Find Dicyclomine Hydrochloride manufacturers, exporters & distributors on PharmaCompass

Dicyclomine Hydrochloride

Dicyclomine Hydrochloride

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

10 API Suppliers, 4 USDMF, 1 CEP/COS, 1 JDMF, 1 EU WC, 3 NDC API, 8 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Imports

DOSSIERs // Finished Dosage Formulations

59 Dossiers, 40 FDA Orange Book, 3 Canada, 7 South Africa, 9 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 35 Kerry, 26 Roquette, 13 Microlex e.U, 10 Sigachi Industries, 10 Corel Pharma Chem, 9 Gangwal Healthcare, 8 Seppic, 8 BASF, 7 Gangwal Chemicals, 6 SPI Pharma, 6 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 6 Lonza Capsugel, 6 DFE Pharma, 5 Actylis, 5 Ideal Cures Pvt Ltd, 4 ACG Worldwide, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 3 Kima Chemical, 3 Prachin Chemical, 3 Vasa Pharmachem, 3 Nanjing Well Pharmaceutical, 3 Ingredion Pharma Solutions, 2 Qualicaps, 2 The Dow Chemical Company, 2 Rochem International Inc, 2 Pharmatrans-Sanaq, 2 DKSH, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Finar, 1 Pfanstiehl, 1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

63 Fillers, Diluents & Binders, 48 Coating Systems & Additives, 27 Direct Compression, 21 Controlled & Modified Release, 19 Disintegrants & Superdisintegrants, 17 Thickeners and Stabilizers, 16 Lubricants & Glidants, 16 Film Formers & Plasticizers, 16 Granulation, 15 Taste Masking, 12 Co-Processed Excipients, 9 Empty Capsules, 8 Chewable & Orodispersible Aids, 8 Parenteral, 5 API Stability Enhancers, 4 Emulsifying Agents, 4 Topical, 4 Vegetarian Capsules, 2 Solubilizers, 2 Rheology Modifiers, 2 Coloring Agents, 1 Soft Gelatin

GLOBAL SALES INFORMATION

6 Finished Drug Prices

6 Finished Drug Prices

MARKET PLACE

13 APIs, 1 DOSSIERS // FDF, 1 EXCIPIENTS

REF. STANDARDS & IMPURITIES

1 USP, 1 Others

DIGITAL CONTENT

19 News

19 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

EU WC

Listed Suppliers

API REF. PRICE (USD / KG)

376

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

198

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: 67-92-5, Dicyclomine hcl, Dicycloverine hydrochloride, Bentyl, Merbentyl, Kolantyl hydrochloride

Molecular Formula

C₁₉H₃₆ClNO₂

Molecular Weight

345.9 g/mol

InChI Key

GUBNMFJOJGDCEL-UHFFFAOYSA-N

FDA UNII

CQ903KQA31

A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.

1 2D Structure

Dicyclomine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate;hydrochloride

2.1.2 InChI

InChI=1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H

2.1.3 InChI Key

GUBNMFJOJGDCEL-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2.Cl

2.2 Other Identifiers

2.2.1 UNII

CQ903KQA31

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Bentyl

2. Bentylol

3. Di Cyclonex

4. Di Spaz

5. Di-cyclonex

6. Di-spaz

7. Dibent

8. Diclomin

9. Dicyclomine

10. Dicycloverin

11. Hydrochloride, Dicyclomine

12. Lomine

13. Merbentyl

14. Or Tyl

15. Or-tyl

16. Spascol

2.3.2 Depositor-Supplied Synonyms

1. 67-92-5

2. Dicyclomine Hcl

3. Dicycloverine Hydrochloride

4. Bentyl

5. Merbentyl

6. Kolantyl Hydrochloride

7. Procyclomin

8. Bentomine

9. Dicyclomine (hydrochloride)

10. Mamiesan

11. Sawamin

12. Atumin

13. Dyspas

14. Oxityl-p

15. Diocyl Hydrochloride

16. Wyovin Hydrochloride

17. Bentylol

18. Wyovin

19. Dicycloverin Hydrochloride

20. 67-92-5 (hcl)

21. 2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate Hydrochloride

22. Mls000028426

23. Mls001074064

24. Cq903kqa31

25. 2-(diethylamino)ethyl (bicyclohexyl)-1-carboxylate Hydrochloride

26. 2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate;hydrochloride

27. Nsc-404381

28. Diethylaminocarbethoxybicyclohexyl Hydrochloride

29. 2-diethylaminoethyl Bicyclohexyl-1-carboxylate Hydrochloride

30. Antispas

31. Benacol

32. Icramin

33. Smr000058440

34. Spasmoject

35. Stannitol

36. Ametil

37. Dibent

38. (bicyclohexyl)-1-carboxylic Acid, 2-(diethylamino)ethyl Ester, Hydrochloride

39. Bis(cyclohexyl)carboxylic Acid Diethylaminoethyl Ester Hydrochloride

40. Beta-diethylaminoethyl 1-cyclohexylcyclohexanecarboxylate Hydrochloride

41. Chebi:4515

42. Bentyl Preservative Free

43. Sr-01000003056

44. Einecs 200-671-1

45. Nsc 404381

46. Unii-cq903kqa31

47. Ai3-18105

48. Dicyclomine Hydrochloride [usp]

49. Prestwick_891

50. Bentyl (tn)

51. Mfcd00079158

52. Opera_id_272

53. Beta-diethylaminoethyl-1-cyclohexylhexahydrobenzoate Hydrochloride

54. Dicyclomine Hydrochloride (preservative-free)

55. Dicyclomine, Hydrochloride

56. Beta-diethylaminoethyl-1-cyclohexylcyclohexanecarboxylate Hydrochloride

57. (1,1'-bicyclohexyl)-1-carboxylic Acid, 2-(diethylamino)ethyl Ester, Hydrochloride

58. 1-cyclohexyl-cyclohexan-1-carbonsaeure-2-diaethylaminoaethylester Hydrochlorid [german]

59. Cloridrato Dell'estere Beta-dietil Aminoetilico Dell'acido Cicloesil-1-cicloesancarbossilico

60. Schembl41670

61. Dicyclominehydrochloride

62. Spectrum1500240

63. Chembl1200479

64. Dtxsid0058778

65. Regid_for_cid_441344

66. Hms1568i17

67. Hms1920e22

68. Pharmakon1600-01500240

69. Dicycloverine For System Suitability

70. Hy-b1339

71. Tox21_500432

72. Ccg-39149

73. Dicyclomine Hydrochloride (jan/usp)

74. Nsc756727

75. Dicyclomine Hydrochloride [mi]

76. (2-(((1,1'-bicyclohexyl)-1-ylcarbonyl)oxy)ethyl)diethylammonium Chloride

77. 1-cyclohexyl-cyclohexan-1-carbonsaeure-2-diaethylaminoaethylester Hydrochlorid

78. Akos015950777

79. Dicyclomine Hydrochloride [jan]

80. Lp00432

81. Nc00504

82. Nsc-756727

83. Dicyclomine Hydrochloride [vandf]

84. Ncgc00093853-01

85. Ncgc00093853-02

86. Ncgc00093853-03

87. Ncgc00093853-04

88. Ncgc00093853-05

89. Ncgc00261117-01

90. Bs-18961

91. Dicyclomine Hydrochloride [usp-rs]

92. Dicycloverine Hydrochloride [mart.]

93. Dicycloverine Hydrochloride [who-dd]

94. Cs-0013089

95. Eu-0100432

96. Ft-0624744

97. Sw197012-3

98. D 7909

99. D00717

100. Dicyclomine Hydrochloride [orange Book]

101. Dicyclomine Hydrochloride [usp Monograph]

102. 067d925

103. Dicyclomine Hydrochloride, >=99% (tlc), Powder

104. Dicycloverine Hydrochloride [ep Monograph]

105. Sr-01000003056-2

106. Sr-01000003056-7

107. Q27106404

108. Diethylaminocarbethoxy-bicyclohexyl Hydrochloride

109. 2-(diethylamino)ethyl Bi(cyclohexane)-1-carboxylate Hydrochloride

110. 2-(diethylamino)ethyl [1,1'-bi(cyclohexane)]-1-carboxylate Hydrochloride

111. 2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate;hydron;chloride

112. Dicycloverine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

113. (1,1'-bicyclohexyl)-1-carboxylic Acid, 2-(diethylamino)ethyl Ester, Hydrochloride (1:1)

114. [1,1'-bicyclohexyl]-1-carboxylic Acid 2-(diethylamino) Ethyl Ester, Hydrochloride

115. 1-cyclohexylhexahydrobenzoic Acid(beta)-diethylaminoethyl Ester Hydrochloride

116. Dicyclomine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₃₆ClNO₂
Molecular Weight	345.9 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	8
Exact Mass	345.2434571 g/mol
Monoisotopic Mass	345.2434571 g/mol
Topological Polar Surface Area	29.5 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	326
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 8
Drug Name	Bentyl
Drug Label	Dicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent. Dicyclomine hydrochloride occurs as a fine, white, crystalline, practically odorless powder with a bitter taste. It is soluble in water, freely soluble in alcoh...
Active Ingredient	Dicyclomine hydrochloride
Dosage Form	Injectable; Tablet; Syrup; Capsule
Route	Injection; Oral
Strength	10mg/5ml; 10mg; 10mg/ml; 20mg
Market Status	Prescription
Company	Aptalis Pharma Us; Forest Labs

2 of 8
Drug Name	Bentyl preservative free
Active Ingredient	Dicyclomine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	10mg/ml
Market Status	Prescription
Company	Forest Labs

3 of 8
Drug Name	Dicyclomine hydrochloride
Active Ingredient	Dicyclomine hydrochloride
Dosage Form	Tablet; Syrup; Capsule
Route	Oral
Strength	10mg/5ml; 10mg; 20mg
Market Status	Prescription
Company	Watson Labs; Lannett; Mikart; Mylan

4 of 8
Drug Name	Dicyclomine hydrochloride
PubMed Health	Dicyclomine
Drug Classes	Gastrointestinal Agent
Drug Label	Dicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent available in the following dosageforms:Dicyclomine Hydrochloride Capsules, USP for oral use contain 10 mg dicyclomine hydrochloride, USP. Dicyclomine hydroch...
Active Ingredient	Dicyclomine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	10mg/ml
Market Status	Prescription
Company	Eurohlth Intl

5 of 8
Drug Name	Bentyl
Drug Label	Dicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent. Dicyclomine hydrochloride occurs as a fine, white, crystalline, practically odorless powder with a bitter taste. It is soluble in water, freely soluble in alcoh...
Active Ingredient	Dicyclomine hydrochloride
Dosage Form	Injectable; Tablet; Syrup; Capsule
Route	Injection; Oral
Strength	10mg/5ml; 10mg; 10mg/ml; 20mg
Market Status	Prescription
Company	Aptalis Pharma Us; Forest Labs

6 of 8
Drug Name	Bentyl preservative free
Active Ingredient	Dicyclomine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	10mg/ml
Market Status	Prescription
Company	Forest Labs

7 of 8
Drug Name	Dicyclomine hydrochloride
Active Ingredient	Dicyclomine hydrochloride
Dosage Form	Tablet; Syrup; Capsule
Route	Oral
Strength	10mg/5ml; 10mg; 20mg
Market Status	Prescription
Company	Watson Labs; Lannett; Mikart; Mylan

8 of 8
Drug Name	Dicyclomine hydrochloride
PubMed Health	Dicyclomine
Drug Classes	Gastrointestinal Agent
Drug Label	Dicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent available in the following dosageforms:Dicyclomine Hydrochloride Capsules, USP for oral use contain 10 mg dicyclomine hydrochloride, USP. Dicyclomine hydroch...
Active Ingredient	Dicyclomine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	10mg/ml
Market Status	Prescription
Company	Eurohlth Intl

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Cholinergic Antagonists [MoA]; Anticholinergic [EPC]