Find ETC-159 manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Etc-159, 1638250-96-0, Etc-1922159, 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-n-(6-phenylpyridazin-3-yl)acetamide, Etc159, Chembl3633802
Molecular Formula
C19H17N7O3
Molecular Weight
391.4  g/mol
InChI Key
QTRXIFVSTWXRJJ-UHFFFAOYSA-N
FDA UNII
5L854240DQ

ETC-159
Porcupine Inhibitor ETC-1922159 is an orally bioavailable inhibitor of the membrane-bound O-acyltransferase (MBOAT) porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, ETC-1922159 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational palmitoylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine catalyzes the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion. Wnt signaling is dysregulated in a variety of cancers.
1 2D Structure

ETC-159

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide
2.1.2 InChI
InChI=1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)
2.1.3 InChI Key
QTRXIFVSTWXRJJ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4
2.2 Other Identifiers
2.2.1 UNII
5L854240DQ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Etc-159

2. Etc-1922159

2.3.2 Depositor-Supplied Synonyms

1. Etc-159

2. 1638250-96-0

3. Etc-1922159

4. 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-n-(6-phenylpyridazin-3-yl)acetamide

5. Etc159

6. Chembl3633802

7. 5l854240dq

8. 2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1h-purin-7-yl)-n-(6-phenylpyridazin-3-yl)acetamide

9. 7h-purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-n-(6-phenyl-3-pyridazinyl)-

10. Unii-5l854240dq

11. Schembl17626176

12. Gtpl11168

13. Etc 159

14. Bcp20688

15. Ex-a2302

16. Bdbm50133866

17. Nsc809251

18. Zinc175660737

19. Cs-5162

20. Etc1922159

21. Nsc-809251

22. Sb18869

23. Ac-35482

24. As-74458

25. Hy-18988

26. S6616

27. A857431

28. 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-n-(6-phenyl-3-pyridazinyl)-7h-purine-7-acetamide

2.4 Create Date
2014-12-08
3 Chemical and Physical Properties
Molecular Weight 391.4 g/mol
Molecular Formula C19H17N7O3
XLogP30.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass391.13928743 g/mol
Monoisotopic Mass391.13928743 g/mol
Topological Polar Surface Area113 Ų
Heavy Atom Count29
Formal Charge0
Complexity654
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1638250-96-0 / ETC-159 API manufacturers, exporters & distributors?

ETC-159 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of ETC-159 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right ETC-159 manufacturer or ETC-159 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred ETC-159 manufacturer or ETC-159 supplier.

PharmaCompass also assists you with knowing the ETC-159 API Price utilized in the formulation of products. ETC-159 API Price is not always fixed or binding as the ETC-159 Price is obtained through a variety of data sources. The ETC-159 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

ETC-159

Synonyms

1638250-96-0, Etc-1922159, 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-n-(6-phenylpyridazin-3-yl)acetamide, Etc159, Chembl3633802, 5l854240dq

Cas Number

1638250-96-0

Unique Ingredient Identifier (UNII)

5L854240DQ

About ETC-159

Porcupine Inhibitor ETC-1922159 is an orally bioavailable inhibitor of the membrane-bound O-acyltransferase (MBOAT) porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, ETC-1922159 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational palmitoylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine catalyzes the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion. Wnt signaling is dysregulated in a variety of cancers.

ETC 159 Manufacturers

A ETC 159 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of ETC 159, including repackagers and relabelers. The FDA regulates ETC 159 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. ETC 159 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

ETC 159 Suppliers

A ETC 159 supplier is an individual or a company that provides ETC 159 active pharmaceutical ingredient (API) or ETC 159 finished formulations upon request. The ETC 159 suppliers may include ETC 159 API manufacturers, exporters, distributors and traders.

ETC 159 GMP

ETC 159 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of ETC 159 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right ETC 159 GMP manufacturer or ETC 159 GMP API supplier for your needs.

ETC 159 CoA

A ETC 159 CoA (Certificate of Analysis) is a formal document that attests to ETC 159's compliance with ETC 159 specifications and serves as a tool for batch-level quality control.

ETC 159 CoA mostly includes findings from lab analyses of a specific batch. For each ETC 159 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

ETC 159 may be tested according to a variety of international standards, such as European Pharmacopoeia (ETC 159 EP), ETC 159 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (ETC 159 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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