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Chemistry

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Also known as: 69739-16-8, Cefodizima, Cefodizimum, Cdzm, Cefodizime disodium, Hr 221
Molecular Formula
C20H20N6O7S4
Molecular Weight
584.7  g/mol
InChI Key
XDZKBRJLTGRPSS-BGZQYGJUSA-N
FDA UNII
Z31298J4HQ

Cefodizima
Cefodizime is a third-generation, aminothiazolyl cephalosporin for parenteral use. Cefodizime has broad-spectrum activity and is stable to most beta-lactamases.
1 2D Structure

Cefodizima

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
2.1.2 InChI
InChI=1S/C20H20N6O7S4/c1-7-10(3-11(27)28)37-20(22-7)36-5-8-4-34-17-13(16(30)26(17)14(8)18(31)32)24-15(29)12(25-33-2)9-6-35-19(21)23-9/h6,13,17H,3-5H2,1-2H3,(H2,21,23)(H,24,29)(H,27,28)(H,31,32)/b25-12-/t13-,17-/m1/s1
2.1.3 InChI Key
XDZKBRJLTGRPSS-BGZQYGJUSA-N
2.1.4 Canonical SMILES
CC1=C(SC(=N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O)CC(=O)O
2.1.5 Isomeric SMILES
CC1=C(SC(=N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)O)CC(=O)O
2.2 Other Identifiers
2.2.1 UNII
Z31298J4HQ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cefodizime Disodium

2. Cefodizime, Dipotassium Salt, (6r-(6alpha,7beta(z)))-isomer

3. Cefodizime, Disodium Salt, (6r-(6alpha,7beta(z)))-isomer

4. Hr 221

5. Hr-221

6. Modivid

2.3.2 Depositor-Supplied Synonyms

1. 69739-16-8

2. Cefodizima

3. Cefodizimum

4. Cdzm

5. Cefodizime Disodium

6. Hr 221

7. Hr-221

8. Chebi:63214

9. Hr 221 [as Sodium]

10. Thr 221 [as Sodium]

11. Z31298j4hq

12. Cefodizime (inn)

13. (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

14. Modivid

15. S 77 1221 B [as Sodium]

16. Thr-221

17. Cefodizime [inn]

18. 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid,7-[[(2z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-, (6r,7r)-

19. 7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

20. Cefodizime Sodium [jan]

21. Cefodizime Acid

22. Thr 221

23. (6r,7r)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-3-(((5-(carboxymethyl)-4-methyl-2-thiazolyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid 7(sup 2)-(z)-(o-methyloxime)

24. Cefodizime [inn:ban]

25. Cefodizimum [inn-latin]

26. Cefodizima [inn-spanish]

27. S 77-1221b

28. S-77-1221b

29. S-77-1221-b

30. Cefodizme

31. Diezime

32. Timecef

33. Neucef

34. Unii-z31298j4hq

35. Cef;cdz

36. Cefodizime [mi]

37. Ec 700-301-3

38. Hr-221 [as Sodium]

39. Cefodizime [who-dd]

40. Thr-221 [as Sodium]

41. Hr 221 Free Acid

42. Hr-221 Free Acid

43. Thr 221 Free Acid

44. Thr-221 Free Acid

45. Schembl151101

46. Chembl2303613

47. Dtxsid2022757

48. S-771221b [as Sodium]

49. Ex-a1379

50. Zinc3871933

51. A0c261

52. Bdbm50422690

53. Mfcd00864926

54. S5235

55. S 77 1221 B Free Acid

56. S-77-1221-b Free Acid

57. Db13470

58. (6r,7r)-7-(((2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl)amino)-3-(((5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl)sulfanyl)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid

59. Hy-108402

60. Cs-0028575

61. D07643

62. J-700161

63. (6r,7r)-3-({[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl)-7-{[(2z)-1-hydroxy-2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)ethylidene]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

64. (6r,7r)-7-({(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-({[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]thio}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

65. (6r,7r)-7-{[(22z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-({[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

66. 7-{[(22z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-({[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl)-3,4-didehydrocepham-4-carboxylic Acid

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 584.7 g/mol
Molecular Formula C20H20N6O7S4
XLogP30.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count15
Rotatable Bond Count10
Exact Mass584.02763169 g/mol
Monoisotopic Mass584.02763169 g/mol
Topological Polar Surface Area305 Ų
Heavy Atom Count37
Formal Charge0
Complexity1030
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


4.2 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01D - Other beta-lactam antibacterials

J01DD - Third-generation cephalosporins

J01DD09 - Cefodizime


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API | Excipient name

Cefodizima

Synonyms

69739-16-8, Cefodizimum, Cdzm, Cefodizime disodium, Hr 221, Hr-221

Cas Number

69739-16-8

Unique Ingredient Identifier (UNII)

Z31298J4HQ

About Cefodizima

Cefodizime is a third-generation, aminothiazolyl cephalosporin for parenteral use. Cefodizime has broad-spectrum activity and is stable to most beta-lactamases.

Cefodizima Manufacturers

A Cefodizima manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cefodizima, including repackagers and relabelers. The FDA regulates Cefodizima manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cefodizima API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cefodizima Suppliers

A Cefodizima supplier is an individual or a company that provides Cefodizima active pharmaceutical ingredient (API) or Cefodizima finished formulations upon request. The Cefodizima suppliers may include Cefodizima API manufacturers, exporters, distributors and traders.

Cefodizima GMP

Cefodizima Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cefodizima GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cefodizima GMP manufacturer or Cefodizima GMP API supplier for your needs.

Cefodizima CoA

A Cefodizima CoA (Certificate of Analysis) is a formal document that attests to Cefodizima's compliance with Cefodizima specifications and serves as a tool for batch-level quality control.

Cefodizima CoA mostly includes findings from lab analyses of a specific batch. For each Cefodizima CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cefodizima may be tested according to a variety of international standards, such as European Pharmacopoeia (Cefodizima EP), Cefodizima JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cefodizima USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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