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Clodronic Acid Disodium Salt

Clodronic Acid Disodium Salt

Synopsis, Chemistry

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Also known as: 22560-50-5, Clodronic acid disodium salt, Disodium clodronate, Clasteon, Loron, Lodronate

Molecular Formula

CH₂Cl₂Na₂O₆P₂

Molecular Weight

288.85 g/mol

InChI Key

HJKBJIYDJLVSAO-UHFFFAOYSA-L

FDA UNII

Y05R4GCQ1H

A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.

1 2D Structure

Clodronic Acid Disodium Salt

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

disodium;[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate

2.1.2 InChI

InChI=1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

2.1.3 InChI Key

HJKBJIYDJLVSAO-UHFFFAOYSA-L

2.1.4 Canonical SMILES

C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

Y05R4GCQ1H

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Acid, Clodronic

2. Acid, Dichloromethanediphosphonic

3. Biphosphonate, Dichloromethylene

4. Bonefos

5. Cl2mdp

6. Clodronate

7. Clodronate Sodium

8. Clodronic Acid

9. Dichloromethane Diphosphonate

10. Dichloromethanediphosphonate

11. Dichloromethanediphosphonic Acid

12. Dichloromethylene Biphosphonate

13. Dichloromethylene Diphosphonate

14. Dichloromethylenebisphosphonate

15. Diphosphonate, Dichloromethane

16. Diphosphonate, Dichloromethylene

17. Disodium, Clodronate

18. Sodium, Clodronate

2.3.2 Depositor-Supplied Synonyms

1. 22560-50-5

2. Clodronic Acid Disodium Salt

3. Disodium Clodronate

4. Clasteon

5. Loron

6. Lodronate

7. Ostac

8. Clodronate Sodium

9. Sodium Clodronate

10. Bonefos

11. Clodronate Disodium Anhydrous

12. Disodium Dichloromethylene Diphosphonate

13. Disodium (dichloromethylene)diphosphonate

14. Disodium (dichloromethylene)bisphosphonate

15. Clodronate (disodium Salt)

16. Disodium Dihydrogen (dichloromethylene)diphosphonate

17. Y05r4gcq1h

18. Chebi:59586

19. Clastoban

20. Clodronic Acid (disodium Salt)

21. Ncgc00016141-02

22. Dichloromethylenediphosphonic Acid Disodium Salt

23. Mebonat

24. Ossiten

25. Bonefos (tn)

26. Sodium (dichloro(phosphono)methyl)phosphonate

27. Chlodronate Sodium

28. Phosphonic Acid, (dichloromethylene)bis-, Disodium Salt

29. Sodium Clodronate Hydrate

30. Clodronate, Disodium Salt

31. Clodron

32. 88416-50-6

33. Dichloromethane Diphosphonate

34. Cl2mdp

35. Einecs 245-078-9

36. Unii-y05r4gcq1h

37. Disodium-dichloromethylene-diphosphonate

38. Abioklad

39. Bm 06011

40. Clodronic Acid, Disodium Salt

41. Lytos

42. Clodronate 2na

43. Dichloromethylene Diphosphonate, Disodium Salt

44. Lopac-d-4434

45. Dsstox_cid_25225

46. Dsstox_rid_80762

47. Dsstox_gsid_45225

48. Schembl28438

49. Phosphonic Acid, (dichloromethylene)di-, Disodium Salt

50. Chembl1520188

51. Dtxsid3045225

52. Kco-692

53. Hms3261o17

54. Tox21_110309

55. Tox21_500398

56. Clodronate Disodium [who-dd]

57. Mfcd01632786

58. S4108

59. Clodronic Acid Disodium Salt Anhydrous

60. Akos005766025

61. Ccg-220684

62. Ccg-221702

63. Lp00398

64. Clodronic Acid, Disodium Salt, Hydrate

65. Ncgc00016141-01

66. Ncgc00093825-01

67. Ncgc00261083-01

68. Cas-22560-50-5

69. Db-013842

70. D4160

71. Eu-0100398

72. D 4434

73. D07720

74. F20591

75. Sodium Dichloromethylenebis(hydrogenphosphonate)

76. (dichloromethylene)bisphosphonate Disodium

77. A816262

78. Dichloromethylenediphosphonic Acid Disodium Salt

79. 22560-50-5, 10596-23-3(free Base)

80. Clodronic Acid Disodium Salt Anhydrous [mi]

81. Cl2mdp; Clodronic Acid Disodium Magnesium Salt; Dmdp

82. Q27126793

83. Disodium (dichloromethanediyl)bis[hydrogen (phosphonate)]

84. Disodium;[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	CH₂Cl₂Na₂O₆P₂
Molecular Weight	288.85 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	287.8499057 g/mol
Monoisotopic Mass	287.8499057 g/mol
Topological Polar Surface Area	121 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	206
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)