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Also known as: 50-98-6, (-)-ephedrine hydrochloride, L-ephedrine hydrochloride, 1-ephedrine hydrochloride, Ephedrine hcl, Ephedrine (hydrochloride)
Molecular Formula
C10H16ClNO
Molecular Weight
201.69  g/mol
InChI Key
BALXUFOVQVENIU-GNAZCLTHSA-N
FDA UNII
NLJ6390P1Z

Ephedrine Hydrochloride
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
1 2D Structure

Ephedrine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride
2.1.2 InChI
InChI=1S/C10H15NO.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H/t8-,10-;/m0./s1
2.1.3 InChI Key
BALXUFOVQVENIU-GNAZCLTHSA-N
2.1.4 Canonical SMILES
CC(C(C1=CC=CC=C1)O)NC.Cl
2.1.5 Isomeric SMILES
C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.Cl
2.2 Other Identifiers
2.2.1 UNII
NLJ6390P1Z
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ephedrine

2. Ephedrine Erythro Isomer

3. Ephedrine Renaudin

4. Ephedrine Sulfate

5. Erythro Isomer Of Ephedrine

6. Hydrochloride, Ephedrine

7. Renaudin, Ephedrine

8. Sal Phedrine

9. Sal-phedrine

10. Salphedrine

11. Sulfate, Ephedrine

2.3.2 Depositor-Supplied Synonyms

1. 50-98-6

2. (-)-ephedrine Hydrochloride

3. L-ephedrine Hydrochloride

4. 1-ephedrine Hydrochloride

5. Ephedrine Hcl

6. Ephedrine (hydrochloride)

7. Nlj6390p1z

8. Nsc-759611

9. Ephedronguent

10. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol Hydrochloride

11. Altusin

12. Dsstox_cid_25825

13. Dsstox_rid_81156

14. Dsstox_gsid_45825

15. Ephedrinium Chloride

16. L-ephedrine, Hydrochloride

17. (-)-ephedrin Hydrochloride

18. Cas-50-98-6

19. Einecs 200-074-6

20. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride

21. Unii-nlj6390p1z

22. Ephedrine Hydrochloride [usan:ban:jan]

23. Ncgc00094665-01

24. Rezipres

25. (1r,2s)-(-)-ephedrine Hydrochloride

26. Ephedrini Hydrochloridum

27. N-methyl-beta-oxy-beta-phenylisopropylaminhydrochlorid [german]

28. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, Hydrochloride, (r-(r*,s*))-

29. Ec 200-074-6

30. Schembl22822

31. Ephedrine Hydrochloride (tn)

32. Ephedrine Hydrochloride Racemic

33. N-methyl-beta-oxy-beta-phenylisopropylaminhydrochlorid

34. Chembl2146102

35. Dtxsid1045825

36. Chebi:31541

37. Hy-b1195a

38. Str01942

39. Ephedrine Hydrochloride [mi]

40. Tox21_111310

41. Ephedrine Hydrochloride (jp17/usp)

42. Ephedrine Hydrochloride [jan]

43. Akos015895154

44. Tox21_111310_1

45. Ccg-229523

46. Cs-4803

47. Ephedrine Hydrochloride [mart.]

48. Ephedrine Hydrochloride [vandf]

49. Nsc 759611

50. Benzenemethanol, .alpha.-[(1s)-1-(methylamino)ethyl]-, Hydrochloride, (.alpha.r)-

51. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, Hydrochloride, (alphar)-

52. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, Hydrochloride, (theta-(theta,s))-

53. Ephedrine Hydrochloride [usp-rs]

54. Ephedrine Hydrochloride [who-dd]

55. Ephedrine Hydrochloride [who-ip]

56. Ncgc00015408-03

57. (1r,2s)-(-)-ephedrinehydrochloride

58. Ephedrine Hydrochloride [ep Impurity]

59. Ephedrine Hydrochloride [orange Book]

60. (-)-ephedrine Hydrochloride [who-ip]

61. (1r,2s)-(-)-ephedrine Hydrochloride, 99%

62. Ephedrine Hydrochloride [ep Monograph]

63. D01386

64. Ephedrine Hydrochloride [usp Monograph]

65. Ephedrini Hydrochloridum [who-ip Latin]

66. 066e127

67. Q27284939

68. (1r,2s)-ephedrine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

69. Ephedrine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

70. (r-(r*,s*))-.alpha.-(1-(methylamino)ethyl)benzenemethanol Hydrochloride [who-ip]

71. Benzenemethanol, .alpha.-(1-(methylamino)ethyl)-, Hydrochloride, (r-(r*,s*))-

72. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, Hydrochloride (1:1), (alphar)-

73. Ephedrine Hydrochloride, Drug Precursor, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 201.69 g/mol
Molecular Formula C10H16ClNO
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass201.0920418 g/mol
Monoisotopic Mass201.0920418 g/mol
Topological Polar Surface Area32.3 Ų
Heavy Atom Count13
Formal Charge0
Complexity121
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Adrenergic Agents

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)


Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


Central Nervous System Stimulants

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)


Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)


4.2 FDA Pharmacological Classification
4.2.1 Pharmacological Classes
Adrenergic beta-Agonists [MoA]; Increased Norepinephrine Activity [PE]; Norepinephrine Releasing Agent [EPC]; alpha-Adrenergic Agonist [EPC]; beta-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]

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ROAD","city":"CHENNAI, TAMIL NADU","supplier":"MALLADI DRUGS AND PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"BANGKOK","customer":"TO THE ORDER OF","customerCountry":"THAILAND","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"53","totalValueFC":"102986.6","currency":"USD","unitRateINR":4407.9189999999999,"date":"09-Apr-2025","totalValueINR":"8815838","totalValueInUsd":"102986.6","indian_port":"Madras Air","hs_no":"29394200","bill_no":"9807130","productDescription":"API","marketType":"","country":"THAILAND","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"NO.9, G.S.T. ROAD, CHENNAI, TAMIL NADU","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1744309800,"product":"PSEUDOEPHEDRINE HYDROCHLORIDE BP\/ PHARM EUR BATCH NO. B204925B MFG DT MARCH 2025 EXP DT FEBRUARY 2030","address":"501, SENTINEL, HIRANANDANI GARDENS","city":"POWAI, MUMBAI. 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MAHARASTRA","supplier":"EMBIO LIMITED","supplierCountry":"INDIA","foreign_port":"DUBAI","customer":"TO THE ORDER","customerCountry":"UNITED ARAB EMIRATES","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"60","totalValueFC":"1404.4","currency":"USD","unitRateINR":4808.7359999999999,"date":"15-Apr-2025","totalValueINR":"120218.4","totalValueInUsd":"1404.4","indian_port":"Bombay Air","hs_no":"29394200","bill_no":"9965473","productDescription":"API","marketType":"","country":"UNITED ARAB EMIRATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"501, SENTINEL, HIRANANDANI GARDENS, POWAI, MUMBAI. MAHARASTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1744741800,"product":"EPHEDRINE HYDROCHLORIDE BP\/PHARM. EUR.\/USP - BATCH NO. 102625 MFG.DT. APRIL 2025 \/ EXP.\/RETEST DT. MARCH 2030","address":"501, SENTINEL, HIRANANDANI GARDENS","city":"POWAI, MUMBAI. MAHARASTRA","supplier":"EMBIO LIMITED","supplierCountry":"INDIA","foreign_port":"SINGAPORE","customer":"TO THE ORDER OF","customerCountry":"SINGAPORE","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"56","totalValueFC":"2670.1","currency":"USD","unitRateINR":4571.3215999999993,"date":"16-Apr-2025","totalValueINR":"228566.08","totalValueInUsd":"2670.1","indian_port":"Bombay Air","hs_no":"29394100","bill_no":"1005367","productDescription":"API","marketType":"","country":"SINGAPORE","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"501, SENTINEL, HIRANANDANI GARDENS, POWAI, MUMBAI. MAHARASTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1744741800,"product":"PSEUDOEPHEDRINE HYDROCHLORIDE USP , BATCH NO: B205125B MFG DT: APRIL 2025, EXP\/RETEST: MARCH 2030","address":"501, SENTINEL, HIRANANDANI GARDENS","city":"POWAI, MUMBAI. 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10-Jan-2022
25-Apr-2025
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DOSAGE - SOLUTION;INTRAVENOUS - 23.5MG/5ML (4...DOSAGE - SOLUTION;INTRAVENOUS - 23.5MG/5ML (4.7MG/ML)

USFDA APPLICATION NUMBER - 213536

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DOSAGE - SOLUTION;INTRAVENOUS - 47MG/10ML (4....DOSAGE - SOLUTION;INTRAVENOUS - 47MG/10ML (4.7MG/ML)

USFDA APPLICATION NUMBER - 213536

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DOSAGE - SOLUTION;INTRAVENOUS - 47MG/ML (47MG...DOSAGE - SOLUTION;INTRAVENOUS - 47MG/ML (47MG/ML)

USFDA APPLICATION NUMBER - 213536

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DOSAGE - SOLUTION;INTRAVENOUS - 47MG/5ML (9.4...DOSAGE - SOLUTION;INTRAVENOUS - 47MG/5ML (9.4MG/ML)

USFDA APPLICATION NUMBER - 213536

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ABOUT THIS PAGE

Looking for 50-98-6 / Ephedrine Hydrochloride API manufacturers, exporters & distributors?

Ephedrine Hydrochloride manufacturers, exporters & distributors 1

10

PharmaCompass offers a list of Ephedrine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ephedrine Hydrochloride manufacturer or Ephedrine Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ephedrine Hydrochloride manufacturer or Ephedrine Hydrochloride supplier.

PharmaCompass also assists you with knowing the Ephedrine Hydrochloride API Price utilized in the formulation of products. Ephedrine Hydrochloride API Price is not always fixed or binding as the Ephedrine Hydrochloride Price is obtained through a variety of data sources. The Ephedrine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ephedrine Hydrochloride

Synonyms

50-98-6, (-)-ephedrine hydrochloride, L-ephedrine hydrochloride, 1-ephedrine hydrochloride, Ephedrine hcl, Ephedrine (hydrochloride)

Cas Number

50-98-6

Unique Ingredient Identifier (UNII)

NLJ6390P1Z

About Ephedrine Hydrochloride

A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.

Ephedrine Hydrochloride Manufacturers

A Ephedrine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ephedrine Hydrochloride, including repackagers and relabelers. The FDA regulates Ephedrine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ephedrine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ephedrine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ephedrine Hydrochloride Suppliers

A Ephedrine Hydrochloride supplier is an individual or a company that provides Ephedrine Hydrochloride active pharmaceutical ingredient (API) or Ephedrine Hydrochloride finished formulations upon request. The Ephedrine Hydrochloride suppliers may include Ephedrine Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Ephedrine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ephedrine Hydrochloride USDMF

A Ephedrine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Ephedrine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Ephedrine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Ephedrine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Ephedrine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Ephedrine Hydrochloride USDMF includes data on Ephedrine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ephedrine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Ephedrine Hydrochloride suppliers with USDMF on PharmaCompass.

Ephedrine Hydrochloride JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Ephedrine Hydrochloride Drug Master File in Japan (Ephedrine Hydrochloride JDMF) empowers Ephedrine Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Ephedrine Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Ephedrine Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Ephedrine Hydrochloride suppliers with JDMF on PharmaCompass.

Ephedrine Hydrochloride KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Ephedrine Hydrochloride Drug Master File in Korea (Ephedrine Hydrochloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Ephedrine Hydrochloride. The MFDS reviews the Ephedrine Hydrochloride KDMF as part of the drug registration process and uses the information provided in the Ephedrine Hydrochloride KDMF to evaluate the safety and efficacy of the drug.

After submitting a Ephedrine Hydrochloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Ephedrine Hydrochloride API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Ephedrine Hydrochloride suppliers with KDMF on PharmaCompass.

Ephedrine Hydrochloride CEP

A Ephedrine Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Ephedrine Hydrochloride Certificate of Suitability (COS). The purpose of a Ephedrine Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Ephedrine Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Ephedrine Hydrochloride to their clients by showing that a Ephedrine Hydrochloride CEP has been issued for it. The manufacturer submits a Ephedrine Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Ephedrine Hydrochloride CEP holder for the record. Additionally, the data presented in the Ephedrine Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Ephedrine Hydrochloride DMF.

A Ephedrine Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Ephedrine Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Ephedrine Hydrochloride suppliers with CEP (COS) on PharmaCompass.

Ephedrine Hydrochloride WC

A Ephedrine Hydrochloride written confirmation (Ephedrine Hydrochloride WC) is an official document issued by a regulatory agency to a Ephedrine Hydrochloride manufacturer, verifying that the manufacturing facility of a Ephedrine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Ephedrine Hydrochloride APIs or Ephedrine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Ephedrine Hydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Ephedrine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Ephedrine Hydrochloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Ephedrine Hydrochloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Ephedrine Hydrochloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Ephedrine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Ephedrine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Ephedrine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Ephedrine Hydrochloride suppliers with NDC on PharmaCompass.

Ephedrine Hydrochloride GMP

Ephedrine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ephedrine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ephedrine Hydrochloride GMP manufacturer or Ephedrine Hydrochloride GMP API supplier for your needs.

Ephedrine Hydrochloride CoA

A Ephedrine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Ephedrine Hydrochloride's compliance with Ephedrine Hydrochloride specifications and serves as a tool for batch-level quality control.

Ephedrine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Ephedrine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ephedrine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Ephedrine Hydrochloride EP), Ephedrine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ephedrine Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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