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1. Recinnamine
2. Reserpinene
3. Trimethoxycinnamoyl Methyl Reserpate
4. Methyl (1r,15s,17r,18r,19s,20s)-6,18-dimethoxy-17-[3-(3,4,5-trimethoxyphenyl)prop-2-enoyloxy]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
5. Ncgc00016787-01
6. 3,4,5-trimethoxycinnamoyl Methyl Reserpate
7. Cas-24815-24-5
8. Prestwick0_000568
9. Prestwick1_000568
10. Dsstox_cid_3554
11. Dsstox_rid_77079
12. Dsstox_gsid_23554
13. Spbio_002575
14. Chembl3182071
15. Tox21_110611
16. Db01180
17. Q27164665
18. (1r,15s,17r,18r,19s,20s)-6,18-dimethoxy-17-[1-oxo-3-(3,4,5-trimethoxyphenyl)prop-2-enoxy]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylic Acid Methyl Ester
Molecular Weight | 634.7 g/mol |
---|---|
Molecular Formula | C35H42N2O9 |
XLogP3 | 4.5 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 10 |
Rotatable Bond Count | 11 |
Exact Mass | 634.28903092 g/mol |
Monoisotopic Mass | 634.28903092 g/mol |
Topological Polar Surface Area | 118 Ų |
Heavy Atom Count | 46 |
Formal Charge | 0 |
Complexity | 1080 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 6 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 1 |
Covalently Bonded Unit Count | 1 |
For the treatment of hypertension.
Used to treat hypertension. Rescinnamine inhibits angiotensin-converting enzyme. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex and general vasoconstriction, both of which lead to increases vascular resistance. By inhibiting angiotensin II, aldosterone reabsorption is decreased as well as vasoconstriction. This combined effect serves to decrease blood pressure.
Rescinnamine Binds to and inhibits the angiotensin converting enzyme. Rescinnamine competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion.
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PharmaCompass offers a list of Rescinnamine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Rescinnamine manufacturer or Rescinnamine supplier for your needs.
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PharmaCompass also assists you with knowing the Rescinnamine API Price utilized in the formulation of products. Rescinnamine API Price is not always fixed or binding as the Rescinnamine Price is obtained through a variety of data sources. The Rescinnamine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A DSSTox_CID_3554 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of DSSTox_CID_3554, including repackagers and relabelers. The FDA regulates DSSTox_CID_3554 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. DSSTox_CID_3554 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A DSSTox_CID_3554 supplier is an individual or a company that provides DSSTox_CID_3554 active pharmaceutical ingredient (API) or DSSTox_CID_3554 finished formulations upon request. The DSSTox_CID_3554 suppliers may include DSSTox_CID_3554 API manufacturers, exporters, distributors and traders.
click here to find a list of DSSTox_CID_3554 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A DSSTox_CID_3554 DMF (Drug Master File) is a document detailing the whole manufacturing process of DSSTox_CID_3554 active pharmaceutical ingredient (API) in detail. Different forms of DSSTox_CID_3554 DMFs exist exist since differing nations have different regulations, such as DSSTox_CID_3554 USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A DSSTox_CID_3554 DMF submitted to regulatory agencies in the US is known as a USDMF. DSSTox_CID_3554 USDMF includes data on DSSTox_CID_3554's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The DSSTox_CID_3554 USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of DSSTox_CID_3554 suppliers with USDMF on PharmaCompass.
DSSTox_CID_3554 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of DSSTox_CID_3554 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right DSSTox_CID_3554 GMP manufacturer or DSSTox_CID_3554 GMP API supplier for your needs.
A DSSTox_CID_3554 CoA (Certificate of Analysis) is a formal document that attests to DSSTox_CID_3554's compliance with DSSTox_CID_3554 specifications and serves as a tool for batch-level quality control.
DSSTox_CID_3554 CoA mostly includes findings from lab analyses of a specific batch. For each DSSTox_CID_3554 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
DSSTox_CID_3554 may be tested according to a variety of international standards, such as European Pharmacopoeia (DSSTox_CID_3554 EP), DSSTox_CID_3554 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (DSSTox_CID_3554 USP).