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    Propoxyphene Napsylate

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    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: 17140-78-2, Propoxyphene napsylate anhydrous, 5o7iw35n3c, Darvon n, [(2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate;naphthalene-2-sulfonic acid, Propoxyphene-n
    Molecular Formula
    C32H37NO5S
    Molecular Weight
    547.7  g/mol
    InChI Key
    VZPXFHVJUUSVLH-MYXGOWFTSA-N
    FDA UNII
    5O7IW35N3C
    Propoxyphene Napsylate is a synthetic diphenyl propionate derivative structurally related to methadone, Propoxyphene Napsylate acts as a central narcotic and analgesic agent by interaction with mu opioid receptors, but with less selectivity then morphine. The dextro-isomer has analgesic effect, while the levo-isomer exerts an antitussive effect. The napsylate salt allows better dosage formulation than the hydrochloride salt. (NCI04)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate;naphthalene-2-sulfonic acid
    2.1.2 InChI
    InChI=1S/C22H29NO2.C10H8O3S/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h6-15,18H,5,16-17H2,1-4H3;1-7H,(H,11,12,13)/t18-,22+;/m1./s1
    2.1.3 InChI Key
    VZPXFHVJUUSVLH-MYXGOWFTSA-N
    2.1.4 Canonical SMILES
    CCC(=O)OC(CC1=CC=CC=C1)(C2=CC=CC=C2)C(C)CN(C)C.C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)O
    2.1.5 Isomeric SMILES
    CCC(=O)O[C@](CC1=CC=CC=C1)(C2=CC=CC=C2)[C@H](C)CN(C)C.C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    5O7IW35N3C
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. D-propoxyphene Napsylate

    2. Dextropropoxyphene Napsylate

    2.3.2 Depositor-Supplied Synonyms

    1. 17140-78-2

    2. Propoxyphene Napsylate Anhydrous

    3. 5o7iw35n3c

    4. Darvon N

    5. [(2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] Propanoate;naphthalene-2-sulfonic Acid

    6. Propoxyphene-n

    7. (+)- Propoxyphene Napsylate

    8. Propoxyphene 2-naphthalenesulfonate

    9. Einecs 241-205-7

    10. Unii-5o7iw35n3c

    11. 2-butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, Propionate, 2-naphthalenesulfonate

    12. Propoxyphene Napsylate ,(s)

    13. 2-naphthalenesulfonic Acid, Compd. With (s-(r*,s*))-3-(dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)p- Ropyl Propanoate (1:1)

    14. Schembl9297768

    15. Dtxsid80937986

    16. Propoxyphene Napsylate, Anhydrous

    17. 2-naphthalenesulfonic Acid, Compd. With (+)-alpha-(2-dimethylamino)-1-methylethyl-alpha-phenylphenethyl Propionate (1:1)

    18. Benzeneethanol, Alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, Propanoate (ester), (1s,2r)-, 2-naphthalenesulfonate (salt)

    19. Benzeneethanol, Alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, Propanoate (ester), (s-(r*,s*))-, 2-naphthalenesulfonate (salt)

    20. Naphthalene-2-sulphonic Acid, Compound With (s-(r*,s*))-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl Propionate (1:1)

    21. Q27262632

    22. (2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl Propionate Naphthalene-2-sulfonate

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 547.7 g/mol
    Molecular Formula C32H37NO5S
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count10
    Exact Mass547.23924445 g/mol
    Monoisotopic Mass547.23924445 g/mol
    Topological Polar Surface Area92.3 Ų
    Heavy Atom Count39
    Formal Charge0
    Complexity688
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2