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Naprod Carboplatin

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Chemistry

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Also known as: Paraplatin, Cbdca, Jm-8, Cis-diammine(1,1-cyclobutanedicarboxylato)platinum, Nsc 241240, Nsc-241240
Molecular Formula
C6H12N2O4Pt
Molecular Weight
371.25  g/mol
InChI Key
OLESAACUTLOWQZ-UHFFFAOYSA-L
FDA UNII
BG3F62OND5

Carboplatin
An organoplatinum compound that possesses antineoplastic activity.
Carboplatin is a Platinum-based Drug.
1 2D Structure

Carboplatin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
azane;cyclobutane-1,1-dicarboxylate;platinum(2+)
2.1.2 InChI
InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2
2.1.3 InChI Key
OLESAACUTLOWQZ-UHFFFAOYSA-L
2.1.4 Canonical SMILES
C1CC(C1)(C(=O)[O-])C(=O)[O-].N.N.[Pt+2]
2.2 Other Identifiers
2.2.1 UNII
BG3F62OND5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Blastocarb

2. Carboplat

3. Carboplatin

4. Carbosin

5. Carbotec

6. Cbdca

7. Cis-diammine(cyclobutanedicarboxylato)platinum Ii

8. Ercar

9. Jm 8

10. Jm-8

11. Jm8

12. Nealorin

13. Neocarbo

14. Nsc 241240

15. Nsc-241240

16. Nsc241240

17. Paraplatin

18. Paraplatine

19. Platinwas

20. Ribocarbo

2.3.2 Depositor-Supplied Synonyms

1. Paraplatin

2. Cbdca

3. Jm-8

4. Cis-diammine(1,1-cyclobutanedicarboxylato)platinum

5. Nsc 241240

6. Nsc-241240

7. Carboplatin [usan]

8. Bg3f62ond5

9. Cis-diammine(1,1-cyclobutanedicarboxylato) Platinum

10. Platinum, Diammine [1,1-cyclobutane-dicarboxylato(2-)-0,0']-,(sp-4-2)

11. Nsc-201345

12. Carboplatin [mi]

13. Carboplatin [inn]

14. Carboplatin [jan]

15. Carboplatin [hsdb]

16. Carboplatin [vandf]

17. Carboplatin [mart.]

18. Carboplatin [usp-rs]

19. Carboplatin [who-dd]

20. Cis-diamine(1,1-cyclobutanedicarboxylato)platinum(ii)

21. Carboplatin [ep Impurity]

22. Carboplatin [orange Book]

23. Carboplatin [ep Monograph]

24. Carboplatin [usp Impurity]

25. Carboplatin [usp Monograph]

26. Amy33401

27. S1215

28. Akos037515487

29. Ccg-268304

30. Ab01568249_01

31. Q415588

32. W-106301

33. Platinum, Diamine(1,1-cyclobutanedicarboxylato (2-)-o,o')-, (sp-4-2)-

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 371.25 g/mol
Molecular Formula C6H12N2O4Pt
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Exact Mass371.044501 g/mol
Monoisotopic Mass371.044501 g/mol
Topological Polar Surface Area82.3 Ų
Heavy Atom Count13
Formal Charge0
Complexity153
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count4
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameCarboplatin
PubMed HealthCarboplatin (Injection)
Drug ClassesAntineoplastic Agent
Drug LabelCarboplatin injection is supplied as a sterile, pyrogen-free, 10 mg/mL aqueous solution of carboplatin. Carboplatin is a platinum coordination compound. The chemical name for carboplatin is platinum, diammine [1,1-cyclobutane-dicarboxylato(2-)-0,0...
Active IngredientCarboplatin
Dosage FormInjectable
RouteIv (infusion)
Strength450mg/45ml (10mg/ml); 150mg/15ml (10mg/ml); 600mg/60ml (10mg/ml); 1gm/100ml (10mg/ml); 50mg/5ml (10mg/ml)
Market StatusPrescription
CompanyPliva Lachema; Actavis Elizabeth; Fresenius Kabi Usa; Hospira; Mylan Institutional; Fresenius Kabi Oncol; Ebewe Pharma; Pharmachemie Bv; Onco Therapies; Teva Pharms Usa; Eurohlth Intl; Sagent Pharms; Cipla; Sun Pharma Global; Akorn

2 of 2  
Drug NameCarboplatin
PubMed HealthCarboplatin (Injection)
Drug ClassesAntineoplastic Agent
Drug LabelCarboplatin injection is supplied as a sterile, pyrogen-free, 10 mg/mL aqueous solution of carboplatin. Carboplatin is a platinum coordination compound. The chemical name for carboplatin is platinum, diammine [1,1-cyclobutane-dicarboxylato(2-)-0,0...
Active IngredientCarboplatin
Dosage FormInjectable
RouteIv (infusion)
Strength450mg/45ml (10mg/ml); 150mg/15ml (10mg/ml); 600mg/60ml (10mg/ml); 1gm/100ml (10mg/ml); 50mg/5ml (10mg/ml)
Market StatusPrescription
CompanyPliva Lachema; Actavis Elizabeth; Fresenius Kabi Usa; Hospira; Mylan Institutional; Fresenius Kabi Oncol; Ebewe Pharma; Pharmachemie Bv; Onco Therapies; Teva Pharms Usa; Eurohlth Intl; Sagent Pharms; Cipla; Sun Pharma Global; Akorn

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Cross-Linking Reagents

Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other. (See all compounds classified as Cross-Linking Reagents.)


5.2 FDA Pharmacological Classification
5.2.1 Active Moiety
CARBOPLATIN
5.2.2 FDA UNII
BG3F62OND5
5.2.3 Pharmacological Classes
Platinum-containing Compounds [EXT]

API Reference Price

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