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Chemistry

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Also known as: 7414-83-7, Didronel, Disodium etidronate, Sodium etidronate, Sodium ethidronate, Sodium ethydronate
Molecular Formula
C2H6Na2O7P2
Molecular Weight
249.99  g/mol
InChI Key
GWBBVOVXJZATQQ-UHFFFAOYSA-L
FDA UNII
M16PXG993G

Etidronate Disodium
A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
1 2D Structure

Etidronate Disodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate
2.1.2 InChI
InChI=1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
2.1.3 InChI Key
GWBBVOVXJZATQQ-UHFFFAOYSA-L
2.1.4 Canonical SMILES
CC(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
M16PXG993G
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (1-hydroxyethylene)diphosphonic Acid

2. (1-hydroxyethylene)diphosphonic Acid, Tetrapotassium Salt

3. 1 Hydroxyethane 1,1 Diphosphonate

4. 1 Hydroxyethylidene 1,1 Bisphosphonate

5. 1,1 Hydroxyethylenediphosphonate

6. 1,1-hydroxyethylenediphosphonate

7. 1-hydroxyethane-1,1-diphosphonate

8. 1-hydroxyethylene Diphosphonate, Disodium

9. 1-hydroxyethylidene-1,1-bisphosphonate

10. Dicalcium Ehdp

11. Dicalcium Etidronate

12. Didronel

13. Diphosphonate, Disodium 1-hydroxyethylene

14. Diphosphonic Acid, Hydroxyethylidene

15. Disodium 1 Hydroxyethylene Diphosphonate

16. Disodium 1-hydroxyethylene Diphosphonate

17. Disodium Etidronate

18. Ehdp

19. Ehdp, Dicalcium

20. Ethanehydroxydiphosphonate

21. Ethanehydroxyphosphate

22. Etidronate

23. Etidronate, Dicalcium

24. Etidronate, Disodium

25. Etidronate, Sodium

26. Etidronate, Tetrapotassium Salt

27. Etidronic Acid

28. Hedp

29. Hedspa

30. Hydroxyethanediphosphonate

31. Hydroxyethylidene Diphosphonic Acid

32. Phosphonic Acid, (1-hydroxyethylidene)bis-, Disodium Salt

33. Salt Etidronate, Tetrapotassium

34. Sodium Etidronate

35. Tetrapotassium Salt Etidronate

36. Xidifon

37. Xidiphon

38. Xydiphone

2.3.2 Depositor-Supplied Synonyms

1. 7414-83-7

2. Didronel

3. Disodium Etidronate

4. Sodium Etidronate

5. Sodium Ethidronate

6. Sodium Ethydronate

7. Disodium Ethydronate

8. Turpinal 2nz

9. Disodium Ethanol-1,1-diphosphonate

10. Etidronic Acid Disodium Salt

11. Etidronatedisodium

12. Disodium (1-hydroxyethylidene)diphosphonate

13. Phosphonic Acid, (1-hydroxyethylidene)bis-, Disodium Salt

14. Disodium 1-hydroxyethylidene Phosphonate

15. Chebi:4906

16. Hedpa;hedp

17. Disodium Dihydrogen (1-hydroxyethylidene)diphosphonate

18. Disodium Ethane-1-hydroxy-1,1-diphosphonate

19. (1-hydroxyethylidene)diphosphonic Acid, Disodium Salt

20. Etidronic Acid, Disodium Salt

21. 1-hydroxyethylidene-1,1-diphosphonic Acid Disodium Salt

22. (1-hydroxyethane-1,1-diyl)diphosphonic Acid Disodium Salt

23. M16pxg993g

24. Didronel R

25. 1-hydroxyethane-1,1-diphosphonic Acid Disodium Salt

26. Nsc-759157

27. Cas-7414-83-7

28. Dsstox_cid_9671

29. Disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate

30. Dsstox_rid_78804

31. Dsstox_gsid_29671

32. Disodium (1-hydroxyethane-1,1-diyl)bis[hydrogen (phosphonate)]

33. Etidronsaeure Dinatriumsalz

34. Etidronate Disodium Hydrate

35. Etidronic Acid Disodium

36. Ncgc00159352-02

37. 29329-71-3

38. Einecs 231-025-7

39. Sm-5600

40. Unii-m16pxg993g

41. Didronel Iv

42. Didronel Pmo

43. Phosphonic Acid, (1-hydroxyethylidene)bis-, Sodium Salt

44. Didronel (tn)

45. Ethane-1-hydroxy-1,1-diphosphonate, Disodium Salt

46. Etidronate Disodium [usan:usp:jan]

47. Mfcd00152567

48. Prestwick_1061

49. Disodium Dihydrogen (1-hydroxyethylidene)bisphosphonate

50. Ethane-1-hydroxy-1,1-diphosphonic Acid, Disodium Salt

51. Phosphonic Acid, (1-hydroxyethylidene)di-, Disodium Salt

52. Disodium Hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate

53. Chembl1201042

54. Dtxsid1029671

55. Etidronate Disodium [jan]

56. Etidronate Disodium (jp17/usp)

57. Disodium Etidronate [inci]

58. Etidronate Disodium [usan]

59. Hms1570n07

60. Hms2093p03

61. Hms2097n07

62. Etidronate Disodium [vandf]

63. Bcp22743

64. Etidronate Disodium [mart.]

65. Tox21_111596

66. Bdbm50247999

67. Etidronate Disodium [usp-rs]

68. Etidronate Disodium [who-dd]

69. Phosphonic Acid, P,p'-(1-hydroxyethylidene)bis-, Sodium Salt (1:2)

70. Akos015961949

71. Tox21_111596_1

72. Ac-2078

73. Ccg-213569

74. Ks-1297

75. Nsc 759157

76. Etidronate Disodium [orange Book]

77. Ncgc00017072-01

78. Ncgc00179380-04

79. Be164429

80. Etidronate Disodium [ep Monograph]

81. Etidronic Acid Disodium Salt [mi]

82. Etidronate Disodium [usp Monograph]

83. Disodium 1-hydroxyethane-1,1-diphosphonate

84. D4159

85. Ft-0630369

86. D00314

87. H11387

88. Etidronate Disodium;hedpa Disodium;hedp Disodium

89. A838033

90. Etidronate Disodium Hydrate, >=97% (nmr), Solid

91. W-104431

92. 1-hydroxyethane 1,1-diphosphonic Acid Disodium Salt

93. Disodium Etidronate;sm-5600; Sm-5600; Sm-5600

94. Q27106537

95. Sodium 1-hydroxyethane-1,1-diylbis(hydrogenphosphonate)

96. Disodium [1-[oxidanidyl(oxidanyl)phosphoryl]-1-oxidanyl-ethyl]-oxidanyl-phosphinate

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 249.99 g/mol
Molecular Formula C2H6Na2O7P2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass249.93841509 g/mol
Monoisotopic Mass249.93841509 g/mol
Topological Polar Surface Area141 Ų
Heavy Atom Count13
Formal Charge0
Complexity206
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameDidronel
Active IngredientEtidronate disodium
Dosage FormTablet
RouteOral
Strength200mg; 400mg
Market StatusPrescription
CompanyProcter And Gamble

2 of 4  
Drug NameEtidronate disodium
PubMed HealthEtidronate (By mouth)
Drug ClassesCalcium Regulator
Drug LabelEtidronate disodium tablets, USP contain either 200 mg or 400 mg of etidronate disodium, the disodium salt of (1-hydroxyethylidene) diphosphonic acid, for oral administration. This compound, also known as EHDP, regulates bone metabolism. Etidronate d...
Active IngredientEtidronate disodium
Dosage FormTablet
RouteOral
Strength200mg; 400mg
Market StatusPrescription
CompanyMylan

3 of 4  
Drug NameDidronel
Active IngredientEtidronate disodium
Dosage FormTablet
RouteOral
Strength200mg; 400mg
Market StatusPrescription
CompanyProcter And Gamble

4 of 4  
Drug NameEtidronate disodium
PubMed HealthEtidronate (By mouth)
Drug ClassesCalcium Regulator
Drug LabelEtidronate disodium tablets, USP contain either 200 mg or 400 mg of etidronate disodium, the disodium salt of (1-hydroxyethylidene) diphosphonic acid, for oral administration. This compound, also known as EHDP, regulates bone metabolism. Etidronate d...
Active IngredientEtidronate disodium
Dosage FormTablet
RouteOral
Strength200mg; 400mg
Market StatusPrescription
CompanyMylan

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)


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ABOUT THIS PAGE

Looking for 29329-71-3 / Etidronate Disodium API manufacturers, exporters & distributors?

Etidronate Disodium manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Etidronate Disodium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Etidronate Disodium manufacturer or Etidronate Disodium supplier for your needs.

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PharmaCompass also assists you with knowing the Etidronate Disodium API Price utilized in the formulation of products. Etidronate Disodium API Price is not always fixed or binding as the Etidronate Disodium Price is obtained through a variety of data sources. The Etidronate Disodium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Etidronate Disodium

Synonyms

7414-83-7, Didronel, Disodium etidronate, Sodium etidronate, Sodium ethidronate, Sodium ethydronate

Cas Number

29329-71-3

Unique Ingredient Identifier (UNII)

M16PXG993G

About Etidronate Disodium

A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.

Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate Manufacturers

A Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate, including repackagers and relabelers. The FDA regulates Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate Suppliers

A Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate supplier is an individual or a company that provides Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate active pharmaceutical ingredient (API) or Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate finished formulations upon request. The Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate suppliers may include Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate API manufacturers, exporters, distributors and traders.

click here to find a list of Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate USDMF

A Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate DMF (Drug Master File) is a document detailing the whole manufacturing process of Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate active pharmaceutical ingredient (API) in detail. Different forms of Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate DMFs exist exist since differing nations have different regulations, such as Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate DMF submitted to regulatory agencies in the US is known as a USDMF. Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate USDMF includes data on Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate USDMF is kept confidential to protect the manufacturer’s intellectual property.

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Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CEP

A Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CEP of the European Pharmacopoeia monograph is often referred to as a Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate Certificate of Suitability (COS). The purpose of a Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate to their clients by showing that a Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CEP has been issued for it. The manufacturer submits a Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CEP holder for the record. Additionally, the data presented in the Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate DMF.

A Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

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Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate GMP

Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate GMP manufacturer or Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate GMP API supplier for your needs.

Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CoA

A Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CoA (Certificate of Analysis) is a formal document that attests to Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate's compliance with Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate specifications and serves as a tool for batch-level quality control.

Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CoA mostly includes findings from lab analyses of a specific batch. For each Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate may be tested according to a variety of international standards, such as European Pharmacopoeia (Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate EP), Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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