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Chemistry

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Also known as: 7440-47-3, Cr, Chromium metal, Chrom, Chrome, Chromium, elemental
Molecular Formula
Cr
Molecular Weight
51.996  g/mol
InChI Key
VYZAMTAEIAYCRO-UHFFFAOYSA-N
FDA UNII
0R0008Q3JB

Chromium
A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.
Chromium is a Standardized Chemical Allergen. The physiologic effect of chromium is by means of Increased Histamine Release, and Cell-mediated Immunity.
1 2D Structure

Chromium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
chromium
2.1.2 InChI
InChI=1S/Cr
2.1.3 InChI Key
VYZAMTAEIAYCRO-UHFFFAOYSA-N
2.1.4 Canonical SMILES
[Cr]
2.2 Other Identifiers
2.2.1 UNII
0R0008Q3JB
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 7440-47-3

2. Cr

3. Chromium Metal

4. Chrom

5. Chrome

6. Chromium, Elemental

7. Cromo

8. Chromium Atom

9. Dinakrome

10. Biochrome

11. Chromium Chips

12. Chromium Powder

13. Chromide(1-)

14. Chromium Ion

15. Chromium(iii) Compounds

16. 24cr

17. Chebi:28073

18. 0r0008q3jb

19. Chrome [french]

20. Chromium Compounds

21. Chrom [german]

22. Chromium, Metal

23. Mfcd00010944

24. 19498-56-7

25. Ccris 159

26. Hsdb 910

27. Einecs 231-157-5

28. Chromium Anion

29. Chromium Flakes

30. Unii-0r0008q3jb

31. Chromium Pellets

32. Chromium Mof

33. Chromium Nanorods

34. Chromium, Metal And Insol. Salts

35. Chromide(-i)

36. Chromium(3+)ion

37. Chromium Nanopowder

38. Chromium Nanoprisms

39. Chromium Trituration

40. Chromium Yeast Dark

41. Chromium Crystallites

42. Chromium Metal Chips

43. Chromium Yeast Light

44. Chromium(3+) Ions

45. Chromium Citrate Trit

46. Chromium Micro Powder

47. Chromium Nanoparticles

48. Chromium Ion(cr3+)

49. Chromium, Ion(cr3+)

50. Chromium [hsdb]

51. Chromium [inci]

52. Chromium [mi]

53. Chromium [vandf]

54. Chromium, Metal And Chromium(iii) Compounds

55. Chromium, Ion (cr1-)

56. Chromium, Ion (cr3 )

57. Chromium Pieces, Irregular

58. Chromium [who-dd]

59. Epitope Id:114071

60. Chromium, Ion (cr 3+)

61. Ec 231-157-5

62. Chromium Metal [chromium And Chromium Compounds]

63. Chromium Arginate 7% 40m

64. Chromium Powder, -60 Mesh

65. Ultra Thin Chromium Nanofoil

66. Chromium Powder, -100 Mesh

67. Chromium Powder, -200 Mesh

68. Chromium Powder, -325 Mesh

69. Cr(-)

70. Unii-x1n4508kf1

71. Chromium Histidinate 8% 40m

72. Chromium, Puriss., 98.0%

73. Chromium Granules, -4+7 Mesh

74. Chromium Metal Organic Framework

75. Chromium Metal-organic Framework

76. Chromium Powder, 99.5% Nano

77. Dtxsid3031022

78. Titanium Metal Organic Framework

79. Chebi:33010

80. Chromium Powder, -10+20 Mesh

81. Chromium Lysinate 0.28% 40m

82. Chromium, 99.5% Lump

83. Chromium Yeast 0.2% Blend Only

84. Chromium, Metallic [iarc]

85. Chromium Powder, Aps <10 Micron

86. Chromium(iii) Compounds, N.o.s.

87. Dtxsid401315238

88. Chromium Powder, -100+325 Mesh

89. Silica (sio2) Photoelectric Crystal

90. Akos015833211

91. Db11136

92. Chromium Pieces, 1-25mm (0.04-1in)

93. Chromium, Powder, 99.5%, -100 Mesh

94. Q725

95. Chromium Pieces, 3-8mm (0.1-0.31in)

96. Chromium, Coating Quality, 99.95%, Grit

97. Chromium Cubes, 12.5mm (0.492in) Square

98. Chromium, Chips, Thickness ~2 Mm, 99.5%

99. Chromium Chunks, 2-15mm (0.08-0.59in)

100. Chromium Flakes, 2-12mm (0.08-0.47in)

101. Chromium Molybdenum Trituration 1% 60 Mesh

102. Chromium Pieces, 3-12mm (0.12-0.47in)

103. Chromium Polynicotinate/nicotinate 0.2% 40m

104. Chromium Rice Chelate 1% 40m W/cr Arginate

105. C06268

106. Chromium, Chips, 99.995% Trace Metals Basis

107. Chromium Pieces, 2-3mm (0.08-0.12in) Thick

108. Chromium, Chunks, >=99.99% Trace Metals Basis

109. Chromium, Bar, 100mm X 2mm X 2mm, 99.7+%

110. Chromium, Rod, 10mm, Diameter 2.0mm, 99.7+%

111. Chromium, Rod, 10mm, Diameter 5.0mm, 99.7+%

112. Chromium, Rod, 25mm, Diameter 2.0mm, 99.7+%

113. Chromium, Rod, 25mm, Diameter 5.0mm, 99.7+%

114. Chromium, Rod, 50mm, Diameter 2.0mm, 99.7+%

115. Chromium, Rod, 50mm, Diameter 5.0mm, 99.7+%

116. Chromium Cubes, Typically 6.35mm (0.25in) Square

117. Chromium, Rod, 100mm, Diameter 2.0mm, 99.7+%

118. Chromium, Rod, 100mm, Diameter 5.0mm, 99.7+%

119. Chromium Crystallite Pieces, 2-15mm (0.08-0.59in)

120. Q27115184

121. Chromium, Plasma Standard Solution, Specpure, Cr 10g/ml

122. Chromium, Aas Standard Solution, Specpure?, Cr 1000?g/ml

123. Chromium, Powder, >=99% Trace Metals Basis, -325 Mesh

124. Chromium, Foil, 100x100mm, Thickness 3.0mm, Hard, 99.95%

125. Chromium, Foil, 25x25mm, Thickness 2.0mm, Hard, 99.7+%

126. Chromium, Foil, 50x50mm, Thickness 2.0mm, Hard, 99.7+%

127. Chromium, Foil, 50x50mm, Thickness 3.0mm, Hard, 99.95%

128. Chromium, Oil Based Standard Solution, Specpure, Cr 5000g/g

129. Chromium Pieces, Electrolytic, 6mm & Down, 99.997% (metals Basis)

130. Chromium, Oil Based Standard Solution, Specpure?, Cr 1000?g/g

131. Chromium, Plasma Standard Solution, Specpure(r), Cr 10,000 ?g/ml

132. Chromium, Plasma Standard Solution, Specpure?, Cr 10,000?g/ml

133. Chromium, Rod, 0.5 Mm Diameter, Length 50 Mm, Purity 99.7+%

134. Chromium, Rod, 1.0 Mm Diameter, Length 50 Mm, Purity 99.7+%

135. Chromium, Rod, 8.0 Mm Diameter, Length 100 Mm, Purity 99.7+%

136. Chromium, Rod, 8.0 Mm Diameter, Length 50 Mm, Purity 99.7+%

137. Chromium, Rod, Length 25 Mm, 0.5 Mm Diameter, Purity 99.7+%

138. Chromium Single Crystal, 8-10mm (0.3-0.4in) Dia, Random Orientation

139. Chromium, Foil, Thickness 0.5 Mm, Size 10 X 10 Mm, Purity 99.7+%

140. Chromium, Foil, Thickness 0.5 Mm, Size 100 X 100 Mm, Purity 99.99%

141. Chromium, Foil, Thickness 0.5 Mm, Size 12.5 X 12.5 Mm, Purity 99.99%

142. Chromium, Foil, Thickness 0.5 Mm, Size 25 X 25 Mm, Purity 99.99%

143. Chromium, Foil, Thickness 0.5 Mm, Size 50 X 50 Mm, Purity 99.99%

144. Chromium, Foil, Thickness 0.75 Mm, Size 25 X 25 Mm, Tolerance 0.2

145. Chromium, Foil, Thickness 1.0 Mm, Size 100 X 100 Mm, Purity 99.99%

146. Chromium, Foil, Thickness 1.0 Mm, Size 12.5 X 12.5 Mm, Purity 99.99%

147. Chromium, Foil, Thickness 1.0 Mm, Size 25 X 25 Mm, Purity 99.99%

148. Chromium, Foil, Thickness 1.0 Mm, Size 50 X 50 Mm, Purity 99.99%

149. Chromium, Foil, Thickness 1.0 Mm, Size 75 X 75 Mm, Purity 99.99%

150. Chromium, Foil, Thickness 1.5 Mm, Size 100 X 100 Mm, Purity 99.99%

151. Chromium, Foil, Thickness 1.5 Mm, Size 25 X 25 Mm, Purity 99.99%

152. Chromium, Foil, Thickness 1.5 Mm, Size 50 X 50 Mm, Purity 99.99%

153. Chromium, Foil, Thickness 2.0 Mm, Size 100 X 100 Mm, Purity 99.99%

154. Chromium, Foil, Thickness 2.0 Mm, Size 25 X 25 Mm, Purity 99.99%

155. Chromium, Foil, Thickness 2.0 Mm, Size 50 X 50 Mm, Purity 99.99%

156. Chromium, Lump, 10 Mm Max. Lump Size, Weight 10 G, Purity 99.99%

157. Chromium, Lump, 10 Mm Max. Lump Size, Weight 100 G, Purity 99.95%

158. Chromium, Lump, 10 Mm Max. Lump Size, Weight 100 G, Purity 99.99%

159. Chromium, Lump, 10 Mm Max. Lump Size, Weight 20 G, Purity 99.95%

160. Chromium, Lump, 10 Mm Max. Lump Size, Weight 20 G, Purity 99.99%

161. Chromium, Lump, 10 Mm Max. Lump Size, Weight 200 G, Purity 99.95%

162. Chromium, Lump, 10 Mm Max. Lump Size, Weight 200 G, Purity 99.99%

163. Chromium, Lump, 10 Mm Max. Lump Size, Weight 50 G, Purity 99.95%

164. Chromium, Lump, 10 Mm Max. Lump Size, Weight 50 G, Purity 99.99%

165. Chromium, Lump, 25 Mm Max. Lump Size, Weight 100 G, Purity 99.95%

166. Chromium, Lump, 25 Mm Max. Lump Size, Weight 1000 G, Purity 99.95%

167. Chromium, Lump, 25 Mm Max. Lump Size, Weight 200 G, Purity 99.95%

168. Chromium, Lump, 25 Mm Max. Lump Size, Weight 50 G, Purity 99.95%

169. Chromium, Lump, 25 Mm Max. Lump Size, Weight 500 G, Purity 99.95%

170. Chromium, Powder, Mean Particle Size <10 Micron, Weight 20 G, Purity 99%

171. Chromium, Powder, Mean Particle Size <10 Micron, Weight 50 G, Purity 99%

172. Chromium Single Crystal, 8-10mm (0.3-0.4in) Dia, (100) Orientation, +/-2 Degrees

173. Chromium Single Crystal, 8-10mm (0.3-0.4in) Dia, (110) Orientation, +/-2 Degrees

174. Chromium Single Crystal, 8-10mm (0.3-0.4in) Dia, (111) Orientation, +/-2 Degrees

175. Chromium Sputtering Target, 50.8mm (2.0in) Dia X 3.18mm (0.125in) Thick

176. Chromium Sputtering Target, 50.8mm (2.0in) Dia X 6.35mm (0.250in) Thick

177. Chromium Sputtering Target, 76.2mm (3.0in) Dia X 6.35mm (0.250in) Thick

178. Chromium, Plasma Standard Solution, Specpure?, Cr 1000?g/ml, Cr In 5% Hcl

179. Chromium, Plasma Standard Solution, Specpure?, Cr 1000?g/ml, Cr(no3)3 In 5% Hno3

180. Chromium, Powder, <10 Mean Particle Size (micron), Weight 100 G, Purity 99%

181. Chromium, Powder, <10 Mean Particle Size (micron), Weight 200 G, Purity 99%

182. Chromium, Powder, 200 Max. Part. Size (micron), Weight 200 G, Purity 99.0+%

183. Chromium, Powder, 200 Max. Part. Size (micron), Weight 2000 G, Purity 99.0+%

184. Chromium, Powder, 200 Max. Part. Size (micron), Weight 50 G, Purity 99.0+%

185. Chromium, Powder, 38 Max. Part. Size (micron), Weight 100 G, Purity 99.0+%

186. Chromium, Powder, Max. Particle Size 200 Micron, Weight 100 G, Purity 99.+%

187. Chromium, Powder, Max. Particle Size 200 Micron, Weight 1000 G, Purity 99.+%

188. Chromium, Powder, Max. Particle Size 200 Micron, Weight 500 G, Purity 99.+%

189. Chromium, Powder, Max. Particle Size 38 Micron, Weight 1000 G, Purity 99.+%

190. Chromium, Powder, Max. Particle Size 38 Micron, Weight 200 G, Purity 99.+%

191. Chromium, Powder, Max. Particle Size 38 Micron, Weight 50 G, Purity 99.+%

192. Chromium, Powder, Max. Particle Size 38 Micron, Weight 500 G, Purity 99.+%

193. Chromium, Powder, Max. Particle Size 45 Micron, Weight 100 G, Min. Particle Size 38 Micron

194. Chromium, Powder, Max. Particle Size 45 Micron, Weight 200 G, Min. Particle Size 38 Micron

195. Chromium, Powder, Max. Particle Size 45 Micron, Weight 50 G, Min. Particle Size 38 Micron

196. Chromium, Powder, Max. Particle Size 45 Micron, Weight 500 G, Min. Particle Size 38 Micron

197. Chromium Single Crystal Disc, 10mm (0.39in) Dia, 1-3mm (0.04-0.1in) Thick, (100) Orientation, +/-0.5 Degrees

198. Chromium Single Crystal Disc, 10mm (0.39in) Dia, 1-3mm (0.04-0.1in) Thick, (110) Orientation, +/-0.5 Degrees

199. Chromium Single Crystal Disc, 10mm (0.39in) Dia, 1-3mm (0.04-0.1in) Thick, (111) Orientation, +/-0.5 Degrees

200. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.005mm, Permanent Polyester Support, 99.99+%

201. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.006mm, Permanent Polyester Support, 99.99+%

202. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.007mm, Permanent Polyester Support, 99.99+%

203. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.008mm, Permanent Polyester Support, 99.99+%

204. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.009mm, Permanent Polyester Support, 99.99+%

205. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.0125mm, Permanent Polyester Support, 99.99+%

206. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.015mm, Permanent Polyester Support, 99.99+%

207. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.01mm, Permanent Polyester Support, 99.99+%

208. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.025mm, Permanent Polyester Support, 99.99+%

209. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.02mm, Permanent Polyester Support, 99.99+%

210. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.03mm, Permanent Polyester Support, 99.99+%

211. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.04mm, Permanent Polyester Support, 99.99+%

212. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.05mm, Permanent Polyester Support, 99.99+%

213. Chromium, Foil, Light Tested, 25x25mm, Thickness 0.075mm, Permanent Polyester Support, 99.99+%

214. Chromium, Foil, Not Light Tested, 100x100mm, Thickness 0.0125mm, Permanent Polyester Support, 99.99+%

215. Chromium, Foil, Not Light Tested, 100x100mm, Thickness 0.015mm, Permanent Polyester Support, 99.99+%

216. Chromium, Foil, Not Light Tested, 100x100mm, Thickness 0.01mm, Permanent Polyester Support, 99.99+%

217. Chromium, Foil, Not Light Tested, 100x100mm, Thickness 0.025mm, Permanent Polyester Support, 99.99+%

218. Chromium, Foil, Not Light Tested, 100x100mm, Thickness 0.02mm, Permanent Polyester Support, 99.99+%

219. Chromium, Foil, Not Light Tested, 100x100mm, Thickness 0.03mm, Permanent Polyester Support, 99.99+%

220. Chromium, Foil, Not Light Tested, 100x100mm, Thickness 0.04mm, Permanent Polyester Support, 99.99+%

221. Chromium, Foil, Not Light Tested, 100x100mm, Thickness 0.05mm, Permanent Polyester Support, 99.99+%

222. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.0015mm, Permanent Polyester Support, 99.99+%

223. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.001mm, Permanent Polyester Support, 99.99+%

224. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.0025mm, Permanent Polyester Support, 99.99+%

225. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.002mm, Permanent Polyester Support, 99.99+%

226. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.003mm, Permanent Polyester Support, 99.99+%

227. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.004mm, Permanent Polyester Support, 99.99+%

228. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.005mm, Permanent Polyester Support, 99.99+%

229. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.006mm, Permanent Polyester Support, 99.99+%

230. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.007mm, Permanent Polyester Support, 99.99+%

231. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.009mm, Permanent Polyester Support, 99.99+%

232. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.0125mm, Permanent Polyester Support, 99.99+%

233. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.015mm, Permanent Polyester Support, 99.99+%

234. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.01mm, Permanent Polyester Support, 99.99+%

235. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.025mm, Permanent Polyester Support, 99.99+%

236. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.02mm, Permanent Polyester Support, 99.99+%

237. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.03mm, Permanent Polyester Support, 99.99+%

238. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.04mm, Permanent Polyester Support, 99.99+%

239. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.05mm, Permanent Polyester Support, 99.99+%

240. Chromium, Foil, Not Light Tested, 25x25mm, Thickness 0.075mm, Permanent Polyester Support, 99.99+%

241. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.001mm, Permanent Polyester Support, 99.99+%

242. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.0025mm, Permanent Polyester Support, 99.99+%

243. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.002mm, Permanent Polyester Support, 99.99+%

244. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.003mm, Permanent Polyester Support, 99.99+%

245. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.004mm, Permanent Polyester Support, 99.99+%

246. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.005mm, Permanent Polyester Support, 99.99+%

247. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.006mm, Permanent Polyester Support, 99.99+%

248. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.007mm, Permanent Polyester Support, 99.99+%

249. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.008mm, Permanent Polyester Support, 99.99+%

250. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.009mm, Permanent Polyester Support, 99.99+%

251. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.0125mm, Permanent Polyester Support, 99.99+%

252. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.015mm, Permanent Polyester Support, 99.99+%

253. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.01mm, Permanent Polyester Support, 99.99+%

254. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.025mm, Permanent Polyester Support, 99.99+%

255. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.02mm, Permanent Polyester Support, 99.99+%

256. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.03mm, Permanent Polyester Support, 99.99+%

257. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.04mm, Permanent Polyester Support, 99.99+%

258. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.05mm, Permanent Polyester Support, 99.99+%

259. Chromium, Foil, Not Light Tested, 50x50mm, Thickness 0.075mm, Permanent Polyester Support, 99.99+%

260. Chromium, Microfoil, Disks, 10mm, Thinness 0.025mum, Specific Density 18.21mug/cm2, Permanent Mylar 3.5mum Support, 99.99+%

261. Chromium, Microfoil, Disks, 10mm, Thinness 0.05mum, Specific Density 37.27mug/cm2, Permanent Mylar 3.5mum Support, 99.99+%

262. Chromium, Microfoil, Disks, 10mm, Thinness 0.25mum, Specific Density 178.7mug/cm2, Permanent Mylar 3.5mum Support, 99.99+%

263. Chromium, Microfoil, Disks, 10mm, Thinness 0.5mum, Specific Density 355mug/cm2, Permanent Mylar 3.5mum Support, 99.99+%

264. Chromium, Microfoil, Disks, 10mm, Thinness 1.0mum, Specific Density 719mug/cm2, Permanent Mylar 3.5mum Support, 99.99+%

265. Chromium, Microfoil, Disks, 25mm, Thinness 0.05mum, Specific Density 37.27mug/cm2, Permanent Mylar 3.5mum Support, 99.99+%

266. Chromium, Microfoil, Disks, 25mm, Thinness 0.25mum, Specific Density 178.7mug/cm2, Permanent Mylar 3.5mum Support, 99.99+%

267. Chromium, Microfoil, Disks, 25mm, Thinness 0.5mum, Specific Density 355mug/cm2, Permanent Mylar 3.5mum Support, 99.99+%

268. Chromium, Microfoil, Disks, 25mm, Thinness 1.0mum, Specific Density 719mug/cm2, Permanent Mylar 3.5mum Support, 99.99+%

269. Chromium, Powder, Max. Particle Size 45 Micron, Weight 1000 G, Min. Particle Size 38 Micron

270. Chromium, Sputtering Target, Diam. X Thickness 3.00 In. X 0.125 In., 99.95% Trace Metals Basis

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 51.996 g/mol
Molecular Formula Cr
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count0
Exact Mass51.940505 g/mol
Monoisotopic Mass51.940505 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count1
Formal Charge0
Complexity0
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN), to maintain chromium serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Trivalent chromium is part of glucose tolerance factor, an essential activator of insulin-mediated reactions. Chromium helps to maintain normal glucose metabolism and peripheral nerve function. Chromium increases insulin binding to cells, increases insulin receptor density and activates insulin receptor kinase leading to enhanced insulin sensitivity. In chromium deficiency, intravenous administration of chromium resulted in normalization of the glucose tolerance curve from the diabetic-like curve typical of chromium deficiency.


5.2 MeSH Pharmacological Classification

Trace Elements

A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) (See all compounds classified as Trace Elements.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
CHROMIUM
5.3.2 FDA UNII
0R0008Q3JB
5.3.3 Pharmacological Classes
Chemical Structure [CS] - Allergens
5.4 Absorption, Distribution and Excretion

Absorption

Chromium compounds are both absorbed by the lung and the gastrointestinal tract. Oral absorption of chromium compounds in humans can range between 0.5% and 10%, with the hexavalent (VI) chromium more easily absorbed than the trivalent (III) form. Absorption of chromium from the intestinal tract is low, ranging from less than 0.4% to 2.5% of the amount consumed. Vitamin C and the vitamin B niacin is reported to enhance chromium absorption. Most hexavalent Cr (VI) undergoes partial intragastric reduction to Cr (III) upon absorption, which is an action mainly mediated by sulfhydryl groups of amino acids. Cr (VI) readily penetrates cell membranes and chromium can be found in both erythrocytes and plasma after gastrointestinal absorption of Cr (IV). In comparison, the presence of chromium is limited to the plasma as Cr (III) displays poor cell membrane penetration. Once transported through the cell membrane, Cr (VI) is rapidly reduced to Cr (III), which subsequently binds to macromolecules or conjugate with proteins. Cr (III) may be bound to transferrin or other plasma proteins, or as complexes, such as glucose tolerance factor (GTF).


Route of Elimination

Absorbed chromium is excreted mainly in the urine, accounting for 80% of total excretion of chromium; small amounts are lost in hair, perspiration and bile. Chromium is excreted primarily in the urine by glomerular filtration or bound to a low molecular-weight organic transporter.


Volume of Distribution

Absorbed chromium is distributed to all tissues of the body and its distribution in the body depends on the species, age, and chemical form. Circulating Cr (III) following oral or parenteral administration of different compounds can be taken up by tissues and accumulates in the liver, kidney, spleen, soft tissue, and bone.


Clearance

Excretion of chromium is via the kidneys ranges from 3 to 50 g/day. The 24-hour urinary excretion rates for normal human subjects are reported to be 0.22 g/day.


The objective of the Part II analysis was to evaluate animal and in vitro toxicology studies of CoCr particles with respect to their physicochemistry and dose relevance to metal-on-metal (MoM) implant patients as derived from Part I. In the various toxicology studies, physicochemical characteristics were infrequently considered and administered doses were orders of magnitude higher than what occurs in patients. Co was consistently shown to rapidly release from CoCr particles for distribution and elimination from the body. CoCr micron sized particles appear more biopersistent in vivo resulting in inflammatory responses that are not seen with similar mass concentrations of nanoparticles. We conclude, that in an attempt to obtain data for a complete risk assessment, future studies need to focus on physicochemical characteristics of nano and micron sized particles and on doses and dose metrics relevant to those generated in patients or in properly conducted hip simulator studies. /CoCr particles/

PMID:25735266 Madl AK et al; Nanomedicine.11 (5): 1285-98 (2015)


The kinetics of metal ions release from orthodontic appliances in in vitro, in in vivo on pigs, and in vivo trials on patients (where hair samples were taken) was discussed. We have evaluated (by means of ICP-OES and ISO 17025) and compared the mass of Cr and Ni ions released. Not all the metal ions released from the appliance were transferred to hair tissue. The transfer factor was expressed as coefficient omega and evaluated as: omegaCr(patients) 33.0%, omegaCr(pigs) 17.2%, omegaNi(patients) 49.8%, omegaNi(pigs) 0.553%. The kinetics was described by a power function. Coefficient omega was used to combine the models: the in vitro and in vivo on animals on the one hand and the in vitro and in vivo on human on the other, which enabled the extrapolation of in vitro and translation of the results into in vivo conditions. The dose of metal ions released during orthodontic treatment was estimated.

PMID:25461553 Chojnacka K, Mikulewicz M; Environ Toxicol Pharmacol. 38 (3): 932-7 (2014)


5.5 Metabolism/Metabolites

The metabolism of Cr (VI) involves reduction by small molecules and enzyme systems to generate Cr (III) and reactive intermediates. During this process, free radicals can be generated, which is thought to induce damage of cellular components and cause toxicity of chromium. The metabolites bind to cellular constituents.


5.6 Biological Half-Life

The elimination half-life of hexavalent chromium is 15 to 41 hours.


Blood: 24 days; body: initial elimination 1/2 life = 2-3 days; extended 1/2 life = 1 month; [TDR, p. 368] After chronic exposure, workers can have high levels of chromium in the urine for years. [ACGIH]

TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 368 ACGIH - Documentation of the TLVs and BEIs, 7th Ed. Cincinnati: ACGIH Worldwide, 2020.


5.7 Mechanism of Action

Chromium is an essential nutrient involved in the metabolism of glucose, insulin and blood lipids. Its role in potentiating insulin signalling cascades has been implicated in several studies. Chromium upregulates insulin-stimulated insulin signal transduction via affecting effector molecules downstream of the insulin receptor (IR). IR-mediated signalling pathway involves phoshorylation of multiple intracellular domains and protein kinases, and downstream effector molecules. Upon activation by ligands, intracellular -subunit of IR autophosphorylates and activates tyrosine kinase domain of the IR, followed by activation and phosphorylation of regulatory proteins and downstream signalling effectors including phosphatidylinositol 2-kinase (PI3K). PI3K activates further downstream reaction cascades to activate protein kinase B (Akt) to ultimately promote translocation of glucose transporter-4 (Glut4)-vesicles from the cytoplasm to the cell surface and regulate glucose uptake. Chromium enhances the kinase activity of insulin receptor and increases the activity of downstream effectors, pI3-kinase and Akt. Under insulin-resistant conditions, chromium also promotes GLUT-4 transporter translocation that is independent of activity of IR, IRS-1, PI3-kinase, or Akt; chromium mediates cholesterol efflux from the membranes via increasing fluidity of the membrane by decreasing the membrane cholesterol and upregulation of sterol regulatory element-binding protein. As a result, intracellular GLUT-4 transporters are stimulated to translocate from intracellular to the plasma membrane, leading to enhanced glucose uptake in muscle cells. Chromium attenuates the activity of PTP-1B _in vitro,_ which is a negative regulator of insulin signaling. It also alleviates ER stress that is observed to be elevated the suppression of insulin signaling. ER stress is thought to activate c-Jun N-terminal kinase (JNK), which subsequently induces serine phosphorylation of IRS and aberration of insulin signalling. Transient upregulation of AMPK by chromium also leads to increased glucose uptake.


While the toxicity of metals and metalloids, like arsenic, cadmium, mercury, lead and chromium, is undisputed, the underlying molecular mechanisms are not entirely clear. General consensus holds that proteins are the prime targets; heavy metals interfere with the physiological activity of specific, particularly susceptible proteins, either by forming a complex with functional side chain groups or by displacing essential metal ions in metalloproteins. Recent studies have revealed an additional mode of metal action targeted at proteins in a non-native state; certain heavy metals and metalloids have been found to inhibit the in vitro refolding of chemically denatured proteins, to interfere with protein folding in vivo and to cause aggregation of nascent proteins in living cells. Apparently, unfolded proteins with motile backbone and side chains are considerably more prone to engage in stable, pluridentate metal complexes than native proteins with their well-defined 3D structure. By interfering with the folding process, heavy metal ions and metalloids profoundly affect protein homeostasis and cell viability. This review describes how heavy metals impede protein folding and promote protein aggregation, how cells regulate quality control systems to protect themselves from metal toxicity and how metals might contribute to protein misfolding disorders.

PMID:24970215 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030994 Tamas MJ et al; Biomolecules. 4(1): 252-67 (2014)


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05-Jan-2022
28-May-2025
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ABOUT THIS PAGE

Looking for 7440-47-3 / Chromium API manufacturers, exporters & distributors?

Chromium manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Chromium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Chromium manufacturer or Chromium supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Chromium manufacturer or Chromium supplier.

PharmaCompass also assists you with knowing the Chromium API Price utilized in the formulation of products. Chromium API Price is not always fixed or binding as the Chromium Price is obtained through a variety of data sources. The Chromium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Chromium

Synonyms

7440-47-3, Cr, Chromium metal, Chrom, Chrome, Chromium, elemental

Cas Number

7440-47-3

Unique Ingredient Identifier (UNII)

0R0008Q3JB

About Chromium

A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.

Chromium Manufacturers

A Chromium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chromium, including repackagers and relabelers. The FDA regulates Chromium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chromium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Chromium Suppliers

A Chromium supplier is an individual or a company that provides Chromium active pharmaceutical ingredient (API) or Chromium finished formulations upon request. The Chromium suppliers may include Chromium API manufacturers, exporters, distributors and traders.

click here to find a list of Chromium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Chromium NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Chromium as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Chromium API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Chromium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Chromium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Chromium NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Chromium suppliers with NDC on PharmaCompass.

Chromium GMP

Chromium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Chromium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Chromium GMP manufacturer or Chromium GMP API supplier for your needs.

Chromium CoA

A Chromium CoA (Certificate of Analysis) is a formal document that attests to Chromium's compliance with Chromium specifications and serves as a tool for batch-level quality control.

Chromium CoA mostly includes findings from lab analyses of a specific batch. For each Chromium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Chromium may be tested according to a variety of international standards, such as European Pharmacopoeia (Chromium EP), Chromium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chromium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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