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Also known as: 985-12-6, Drotaverine hcl, Drotin; isodihydroperparine hydrochloride; nosh-bra; no-spa, Dihydroisoperparine; drotaverin; isodihydroperparine; perparine, isodihydro-, 1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2h-isoquinoline;hydrochloride, Bcp32864
Molecular Formula
C24H32ClNO4
Molecular Weight
434.0  g/mol
InChI Key
JBFLYOLJRKJYNV-UHFFFAOYSA-N

Drotaverine
1 2D Structure

Drotaverine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline;hydrochloride
2.1.2 InChI
InChI=1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H
2.1.3 InChI Key
JBFLYOLJRKJYNV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCOC1=C(C=C(C=C1)C=C2C3=CC(=C(C=C3CCN2)OCC)OCC)OCC.Cl
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Dihydroisoperparine

2. Drotaverin

3. Drotaverine

4. Isodihydroperparine

5. No-shpa

6. No-spa

7. Nospan

8. Nospanum

2.2.2 Depositor-Supplied Synonyms

1. 985-12-6

2. Drotaverine Hcl

3. Drotin; Isodihydroperparine Hydrochloride; Nosh-bra; No-spa

4. Dihydroisoperparine; Drotaverin; Isodihydroperparine; Perparine, Isodihydro-

5. 1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2h-isoquinoline;hydrochloride

6. Bcp32864

7. Akos030255224

8. Db-057733

9. Ft-0603535

10. Drotaverine Hcl;tetraspasmin-lefa; Ctk8f9383

11. 1-[(3,4-diethoxy Phenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride

2.3 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 434.0 g/mol
Molecular Formula C24H32ClNO4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass433.2019862 g/mol
Monoisotopic Mass433.2019862 g/mol
Topological Polar Surface Area49 Ų
Heavy Atom Count30
Formal Charge0
Complexity511
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Analgesics

Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)


EU WC

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01

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Virtual BoothCohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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Drotaverine Hydrochloride IH

Date of Issue : 2025-07-24

Valid Till : 2028-07-21

Written Confirmation Number : WC-0150N

Address of the Firm : API Unit-l, R.S. No. 50/1, Mukteswarapuram Village,\r\nJaggaiahpet Mandal, NTR D...

Cohance

02

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Drotaverine Hydrochloride IH

Date of Issue : 2025-08-08

Valid Till : 2028-03-27

Written Confirmation Number : WC-0051

Address of the Firm : Village Kolimajra & Samalheri, P.O. Lalru,\\nDistrict Sahibzada Ajit Singh Nagar...

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EUROAPI

France
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Virtual BoothEUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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Drotaverine Hydrochloride

About the Company : EUROAPI is focused on reinventing active ingredient solutions to meet the needs of customers and patients worldwide sustainably. We are a leading player in APIs with approximately ...

EUROAPI is focused on reinventing active ingredient solutions to meet the needs of customers and patients worldwide sustainably. We are a leading player in APIs with approximately 200 products in our portfolio, offering a large span of technologies while developing innovative molecules through our CDMO activities. Taking action for health by enabling access to essential therapies inspires our 3,650 people every day. With strong research and development capabilities and six manufacturing sites, all located in Europe, EUROAPI ensures API manufacturing of the highest quality to supply customers in more than 80 countries.
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02

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Virtual BoothCohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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Drotaverine Hydrochloride

About the Company : Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our...

Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our expertise in complex chemistries, we provide end-to-end CDMO services to global innovators and have delivered numerous projects from concept to commercialization over the years.As a global API player, we serve customers across nearly 60 countries with 80+ molecules backed by robust R&D, regulatory capabilities and manufacturing infrastructure. We are among the top backward integrated exporters of pellets and have strong development and manufacturing capabilities.
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03

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Virtual BoothJai Radhe Sales is your partner for all your sourcing needs.

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Drotaverine

About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.
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04

HRV Pharma

India
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Virtual BoothHRV Pharma - Market Expansion Leader in Pharmaceuticals.

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Drotaverine

About the Company : HRV Pharma is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Pharma is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Pharma effectively promote projects and products. HRV Pharma represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Pharma has offices in the US, Switzerland, Dubai, Lithuania & Turkey.
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Virtual BoothSynthokem Labs specializes in producing APIs and intermediates for the global pharma industry.

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Drotaverine Hydrochloride

About the Company : Synthokem Labs Pvt Ltd is a privately owned company established in 1978, specializing in the production of Active Pharmaceutical Ingredients and Drug Intermediates. Operating acros...

Synthokem Labs Pvt Ltd is a privately owned company established in 1978, specializing in the production of Active Pharmaceutical Ingredients and Drug Intermediates. Operating across two states, Telangana and Andhra Pradesh, in India, the company has earned global recognition for its expertise in manufacturing and distributing a diverse range of products. With a strong focus on research and development, Synthokem Labs is dedicated to offering accessible and affordable pharmaceutical solutions to those in need.
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Drotaverine

About the Company : Shamrock Pharmachemi Pvt Ltd. is a globally recognized API leader with over 26 years of expertise in human and veterinary pharmaceuticals. Operating in 40+ countries, we own two st...

Shamrock Pharmachemi Pvt Ltd. is a globally recognized API leader with over 26 years of expertise in human and veterinary pharmaceuticals. Operating in 40+ countries, we own two state-of-the-art manufacturing facilities in Gujarat and collaborate with 16+ exclusive partner plants. Proudly holding the title of 'Largest Exporter for 12 Molecules Worldwide', we maintain the highest quality standards including USFDA, EU-GMP, WHO-GMP, and other stringent international certifications. Our robust regulatory compliance (DMF, CEP, ICH Q7) and customer-focused approach make us the preferred 'API Partner in India' for pharmaceutical companies worldwide
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07

Aquaexpo
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Drotaverine

About the Company : Akums Lifescience Ltd. is a research-based, vertically integrated company specializing in the development, manufacturing and sale of APIs and intermediates. Akums has established i...

Akums Lifescience Ltd. is a research-based, vertically integrated company specializing in the development, manufacturing and sale of APIs and intermediates. Akums has established itself as a leading generic medicine manufacturing company from India, with clients in over 51 countries. It has a facility dedicated to custom research and synthesis. Akums’ manufacturing facilities are spread across three locations in two Indian states. Its stringent policies and procedures ensure that that all regulatory requirements, environmental standards, and technological trends are met. Akums is EU-GMP, KFDA, WHO-GMP and PMDA certified.
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Drotaverine HCl

About the Company : Delta Finochem Pvt Ltd. is a privately owned and professionally managed company, accredited by WHO-GMP & ISO 9001:2015 (Year of establishment 1994) Delta Finochem is a leading manu...

Delta Finochem Pvt Ltd. is a privately owned and professionally managed company, accredited by WHO-GMP & ISO 9001:2015 (Year of establishment 1994) Delta Finochem is a leading manufacturers of Active Pharmaceutical Ingredients (Generics), Drug Intermediates, Quaternary Ammonium Compounds, Quaternary Phosphonium compounds. Our focus is on niche products, with a presence in several countries. Our partners are essentially innovators and generic drug companies across the globe for whom we develop a range of new niche products.
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Drotaverine

About the Company : At Freemen Nutra, the focus is on empowering both individuals and customers to achieve greater success. The company specializes in providing high-quality nutritional ingredients an...

At Freemen Nutra, the focus is on empowering both individuals and customers to achieve greater success. The company specializes in providing high-quality nutritional ingredients and solutions for various industries, including food and beverage, dietary supplements, personal care, and animal nutrition. Freemen Nutra is dedicated to assisting clients in these markets to bring their innovative ideas to fruition. The company stands out as a leading distributor of raw ingredients, offering ethically sourced and exceptional ingredients that contribute to improved product performance, taste, and nutritional benefits for brands.
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Drotaverine Hydrochloride

About the Company : Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Ex...

Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Excipients, Herbal extracts, Formulation of Chinese & Western Medicine. With abundant economic strength, the group has successfully developed to a pharmaceutical group enterprise wich intergrets operation of medicine & related products, processing & manufacturing, and importation & exportation together.
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10-Jan-2022
31-Aug-2025
KGS
overview
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Average Price (USD/KGS)

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Quantity (KGS) & Unit rate (USD/KGS) over time

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API Imports and Exports

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FDF Dossiers

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01

Aquaexpo
Not Confirmed
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Aquaexpo
Not Confirmed

Aceclofenac; Drotaverin

Brand Name :

Dosage Form : ENTERIC COATED TABLET

Dosage Strength : 80MG; 500MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : India

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02

Aquaexpo
Not Confirmed
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Aquaexpo
Not Confirmed

Drotaverine

Brand Name :

Dosage Form : Tablet

Dosage Strength : 80MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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03

Aquaexpo
Not Confirmed
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Aquaexpo
Not Confirmed

Drotaverine

Brand Name :

Dosage Form : Liquid Injection

Dosage Strength : 20MG/ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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04

Aquaexpo
Not Confirmed
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Aquaexpo
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Drotaverin

Brand Name :

Dosage Form : Granules

Dosage Strength : 40MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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Drotaverin

Brand Name :

Dosage Form : Granules

Dosage Strength : 80MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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06

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DROTAVERINE HYDROCHLORIDE

Brand Name :

Dosage Form : Injection

Dosage Strength : 40MG/2ML

Packaging : Ampoule

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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07

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Drotaverin

Brand Name :

Dosage Form : Tablet

Dosage Strength : 40MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : India

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Drotaverin

Brand Name :

Dosage Form : Tablet

Dosage Strength : 80MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : India

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Drotaverin

Brand Name :

Dosage Form : TABLET

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : India

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DROTAVERINE HYDROCHLORIDE; Mefenamic Acid

Brand Name :

Dosage Form : Tablet

Dosage Strength : 80MG; 250MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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Looking for 985-12-6 / Drotaverine API manufacturers, exporters & distributors?

Drotaverine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Drotaverine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Drotaverine manufacturer or Drotaverine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Drotaverine manufacturer or Drotaverine supplier.

PharmaCompass also assists you with knowing the Drotaverine API Price utilized in the formulation of products. Drotaverine API Price is not always fixed or binding as the Drotaverine Price is obtained through a variety of data sources. The Drotaverine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Drotaverine

Synonyms

985-12-6, Drotaverine hcl, Drotin; isodihydroperparine hydrochloride; nosh-bra; no-spa, Dihydroisoperparine; drotaverin; isodihydroperparine; perparine, isodihydro-, 1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2h-isoquinoline;hydrochloride, Bcp32864

Cas Number

985-12-6

Drotaverine Manufacturers

A Drotaverine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Drotaverine, including repackagers and relabelers. The FDA regulates Drotaverine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Drotaverine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Drotaverine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Drotaverine Suppliers

A Drotaverine supplier is an individual or a company that provides Drotaverine active pharmaceutical ingredient (API) or Drotaverine finished formulations upon request. The Drotaverine suppliers may include Drotaverine API manufacturers, exporters, distributors and traders.

click here to find a list of Drotaverine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Drotaverine WC

A Drotaverine written confirmation (Drotaverine WC) is an official document issued by a regulatory agency to a Drotaverine manufacturer, verifying that the manufacturing facility of a Drotaverine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Drotaverine APIs or Drotaverine finished pharmaceutical products to another nation, regulatory agencies frequently require a Drotaverine WC (written confirmation) as part of the regulatory process.

click here to find a list of Drotaverine suppliers with Written Confirmation (WC) on PharmaCompass.

Drotaverine GMP

Drotaverine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Drotaverine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Drotaverine GMP manufacturer or Drotaverine GMP API supplier for your needs.

Drotaverine CoA

A Drotaverine CoA (Certificate of Analysis) is a formal document that attests to Drotaverine's compliance with Drotaverine specifications and serves as a tool for batch-level quality control.

Drotaverine CoA mostly includes findings from lab analyses of a specific batch. For each Drotaverine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Drotaverine may be tested according to a variety of international standards, such as European Pharmacopoeia (Drotaverine EP), Drotaverine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Drotaverine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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