Find Darigabat manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Pf-06372865, 1614245-70-3, Darigabat [inn], Darigabat [usan], Cvl-865, O9bp19hz3q
Molecular Formula
C22H21FN4O3S
Molecular Weight
440.5  g/mol
InChI Key
PTTQXDBPTFOCMT-UHFFFAOYSA-N
FDA UNII
O9BP19HZ3Q

Darigabat
1 2D Structure

Darigabat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7-ethyl-4-[3-(4-ethylsulfonyl-2-methoxyphenyl)-4-fluorophenyl]imidazo[4,5-c]pyridazine
2.1.2 InChI
InChI=1S/C22H21FN4O3S/c1-4-27-13-24-21-18(12-25-26-22(21)27)14-6-9-19(23)17(10-14)16-8-7-15(11-20(16)30-3)31(28,29)5-2/h6-13H,4-5H2,1-3H3
2.1.3 InChI Key
PTTQXDBPTFOCMT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN1C=NC2=C1N=NC=C2C3=CC(=C(C=C3)F)C4=C(C=C(C=C4)S(=O)(=O)CC)OC
2.2 Other Identifiers
2.2.1 UNII
O9BP19HZ3Q
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 7-ethyl-4-(3-(4-ethylsulfonyl-2-methoxyphenyl)-4-fluorophenyl)imidazo(4,5-c)pyridazine

2. Pf-06372865

2.3.2 Depositor-Supplied Synonyms

1. Pf-06372865

2. 1614245-70-3

3. Darigabat [inn]

4. Darigabat [usan]

5. Cvl-865

6. O9bp19hz3q

7. 7-ethyl-4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7h-imidazo[4,5-c]pyridazine

8. 7-ethyl-4-[3-(4-ethylsulfonyl-2-methoxyphenyl)-4-fluorophenyl]imidazo[4,5-c]pyridazine

9. 7h-imidazo(4,5-c)pyridazine, 7-ethyl-4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxy(1,1'-biphenyl)-3-yl)-

10. 7-ethyl-4-[4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl]-7h-imidazo[4,5-c]pyridazine

11. Unii-o9bp19hz3q

12. Gtpl9798

13. Chembl3647536

14. Schembl15794150

15. Bdbm144227

16. Tq0078

17. Who 11498

18. Example 4 [wo2014091368]

19. Bp166580

20. Hy-120874

21. Cs-0079452

22. Pf06372865

23. Pf 06372865

24. Us8952008, 4

25. 7-ethyl-4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxy-[1,1'-biphenyl]-3-yl)-7h-imidazo[4,5-c]pyridazine

26. 7-ethyl-4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7h-imidazo(4,5-c)-pyridazine

27. 7-ethyl-4-(4'-(ethylsulfonyl)-6-fluoro-2'methoxybiphenyl-3-yl)-7h-imidazo[4,5-c]pyridazine

2.4 Create Date
2014-07-28
3 Chemical and Physical Properties
Molecular Weight 440.5 g/mol
Molecular Formula C22H21FN4O3S
XLogP32.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass440.13183988 g/mol
Monoisotopic Mass440.13183988 g/mol
Topological Polar Surface Area95.4 Ų
Heavy Atom Count31
Formal Charge0
Complexity705
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)


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Looking for 1614245-70-3 / Darigabat API manufacturers, exporters & distributors?

Darigabat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Darigabat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Darigabat manufacturer or Darigabat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Darigabat manufacturer or Darigabat supplier.

PharmaCompass also assists you with knowing the Darigabat API Price utilized in the formulation of products. Darigabat API Price is not always fixed or binding as the Darigabat Price is obtained through a variety of data sources. The Darigabat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Darigabat

Synonyms

Pf-06372865, 1614245-70-3, Darigabat [inn], Darigabat [usan], Cvl-865, O9bp19hz3q

Cas Number

1614245-70-3

Unique Ingredient Identifier (UNII)

O9BP19HZ3Q

Darigabat Manufacturers

A Darigabat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Darigabat, including repackagers and relabelers. The FDA regulates Darigabat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Darigabat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Darigabat Suppliers

A Darigabat supplier is an individual or a company that provides Darigabat active pharmaceutical ingredient (API) or Darigabat finished formulations upon request. The Darigabat suppliers may include Darigabat API manufacturers, exporters, distributors and traders.

Darigabat GMP

Darigabat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Darigabat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Darigabat GMP manufacturer or Darigabat GMP API supplier for your needs.

Darigabat CoA

A Darigabat CoA (Certificate of Analysis) is a formal document that attests to Darigabat's compliance with Darigabat specifications and serves as a tool for batch-level quality control.

Darigabat CoA mostly includes findings from lab analyses of a specific batch. For each Darigabat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Darigabat may be tested according to a variety of international standards, such as European Pharmacopoeia (Darigabat EP), Darigabat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Darigabat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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