Propoxyphene Napsylate

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

10 Suppliers, 10 USDMF

DOSSIERs // Finished Dosage Forms

38 Dossiers, 36 FDA Orange Book, 2 South Africa

RELATED EXCIPIENT COMPANIES

Suppliers, 31 BASF, 30 Kerry, 19 Roquette, 14 Microlex e.U, 13 Seppic, 11 Gangwal Chemicals, 10 Sigachi Industries, 10 Corel Pharma Chem, 8 Gangwal Healthcare, 8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 6 Lonza Capsugel, 5 Actylis, 5 Boai NKY Pharmaceuticals Ltd, 5 DFE Pharma, 5 Ideal Cures Pvt Ltd, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 4 Pharmatrans-Sanaq, 4 SPI Pharma, 3 Ingredion Pharma Solutions, 3 Kima Chemical, 3 Prachin Chemical, 3 Nanjing Well Pharmaceutical, 3 Vasa Pharmachem, 2 Nomisma Healthcare, 2 Seqens, 2 The Dow Chemical Company, 2 Ulanqab Kema New Material, 1 Qualicaps, 1 Nanjing Bold Chemical, 1 Finar, 1 Alcedo Pharmachem, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Jai Radhe Sales, 1 ACG Worldwide

EXCIPIENTS BY APPLICATIONS

58 Fillers, Diluents & Binders, 46 Coating Systems & Additives, 34 Direct Compression, 32 Disintegrants & Superdisintegrants, 28 Controlled & Modified Release, 25 Granulation, 24 Solubilizers, 22 Thickeners and Stabilizers, 16 Lubricants & Glidants, 12 Film Formers & Plasticizers, 12 Co-Processed Excipients, 12 Topical, 11 Parenteral, 9 Taste Masking, 9 Chewable & Orodispersible Aids, 6 Emulsifying Agents, 5 Empty Capsules, 5 API Stability Enhancers, 4 Vegetarian Capsules, 3 Rheology Modifiers, 2 Surfactant & Foaming Agents, 2 Coloring Agents

REF. STANDARDS & IMPURITIES

2 Others

2 Others

DIGITAL CONTENT

1 News

1 News

1. Also known as: 17140-78-2, Propoxyphene napsylate anhydrous, 5o7iw35n3c, Darvon n, [(2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate;naphthalene-2-sulfonic acid, Propoxyphene-n

Molecular Formula

C₃₂H₃₇NO₅S

Molecular Weight

547.7 g/mol

InChI Key

VZPXFHVJUUSVLH-MYXGOWFTSA-N

FDA UNII

5O7IW35N3C

Propoxyphene Napsylate is a synthetic diphenyl propionate derivative structurally related to methadone, Propoxyphene Napsylate acts as a central narcotic and analgesic agent by interaction with mu opioid receptors, but with less selectivity then morphine. The dextro-isomer has analgesic effect, while the levo-isomer exerts an antitussive effect. The napsylate salt allows better dosage formulation than the hydrochloride salt. (NCI04)

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate;naphthalene-2-sulfonic acid

2.1.2 InChI

InChI=1S/C22H29NO2.C10H8O3S/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h6-15,18H,5,16-17H2,1-4H3;1-7H,(H,11,12,13)/t18-,22+;/m1./s1

2.1.3 InChI Key

VZPXFHVJUUSVLH-MYXGOWFTSA-N

2.1.4 Canonical SMILES

CCC(=O)OC(CC1=CC=CC=C1)(C2=CC=CC=C2)C(C)CN(C)C.C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)O

2.1.5 Isomeric SMILES

CCC(=O)O[C@](CC1=CC=CC=C1)(C2=CC=CC=C2)[C@H](C)CN(C)C.C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

5O7IW35N3C

2.3 Synonyms

2.3.1 MeSH Synonyms

1. D-propoxyphene Napsylate

2. Dextropropoxyphene Napsylate

2.3.2 Depositor-Supplied Synonyms

1. 17140-78-2

2. Propoxyphene Napsylate Anhydrous

3. 5o7iw35n3c

4. Darvon N

5. [(2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] Propanoate;naphthalene-2-sulfonic Acid

6. Propoxyphene-n

7. (+)- Propoxyphene Napsylate

8. Propoxyphene 2-naphthalenesulfonate

9. Einecs 241-205-7

10. Unii-5o7iw35n3c

11. 2-butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, Propionate, 2-naphthalenesulfonate

12. Propoxyphene Napsylate ,(s)

13. 2-naphthalenesulfonic Acid, Compd. With (s-(r*,s*))-3-(dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)p- Ropyl Propanoate (1:1)

14. Schembl9297768

15. Dtxsid80937986

16. Propoxyphene Napsylate, Anhydrous

17. 2-naphthalenesulfonic Acid, Compd. With (+)-alpha-(2-dimethylamino)-1-methylethyl-alpha-phenylphenethyl Propionate (1:1)

18. Benzeneethanol, Alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, Propanoate (ester), (1s,2r)-, 2-naphthalenesulfonate (salt)

19. Benzeneethanol, Alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, Propanoate (ester), (s-(r*,s*))-, 2-naphthalenesulfonate (salt)

20. Naphthalene-2-sulphonic Acid, Compound With (s-(r*,s*))-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl Propionate (1:1)

21. Q27262632

22. (2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl Propionate Naphthalene-2-sulfonate

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₃₂H₃₇NO₅S
Molecular Weight	547.7 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	10
Exact Mass	547.23924445 g/mol
Monoisotopic Mass	547.23924445 g/mol
Topological Polar Surface Area	92.3 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	688
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

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