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Chemistry

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Also known as: 17140-78-2, Propoxyphene napsylate anhydrous, 5o7iw35n3c, Darvon n, [(2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate;naphthalene-2-sulfonic acid, Propoxyphene-n
Molecular Formula
C32H37NO5S
Molecular Weight
547.7  g/mol
InChI Key
VZPXFHVJUUSVLH-MYXGOWFTSA-N
FDA UNII
5O7IW35N3C

Propoxyphene Napsylate
Propoxyphene Napsylate is a synthetic diphenyl propionate derivative structurally related to methadone, Propoxyphene Napsylate acts as a central narcotic and analgesic agent by interaction with mu opioid receptors, but with less selectivity then morphine. The dextro-isomer has analgesic effect, while the levo-isomer exerts an antitussive effect. The napsylate salt allows better dosage formulation than the hydrochloride salt. (NCI04)
1 2D Structure

Propoxyphene Napsylate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate;naphthalene-2-sulfonic acid
2.1.2 InChI
InChI=1S/C22H29NO2.C10H8O3S/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h6-15,18H,5,16-17H2,1-4H3;1-7H,(H,11,12,13)/t18-,22+;/m1./s1
2.1.3 InChI Key
VZPXFHVJUUSVLH-MYXGOWFTSA-N
2.1.4 Canonical SMILES
CCC(=O)OC(CC1=CC=CC=C1)(C2=CC=CC=C2)C(C)CN(C)C.C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)O
2.1.5 Isomeric SMILES
CCC(=O)O[C@](CC1=CC=CC=C1)(C2=CC=CC=C2)[C@H](C)CN(C)C.C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
5O7IW35N3C
2.3 Synonyms
2.3.1 MeSH Synonyms

1. D-propoxyphene Napsylate

2. Dextropropoxyphene Napsylate

2.3.2 Depositor-Supplied Synonyms

1. 17140-78-2

2. Propoxyphene Napsylate Anhydrous

3. 5o7iw35n3c

4. Darvon N

5. [(2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] Propanoate;naphthalene-2-sulfonic Acid

6. Propoxyphene-n

7. (+)- Propoxyphene Napsylate

8. Propoxyphene 2-naphthalenesulfonate

9. Einecs 241-205-7

10. Unii-5o7iw35n3c

11. 2-butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, Propionate, 2-naphthalenesulfonate

12. Propoxyphene Napsylate ,(s)

13. 2-naphthalenesulfonic Acid, Compd. With (s-(r*,s*))-3-(dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)p- Ropyl Propanoate (1:1)

14. Schembl9297768

15. Dtxsid80937986

16. Propoxyphene Napsylate, Anhydrous

17. 2-naphthalenesulfonic Acid, Compd. With (+)-alpha-(2-dimethylamino)-1-methylethyl-alpha-phenylphenethyl Propionate (1:1)

18. Benzeneethanol, Alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, Propanoate (ester), (1s,2r)-, 2-naphthalenesulfonate (salt)

19. Benzeneethanol, Alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, Propanoate (ester), (s-(r*,s*))-, 2-naphthalenesulfonate (salt)

20. Naphthalene-2-sulphonic Acid, Compound With (s-(r*,s*))-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl Propionate (1:1)

21. Q27262632

22. (2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl Propionate Naphthalene-2-sulfonate

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 547.7 g/mol
Molecular Formula C32H37NO5S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count10
Exact Mass547.23924445 g/mol
Monoisotopic Mass547.23924445 g/mol
Topological Polar Surface Area92.3 Ų
Heavy Atom Count39
Formal Charge0
Complexity688
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

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ABOUT THIS PAGE

Looking for 17140-78-2 / Propoxyphene Napsylate API manufacturers, exporters & distributors?

Propoxyphene Napsylate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Propoxyphene Napsylate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Propoxyphene Napsylate manufacturer or Propoxyphene Napsylate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Propoxyphene Napsylate manufacturer or Propoxyphene Napsylate supplier.

PharmaCompass also assists you with knowing the Propoxyphene Napsylate API Price utilized in the formulation of products. Propoxyphene Napsylate API Price is not always fixed or binding as the Propoxyphene Napsylate Price is obtained through a variety of data sources. The Propoxyphene Napsylate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Propoxyphene Napsylate

Synonyms

17140-78-2, Propoxyphene napsylate anhydrous, 5o7iw35n3c, Darvon n, [(2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate;naphthalene-2-sulfonic acid, Propoxyphene-n

Cas Number

17140-78-2

Unique Ingredient Identifier (UNII)

5O7IW35N3C

About Propoxyphene Napsylate

Propoxyphene Napsylate is a synthetic diphenyl propionate derivative structurally related to methadone, Propoxyphene Napsylate acts as a central narcotic and analgesic agent by interaction with mu opioid receptors, but with less selectivity then morphine. The dextro-isomer has analgesic effect, while the levo-isomer exerts an antitussive effect. The napsylate salt allows better dosage formulation than the hydrochloride salt. (NCI04)

dextropropoxyphene napsylate Manufacturers

A dextropropoxyphene napsylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of dextropropoxyphene napsylate, including repackagers and relabelers. The FDA regulates dextropropoxyphene napsylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. dextropropoxyphene napsylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

dextropropoxyphene napsylate Suppliers

A dextropropoxyphene napsylate supplier is an individual or a company that provides dextropropoxyphene napsylate active pharmaceutical ingredient (API) or dextropropoxyphene napsylate finished formulations upon request. The dextropropoxyphene napsylate suppliers may include dextropropoxyphene napsylate API manufacturers, exporters, distributors and traders.

click here to find a list of dextropropoxyphene napsylate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

dextropropoxyphene napsylate USDMF

A dextropropoxyphene napsylate DMF (Drug Master File) is a document detailing the whole manufacturing process of dextropropoxyphene napsylate active pharmaceutical ingredient (API) in detail. Different forms of dextropropoxyphene napsylate DMFs exist exist since differing nations have different regulations, such as dextropropoxyphene napsylate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A dextropropoxyphene napsylate DMF submitted to regulatory agencies in the US is known as a USDMF. dextropropoxyphene napsylate USDMF includes data on dextropropoxyphene napsylate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The dextropropoxyphene napsylate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of dextropropoxyphene napsylate suppliers with USDMF on PharmaCompass.

dextropropoxyphene napsylate GMP

dextropropoxyphene napsylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of dextropropoxyphene napsylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right dextropropoxyphene napsylate GMP manufacturer or dextropropoxyphene napsylate GMP API supplier for your needs.

dextropropoxyphene napsylate CoA

A dextropropoxyphene napsylate CoA (Certificate of Analysis) is a formal document that attests to dextropropoxyphene napsylate's compliance with dextropropoxyphene napsylate specifications and serves as a tool for batch-level quality control.

dextropropoxyphene napsylate CoA mostly includes findings from lab analyses of a specific batch. For each dextropropoxyphene napsylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

dextropropoxyphene napsylate may be tested according to a variety of international standards, such as European Pharmacopoeia (dextropropoxyphene napsylate EP), dextropropoxyphene napsylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (dextropropoxyphene napsylate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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