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Also known as: 120011-70-3, Donepezil hcl, Aricept, Bnag, 110119-84-1, 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1h-inden-1-one hydrochloride
Molecular Formula
C24H30ClNO3
Molecular Weight
416.0  g/mol
InChI Key
XWAIAVWHZJNZQQ-UHFFFAOYSA-N
FDA UNII
3O2T2PJ89D

Donepezil
An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
1 2D Structure

Donepezil

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride
2.1.2 InChI
InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
2.1.3 InChI Key
XWAIAVWHZJNZQQ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
2.2 Other Identifiers
2.2.1 UNII
3O2T2PJ89D
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hydrochloride

2. Aricept

3. Donepezil

4. Donepezilium Oxalate Trihydrate

5. E 2020

6. E-2020

7. E2020

8. Eranz

2.3.2 Depositor-Supplied Synonyms

1. 120011-70-3

2. Donepezil Hcl

3. Aricept

4. Bnag

5. 110119-84-1

6. 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1h-inden-1-one Hydrochloride

7. E2020

8. Donepezilhcl

9. E-2020

10. Aricept Odt

11. E 2020

12. Donepezil (hydrochloride)

13. Donepezil, Hcl

14. 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1h-inden-1-one Hydrochloride

15. Nsc-737535

16. Nsc-758882

17. Chembl1678

18. 3o2t2pj89d

19. 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride

20. 2-(1-benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone Hydrochloride

21. 120011-70-3 (hcl)

22. E2020;e-2020

23. Dsstox_cid_26698

24. Dsstox_rid_81832

25. Dsstox_gsid_46698

26. 1h-inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, Hydrochloride (1:1)

27. Eranz

28. 2-(1-benzyl-piperidin-4-ylmethyl)-5,6-dimethoxy-indan-1-one Hydrochloride

29. E 2020 (pharmaceutical)

30. Smr000449292

31. Cas-120011-70-3

32. Donepezil Hydrochloride [usan]

33. Nsc 737535

34. Nsc 758882

35. Ncgc00167537-01

36. Unii-3o2t2pj89d

37. Memorit

38. Memac

39. Aricept Evess

40. Donepezil,hcl

41. Aricept D

42. (+/-)-2-((1-benzyl-4-piperidyl)methyl)-5,6-dimethoxy-1-indanone Hydrochloride

43. (+/-)-2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-1-indanone Hydrochloride

44. Aricept (tn)

45. Donepezil Hydrochloride [usan:usp]

46. Adlarity

47. Donepezil, Hydrochloride

48. 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hcl

49. Donepezil Hcl (aricept)

50. Donepezil Hcl - Bio-x

51. Schembl1815

52. Donepezil Hydrochloride,(s)

53. Mls000758276

54. Mls001401387

55. Chebi:4696

56. Dtxsid0046698

57. Pharmakon1600-01504403

58. Act02683

59. Amy40527

60. Bcp02205

61. Bcp24884

62. Hy-b0034

63. Donepezil Hydrochloride [mi]

64. Tox21_112534

65. Ac-913

66. Donepezil Hydrochloride (jp17/usp)

67. Donepezil Hydrochloride [jan]

68. Mfcd00881312

69. Nsc737535

70. Nsc758882

71. S2462

72. Akos000277343

73. Akos016340656

74. Tox21_112534_1

75. Ccg-101043

76. Ccg-213309

77. Cs-0863

78. Donepezil Hydrochloride [mart.]

79. Donepezil Hydrochloride [vandf]

80. Ks-1051

81. Nc00293

82. (+-)-2-((1-benzyl-4-piperidyl)methyl)-5,6-dimethoxy-1-indanone Hydrochloride

83. Donepezil Hydrochloride [usp-rs]

84. Donepezil Hydrochloride [who-dd]

85. Ncgc00167537-02

86. 1h-inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-, Hydrochloride

87. Bd164380

88. D4099

89. Donepezil Hydrochloride [orange Book]

90. Ft-0602354

91. Ft-0625589

92. Donepezil Hydrochloride [ep Monograph]

93. D00670

94. Donepezil Hydrochloride [usp Monograph]

95. E-2022

96. Namzaric Component Donepezil Hydrochloride

97. 119d841

98. A804411

99. Donepezil Hydrochloride Component Of Namzaric

100. Donepezil Hydrochloride Monohydrate, >=98% (hplc)

101. Q-100096

102. Q-201040

103. Q27106438

104. Donepezil Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

105. 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inden-1-one Hcl

106. 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]-1h-inden-1-one

107. (+-)-2,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1h-inden-1-one Hydrochloride

108. 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1h-inden-1-one Hydrochloride 120014-06-

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 416.0 g/mol
Molecular Formula C24H30ClNO3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass415.1914215 g/mol
Monoisotopic Mass415.1914215 g/mol
Topological Polar Surface Area38.8 Ų
Heavy Atom Count29
Formal Charge0
Complexity510
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameAricept
PubMed HealthDonepezil (By mouth)
Drug ClassesCentral Nervous System Agent
Drug LabelARICEPT (donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ()-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is c...
Active IngredientDonepezil hydrochloride
Dosage FormTablet
RouteOral
Strength5mg; 23mg; 10mg
Market StatusPrescription
CompanyEisai

2 of 4  
Drug NameDonepezil hydrochloride
Drug LabelDonepezil hydrochloride is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ()-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is commonly refe...
Active IngredientDonepezil hydrochloride
Dosage FormTablet, orally disintegrating; Tablet
Routeoral; Oral
Strength5mg; 23mg; 10mg
Market StatusTentative Approval; Prescription
CompanyWockhardt; Mylan Pharms; Ranbaxy; Macleods Pharms; Jubilant Generics; Vivimed Labs; Teva; Apotex; Aurobindo; Indicus Pharma; Alembic Pharms; Cspc Ouyi Pharm; Sun Pharm Inds; Pliva Hrvatska Doo; Torrent Pharms; Zydus Pharms Usa; Dr Reddys Labs; Sandoz; Pri

3 of 4  
Drug NameAricept
PubMed HealthDonepezil (By mouth)
Drug ClassesCentral Nervous System Agent
Drug LabelARICEPT (donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ()-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is c...
Active IngredientDonepezil hydrochloride
Dosage FormTablet
RouteOral
Strength5mg; 23mg; 10mg
Market StatusPrescription
CompanyEisai

4 of 4  
Drug NameDonepezil hydrochloride
Drug LabelDonepezil hydrochloride is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ()-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is commonly refe...
Active IngredientDonepezil hydrochloride
Dosage FormTablet, orally disintegrating; Tablet
Routeoral; Oral
Strength5mg; 23mg; 10mg
Market StatusTentative Approval; Prescription
CompanyWockhardt; Mylan Pharms; Ranbaxy; Macleods Pharms; Jubilant Generics; Vivimed Labs; Teva; Apotex; Aurobindo; Indicus Pharma; Alembic Pharms; Cspc Ouyi Pharm; Sun Pharm Inds; Pliva Hrvatska Doo; Torrent Pharms; Zydus Pharms Usa; Dr Reddys Labs; Sandoz; Pri

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Cholinesterase Inhibitors

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholineste