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    Also known as: 562-10-7, Decapryn, Doxylamine (succinate), Gittalun, Unisom, Doxylamine hydrogen succinate
    Molecular Formula
    C21H28N2O5
    Molecular Weight
    388.5  g/mol
    InChI Key
    KBAUFVUYFNWQFM-UHFFFAOYSA-N
    FDA UNII
    V9BI9B5YI2
    Doxylamine Succinate
    Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes.
    1 2D Structure

    Doxylamine Succinate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    butanedioic acid;N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine
    2.1.2 InChI
    InChI=1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
    2.1.3 InChI Key
    KBAUFVUYFNWQFM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C.C(CC(=O)O)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    V9BI9B5YI2
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 562-10-7

    2. Decapryn

    3. Doxylamine (succinate)

    4. Gittalun

    5. Unisom

    6. Doxylamine Hydrogen Succinate

    7. Doxylamine Succinate Salt

    8. Hoggar N

    9. Doxy-sleep-aid

    10. Evigoa D

    11. A-h Injection

    12. Decapryn Succinate

    13. Doxylamine Succinate (1:1)

    14. Alsadorm

    15. Mereprine

    16. Decapryn Succinate (1:1)

    17. Alsodorm

    18. Donormil

    19. Donormyl

    20. Dormidina

    21. Meraprina

    22. Nsc-74772

    23. Doxylamine Succinate [usp]

    24. V9bi9b5yi2

    25. Butanedioic Acid;n,n-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine

    26. Mls000028417

    27. 2-dimethylaminoethoxyphenylmethyl-2-picoline Succinate (1:1)

    28. Chebi:82461

    29. N,n-dimethyl-2-(1-phenyl-1-(pyridin-2-yl)ethoxy)ethanamine Succinate

    30. Sedaplus

    31. Smr000058436

    32. Decapryn (tn)

    33. Dsstox_cid_552

    34. Doxylamine Succinate (usp)

    35. Butanedioic Acid, Compd. With N,n-dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine (1:1)

    36. Dsstox_rid_75656

    37. Ethanamine, N,n-dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)-, Butanedioate (1:1)

    38. Dsstox_gsid_20552

    39. Butanedioic Acid, Compd. Withn,n-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine (1:1)other Ca Index Names:ethanamine, N,n-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]-,butanedioate (1:1)

    40. N,n-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine Succinate

    41. Topcare Sleep Aid

    42. Butanedioic Acid, Compd. With N,n-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine (1:1)

    43. Ccris 4811

    44. Sr-01000003036

    45. Einecs 209-228-7

    46. Equaline Sleep Aid

    47. Mfcd00056168

    48. Nsc 74772

    49. Doxylamine Succinate Liquid

    50. Unii-v9bi9b5yi2

    51. Safetussin

    52. Ai3-23993

    53. Ncgc00017028-02

    54. Cas-562-10-7

    55. Prestwick_887

    56. Dimethylaminoethoxy-methyl-benzyl-pyridine Succinate

    57. Decamium

    58. 2-dimethylaminoethoxyphenylmethyl-2-picoline Succinate

    59. Opera_id_566

    60. Phenyl2-pyridylmethyl-beta-n,n-dimethylaminoethyl Ether Succinate

    61. 2-(alpha-(2-dimethylaminoethoxy)-alpha-methylbenzyl)pyridine Succinate

    62. 2-(alpha(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine Succinate (1:1)

    63. Alpha-(2-dimethylaminoethoxy)-alpha-methyl-alpha-phenyl-2-picoline Acid Succinate

    64. Pyridine, Succinate (1:1)

    65. Mls000758288

    66. Mls001076141

    67. Mls001424137

    68. Mls002222274

    69. Schembl160443

    70. Spectrum1500267

    71. Chembl1200392

    72. Dtxsid7020552

    73. Doxylamine For System Suitability

    74. Hms502k03

    75. Doxylamine Succinate [mi]

    76. Hms1568e15

    77. Hms1920k04

    78. Hms2051f14

    79. Hms2091b09

    80. Hms2095e15

    81. Hms2231g05

    82. Hms3261e17

    83. Hms3370k04

    84. Hms3393f14

    85. Hms3652h19

    86. Hms3712e15

    87. Hms3885d13

    88. Pharmakon1600-01500267

    89. Doxylamine Succinate [iarc]

    90. Bcp24067

    91. Hy-a0069

    92. Nsc74772

    93. Doxylamine Succinate [vandf]

    94. Tox21_113515

    95. Tox21_202078

    96. Tox21_302861

    97. Tox21_500348

    98. Ccg-38929

    99. Doxylamine Succinate [mart.]

    100. Nsc756752

    101. S4240

    102. Doxylamine Succinate [usp-rs]

    103. Doxylamine Succinate [who-dd]

    104. Akos025310916

    105. Butanedioic Acid,n,n-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine

    106. Tox21_113515_1

    107. Ac-4487

    108. Ccg-101033

    109. Cs-3232

    110. Lp00348

    111. Nc00283

    112. Nsc-756752

    113. Pyridine, 2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)-, Succinate (1:1)

    114. Doxylamine Succinate [green Book]

    115. Ncgc00016140-02

    116. Ncgc00016140-03

    117. Ncgc00016140-04

    118. Ncgc00021147-11

    119. Ncgc00089789-03

    120. Ncgc00093785-01

    121. Ncgc00093785-02

    122. Ncgc00093785-03

    123. Ncgc00256517-01

    124. Ncgc00259627-01

    125. Ncgc00261033-01

    126. As-13661

    127. Doxylamine Succinate [orange Book]

    128. Succinic Acid, Compd. With 2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine (1:1)

    129. Db-052868

    130. Doxylamine Succinate [usp Monograph]

    131. D5583

    132. Eu-0100348

    133. Ft-0625595

    134. Ft-0667789

    135. Sw197008-4

    136. Wln: T6nj Bx1&r&o2n1&1 &ov2vo

    137. Bonjesta Component Doxylamine Succinate

    138. Diclegis Component Doxylamine Succinate

    139. Bendectin Component Doxylamine Succinate

    140. C19414

    141. D 3775

    142. D-9200

    143. D02327

    144. D81886

    145. Diclectin Component Doxylamine Succinate

    146. Doxylamine Succinate Component Of Bonjesta

    147. Doxylamine Succinate Component Of Diclegis

    148. Doxylamine Hydrogen Succinate [ep Impurity]

    149. Doxylamine Succinate Component Of Bendectin

    150. Doxylamine Hydrogen Succinate [ep Monograph]

    151. Sr-01000003036-2

    152. Sr-01000003036-6

    153. Sr-01000003036-9

    154. (dimethylamino)ethoxy-methyl-benzyl-pyridine Succinate

    155. F2173-1155

    156. [[[(2-dimethylamino)ethoxy]phenyl]methyl]-2-picoline Succinate

    157. 2-[a-[2-(dimethylamino)ethoxy]-a-methylbenzyl]pyridine Succinate

    158. Doxylamine Hydrogen Succinate 1.0 Mg/ml In Methanol (as Free Base)

    159. Doxylamine Succinate, United States Pharmacopeia (usp) Reference Standard

    160. N,n-dimethyl-2-(1-phenyl-1-(pyridin-2-yl)ethoxy)ethanaminesuccinate

    161. Phenyl2-pyridylmethyl-(.beta.-n,n-dimethylamino)ethyl Ether Succinate

    162. 2-(.alpha.(2-(dimethylamino)ethoxy)-.alpha.-methylbenzyl)pyridine Succinate (1:1)

    163. 2-[[.alpha.-(2-dimethylamino)ethoxy]-.alpha.-methylbenzyl]pyridine Succinate

    164. Butanedioic Acid,n-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine (1:1)

    165. Doxylamine For System Suitability, European Pharmacopoeia (ep) Reference Standard

    166. Doxylamine Hydrogen Succinate, European Pharmacopoeia (ep) Reference Standard

    167. Doxylamine Succinate, Pharmaceutical Secondary Standard; Certified Reference Material

    168. Doxylamine Succinate Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    169. N,n-dimethyl-2-((1rs)-1-phenyl-1-(pyridin-2-yl)ethoxy(ethanamine Hydrogen Butanedioate

    170. Succinic Acid, Compd. With 2-[.alpha.-[2-(dimethylamino)ethoxy]-.alpha.-methylbenzyl]pyridine (1:1)

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 388.5 g/mol
    Molecular Formula C21H28N2O5
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count9
    Exact Mass388.19982200 g/mol
    Monoisotopic Mass388.19982200 g/mol
    Topological Polar Surface Area100 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity369
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameDoxylamine succinate
    Drug LabelTAMPER EVIDENT: Do not use if printed foil inner seal under bottle cap is broken or missing. Failure to follow these warnings could result in serious consequences.www.sambrosadreams.comProcessed in the United States with Foreign IngredientsDist. by S...
    Active IngredientDoxylamine succinate
    Dosage FormTablet
    RouteOral
    Strength25mg
    Market StatusOver the Counter
    CompanyPerrigo; Lnk

    2 of 4  
    Drug NameUnisom
    PubMed HealthDoxylamine (By mouth)
    Drug ClassesRespiratory Agent
    Active IngredientDoxylamine succinate
    Dosage FormTablet
    RouteOral
    Strength25mg
    Market StatusOver the Counter
    CompanyChattem

    3 of 4  
    Drug NameDoxylamine succinate
    Drug LabelTAMPER EVIDENT: Do not use if printed foil inner seal under bottle cap is broken or missing. Failure to follow these warnings could result in serious consequences.www.sambrosadreams.comProcessed in the United States with Foreign IngredientsDist. by S...
    Active IngredientDoxylamine succinate
    Dosage FormTablet
    RouteOral
    Strength25mg
    Market StatusOver the Counter
    CompanyPerrigo; Lnk

    4 of 4  
    Drug NameUnisom
    PubMed HealthDoxylamine (By mouth)
    Drug ClassesRespiratory Agent
    Active IngredientDoxylamine succinate
    Dosage FormTablet
    RouteOral
    Strength25mg
    Market StatusOver the Counter
    CompanyChattem

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Histamine Receptor Antagonists [MoA]; Antihistamine [EPC]

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SDNF","customerAddress":"54-A, SIR MATHURADAS VASANJI ROAD"}]
    12-Jan-2022
    23-Apr-2025
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    ABOUT THIS PAGE

    Looking for 562-10-7 / Doxylamine Succinate API manufacturers, exporters & distributors?

    Doxylamine Succinate manufacturers, exporters & distributors 1

    44

    PharmaCompass offers a list of Doxylamine Succinate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Doxylamine Succinate manufacturer or Doxylamine Succinate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Doxylamine Succinate manufacturer or Doxylamine Succinate supplier.

    PharmaCompass also assists you with knowing the Doxylamine Succinate API Price utilized in the formulation of products. Doxylamine Succinate API Price is not always fixed or binding as the Doxylamine Succinate Price is obtained through a variety of data sources. The Doxylamine Succinate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Doxylamine Succinate

    Synonyms

    562-10-7, Decapryn, Doxylamine (succinate), Gittalun, Unisom, Doxylamine hydrogen succinate

    Cas Number

    562-10-7

    Unique Ingredient Identifier (UNII)

    V9BI9B5YI2

    About Doxylamine Succinate

    Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes.

    Doxylamine succinate [USP] Manufacturers

    A Doxylamine succinate [USP] manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Doxylamine succinate [USP], including repackagers and relabelers. The FDA regulates Doxylamine succinate [USP] manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Doxylamine succinate [USP] API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Doxylamine succinate [USP] manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Doxylamine succinate [USP] Suppliers

    A Doxylamine succinate [USP] supplier is an individual or a company that provides Doxylamine succinate [USP] active pharmaceutical ingredient (API) or Doxylamine succinate [USP] finished formulations upon request. The Doxylamine succinate [USP] suppliers may include Doxylamine succinate [USP] API manufacturers, exporters, distributors and traders.

    click here to find a list of Doxylamine succinate [USP] suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Doxylamine succinate [USP] USDMF

    A Doxylamine succinate [USP] DMF (Drug Master File) is a document detailing the whole manufacturing process of Doxylamine succinate [USP] active pharmaceutical ingredient (API) in detail. Different forms of Doxylamine succinate [USP] DMFs exist exist since differing nations have different regulations, such as Doxylamine succinate [USP] USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Doxylamine succinate [USP] DMF submitted to regulatory agencies in the US is known as a USDMF. Doxylamine succinate [USP] USDMF includes data on Doxylamine succinate [USP]'s chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Doxylamine succinate [USP] USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Doxylamine succinate [USP] suppliers with USDMF on PharmaCompass.

    Doxylamine succinate [USP] CEP

    A Doxylamine succinate [USP] CEP of the European Pharmacopoeia monograph is often referred to as a Doxylamine succinate [USP] Certificate of Suitability (COS). The purpose of a Doxylamine succinate [USP] CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Doxylamine succinate [USP] EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Doxylamine succinate [USP] to their clients by showing that a Doxylamine succinate [USP] CEP has been issued for it. The manufacturer submits a Doxylamine succinate [USP] CEP (COS) as part of the market authorization procedure, and it takes on the role of a Doxylamine succinate [USP] CEP holder for the record. Additionally, the data presented in the Doxylamine succinate [USP] CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Doxylamine succinate [USP] DMF.

    A Doxylamine succinate [USP] CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Doxylamine succinate [USP] CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Doxylamine succinate [USP] suppliers with CEP (COS) on PharmaCompass.

    Doxylamine succinate [USP] WC

    A Doxylamine succinate [USP] written confirmation (Doxylamine succinate [USP] WC) is an official document issued by a regulatory agency to a Doxylamine succinate [USP] manufacturer, verifying that the manufacturing facility of a Doxylamine succinate [USP] active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Doxylamine succinate [USP] APIs or Doxylamine succinate [USP] finished pharmaceutical products to another nation, regulatory agencies frequently require a Doxylamine succinate [USP] WC (written confirmation) as part of the regulatory process.

    click here to find a list of Doxylamine succinate [USP] suppliers with Written Confirmation (WC) on PharmaCompass.

    Doxylamine succinate [USP] NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Doxylamine succinate [USP] as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Doxylamine succinate [USP] API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Doxylamine succinate [USP] as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Doxylamine succinate [USP] and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Doxylamine succinate [USP] NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Doxylamine succinate [USP] suppliers with NDC on PharmaCompass.

    Doxylamine succinate [USP] GMP

    Doxylamine succinate [USP] Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Doxylamine succinate [USP] GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Doxylamine succinate [USP] GMP manufacturer or Doxylamine succinate [USP] GMP API supplier for your needs.

    Doxylamine succinate [USP] CoA

    A Doxylamine succinate [USP] CoA (Certificate of Analysis) is a formal document that attests to Doxylamine succinate [USP]'s compliance with Doxylamine succinate [USP] specifications and serves as a tool for batch-level quality control.

    Doxylamine succinate [USP] CoA mostly includes findings from lab analyses of a specific batch. For each Doxylamine succinate [USP] CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Doxylamine succinate [USP] may be tested according to a variety of international standards, such as European Pharmacopoeia (Doxylamine succinate [USP] EP), Doxylamine succinate [USP] JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Doxylamine succinate [USP] USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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