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1. Zp1609
1. 943134-39-2
2. Gap-134
3. (2s,4r)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic Acid
4. Danegaptida
5. Zp1609
6. Pa0y7735at
7. Zp-1609
8. Glycyl-(4r)-4-(benzoylamino)-l-proline
9. L-proline, Glycyl-4-(benzoylamino)-, (4r)-
10. Dtxsid201026039
11. (2s,4r)-1-(aminoacetyl)-4-(benzoylamino)pyrrolidine-2-carboxylic Acid
12. Danegaptidum
13. [2s,4r]-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic Acid
14. Refchem:919625
15. Dtxcid301510295
16. 943134-39-2 (free Base)
17. (2s,4r)-4-benzamido-1-glycylpyrrolidine-2-carboxylic Acid
18. Mfcd16619374
19. Danegaptide [usan]
20. Danegaptide [usan:inn]
21. Unii-pa0y7735at
22. (2s,4r)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylicacid
23. Danegaptide [inn]
24. Danegaptide (usan/inn)
25. Danegaptide [who-dd]
26. Chembl560592
27. Schembl2399763
28. Bizkihujgmsvfd-mnovxskesa-n
29. Chebi:177853
30. Akos030527026
31. Cs-1100
32. Db11821
33. Hy-10913
34. Db-289821
35. Ns00072457
36. D09599
37. D95155
38. 134a392
39. Brd-k35589454-003-01-1
40. Q27286426
41. (2s,4r) 1-(2-amino-acetyl)-4-benzoylamino-pyrrolidine-2-carboxylic Acid
42. (2s,4r)-1-(2-azanylethanoyl)-4-benzamido-pyrrolidine-2-carboxylic Acid
43. (2s4r) 1-(2-amino-acetyl)-4-benzoylamino-pyrrolidine-2-carboxylic Acid
44. (2s4r)1-(2-amino-acetyl)-4-benzoylamino-pyrrolidine-2-carboxylic Acid
| Molecular Weight | 291.30 g/mol |
|---|---|
| Molecular Formula | C14H17N3O4 |
| XLogP3 | -2.7 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 4 |
| Exact Mass | Da |
| Monoisotopic Mass | Da |
| Topological Polar Surface Area | 113 |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 420 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Danegaptide, a small modified dipeptide, is a selective second generation gap junction modifier with oral bioavailability. Danegaptide prevents postoperative atrial fibrillation (AF) and chronic AF in large animal models. In a canine model of acute sterile pericarditis, Danegaptide significantly reduced AF duration and overall AF burden. Danegaptide has a similar mechanism of action to its parent compound rotigaptide. Rotigaptide is a synthetic antiarrhythmic peptide (AAP) analogue which has been tested in vitro which shows prevention of prevents metabolic stress-induced atrial conduction velocity (CV) and rapidly reverts established atrial CV slowing. Rogitapeptide enhances gap junction conductance and coupling, increasing the amount of small molecules such as ions, metabolites and secondary messengers passing from one cell to another.
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PharmaCompass offers a list of Danegaptide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Danegaptide manufacturer or Danegaptide supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Danegaptide manufacturer or Danegaptide supplier.
A Danegaptide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Danegaptide, including repackagers and relabelers. The FDA regulates Danegaptide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Danegaptide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Danegaptide supplier is an individual or a company that provides Danegaptide active pharmaceutical ingredient (API) or Danegaptide finished formulations upon request. The Danegaptide suppliers may include Danegaptide API manufacturers, exporters, distributors and traders.
Danegaptide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Danegaptide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Danegaptide GMP manufacturer or Danegaptide GMP API supplier for your needs.
A Danegaptide CoA (Certificate of Analysis) is a formal document that attests to Danegaptide's compliance with Danegaptide specifications and serves as a tool for batch-level quality control.
Danegaptide CoA mostly includes findings from lab analyses of a specific batch. For each Danegaptide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Danegaptide may be tested according to a variety of international standards, such as European Pharmacopoeia (Danegaptide EP), Danegaptide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Danegaptide USP).
