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Chemistry

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Also known as: Emvododstat, Ptc299, Ptc-299, 1256565-36-2, Emvododstat [usan], 053qd2i96a
Molecular Formula
C25H20Cl2N2O3
Molecular Weight
467.3  g/mol
InChI Key
SRSHBZRURUNOSM-DEOSSOPVSA-N
FDA UNII
053QD2I96A

Emvododstat
Emvododstat is an orally bioavailable, small molecule inhibitor of vascular endothelial growth factor (VEGF) synthesis with potential antiangiogenesis and antineoplastic activities. Emvododstat targets post-transcriptionally by selectively binding the 5'- and 3'-untranslated regions (UTR) of VEGF messenger RNA (mRNA), thereby preventing translation of VEGF. This inhibits VEGF protein production and decreases its levels in the tumor and bloodstream. In turn, this may result in the inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and eventually the induction of tumor cell death. VEGFs are upregulated in a variety of tumor cell types and play key roles during angiogenesis. In addition, emvododstat may enhance the antitumor activity of other chemotherapeutic agents.
1 2D Structure

Emvododstat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
2.1.2 InChI
InChI=1S/C25H20Cl2N2O3/c1-31-18-7-2-15(3-8-18)24-23-20(21-14-17(27)6-11-22(21)28-23)12-13-29(24)25(30)32-19-9-4-16(26)5-10-19/h2-11,14,24,28H,12-13H2,1H3/t24-/m0/s1
2.1.3 InChI Key
SRSHBZRURUNOSM-DEOSSOPVSA-N
2.1.4 Canonical SMILES
COC1=CC=C(C=C1)C2C3=C(CCN2C(=O)OC4=CC=C(C=C4)Cl)C5=C(N3)C=CC(=C5)Cl
2.1.5 Isomeric SMILES
COC1=CC=C(C=C1)[C@H]2C3=C(CCN2C(=O)OC4=CC=C(C=C4)Cl)C5=C(N3)C=CC(=C5)Cl
2.2 Other Identifiers
2.2.1 UNII
053QD2I96A
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6-chloro-1,3,4,9-tetrahydro-1-(4-methoxyphenyl)-, 4-chlorophenyl Ester, (1s)-2h-pyrido(3,4-b)indole-2-carboxylic Acid

2. Emvododstat

3. Ptc299

2.3.2 Depositor-Supplied Synonyms

1. Emvododstat

2. Ptc299

3. Ptc-299

4. 1256565-36-2

5. Emvododstat [usan]

6. 053qd2i96a

7. Emvododstat [inn]

8. Emvododstat [who-dd]

9. Schembl8509210

10. Chembl4650336

11. Gtpl11421

12. 1219951-09-3

13. 2h-pyrido(3,4-b)indole-2-carboxylic Acid, 6-chloro-1,3,4,9-tetrahydro-1-(4-methoxyphenyl)-, 4-chlorophenyl Ester, (1s)-

14. Ex-a5798

15. At24059

16. Hy-124593

17. Cs-0087039

18. 4-chlorophenyl (1s)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydro-2h-pyrido(3,4-b)indole-2-carboxylate

19. 4-chlorophenyl (s)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indole-2-carboxylate

2.4 Create Date
2010-12-13
3 Chemical and Physical Properties
Molecular Weight 467.3 g/mol
Molecular Formula C25H20Cl2N2O3
XLogP36.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass466.0850979 g/mol
Monoisotopic Mass466.0850979 g/mol
Topological Polar Surface Area54.6 Ų
Heavy Atom Count32
Formal Charge0
Complexity651
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.


5 Pharmacology and Biochemistry
5.1 Pharmacology

PTC299 demonstrated a broad range of activity in blocking VEGF synthesis in multiple tumor types, including breast, cervical, colorectal, fibrosarcoma, gastric, lung, melanoma, neuroblastoma, ovarian, pancreatic, prostate and renal cell cancer lines. PTC299 as a monotherapy significantly reduced VEGF concentrations in tumors and plasma, reduced tumor blood vessel density, and substantially impeded tumor progression.


5.2 Mechanism of Action

PTC299 was designed to inhibit VEGF production in tumors by targeting the post-transcriptional control processes that regulate VEGF formation. Because PTC299 inhibits VEGF production, its action occurs at a different point in the VEGF pathway than therapies, such as Avastin or Sutent. PTC299 may be active both as a single agent or when used in combination with other anti-angiogenic agents or with chemotherapy agents for the treatment of cancers.


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Looking for 1219951-09-3 / Emvododstat API manufacturers, exporters & distributors?

Emvododstat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Emvododstat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Emvododstat manufacturer or Emvododstat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Emvododstat manufacturer or Emvododstat supplier.

PharmaCompass also assists you with knowing the Emvododstat API Price utilized in the formulation of products. Emvododstat API Price is not always fixed or binding as the Emvododstat Price is obtained through a variety of data sources. The Emvododstat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Emvododstat

Synonyms

Ptc299, Ptc-299, 1256565-36-2, Emvododstat [usan], 053qd2i96a, Emvododstat [inn]

Cas Number

1219951-09-3

Unique Ingredient Identifier (UNII)

053QD2I96A

About Emvododstat

Emvododstat is an orally bioavailable, small molecule inhibitor of vascular endothelial growth factor (VEGF) synthesis with potential antiangiogenesis and antineoplastic activities. Emvododstat targets post-transcriptionally by selectively binding the 5'- and 3'-untranslated regions (UTR) of VEGF messenger RNA (mRNA), thereby preventing translation of VEGF. This inhibits VEGF protein production and decreases its levels in the tumor and bloodstream. In turn, this may result in the inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and eventually the induction of tumor cell death. VEGFs are upregulated in a variety of tumor cell types and play key roles during angiogenesis. In addition, emvododstat may enhance the antitumor activity of other chemotherapeutic agents.

Emvododstat Manufacturers

A Emvododstat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Emvododstat, including repackagers and relabelers. The FDA regulates Emvododstat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Emvododstat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Emvododstat Suppliers

A Emvododstat supplier is an individual or a company that provides Emvododstat active pharmaceutical ingredient (API) or Emvododstat finished formulations upon request. The Emvododstat suppliers may include Emvododstat API manufacturers, exporters, distributors and traders.

Emvododstat GMP

Emvododstat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Emvododstat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Emvododstat GMP manufacturer or Emvododstat GMP API supplier for your needs.

Emvododstat CoA

A Emvododstat CoA (Certificate of Analysis) is a formal document that attests to Emvododstat's compliance with Emvododstat specifications and serves as a tool for batch-level quality control.

Emvododstat CoA mostly includes findings from lab analyses of a specific batch. For each Emvododstat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Emvododstat may be tested according to a variety of international standards, such as European Pharmacopoeia (Emvododstat EP), Emvododstat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Emvododstat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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