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Chemistry

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Also known as: Coactinon, 149950-60-7, Mkc-442, I-ebu, 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil, 6-benzyl-1-ethoxymethyl-5-isopropyl uracil
Molecular Formula
C17H22N2O3
Molecular Weight
302.37  g/mol
InChI Key
MLILORUFDVLTSP-UHFFFAOYSA-N
FDA UNII
X87G8IX72O

Emivirine
Emivirine is a non-nucleoside reverse transcriptase inhibitor. Emivirine has a structure typical of a nucleoside analog but has been shown to bind directly to the reverse transcriptase and act as an NNRTI. However, it is no longer in development due to the fact that it causes an increasingly rapid breakdown of other drugs metabolized by the cytochrome P450 enzyme.
1 2D Structure

Emivirine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-benzyl-1-(ethoxymethyl)-5-propan-2-ylpyrimidine-2,4-dione
2.1.2 InChI
InChI=1S/C17H22N2O3/c1-4-22-11-19-14(10-13-8-6-5-7-9-13)15(12(2)3)16(20)18-17(19)21/h5-9,12H,4,10-11H2,1-3H3,(H,18,20,21)
2.1.3 InChI Key
MLILORUFDVLTSP-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCOCN1C(=C(C(=O)NC1=O)C(C)C)CC2=CC=CC=C2
2.2 Other Identifiers
2.2.1 UNII
X87G8IX72O
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(ethoxymethyl)-5-(1-methylethyl)-6-(phenylmethyl)-2,4(1h,3h)-pyrimidinedione

2. 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil

3. 6-benzyl-1-ethoxymethyl-5-isopropyluracil

4. Mkc 442

5. Mkc-442

2.3.2 Depositor-Supplied Synonyms

1. Coactinon

2. 149950-60-7

3. Mkc-442

4. I-ebu

5. 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil

6. 6-benzyl-1-ethoxymethyl-5-isopropyl Uracil

7. 6-benzyl-1-(ethoxymethyl)-5-isopropylpyrimidine-2,4(1h,3h)-dione

8. 1-(ethoxymethyl)-5-(1-methylethyl)-6-(phenylmethyl)-2,4(1h,3h)-pyrimidinedione

9. Chembl35033

10. X87g8ix72o

11. Chebi:44143

12. Hept Deriv.

13. 6-benzyl-1-(ethoxymethyl)-5-(1-methylethyl)uracil

14. 2,4(1h,3h)-pyrimidinedione, 1-(ethoxymethyl)-5-(1-methylethyl)-6-(phenylmethyl)-

15. 1-(ethoxymethyl)-5-(1-methylethyl)-6-(phenylmethyl)pyrimidine-2,4(1h,3h)-dione

16. 1etome6bz5i-pr-u

17. Emivirine [usan:inn]

18. 6-benzyl-1-(ethoxymethyl)-5-(1-methylethyl)pyrimidine-2,4(1h,3h)-dione

19. 6-benzyl-1-(ethoxymethyl)-5-(propan-2-yl)pyrimidine-2,4(1h,3h)-dione

20. Drg-0302

21. Unii-x87g8ix72o

22. Coactinon (tm)

23. Coactinon (tn)

24. 1rt1

25. Emivirine [inn]

26. 6-benzyl-1-(ethoxymethyl)-5-propan-2-ylpyrimidine-2,4-dione

27. Emivirine (usan/inn)

28. Emivirine [usan]

29. Emivirine [mart.]

30. Emivirine [who-dd]

31. Schembl140546

32. Bdbm2337

33. Dtxsid80164437

34. Zinc1536588

35. Akos015913753

36. Db08188

37. Sb58684

38. Hy-15353

39. 6-benzyl-1-ethoxymethyl-5-isopropyluracil

40. Cs-0005980

41. D01055

42. Q906062

43. 6-benzyl-1-(ethoxymethyl)-5-isopropyl-pyrimidine-2,4-dione

44. 6-benzyl-1-(ethoxymethyl)-5-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 302.37 g/mol
Molecular Formula C17H22N2O3
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass302.16304257 g/mol
Monoisotopic Mass302.16304257 g/mol
Topological Polar Surface Area58.6 Ų
Heavy Atom Count22
Formal Charge0
Complexity451
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Reverse Transcriptase Inhibitors

Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. (See all compounds classified as Reverse Transcriptase Inhibitors.)


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Looking for 149950-60-7 / Emivirine API manufacturers, exporters & distributors?

Emivirine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Emivirine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Emivirine manufacturer or Emivirine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Emivirine manufacturer or Emivirine supplier.

PharmaCompass also assists you with knowing the Emivirine API Price utilized in the formulation of products. Emivirine API Price is not always fixed or binding as the Emivirine Price is obtained through a variety of data sources. The Emivirine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Emivirine

Synonyms

Coactinon, 149950-60-7, Mkc-442, I-ebu, 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil, 6-benzyl-1-ethoxymethyl-5-isopropyl uracil

Cas Number

149950-60-7

Unique Ingredient Identifier (UNII)

X87G8IX72O

About Emivirine

Emivirine is a non-nucleoside reverse transcriptase inhibitor. Emivirine has a structure typical of a nucleoside analog but has been shown to bind directly to the reverse transcriptase and act as an NNRTI. However, it is no longer in development due to the fact that it causes an increasingly rapid breakdown of other drugs metabolized by the cytochrome P450 enzyme.

Emivirine Manufacturers

A Emivirine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Emivirine, including repackagers and relabelers. The FDA regulates Emivirine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Emivirine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Emivirine Suppliers

A Emivirine supplier is an individual or a company that provides Emivirine active pharmaceutical ingredient (API) or Emivirine finished formulations upon request. The Emivirine suppliers may include Emivirine API manufacturers, exporters, distributors and traders.

Emivirine GMP

Emivirine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Emivirine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Emivirine GMP manufacturer or Emivirine GMP API supplier for your needs.

Emivirine CoA

A Emivirine CoA (Certificate of Analysis) is a formal document that attests to Emivirine's compliance with Emivirine specifications and serves as a tool for batch-level quality control.

Emivirine CoA mostly includes findings from lab analyses of a specific batch. For each Emivirine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Emivirine may be tested according to a variety of international standards, such as European Pharmacopoeia (Emivirine EP), Emivirine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Emivirine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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