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Ephedrine Hydrochloride

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

16 API Suppliers, 10 USDMF, 4 CEP/COS, 2 JDMF, 4 EU WC, 1 KDMF, 4 NDC API, 4 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Imports

DOSSIERs // Finished Dosage Formulations

13 Dossiers, 4 FDA Orange Book, 3 Europe, 1 Canada, 1 South Africa, 4 Listed Dossiers

DRUG PRODUCT COMPOSITION

SOLUTION;INTRAVENOUS - 23.5MG/5ML (4.7MG/ML), SOLUTION;INTRAVENOUS - 47MG/10ML (4.7MG/ML), SOLUTION;INTRAVENOUS - 47MG/ML (47MG/ML), SOLUTION;INTRAVENOUS - 47MG/5ML (9.4MG/ML)

SOLUTION;INTRAVENOUS - 23.5MG/5ML (4.7MG/ML)
SOLUTION;INTRAVENOUS - 47MG/10ML (4.7MG/ML)
SOLUTION;INTRAVENOUS - 47MG/ML (47MG/ML)
SOLUTION;INTRAVENOUS - 47MG/5ML (9.4MG/ML)

RELATED EXCIPIENT COMPANIES

Suppliers, 25 Roquette, 12 BASF, 10 Sigachi Industries, 10 Microlex e.U, 9 Gangwal Healthcare, 8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 5 Gangwal Chemicals, 5 SPI Pharma, 4 Prachin Chemical, 4 Vasa Pharmachem, 4 Kerry, 4 Ingredion Pharma Solutions, 4 DFE Pharma, 3 Boai NKY Pharmaceuticals Ltd, 3 Pharmatrans-Sanaq, 2 Rochem International Inc, 2 Ulanqab Kema New Material, 1 Pharm-RX Chemical, 1 Ideal Cures Pvt Ltd, 1 Bioplus Life Sciences, 1 Jai Radhe Sales, 1 Nanjing Well Pharmaceutical, 1 Seppic, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Actylis, 1 Finar

EXCIPIENTS BY APPLICATIONS

47 Fillers, Diluents & Binders, 29 Disintegrants & Superdisintegrants, 23 Direct Compression, 16 Granulation, 16 Thickeners and Stabilizers, 16 Lubricants & Glidants, 11 Solubilizers, 10 Taste Masking, 9 Co-Processed Excipients, 8 Film Formers & Plasticizers, 8 Controlled & Modified Release, 8 Coating Systems & Additives, 6 Chewable & Orodispersible Aids, 3 Topical, 3 Parenteral, 2 API Stability Enhancers, 2 Rheology Modifiers, 2 Emulsifying Agents

MARKET PLACE

15 APIs, 6 DOSSIERS // FDF

ANALYTICAL SOLUTION(s)

1 EDQM Standards, 1 USP Standards, 1 Other Ref. Standards

Also known as: 50-98-6, (-)-ephedrine hydrochloride, L-ephedrine hydrochloride, 1-ephedrine hydrochloride, Ephedrine hcl, Ephedrine (hydrochloride)

Molecular Formula

C₁₀H₁₆ClNO

Molecular Weight

201.69 g/mol

InChI Key

BALXUFOVQVENIU-GNAZCLTHSA-N

FDA UNII

NLJ6390P1Z

A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.

1 2D Structure

Ephedrine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride

2.1.2 InChI

InChI=1S/C10H15NO.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H/t8-,10-;/m0./s1

2.1.3 InChI Key

BALXUFOVQVENIU-GNAZCLTHSA-N

2.1.4 Canonical SMILES

CC(C(C1=CC=CC=C1)O)NC.Cl

2.1.5 Isomeric SMILES

C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.Cl

2.2 Other Identifiers

2.2.1 UNII

NLJ6390P1Z

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ephedrine

2. Ephedrine Erythro Isomer

3. Ephedrine Renaudin

4. Ephedrine Sulfate

5. Erythro Isomer Of Ephedrine

6. Hydrochloride, Ephedrine

7. Renaudin, Ephedrine

8. Sal Phedrine

9. Sal-phedrine

10. Salphedrine

11. Sulfate, Ephedrine

2.3.2 Depositor-Supplied Synonyms

1. 50-98-6

2. (-)-ephedrine Hydrochloride

3. L-ephedrine Hydrochloride

4. 1-ephedrine Hydrochloride

5. Ephedrine Hcl

6. Ephedrine (hydrochloride)

7. Nlj6390p1z

8. Nsc-759611

9. Ephedronguent

10. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol Hydrochloride

11. Altusin

12. Dsstox_cid_25825

13. Dsstox_rid_81156

14. Dsstox_gsid_45825

15. Ephedrinium Chloride

16. L-ephedrine, Hydrochloride

17. (-)-ephedrin Hydrochloride

18. Cas-50-98-6

19. Einecs 200-074-6

20. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride

21. Unii-nlj6390p1z

22. Ephedrine Hydrochloride [usan:ban:jan]

23. Ncgc00094665-01

24. Rezipres

25. (1r,2s)-(-)-ephedrine Hydrochloride

26. Ephedrini Hydrochloridum

27. N-methyl-beta-oxy-beta-phenylisopropylaminhydrochlorid [german]

28. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, Hydrochloride, (r-(r*,s*))-

29. Ec 200-074-6

30. Schembl22822

31. Ephedrine Hydrochloride (tn)

32. Ephedrine Hydrochloride Racemic

33. N-methyl-beta-oxy-beta-phenylisopropylaminhydrochlorid

34. Chembl2146102

35. Dtxsid1045825

36. Chebi:31541

37. Hy-b1195a

38. Str01942

39. Ephedrine Hydrochloride [mi]

40. Tox21_111310

41. Ephedrine Hydrochloride (jp17/usp)

42. Ephedrine Hydrochloride [jan]

43. Akos015895154

44. Tox21_111310_1

45. Ccg-229523

46. Cs-4803

47. Ephedrine Hydrochloride [mart.]

48. Ephedrine Hydrochloride [vandf]

49. Nsc 759611

50. Benzenemethanol, .alpha.-[(1s)-1-(methylamino)ethyl]-, Hydrochloride, (.alpha.r)-

51. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, Hydrochloride, (alphar)-

52. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, Hydrochloride, (theta-(theta,s))-

53. Ephedrine Hydrochloride [usp-rs]

54. Ephedrine Hydrochloride [who-dd]

55. Ephedrine Hydrochloride [who-ip]

56. Ncgc00015408-03

57. (1r,2s)-(-)-ephedrinehydrochloride

58. Ephedrine Hydrochloride [ep Impurity]

59. Ephedrine Hydrochloride [orange Book]

60. (-)-ephedrine Hydrochloride [who-ip]

61. (1r,2s)-(-)-ephedrine Hydrochloride, 99%

62. Ephedrine Hydrochloride [ep Monograph]

63. D01386

64. Ephedrine Hydrochloride [usp Monograph]

65. Ephedrini Hydrochloridum [who-ip Latin]

66. 066e127

67. Q27284939

68. (1r,2s)-ephedrine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

69. Ephedrine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

70. (r-(r*,s*))-.alpha.-(1-(methylamino)ethyl)benzenemethanol Hydrochloride [who-ip]

71. Benzenemethanol, .alpha.-(1-(methylamino)ethyl)-, Hydrochloride, (r-(r*,s*))-

72. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, Hydrochloride (1:1), (alphar)-

73. Ephedrine Hydrochloride, Drug Precursor, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₆ClNO
Molecular Weight	201.69 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	201.0920418 g/mol
Monoisotopic Mass	201.0920418 g/mol
Topological Polar Surface Area	32.3 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	121
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic Agents

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

Central Nervous System Stimulants

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)

Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

4.2 FDA Pharmacological Classification

4.2.1 Pharmacological Classes

Adrenergic beta-Agonists [MoA]; Increased Norepinephrine Activity [PE]; Norepinephrine Releasing Agent [EPC]; alpha-Adrenergic Agonist [EPC]; beta-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]

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