

6. Glycol Monosalicylate

7. Rheumacyl

8. Sarocol

9. Spirosal

10. Glysal

11. Ethylene Glycol Salicylate

12. Phlogont

13. Monoglycol Salicylate

14. Gl 7

15. Benzoic Acid, 2-hydroxy-, 2-hydroxyethyl Ester

16. Glykolsalicylat

17. Traumasenex

18. Ethylene Glycol, Salicylate

19. Kytta-gel

20. Ethylene Glycol, Monosalicylate

21. 1,2-ethylene Glycol Monosalicylate

22. Aethylenglykolsalicylat

23. Hydroxyethyl Salicylate

24. 2-hydroxybenzoic Acid 2-hydroxyethyl Ester

25. Salicylic Acid, 2-hydroxyethyl Ester

26. Ethylenglycol-monosalicylsaeureester

27. Nsc-72097

28. 3i1vbb7axh

29. .beta.-hydroxyethyl Salicylate

30. Chebi:86541

31. 2-hydroxyethyl 2-oxidanylbenzoate

32. Mfcd00002862

33. Ncgc00159379-03

34. 2-hydroxybenzoic Acid, 2-hydroxyethyl Ester

35. Glycol Salicylate (jan)

36. Glycol Salicylate [jan]

37. Unii-3i1vbb7axh

38. Norgesic (tn)

39. Phlogont (tn)

40. Einecs 201-737-2

41. Nsc 72097

42. Ai3-05033

43. 2-hydroxyethyl-salicylate

44. Bmse000750

45. Dsstox_cid_28913

46. Dsstox_rid_83181

47. Dsstox_gsid_48987

48. Schembl15402

49. Salicylic Acid Ethylene Glycol

50. Glycol Salicylate [mi]

51. Chembl173562

52. Dtxsid4048987

53. Glycol Salicylate [inci]

54. Lvylcbnxhhhpsb-uhfffaoysa-

55. Glycol Salicylate [mart.]

56. Glycol Salicylate [who-dd]

57. Cs-b1707

58. Hy-b2208

59. Nsc72097

60. Zinc1698306

61. Salicylic Acid 2-hydroxyethyl Ester

62. Tox21_113462

63. Akos009075810

64. Db11323

65. Cas-87-28-5

66. Ncgc00159379-02

67. Ncgc00159379-04

68. 2-hydroxy-benzoicacid2-hydroxyethyl Ester

69. Sy032913

70. E0113

71. Ft-0626298

72. Salicylic Acid, 2-hydroxyethyl Ester (8ci)

73. Hydroxyethyl Salicylate [ep Monograph]

74. D01557

75. E78954

76. Ethylene Glycol Monosalicylate, >=98.0% (gc)

77. A842078

78. Q117422

79. Sr-01000944719

80. Sr-01000944719-1

81. W-104034

82. Hydroxyethyl Salicylate, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 182.17 g/mol
Molecular Formula C9H10O4
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass182.05790880 g/mol
Monoisotopic Mass182.05790880 g/mol
Topological Polar Surface Area66.8 Ų
Heavy Atom Count13
Formal Charge0
Complexity169
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

This drug is only recommended for topical usages for the relief of muscular and rheumatic pain in human and animals.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Temporarily relieves minor to moderate aches and pains. Works with ingredients such as menthol, which has counter-irritant properties. Counter-irritants are externally applied, and lead to irritation or mild inflammation of the skin to relieve pain in muscles or joints by reducing inflammation in deeper adjacent structures. Counter-irritants relieve pain by disrupting the brain from receiving pain signals resulting from conditions such as osteoarthritis (OA) or injuries such as sprains or strains. These agents may cause vasodilatation or skin irritation, leading to a false sensation of heat or warmth.


5.2 Absorption, Distribution and Excretion

Absorption

Salicylate absorption follows first-order kinetics with an absorption half-life ranging from 5 to 16 minutes.


Route of Elimination

Salicylates are generally excreted.


5.3 Metabolism/Metabolites

The metabolism of glycol salicylate is similar to that of [DB00945] at other salicylates. Metabolism of salicylic acid occurs through glucuronide formation (to produce salicyl acyl glucuronide and salicyl phenolic glucuronide), conjugation with glycine (to produce salicyluric acid), and oxidation to gentisic acid. The rate of formation of salicyl phenolic glucuronide and salicyluric acid are readily saturated at low salicylic acid concentrations and their formation is described by Michaelis-Menten kinetics. The larger the dose administered, the longer it will take to reach steady-state concentrations of salicylates. There is also evidence that enzyme induction of salicyluric acid formation occurs during the metabolism of salicylates.


5.4 Biological Half-Life

The serum half-life of [DB00945], a similar salicylate, is 20 min.


5.5 Mechanism of Action

Similar to other salicylates. Salicylates and other analgesics and anti-inflammatory drugs, particularly the non-steroidal anti-inflammatory drugs (NSAID) mainly used in rheumatology, inhibit cyclooxygenase, therefore reducing prostaglandin synthesis.


API SUPPLIERS

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Curia

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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JQC (Huayin) Pharmaceutical Co.,Lt...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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UBE Corporation Europe

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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UBE Corporation Europe

Germany

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Curia

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Curia

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Hydroxyethyl Salicylate

About the Company : Curia is a global contract research, development and manufacturing organization (CDMO), offering products and services across the drug development spectrum to help our partners tur...

Curia is a global contract research, development and manufacturing organization (CDMO), offering products and services across the drug development spectrum to help our partners turn their ideas into real-world impact. We partner closely with pharmaceutical and biotechnology companies to boost business performance and improve patients’ lives. From early discovery and development through manufacturing and commercialization, our suite of custom solutions allows us to tailor every engagement to your precise needs, whether that’s an independent project or an opportunity that cuts across the drug continuum.
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glycol salicylate

About the Company : Founded in 2002, JQC (Huayin) Pharmaceutical Co., Ltd. is a private pharmaceutical enterprise, that focus in Salicylic acid series API & intermediates production and research devel...

Founded in 2002, JQC (Huayin) Pharmaceutical Co., Ltd. is a private pharmaceutical enterprise, that focus in Salicylic acid series API & intermediates production and research development. The predecessor was a state-owned corporation-“Northwest Second Synthesis Pharmaceutical”. The company’s register capital is 11.18 million RMB and the current net capital is nearly 150 million RMB. The company passed GMP issued by the State Food and Drug Administration (SFDA) in 2004, 2010 and 2015.Meanwhile, our quality system passed US FDA inspection In January 26, 2013, and NDC code was registered in D&B.
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Acidum flufenamicum; Hydroxyethyl salicylas; Heparinum natricum

Brand Name : Assan

Dosage Form : Emgel

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Registration Country : Switzerland

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Acidum flufenamicum; Hydroxyethyl salicylas; Heparinum natricum

Brand Name : Assan

Dosage Form : Gel

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Registration Country : Switzerland

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Hydroxyethyl salicylate; Dimethyl sulfoxidum; Macrogol 9aether laurilicus; Levomenthol; Camphora racemica; Dexpanthenol

Brand Name : Assan rem

Dosage Form : Spray

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Registration Country : Switzerland

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Hydroxyethyl salicylate; Heparinum natricum; Dimethyl sulfoxidum; Macrogol 9aether laurilicus

Brand Name : Sportusal

Dosage Form : Gel

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Registration Country : Switzerland

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Hydroxyethyl salicylate; Heparinum natricum; Dimethyl sulfoxidum; Macrogol 9aether laurilicus

Brand Name : Sportusal

Dosage Form : Gel

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Registration Country : Switzerland

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Hydroxyethyl salicylate; Heparinum natricum; Dimethyl sulfoxidum; Macrogol 9aether laurilicus

Brand Name : Sportusal

Dosage Form : Emgel

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Regulatory Info :

Registration Country : Switzerland

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Hydroxyethyl salicylate; Heparinum natricum; Dimethyl sulfoxidum; Macrogol 9aether laurilicus

Brand Name : Sportusal

Dosage Form : Emgel

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Approval Date :

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Regulatory Info :

Registration Country : Switzerland

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Hydroxyethyl salicylate; Heparinum natricum; Dimethyl sulfoxidum; Macrogol 9aether laurilicus

Brand Name : Venucreme

Dosage Form : Cream

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Registration Country : Switzerland

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Hydroxyethyl salicylate; Heparinum natricum; Dimethyl sulfoxidum; Macrogol 9aether laurilicus

Brand Name : Venugel

Dosage Form : Gel

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Registration Country : Switzerland

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Hydroxyethyl salicylate; Heparinum natricum; Dimethyl sulfoxidum; Macrogol 9aether laurilicus

Brand Name : Venugel

Dosage Form : Gel

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Registration Country : Switzerland

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ABOUT THIS PAGE

Looking for 87-28-5 / Hydroxyethyl Salicylate API manufacturers, exporters & distributors?

Hydroxyethyl Salicylate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Hydroxyethyl Salicylate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Hydroxyethyl Salicylate manufacturer or Hydroxyethyl Salicylate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Hydroxyethyl Salicylate manufacturer or Hydroxyethyl Salicylate supplier.

PharmaCompass also assists you with knowing the Hydroxyethyl Salicylate API Price utilized in the formulation of products. Hydroxyethyl Salicylate API Price is not always fixed or binding as the Hydroxyethyl Salicylate Price is obtained through a variety of data sources. The Hydroxyethyl Salicylate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Hydroxyethyl Salicylate

Synonyms

87-28-5, Glycol salicylate, 2-hydroxyethyl 2-hydroxybenzoate, Ethylene glycol monosalicylate, Espirosal, Glycol monosalicylate

Cas Number

87-28-5

Unique Ingredient Identifier (UNII)

3I1VBB7AXH

About Hydroxyethyl Salicylate

Glycol salicylate, also known as 2-hydroxyethyl salicylate, is a benzoate ester formed from the condensation of the carboxy group of salicylic acid with one of the hydroxy groups of ethylene glycol. It is found as an active ingredient and topical analgesic in patches used to provide relief for mild to moderate muscle and joint pain. This drug belongs to the salicylate group of drugs, which are used as analgesic agents for the treatment of mild to moderate pain. Glycol salicylate (GS), composed of salicylic acid (SA) and ethylene glycol, is a non-steroidal anti-inflammatory drug. This ingredient is an important component of many topical creams and sprays for the relief of aches, pains, and stiffness of the muscles, joints, and tendons.

Ethylene glycol monosalicylate Manufacturers

A Ethylene glycol monosalicylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ethylene glycol monosalicylate, including repackagers and relabelers. The FDA regulates Ethylene glycol monosalicylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ethylene glycol monosalicylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ethylene glycol monosalicylate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ethylene glycol monosalicylate Suppliers

A Ethylene glycol monosalicylate supplier is an individual or a company that provides Ethylene glycol monosalicylate active pharmaceutical ingredient (API) or Ethylene glycol monosalicylate finished formulations upon request. The Ethylene glycol monosalicylate suppliers may include Ethylene glycol monosalicylate API manufacturers, exporters, distributors and traders.

click here to find a list of Ethylene glycol monosalicylate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ethylene glycol monosalicylate CEP

A Ethylene glycol monosalicylate CEP of the European Pharmacopoeia monograph is often referred to as a Ethylene glycol monosalicylate Certificate of Suitability (COS). The purpose of a Ethylene glycol monosalicylate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Ethylene glycol monosalicylate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Ethylene glycol monosalicylate to their clients by showing that a Ethylene glycol monosalicylate CEP has been issued for it. The manufacturer submits a Ethylene glycol monosalicylate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Ethylene glycol monosalicylate CEP holder for the record. Additionally, the data presented in the Ethylene glycol monosalicylate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Ethylene glycol monosalicylate DMF.

A Ethylene glycol monosalicylate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Ethylene glycol monosalicylate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Ethylene glycol monosalicylate suppliers with CEP (COS) on PharmaCompass.

Ethylene glycol monosalicylate GMP

Ethylene glycol monosalicylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ethylene glycol monosalicylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ethylene glycol monosalicylate GMP manufacturer or Ethylene glycol monosalicylate GMP API supplier for your needs.

Ethylene glycol monosalicylate CoA

A Ethylene glycol monosalicylate CoA (Certificate of Analysis) is a formal document that attests to Ethylene glycol monosalicylate's compliance with Ethylene glycol monosalicylate specifications and serves as a tool for batch-level quality control.

Ethylene glycol monosalicylate CoA mostly includes findings from lab analyses of a specific batch. For each Ethylene glycol monosalicylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ethylene glycol monosalicylate may be tested according to a variety of international standards, such as European Pharmacopoeia (Ethylene glycol monosalicylate EP), Ethylene glycol monosalicylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ethylene glycol monosalicylate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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