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Looking for 1071992-99-8 / Xevinapant API manufacturers, exporters & distributors?

Xevinapant manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Xevinapant API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Xevinapant manufacturer or Xevinapant supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Xevinapant manufacturer or Xevinapant supplier.

PharmaCompass also assists you with knowing the Xevinapant API Price utilized in the formulation of products. Xevinapant API Price is not always fixed or binding as the Xevinapant Price is obtained through a variety of data sources. The Xevinapant Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Xevinapant

Synonyms

1071992-99-8, At-406, Debio-1143, N65wc8pxdd, Sm-406, Unii-n65wc8pxdd

Cas Number

1071992-99-8

Unique Ingredient Identifier (UNII)

N65WC8PXDD

About Xevinapant

Xevinapant is an orally available mimetic of the natural second mitochondrial-derived activator of caspases (Smac) and inhibitor of Inhibitor of Apoptosis Proteins (IAPs), with potential immunomodulating, apoptotic-inducing, chemo-radio-sensitizing and antineoplastic activities. Upon oral administration,xevinapant targets and binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP), and the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2). This inhibits the activities of these IAPs and promotes the induction of apoptosis. Additionally, as xevinapant inhibits the activity of IAPs, it may work synergistically with cytotoxic drugs and/or radiation to overcome tumor cell resistance to apoptosis. As IAPs regulate nuclear factor-kappa B (NFkB) signaling pathways, which drives the expression of genes involved in immune and inflammatory responses, xevinapant may enhance anti-tumor immune responses when administered with certain immunomodulating agents, such as immune checkpoint inhibitors. IAPs are overexpressed by many cancer cell types and suppress both intrinsic and extrinsic apoptosis by binding to and inhibiting active caspases via their baculoviral lAP repeat (BIR) domains. They contribute to chemo-radio-resistance of cancer cells to certain cytotoxic agents and radiation, promote tumor cell survival and are associated with poor prognosis in certain types of cancer. SMAC, a pro-apoptotic mitochondrial protein, is an endogenous inhibitor of the IAPs family of cellular proteins.

Debio 1143 Manufacturers

A Debio 1143 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Debio 1143, including repackagers and relabelers. The FDA regulates Debio 1143 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Debio 1143 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Debio 1143 Suppliers

A Debio 1143 supplier is an individual or a company that provides Debio 1143 active pharmaceutical ingredient (API) or Debio 1143 finished formulations upon request. The Debio 1143 suppliers may include Debio 1143 API manufacturers, exporters, distributors and traders.

Debio 1143 GMP

Debio 1143 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Debio 1143 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Debio 1143 GMP manufacturer or Debio 1143 GMP API supplier for your needs.

Debio 1143 CoA

A Debio 1143 CoA (Certificate of Analysis) is a formal document that attests to Debio 1143's compliance with Debio 1143 specifications and serves as a tool for batch-level quality control.

Debio 1143 CoA mostly includes findings from lab analyses of a specific batch. For each Debio 1143 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Debio 1143 may be tested according to a variety of international standards, such as European Pharmacopoeia (Debio 1143 EP), Debio 1143 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Debio 1143 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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