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Chemistry

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Also known as: 67-92-5, Dicyclomine hcl, Dicycloverine hydrochloride, Bentyl, Merbentyl, Kolantyl hydrochloride
Molecular Formula
C19H36ClNO2
Molecular Weight
345.9  g/mol
InChI Key
GUBNMFJOJGDCEL-UHFFFAOYSA-N
FDA UNII
CQ903KQA31

Dicyclomine Hydrochloride
A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.
1 2D Structure

Dicyclomine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate;hydrochloride
2.1.2 InChI
InChI=1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H
2.1.3 InChI Key
GUBNMFJOJGDCEL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2.Cl
2.2 Other Identifiers
2.2.1 UNII
CQ903KQA31
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bentyl

2. Bentylol

3. Di Cyclonex

4. Di Spaz

5. Di-cyclonex

6. Di-spaz

7. Dibent

8. Diclomin

9. Dicyclomine

10. Dicycloverin

11. Hydrochloride, Dicyclomine

12. Lomine

13. Merbentyl

14. Or Tyl

15. Or-tyl

16. Spascol

2.3.2 Depositor-Supplied Synonyms

1. 67-92-5

2. Dicyclomine Hcl

3. Dicycloverine Hydrochloride

4. Bentyl

5. Merbentyl

6. Kolantyl Hydrochloride

7. Procyclomin

8. Bentomine

9. Dicyclomine (hydrochloride)

10. Mamiesan

11. Sawamin

12. Atumin

13. Dyspas

14. Oxityl-p

15. Diocyl Hydrochloride

16. Wyovin Hydrochloride

17. Bentylol

18. Wyovin

19. Dicycloverin Hydrochloride

20. 67-92-5 (hcl)

21. 2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate Hydrochloride

22. Mls000028426

23. Mls001074064

24. Cq903kqa31

25. 2-(diethylamino)ethyl (bicyclohexyl)-1-carboxylate Hydrochloride

26. 2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate;hydrochloride

27. Nsc-404381

28. Diethylaminocarbethoxybicyclohexyl Hydrochloride

29. 2-diethylaminoethyl Bicyclohexyl-1-carboxylate Hydrochloride

30. Antispas

31. Benacol

32. Icramin

33. Smr000058440

34. Spasmoject

35. Stannitol

36. Ametil

37. Dibent

38. (bicyclohexyl)-1-carboxylic Acid, 2-(diethylamino)ethyl Ester, Hydrochloride

39. Bis(cyclohexyl)carboxylic Acid Diethylaminoethyl Ester Hydrochloride

40. Beta-diethylaminoethyl 1-cyclohexylcyclohexanecarboxylate Hydrochloride

41. Chebi:4515

42. Bentyl Preservative Free

43. Sr-01000003056

44. Einecs 200-671-1

45. Nsc 404381

46. Unii-cq903kqa31

47. Ai3-18105

48. Dicyclomine Hydrochloride [usp]

49. Prestwick_891

50. Bentyl (tn)

51. Mfcd00079158

52. Opera_id_272

53. Beta-diethylaminoethyl-1-cyclohexylhexahydrobenzoate Hydrochloride

54. Dicyclomine Hydrochloride (preservative-free)

55. Dicyclomine, Hydrochloride

56. Beta-diethylaminoethyl-1-cyclohexylcyclohexanecarboxylate Hydrochloride

57. (1,1'-bicyclohexyl)-1-carboxylic Acid, 2-(diethylamino)ethyl Ester, Hydrochloride

58. 1-cyclohexyl-cyclohexan-1-carbonsaeure-2-diaethylaminoaethylester Hydrochlorid [german]

59. Cloridrato Dell'estere Beta-dietil Aminoetilico Dell'acido Cicloesil-1-cicloesancarbossilico

60. Schembl41670

61. Dicyclominehydrochloride

62. Spectrum1500240

63. Chembl1200479

64. Dtxsid0058778

65. Regid_for_cid_441344

66. Hms1568i17

67. Hms1920e22

68. Pharmakon1600-01500240

69. Dicycloverine For System Suitability

70. Hy-b1339

71. Tox21_500432

72. Ccg-39149

73. Dicyclomine Hydrochloride (jan/usp)

74. Nsc756727

75. Dicyclomine Hydrochloride [mi]

76. (2-(((1,1'-bicyclohexyl)-1-ylcarbonyl)oxy)ethyl)diethylammonium Chloride

77. 1-cyclohexyl-cyclohexan-1-carbonsaeure-2-diaethylaminoaethylester Hydrochlorid

78. Akos015950777

79. Dicyclomine Hydrochloride [jan]

80. Lp00432

81. Nc00504

82. Nsc-756727

83. Dicyclomine Hydrochloride [vandf]

84. Ncgc00093853-01

85. Ncgc00093853-02

86. Ncgc00093853-03

87. Ncgc00093853-04

88. Ncgc00093853-05

89. Ncgc00261117-01

90. Bs-18961

91. Dicyclomine Hydrochloride [usp-rs]

92. Dicycloverine Hydrochloride [mart.]

93. Dicycloverine Hydrochloride [who-dd]

94. Cs-0013089

95. Eu-0100432

96. Ft-0624744

97. Sw197012-3

98. D 7909

99. D00717

100. Dicyclomine Hydrochloride [orange Book]

101. Dicyclomine Hydrochloride [usp Monograph]

102. 067d925

103. Dicyclomine Hydrochloride, >=99% (tlc), Powder

104. Dicycloverine Hydrochloride [ep Monograph]

105. Sr-01000003056-2

106. Sr-01000003056-7

107. Q27106404

108. Diethylaminocarbethoxy-bicyclohexyl Hydrochloride

109. 2-(diethylamino)ethyl Bi(cyclohexane)-1-carboxylate Hydrochloride

110. 2-(diethylamino)ethyl [1,1'-bi(cyclohexane)]-1-carboxylate Hydrochloride

111. 2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate;hydron;chloride

112. Dicycloverine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

113. (1,1'-bicyclohexyl)-1-carboxylic Acid, 2-(diethylamino)ethyl Ester, Hydrochloride (1:1)

114. [1,1'-bicyclohexyl]-1-carboxylic Acid 2-(diethylamino) Ethyl Ester, Hydrochloride

115. 1-cyclohexylhexahydrobenzoic Acid(beta)-diethylaminoethyl Ester Hydrochloride

116. Dicyclomine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 345.9 g/mol
Molecular Formula C19H36ClNO2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Exact Mass345.2434571 g/mol
Monoisotopic Mass345.2434571 g/mol
Topological Polar Surface Area29.5 Ų
Heavy Atom Count23
Formal Charge0
Complexity326
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 8  
Drug NameBentyl
Drug LabelDicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent. Dicyclomine hydrochloride occurs as a fine, white, crystalline, practically odorless powder with a bitter taste. It is soluble in water, freely soluble in alcoh...
Active IngredientDicyclomine hydrochloride
Dosage FormInjectable; Tablet; Syrup; Capsule
RouteInjection; Oral
Strength10mg/5ml; 10mg; 10mg/ml; 20mg
Market StatusPrescription
CompanyAptalis Pharma Us; Forest Labs

2 of 8  
Drug NameBentyl preservative free
Active IngredientDicyclomine hydrochloride
Dosage FormInjectable
RouteInjection
Strength10mg/ml
Market StatusPrescription
CompanyForest Labs

3 of 8  
Drug NameDicyclomine hydrochloride
Active IngredientDicyclomine hydrochloride
Dosage FormTablet; Syrup; Capsule
RouteOral
Strength10mg/5ml; 10mg; 20mg
Market StatusPrescription
CompanyWatson Labs; Lannett; Mikart; Mylan

4 of 8  
Drug NameDicyclomine hydrochloride
PubMed HealthDicyclomine
Drug ClassesGastrointestinal Agent
Drug LabelDicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent available in the following dosageforms:Dicyclomine Hydrochloride Capsules, USP for oral use contain 10 mg dicyclomine hydrochloride, USP. Dicyclomine hydroch...
Active IngredientDicyclomine hydrochloride
Dosage FormInjectable
RouteInjection
Strength10mg/ml
Market StatusPrescription
CompanyEurohlth Intl

5 of 8  
Drug NameBentyl
Drug LabelDicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent. Dicyclomine hydrochloride occurs as a fine, white, crystalline, practically odorless powder with a bitter taste. It is soluble in water, freely soluble in alcoh...
Active IngredientDicyclomine hydrochloride
Dosage FormInjectable; Tablet; Syrup; Capsule
RouteInjection; Oral
Strength10mg/5ml; 10mg; 10mg/ml; 20mg
Market StatusPrescription
CompanyAptalis Pharma Us; Forest Labs

6 of 8  
Drug NameBentyl preservative free
Active IngredientDicyclomine hydrochloride
Dosage FormInjectable
RouteInjection
Strength10mg/ml
Market StatusPrescription
CompanyForest Labs

7 of 8  
Drug NameDicyclomine hydrochloride
Active IngredientDicyclomine hydrochloride
Dosage FormTablet; Syrup; Capsule
RouteOral
Strength10mg/5ml; 10mg; 20mg
Market StatusPrescription
CompanyWatson Labs; Lannett; Mikart; Mylan

8 of 8  
Drug NameDicyclomine hydrochloride
PubMed HealthDicyclomine
Drug ClassesGastrointestinal Agent
Drug LabelDicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent available in the following dosageforms:Dicyclomine Hydrochloride Capsules, USP for oral use contain 10 mg dicyclomine hydrochloride, USP. Dicyclomine hydroch...
Active IngredientDicyclomine hydrochloride
Dosage FormInjectable
RouteInjection
Strength10mg/ml
Market StatusPrescription
CompanyEurohlth Intl

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)


Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Cholinergic Antagonists [MoA]; Anticholinergic [EPC]

API Reference Price

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LIMITED","customerCountry":"INDIA","quantity":"0.99","actualQuantity":"0.99","unit":"KGS","unitRateFc":"41000","totalValueFC":"40952.4","currency":"USD","unitRateINR":"3152900","date":"31-Mar-2022","totalValueINR":"3121371","totalValueInUsd":"40952.4","indian_port":"MADRAS AIR","hs_no":"29420090","bill_no":"8080480","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"Ashvich Towers Plot No.3 Developed Plots Industria"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1683311400,"product":"DICYCLOMINE HYDROCHLORIDE BP","address":"NO.49D, BOMMASANDRA INDUSTRIAL AREA, ANEKAL TQ.","city":"BANGALORE","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"ADCOCK INGRAM","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"290","totalValueFC":"8123.7","currency":"EUR","unitRateINR":"26738","date":"06-May-2023","totalValueINR":"668450","totalValueInUsd":"8123.7","indian_port":"BANGALORE AIR","hs_no":"29420011","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"Italy","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN","supplierAddress":"","customerAddress":"NO.49D, BOMMASANDRA INDUSTRIAL AREA, ANEKAL TQ."},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719253800,"product":"DICYCLOMINE HYDROCHLORIDE BP","address":"NO.49D, BOMMASANDRA INDUSTRIAL","city":"BANGALORE","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"ADCOCK INGRAM","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"290","totalValueFC":"7962.2","currency":"EUR","unitRateINR":"26448","date":"25-Jun-2024","totalValueINR":"661200","totalValueInUsd":"7962.2","indian_port":"Bangalore Air","hs_no":"29420011","bill_no":"4169972","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"STRADA RIVOLTANA KM 6\/720053 RODANO MISDNF ITALY","customerAddress":"NO.49D, BOMMASANDRA INDUSTRIAL"}]
19-Jan-2021
28-Aug-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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