Bora CDMO Bora CDMO

X

Find Carbon manufacturers, exporters & distributors on PharmaCompass

PharmaCompass
API SUPPLIERS
API Suppliers

API Suppliers

US DMFs Filed

US DMFs Filed

CEP/COS Certifications

CEP/COS Certifications

JDMFs Filed

JDMFs Filed

0

Other Certificates

Other Certificates

0

Other Suppliers

Other Suppliers

API REF. PRICE (USD / KG)
88
INTERMEDIATES

0

DOSSIERS // FDF
USA (Orange Book)

USA (Orange Book)

0

Europe

Europe

Canada

Canada

Australia

Australia

0

South Africa

South Africa

0

Uploaded Dossiers

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

0

Annual Reports

0

EXCIPIENTS
PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

0

USFDA Exclusivities

0

DIGITAL CONTENT

Blog #PharmaFlow

0

News

REF STANDARD

EDQM

0

USP

JP

0

Other Listed Suppliers

0

SERVICES

0

Carbon
Also known as: 05105_fluka, 05110_fluka, 05112_fluka, 05113_fluka, 05120_fluka, 05123_fluka
Molecular Formula
C
Molecular Weight
12.011  g/mol
InChI Key
OKTJSMMVPCPJKN-UHFFFAOYSA-N

Nanometer-sized tubes composed mainly of CARBON. Such nanotubes are used as probes for high-resolution structural and chemical imaging of biomolecules with ATOMIC FORCE MICROSCOPY.
1 2D Structure

Carbon

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
carbon
2.1.2 InChI
InChI=1S/C
2.1.3 InChI Key
OKTJSMMVPCPJKN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
[C]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Buckytube

2. Buckytubes

3. Carbon Nanotube

4. Carbon Nanotubes

5. Nanoribbon

6. Nanoribbons

7. Nanotube, Carbon

8. Nanotubes, Carbon

2.2.2 Depositor-Supplied Synonyms

1. 05105_fluka

2. 05110_fluka

3. 05112_fluka

4. 05113_fluka

5. 05120_fluka

6. 05123_fluka

7. 101239-80-9

8. 106907-70-4

9. 109766-76-9

10. 114680-00-1

11. 115344-49-5

12. 116788-82-0

13. 12424-49-6

14. 124760-06-1

15. 12751-41-6

16. 12768-98-8

17. 12789-22-9

18. 130960-03-1

19. 131640-45-4

20. 133136-50-2

21. 1333-86-4

22. 1343-03-9

23. 137322-21-5

24. 137906-62-8

25. 138464-41-2

26. 1399-57-1

27. 147335-73-7

28. 155660-93-8

29. 156854-02-3

30. 158271-80-8

31. 159251-18-0

32. 161551_sial

33. 16291-96-6

34. 16291-96-6 (parent)

35. 164973-65-3

36. 179607-25-1

37. 18002_riedel

38. 18002_supelco

39. 18006_riedel

40. 18008_riedel

41. 18008_sial

42. 181719-82-4

43. 182761-22-4

44. 186708-92-9

45. 186708-96-3

46. 208519-32-8

47. 208728-20-5

48. 208728-21-6

49. 214540-86-0

50. 22874_fluka

51. 22874_sial

52. 242233_sial

53. 242241_sial

54. 242268_sial

55. 242276_sial

56. 26837-67-2

57. 282863_aldrich

58. 282863_sial

59. 29204_fluka

60. 29204_sial

61. 29238_fluka

62. 292591_sial

63. 2p3vwu3h10

64. 308068-56-6

65. 326874-96-8

66. 329428_sial

67. 332461_aldrich

68. 332461_sial

69. 37196-29-5

70. 37265-44-4

71. 37265-48-8

72. 37771_fluka

73. 37771_sial

74. 37996_fluka

75. 37996_sial

76. 390127_sial

77. 39422-04-3

78. 39434-34-9

79. 39988_fluka

80. 3b4-2186

81. 429685-07-4

82. 484164_aldrich

83. 496537_aldrich

84. 496545_aldrich

85. 496553_aldrich

86. 496561_aldrich

87. 496588_aldrich

88. 496596_aldrich

89. 50814-81-8

90. 51127_fluka

91. 51127_sial

92. 519308_aldrich

93. 52623-24-2

94. 53095-52-6

95. 53663_fluka

96. 53663_sial

97. 53851-02-8

98. 55353-42-9

99. 55607-95-9

100. 56257-79-5

101. 56257-80-8

102. 56274-59-0

103. 566149-76-6

104. 56729-25-0

105. 56729-26-1

106. 572497_aldrich

107. 58517-29-6

108. 58899_fluka

109. 61512-59-2

110. 633100_aldrich

111. 636398_aldrich

112. 63661-31-4

113. 64365-11-3

114. 64365-11-3 (activated)

115. 64427-56-1

116. 64900-31-8

117. 65407-06-9

118. 67167-41-3

119. 675342_sial

120. 681225-93-4

121. 6c

122. 72343_fluka

123. 72343_sial

124. 72536-89-1

125. 72840-52-9

126. 73560-38-0

127. 7440-44-0

128. 75026-75-4

129. 76416-61-0

130. 76632-92-3

131. 7782-40-3

132. 7782-42-5

133. 798556-12-4

134. 798556-14-6

135. 79921-09-8

136. 81180-26-9

137. 82600-58-6

138. 82696-74-0

139. 82696-75-1

140. 82701-02-8

141. 82701-03-9

142. 82701-04-0

143. 82701-05-1

144. 82701-06-2

145. 82709-42-0

146. 83138-28-7

147. 83797-07-3

148. 84739-05-9

149. 857167-12-5

150. 87934-03-0

151. 89341_fluka

152. 89341_sial

153. 89440_aldrich

154. 89440_fluka

155. 90452-98-5

156. 90597-58-3

157. 93067_fluka

158. 93067_sial

159. 95681_fluka

160. 95681_sial

161. 96831_fluka

162. 96831_sial

163. 97708-44-6

164. 97793-37-8

165. 97876_fluka

166. 97876_sial

167. Ac1nuwbm

168. Acetylene Black

169. Acticarbone

170. Actidose

171. Activated Carbon

172. Activated Charcoal

173. Activated Charcoal Norit

174. Activated Charcoal Norit(r)

175. Activated Charcoal, Iodinated

176. Adsorba

177. Adsorbit

178. Aerodag G

179. Ag 1500

180. Ag 3 (adsorbent)

181. Ag 5

182. Ag 5 (adsorbent)

183. Agn-pc-0lquf1

184. Ak (adsorbent)

185. Akos015914131

186. Amoco Px 21

187. Animal Bone Charcoal

188. Anthrasorb

189. Aqua Nuchar

190. Aquadag

191. Ar 3

192. Aroflow

193. Arogen

194. Arotone

195. Arovel

196. Arrow

197. Art 2

198. As 1

199. At 20

200. Atj-s

201. Atj-s Graphite

202. Atlantic

203. Au 3

204. Bau

205. Bg 6080

206. Black 140

207. Black Kosmos 33

208. Black Lead

209. Black Pearls

210. Bone Charcoal

211. C

212. C.i. 77265

213. C.i. 77266

214. C.i. Pigment Black 10

215. C.i. Pigment Black 6

216. C.i. Pigment Black 7

217. C2194

218. C2764_sial

219. C2889_sial

220. C3014_sial

221. C3345_sial

222. C4386_sial

223. C5510_sial

224. C6289_sial

225. C9157_sial

226. Calcotone Black

227. Cancarb

228. Canesorb

229. Canlub

230. Carbo Activatus

231. Carbo Vegetabilis

232. Carbodis

233. Carbolac

234. Carbolac 1

235. Carbomet

236. Carbomix

237. Carbon Activated

238. Carbon Black

239. Carbon Black Bv And V

240. Carbon Black, Acetylene

241. Carbon Black, Channel

242. Carbon Black, Furnace

243. Carbon Black, Lamp

244. Carbon Black, Thermal

245. Carbon Nanotube

246. Carbon Nanotube, Single-walled

247. Carbon Powder

248. Carbon, Activate

249. Carbon, Activated

250. Carbon, Activated [un1362] [spontaneously Combustible]

251. Carbon, Amorphous

252. Carbon, Colloidal

253. Carbon, Vitreous

254. Carbon-12

255. Carbone

256. Carbonium

257. Carbono

258. Carbopol Extra

259. Carbopol M

260. Carbopol Z 4

261. Carbopol Z Extra

262. Carbosieve

263. Carbosorbit R

264. Caswell No. 161

265. Cb 50

266. Ccris 7235

267. Ccris 8681

268. Ccris 9467

269. Cecarbon

270. Ceylon Black Lead

271. Cf 8

272. Cf 8 (carbon)

273. Channel Black

274. Char, From Refuse Burner

275. Charbon

276. Charcoal

277. Charcoal Bone

278. Charcoal Activated

279. Charcoal Activated Norit

280. Charcoal Activated Norit(r)

281. Charcoal Bone

282. Charcoal, Activated

283. Charcoal, Activated [usp]

284. Charcoal, Except Activated

285. Charcodote

286. Chebi:27594

287. Ci 77266

288. Ci Pigment Black 7

289. Ck3

290. Clf Ii

291. Cmb 200

292. Cmb 50

293. Coke Powder

294. Colgon Bpl

295. Colgon Pcb 12x30

296. Colgon Pcb-d

297. Collocarb

298. Columbia Carbon

299. Columbia Lck

300. Conductex

301. Conductex 900

302. Continex

303. Corax A

304. Corax P

305. Cpb 5000

306. Croflex

307. Crolac

308. Cuz 3

309. Cwn 2

310. D&c Black No. 2

311. D002244

312. D006108

313. Darco

314. Dc 2

315. Degussa

316. Delussa Black Fw

317. Diamond

318. Durex O

319. Eagle Germantown

320. Eg 0

321. Einecs 215-609-9

322. Einecs 231-153-3

323. Einecs 231-953-2

324. Einecs 231-955-3

325. Einecs 264-846-4

326. Electrographite

327. Elf 78

328. Elftex

329. Epa Pesticide Chemical Code 016001

330. Essex

331. Excelsior

332. Exp-f

333. Explosion Acetylene Black

334. Explosion Black

335. Farbruss

336. Fecto

337. Filtrasorb

338. Filtrasorb 200

339. Filtrasorb 400

340. Flamruss

341. Formocarbine

342. Fortafil 5y

343. Ft-0621888

344. Ft-0623469

345. Fullerene Soot

346. Furnace Black

347. Furnal

348. Furnex

349. Furnex N 765

350. Gas Black

351. Gas-furnace Black

352. Gastex

353. Gk 2

354. Gk 3

355. Gp 60

356. Gp 60s

357. Gp 63

358. Grafoil

359. Grafoil Gta

360. Graphene

361. Graphite

362. Graphite (all Forms Except Graphite Fibers)

363. Graphite (natural), Dust

364. Graphite (synthetic)

365. Graphite, Natural

366. Graphite, Synthetic

367. Graphitic Acid

368. Graphnol N 3m

369. Grosafe

370. Gs 2

371. Gy 70

372. H 451

373. Hitco Hmg 50

374. Hsdb 2017

375. Hsdb 5037

376. Hsdb 7713

377. Hsdb 953

378. Huber

379. Humenegro

380. Hydrodarco

381. I14-114468

382. I14-45191

383. I14-52609

384. Ig 11

385. Impingement Black

386. Impingement Carbons

387. Irgalite 1104

388. Jado

389. K 257

390. Ketjenblack Ec

391. Kohlenstoff

392. Korobon

393. Kosmink

394. Kosmobil

395. Kosmolak

396. Kosmos

397. Kosmotherm

398. Kosmovar

399. Lamp Black

400. Lampblack

401. Ls-51900

402. Ls-59580

403. Ma 100 (carbon)

404. Magecol

405. Medicinal Carbon

406. Metanex

407. Mg 1

408. Micronex

409. Miike 20

410. Mineral Carbon

411. Modulex

412. Mogul

413. Mogul L

414. Molacco

415. Monarch 1300

416. Monarch 700

417. Mpg 6

418. Neo Spectra Beads Ag

419. Neo-spectra Ii

420. Neo-spectra Mark Ii

421. Neotex

422. Niteron 55

423. Norit

424. Norit A, U.s.p.

425. Nuchar

426. Oil-furnace Black

427. Ou-b

428. P 33 (carbon Black)

429. P1250

430. P68

431. Papyex

432. Peach Black

433. Pelikan C 11/1431a

434. Pelletex

435. Permablak 663

436. Pg 50

437. Philblack

438. Philblack N 550

439. Philblack N 765

440. Philblack O

441. Pigment Black 6

442. Pigment Black 7

443. Plumbago

444. Plumbago (graphite)

445. Printex

446. Printex 60

447. Pyro-carb 406

448. Raven

449. Raven 30

450. Raven 420

451. Raven 500

452. Raven 8000

453. Rebonex

454. Regal

455. Regal 300

456. Regal 330

457. Regal 400r

458. Regal 600

459. Regal 99

460. Regal Srf

461. Regent

462. Rl04457

463. Rocol X 7119

464. Royal Spectra

465. Rtr-024045

466. S 1

467. S 1 (graphite)

468. Schungite

469. Sevacarb

470. Seval

471. Shawinigan Acetylene Black

472. Shell Carbon

473. Shungite

474. Silver Graphite

475. Single Wall Carbon Nanotube

476. Skg

477. Skln 1

478. Skt

479. Skt (adsorbent)

480. Special Black 1v & V

481. Special Schwarz

482. Spheron

483. Spheron 6

484. Statex

485. Statex N 550

486. Sterling Mt

487. Sterling N 765

488. Sterling Ns

489. Sterling So 1

490. Stove Black

491. Su 2000

492. Suchar 681

493. Super-carbovar

494. Super-spectra

495. Superba

496. Supersorbon Iv

497. Supersorbon S 1

498. Swcnt

499. Swedish Black Lead

500. Swine Fly Ash

501. Swnt

502. Therma-atomic Black

503. Thermal Acetylene Black

504. Thermal Black

505. Thermatomic

506. Thermax

507. Thermblack

508. Tinolite

509. Tm 30

510. Toka Black 4500

511. Toka Black 5500

512. Toka Black 8500

513. Tr-024045

514. U 02

515. Ucar 38

516. Ultracarbon

517. Un1362

518. Unii-2p3vwu3h10

519. Unii-4qqn74lh4o

520. Unii-4xyu5u00c4

521. Vitreous Carbon

522. Vvp 66-95

523. W8209

524. Watercarb

525. Whetlerite

526. Witcarb 940

527. Xe 340

528. Xf 4175l

529. Graphite Powder

530. Mfcd00133992

531. Carbon Nanotubes

532. Mfcd00144065

533. Mfcd00146977

534. Mfcd00211867

535. Single-walled Carbon Nanotubes (swnts)

536. Multi-walled Carbon Nanotubes (mwnts), 95+%

537. Graphite Rod, 6.15mm (0.242in) Dia X 152mm (6in) Long

538. Graphite Rod, 6.15mm (0.242in) Dia X 305mm (12in) Long

539. Acetylene Carbon

540. Coconut Charcoal

541. Carbon Rods, 5n

542. 1034343-98-0

543. Activated Carbon, Pellets 3mm

544. Carbon, Activated, -4+8 Mesh

545. Carbon, Activated, 2mm & Down

546. Diamond Synthesized, 95% Nano

547. Carbon Conductive Cement Adhesive

548. Carbon Black, Super P Conductive

549. Carbon Slug, Activated, 6-8 Mesh

550. Carbon, Activated, -20+40 Mesh

551. Carbon Powder, 99.999%, 5n

552. Graphite Flake, Natural, -10 Mesh

553. Graphite Ink For Tantalum Capacitors

554. Diamond Powder (gray), 97+% Nano

555. Diamond Powder (gray), 98+% Nano

556. Graphite Flake, Median 7-10 Micron

557. Mfcd06411993

558. Mfcd07370731

559. Graphite Flake, Natural, -325 Mesh

560. Graphite Foil, 1mm (0.04in) Thick

561. Diamond Powder, Synthetic, <1 Mircron

562. Graphite Rod, 5.0mm (0.20in) Dia

563. Carbon Felt, 1.27cm (0.5in) Thick

564. Carbon Felt, 2.54cm (1.0in) Thick

565. Carbon, Darco™ G-60, Activated

566. Double-walled Carbon Nanotubes (dwnts)

567. Graphite Plate, 2.5cm (1.0in) Thick

568. Carbon Black, Acetylene, 50% Compressed

569. Carbon Felt, 6.35mm (0.25in) Thick

570. Diamond Powder (black), 52-65% Nano

571. Graphite Foil, 0.5mm (0.02in) Thick

572. Graphite Rod, 10.0mm (0.40in) Dia

573. Graphite Plate, 1.27cm (0.5in) Thick

574. Acetylene Carbon Black (100% Compressed)

575. Carbon Felt, 3.18mm (0.125in) Thick

576. Diamond Powder, Synthetic, 40-60 Micron

577. Graphite Foil, 0.4mm (0.015in) Thick

578. Graphite Powders, 99.9% (metals Basis)

579. Graphite Foil, 0.13mm (0.005in) Thick

580. Graphite Foil, 0.254mm (0.01in) Thick

581. Graphite Powder, Nickel Coated, -100 Mesh

582. Graphite Powder, Synthetic, -20+100 Mesh

583. Carbon Nanotubes, Single-walled/double-walled

584. G0500

585. G0501

586. G0502

587. N0968

588. N0969

589. Single-walled Carbon Nanotubes (swnts-cooh)

590. Carbon Nanotubes, Multi-walled, Core Material

591. Graphite Powder, Synthetic, Aps 7-11 Micron

592. Graphite, Colloidal, Lubricant, Aerosol Spray

593. Multi-walled Carbon Nanotubes (mwnts), 95%

594. Glassy Carbon Rod, 3mm (0.1in) Dia, Type 1

595. Glassy Carbon Rod, 3mm (0.1in) Dia, Type 2

596. Glassy Carbon Rod, 5mm (0.2in) Dia, Type 1

597. Glassy Carbon Rod, 5mm (0.2in) Dia, Type 2

598. Multi-walled Carbon Nanotubes (mwnts), 90+%

599. Glassy Carbon Rod, 1mm (0.04in) Dia, Type 1

600. Glassy Carbon Rod, 1mm (0.04in) Dia, Type 2

601. Glassy Carbon Rod, 2mm (0.08in) Dia, Type 1

602. Glassy Carbon Rod, 2mm (0.08in) Dia, Type 2

603. Glassy Carbon Rod, 4mm (0.16in) Dia, Type 1

604. Glassy Carbon Rod, 4mm (0.16in) Dia, Type 2

605. Glassy Carbon Rod, 6mm (0.24in) Dia, Type 1

606. Glassy Carbon Rod, 6mm (0.24in) Dia, Type 2

607. Glassy Carbon Rod, 7mm (0.28in) Dia, Type 1

608. Glassy Carbon Rod, 7mm (0.28in) Dia, Type 2

609. Glassy Carbon Plate, 3mm (0.1in) Thick, Type 1

610. Glassy Carbon Plate, 3mm (0.1in) Thick, Type 2

611. Graphite Powder, Natural, High Purity, -200 Mesh

612. Carbon Nanotubes, Multi-walled, Ground Core Material

613. Glassy Carbon Plate, 1mm (0.04in) Thick, Type 1

614. Glassy Carbon Plate, 1mm (0.04in) Thick, Type 2

615. Glassy Carbon Plate, 2mm (0.08in) Thick, Type 1

616. Glassy Carbon Plate, 2mm (0.08in) Thick, Type 2

617. Glassy Carbon Plate, 4mm (0.16in) Thick, Type 1

618. Glassy Carbon Plate, 4mm (0.16in) Thick, Type 2

619. Glassy Carbon Splinter Powder, 20-50 Micron, Type 1

620. Graphite Powder, Natural, Universal Grade, -200 Mesh

621. Nanodiamond (particle Size : <10nm) (amine-modified)

622. Carbon Yarn, Woven From 0.076mm (0.003in) Dia Fibers

623. Glassy Carbon Spherical Powder, 0.4-12 Micron, Type 1

624. Glassy Carbon Spherical Powder, 0.4-12 Micron, Type 2

625. Glassy Carbon Spherical Powder, 10-20 Micron, Type 1

626. Glassy Carbon Spherical Powder, 10-20 Micron, Type 2

627. Glassy Carbon Splinter Powder, 0.4-12 Micron, Type 1

628. Glassy Carbon Splinter Powder, 0.4-12 Micron, Type 2

629. Glassy Carbon Splinter Powder, 80-200 Micron, Type 1

630. Glassy Carbon Splinter Powder, 80-200 Micron, Type 2

631. Graphite Powder, Natural, Briquetting Grade, -100 Mesh

632. Graphite Powder, Natural, Briquetting Grade, -200 Mesh

633. Graphite Powder, Synthetic, Conducting Grade, -200 Mesh

634. Graphite Powder, Synthetic, Conducting Grade, -325 Mesh

635. Graphite Rod, 3.8cm (1.5in) Dia X 61cm (24in) Long

636. Carbon Nanotubes, Multi-walled, As Produced Cathode Deposit

637. Fullerene, Buckytube/nanotube, Single Walled, > 60% Swnt

638. Fullerene, Buckytube/nanotube, Single Walled, 20-35% Swnt

639. Funct. Multi-walled Carbon Nanotubes (mwnts-cooh), 95+%

640. Glassy Carbon Spherical Powder, 200-400 Micron, Type 1

641. Glassy Carbon Spherical Powder, 200-400 Micron, Type 2

642. Glassy Carbon Spherical Powder, 400-630 Micron, Type 2

643. Glassy Carbon Spherical Powder, 630-1000 Micron, Type 1

644. Glassy Carbon Spherical Powder, 630-1000 Micron, Type 2

645. Graphite Plate, Resin Impregnated, 6.35mm (0.25in) Thick

646. Graphite Rod, 1.27cm (0.5in) Dia X 61cm (24in) Long

647. Graphite Rod, 2.54cm (1.0in) Dia X 61cm (24in) Long

648. Graphite Rod, 6.3mm (0.25in) Dia. X 61cm (24in) Long

649. Nanodiamond (particle Size : <10nm) (carboxyl-modified)

650. Carbon, Activated, Norit Row 0.8mm Pellets, Steam Activated

651. Graphite Powder, Natural, Microcrystal Grade, Aps 2-15 Micron

652. Graphite Rod, 3.05mm (0.12in) Dia X 305mm (12in) Long

653. Graphite Rod, 6.15mm (0.242in) Dia X 102mm (4in) Long

654. Multi-walled Carbon Nanotubes (mwnts), 95%, Od 40-60 Nm

655. Multi-walled Carbon Nanotubes (mwnts), 95+%, Od 50-80 Nm

656. Carbon Nanotube Multi-walled 10-20nm(diam.), 5-15microm(length)

657. Carbon Nanotube Multi-walled 10-30nm(diam.), 5-15microm(length)

658. Carbon Nanotube Multi-walled 20-40nm(diam.), 1-2microm(length)

659. Carbon Nanotube Multi-walled 20-40nm(diam.), 5-15microm(length)

660. Carbon Nanotube Multi-walled 40-60nm(diam.), 1-2microm(length)

661. Carbon Nanotube Multi-walled 40-60nm(diam.), 5-15microm(length)

662. Carbon Nanotube Multi-walled 60-100nm(diam.), >5microm(length)

663. Carbon Powder, Activated, Norit Gsx, Steam Activated, Acid Washed

664. Fullerene, Nanotube, Multi-walled, 20 Nm Od, 5-20 Micron Long

665. Graphite, Fusion Crucible, Drillpoint, Unpurified, Volume 7.5cc

666. Graphite, Fusion Crucible, Drillpoint, Unpurified, Volume 7.88cc

667. Carbon Nanotube Aligned Multi-walled 10-20nm(diam.), 5-15microm(length)

668. Carbon Sputtering Target, 50.8mm (2.0in) Dia X 3.18mm (0.125in) Thick

669. Carbon Sputtering Target, 76.2mm (3.0in) Dia X 3.18mm (0.125in) Thick

670. Graphite Electrode, Counter-pointed Tip, 3.06mm Dia, 38.10 Mm Long

671. Graphite Electrode, Counter-spherical Tip, 6.15mm Dia, 38.10 Mm Long

672. Graphite Plate, Pyrolytic, 1.27x9.98x9.98mm (0.05x0.393x.393in)

673. Graphite Powder, Microcrystalline, -300 Mesh, 75-82% C, 18-25% Ash

674. Graphite Rod, Pyrolytic Coated, 2mm (0.08in) Dia X 152mm (6in) Long

675. Metals Scavenging Agent, Phosphotungstic Acid Modified Activated Carbon

676. Multi-walled Carbon Nanotubes (mwnts), 95%, Outside Diameter 10-20 Nm

677. Multi-walled Carbon Nanotubes (mwnts), 95%, Outside Diameter 20-30 Nm

678. Carbon Nanotube Array, Multi-walled, On Quartz (diameter= 100nm, Length=30 Microns)

679. Carbon Nanotubes, Multi-walled (diameter= 140nm, Length= 7microns)(>90%nanotubes)

680. Fullerene, Nanotube, Multi-walled, As-produced Cathode Deposits, Core And Shell

681. Total Organic Carbon (toc), Standard Solution, Specpure(r), 1000 Microgram/ml

682. Carbon Nanotube Single-walled (>85%) Below 3nm(average Diam.), Over 5microm(average Length)

683. Carbon Nanotubes, Multi-walled, Arc-produced (diameter = 2-50nm, Length = >2 Microns) (55-65wt% Nanotubes)

684. Graphite Electrode, Crater-drillpoint/undercut, 4.57mm Dia, 38.10mm Length, Volume 0.040cc

685. Graphite Fusion Crucible Lid For Stock Number 40794, 2.54cm (1.0in) Dia, 6.35mm (0.25in) Thick

686. Graphite Plate, Highly Oriented Pyrolytic Graphite (hopg), 10x10x(1.6min)mm (0.394x0.394x0.079in), 0.4 +0.1 O Mosaic Angle

687. Graphite Plate, Highly Oriented Pyrolytic Graphite (hopg), 10x10x(1.6min)mm (0.394x0.394x0.079in), 0.8 +0.2 O Mosaic Angle

688. Graphite Plate, Highly Oriented Pyrolytic Graphite (hopg), 10x10x1mm (0.394x0.394x0.039in), 0.4 +0.1 O Mosaic Angle

689. Graphite Plate, Highly Oriented Pyrolytic Graphite (hopg), 10x10x1mm (0.394x0.394x0.039in), 0.8 +0.2 O Mosaic Angle

690. Oh Functionalized Single-walled Carbon Nanotubes (swnts-oh), Purity (excluding -oh): 90% Cnts, 60% Swnts, Content Of -oh: 3.76-4.16 Wt%

691. Oh Functionalized Single-walled Carbon Nanotubes (swnts-oh), Purity (excluding -oh): 95% Cnts, 90% Swnts, Content Of -oh: 3.76-4.16 Wt%

2.3 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 12.011 g/mol
Molecular Formula C
XLogP30.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count0
Exact Mass12 g/mol
Monoisotopic Mass12 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count1
Formal Charge0
Complexity0
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

Antidotes

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


Activated charcoal has been used in the management of erythropoietic porphyria (to interrupt the enterohepatic recycling of protoporphyrin and lower plasma porphyrin concentrations) and for symptomatic relief of pruritis in patients with renal failure.

American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 2966


Activated charcoal also has been used topically in wound or ulcer dressings to decrease odor and promote healing.102

American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 2966


Activated charcoal has been used to adsorb intestinal gases in the treatment of flatulence, intestinal distension, and dyspepsia; however, the US Food and Drug Administration (FDA) has classified activated charcoal as lacking substantial evidence of efficacy as an antiflatulent or digestive aid. Activated charcoal has been used alone or in combination with kaolin in the management of diarrhea but its value has not been established.

American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 2966


For more Therapeutic Uses (Complete) data for ACTIVATED CHARCOAL (28 total), please visit the HSDB record page.


/EXPL THER/ Single-walled carbon nanotubes (SWCNTs) were covalently linked to epidermal growth factor (EGF) proteins through an esterification process that was found to be responsible for the docking of SWCNTs on the human pancreatic cancer cells (PANC-1) surface, thus providing a mechanism for the enhanced delivery and internalization of the nanotubes. Micro Raman spectroscopy and enzyme-linked immunosorbent assay were used to evaluate the delivery process and kinetics of the SWCNTs. In vitro studies indicated that the delivery kinetics of SWCNT-EGF conjugates, at a concentration of 85 ug/mL, to the PANC-1 cell surfaces was significant in the first 30 min of incubation, but reached a plateau with time in accordance with the establishment of equilibrium between the association and the dissociation of EGF with the cell receptors. SWCNT-EGF conjugates could act as strong thermal ablation agents and could induce higher percentages of cellular death compared with the nontargeted SWCNTs alone. /Molecular carrier system/

PMID:22147491 Karmakar A et al; J Appl Toxicol 32 (5): 365-75 (2012)


/EXPL THER/ Single-walled carbon nanotubes are currently under evaluation in biomedical applications, including in vivo delivery of drugs, proteins, peptides and nucleic acids (for gene transfer or gene silencing), in vivo tumor imaging and tumor targeting of single-walled carbon nanotubes as an anti-neoplastic treatment. /Single-walled carbon nanotubes/

Schipper ML et al; Nature Nanotechnology 3, 216 - 221 (2008)


/EXPL THER/ The development of nanomaterials for biomedical and biotechnological applications is an area of research that holds great promise and intense interest, and ... carbon nanotubes (CNTs) are attracting an increasing level of attention. One of the key advantages that CNTs offer is the possibility of effectively crossing biological barriers, which would allow their use in the delivery of therapeutically active molecules. ... Laboratories have been investigating the use of CNTs ... as nanovectors for therapeutic agent delivery. The interaction between cells and CNTs is a critical issue that will determine any future biological application of such structures. ... Various types of functionalized carbon nanotubes (f-CNTs) exhibit a capacity to be taken up by a wide range of cells and can intracellularly traffic through different cellular barriers. /Molecular carrier system/

Kostarelos K et al; Nature Nanotechnology 2, 108 - 113 (2006)


/EXPL THER/ An array of chemiresistive random network of single-walled carbon nanotubes coated with nonpolymeric organic materials shows a high potential for diagnosis of lung cancer via breath samples. The sensors array shows excellent discrimination between the volatile organic compounds (VOCs) found in the breath of patients with lung cancer, relative to healthy controls, especially if the sensors array is preceded with either water extractor and/or preconcentrator of VOCs. The pattern compositions of the healthy and cancerous states were determined by gas-chromatography linked with mass-spectroscopy (GC-MS) analysis of real exhaled breath. /Single-walled carbon nanotubes/

PMID:18839997 Peng G et al; Nano Lett 8 (11): 3631-5 (2008)


For more Therapeutic Uses (Complete) data for CARBON NANOTUBES (7 total), please visit the HSDB record page.


4.2 Drug Warning

Charcoal bezoars are a rare complication of activated charcoal administration. They have been associated with treatments for intoxication with carbamazepine, amitriptyline, theophylline, benzodiazepines and barbiturates. The parasympatholytic effects of the drugs can precipitate or contribute to paralytic ileus, allowing charcoal to accumulate (potentially with remnants of undigested tablets) and form bezoars. Additional factors that influence bowel obstruction secondary to charcoal administration include the dose and timing of activated charcoal therapy, patient age and comorbidities, and previous intra-abdominal surgery. Gastrointestinal complications should be considered whenever activated charcoal is administered. Prompt recognition and treatment at the first sign of ileus or obstruction may prevent bowel necrosis and subsequent perforation/peritonitis. Charcoal-stained vomiting, abdominal distension and ongoing pain should raise the suspicion of mechanical obstruction. ... Gastrografin follow-through /was advocated/ as both a diagnostic and potentially therapeutic tool in incomplete obstruction. However, complete obstruction may signal the need for early laparotomy.

PMID:16296970 Chan JCY; Med J Australia 183 (10): 537 (2005)


/VET/ ... Six healthy adult dogs were administered 4 g/kg activated charcoal (AC) in a commercially available suspension that contained propylene glycol and glycerol as vehicles. Blood samples were taken before and 1, 4, 6, 8, 12, and 24 hours after the administration of the test suspension /and/ ... analyzed for osmolality, blood gases, and concentrations of lactate, sodium, potassium, serum urea nitrogen, and glucose. ... Three of the 6 dogs vomited between 1 and 3 hours after the administration of the test suspension, and 4 of 6 dogs were lethargic. All dogs drank frequently after AC administration. Commercial AC suspension administered at a clinically relevant dose /significantly increased/ serum osmolality, osmolal gap, and lactate concentration in dogs. These laboratory measures, ...clinical signs ... and increased frequency of drinking might complicate the diagnosis or monitoring of some intoxications (such as ethylene glycol) in dogs that have previously received AC suspension containing propylene glycol, glycerol, or both as vehicles.

PMID:16231712 Burkitt JM et al; J Vet Intern Med 19 (5): 683-6 (2005)


Although activated charcoal is widely used for the treatment of self-poisoning, its effectiveness is unknown. An important consideration is patient compliance since poor compliance will limit effectiveness. ... 1,103 patients randomized to single or multiple (six doses q4h) 50 g doses of superactivated charcoal were prospectively observed. Charcoal was given by study doctors who recorded the amount ingested and the amount of persuasion required for the patients to drink the charcoal. ... 559 patients were randomized to receive one dose and 544 to receive six doses. Data was available for 1,071 (97%) patients. Eighty-eight were unable to complete their course; 98 required a NG tube, leaving 885 patients that received the first dose by mouth. The mean estimated amount of the prescribed dose of charcoal taken orally as a single or first dose was 83% (95% C.I. 82-84%). For patients receiving multiple doses, this amount fell over the next five doses to 66% (63-69%). While only 3.2% of patients refused the first dose, 12.3% refused the sixth. Relatively less persuasion was required for patients ingesting the first or single dose; 38% of patients required intense persuasion by the sixth dose.

PMID:17364629 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950600 Mohamed F et al; Clin Toxicol (Phila) 45 (2): 132-5 (2007)


... The incidence of aspiration pneumonia in intubated overdose patients who then received activated charcoal (AC) /was estimated by /... a retrospective review from January 1994 to April 1997 of intubated patients who then received AC. Patients were transferred to, or primarily treated at, an 843-bed tertiary medical center with an annual emergency department volume of 100,000 patients. Objective evidence of infiltrate on chest radiograph during initial 48 hr of hospitalization was used to determine the incidence of aspiration pneumonia. Patients with known preexisting pneumonia or with administration of AC before intubation were excluded. There were 64 patients identified. Fourteen were excluded for clinical aspiration before intubation, receiving activated charcoal before intubation, or abnormal immediate post-intubation chest radiographs. The remaining 50 patients, ages 1-64 years, 33% male, overdosing on a large variety of substances, required acute intubation and then received AC. Only two patients of these 50 (4%) with initial negative radiographs developed a new infiltrate after intubation and AC. Administration of AC to intubated overdose patients is associated with a low incidence of aspiration pneumonia.

PMID:10195487 Moll J et al; J Emerg Med 17 (2): 279-83 (1999)


For more Drug Warnings (Complete) data for ACTIVATED CHARCOAL (16 total), please visit the HSDB record page.


5 Pharmacology and Biochemistry
5.1 Absorption, Distribution and Excretion

Uptake and retention of carbon black particles in lung macrophages have been observed following inhalation ... as well as following injection into the cerebral ventricles of rats ... or into the bladder wall of rats. ... Carbon black particles perfused into the abdominal aorta of rabbits were observed in the endothelial cells of the vessel.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V33 70 (1984)


Particles were found in phagocytic cells in the proximal convoluted tubules and glomeruli of the kidneys in mice, together with amyloidosis and renal fibrosis. It was later reported that carbon black particles also accumulated in the lungs of exposed monkeys (total duration of exposure, 5784 hr) ...

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V33 69 (1984)


Mice (for their lifespan), guinea pigs, and monkeys (up to 13,000 total hr) were exposed to 1.6 mg/cu m of various types of furnace blacks for 7 hr/day, 5 days/wk. ... Carbon black was found scattered in lung tissue, both free-lying and inside macrophages (scavenger cells). In mice, the black was diffuse and finely distributed, while monkeys progressively developed diffusely distributed areas of nodularity where the black was concentrated. ... Carbon black was observed to infiltrate the pulmonary lymph nodes, and was also present in the liver, spleen, and kidneys of exposed animals.

USEPA; Chemical Hazard Information Profile: Carbon Black p.67 (1978) EPA-560/11-80-011


The effect of continuous exposure to inert carbonaceous particles on the pulmonary clearance of inhaled diesel tracer particles was studied in male Fischer 344 rats. Submicron carbon black particles with a mass median aerodynamic diameter of 0.22 um and having a size distribution similar to those particles from a GM 5.7 liter diesel engine were successfully generated and admin to test animals at a nominal concn of 6 mg/cu m for 20 hr/day, 7 day/wk, for periods lasting 1 to 11 wk. Immediately after the carbon black exposure, test animals were admin (14)C tagged diesel particles for 45 min in a nose only chamber. The pulmonary retention of inhaled radioactive tracer particles was determined at preselected time intervals. Based upon the data collected up to six months post exposure, prolonged exposure to carbon black particles exhibits the same inhibitory effect on pulmonary clearance as prolonged exposure to diesel exhaust with a comparable particulate dose. This observation, coupled with the observation that continuous exposure to nitrogen oxide at 2 ppm produced no significant incr on the pulmonary retention of radioactive diesel test particles, indicates that the accumulation of inert carbonaceous material is the predominant cause of impaired lung clearance.

Lee PS et al; Fed Proc 43 (3): (1984)


For more Absorption, Distribution and Excretion (Complete) data for CARBON BLACK (10 total), please visit the HSDB record page.


Activated charcoal is neither absorbed in the GI tract nor metabolized, and it is excreted in feces.

American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 2968


EXPTL INTRAVENOUS INJECTION OF PURE CARBON SUSPENSIONS IN RABBITS PRODUCES NO OCULAR INFLAMMATION, ALTHOUGH CARBON PARTICLES ARE DEPOSITED WITHIN THE BLOOD VESSELS.

Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 178


Individualized, chemically pristine single-walled carbon nanotubes have been intravenously administered to rabbits and monitored through their characteristic near-infrared fluorescence. Spectra indicated that blood proteins displaced the nanotube coating of synthetic surfactant molecules within seconds. The nanotube concentration in the blood serum decreased exponentially with a half-life of 1.0 +/- 0.1 hr. No adverse effects from low-level nanotube exposure could be detected from behavior or pathological examination. At 24 hr after iv administration, significant concentrations of nanotubes were found only in the liver. These results demonstrate that debundled single-walled carbon nanotubes are high-contrast near-infrared fluorophores that can be sensitively and selectively tracked in mammalian tissues using optical methods. In addition, the absence of acute toxicity and promising circulation persistence suggest the potential of carbon nanotubes in future pharmaceutical applications. /Single-walled carbon nanotubes/

PMID:17135351 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665645 Cherukuri P et al; Proc Natl Acad Sci U S A 103 (50): 18882-6 (2006)


Single-walled carbon nanotubes (SWNTs) exhibit unique size, shape and physical properties that make them promising candidates for biological applications. Here, ... the biodistribution of radio-labelled SWNTs in mice /is investigated/ by in vivo positron emission tomography (PET), ex vivo biodistribution and Raman spectroscopy. It is found that SWNTs that are functionalized with phospholipids bearing polyethylene-glycol (PEG) are surprisingly stable in vivo. The effect of PEG chain length on the biodistribution and circulation of the SWNTs is studied. Effectively PEGylated SWNTs exhibit relatively long blood circulation times and low uptake by the reticuloendothelial system (RES). Efficient targeting of integrin positive tumor in mice is achieved with SWNTs coated with PEG chains linked to an arginine-glycine-aspartic acid (RGD) peptide. A high tumor accumulation is attributed to the multivalent effect of the SWNTs... /Functionalized single-walled carbon nanotubes/

Liu Z et al; Nature Nanotechnology 2, 47 - 52 (2006)


Carbon nanotubes are promising new materials for molecular delivery in biological systems. The long-term fate of nanotubes intravenously injected into animals in vivo is currently unknown, an issue critical to potential clinical applications of these materials. Here, using the intrinsic Raman spectroscopic signatures of single-walled carbon nanotubes (SWNTs), ... the blood circulation of intravenously injected SWNTs and detect SWNTs /was measured/ in various organs and tissues of mice ex vivo over a period of three months. Functionalization of SWNTs by branched polyethylene-glycol (PEG) chains was developed, enabling thus far the longest SWNT blood circulation up to 1 day, relatively low uptake in the reticuloendothelial system (RES), and near-complete clearance from the main organs in approximately 2 months. Raman spectroscopy detected SWNT in the intestine, feces, kidney, and bladder of mice, suggesting excretion and clearance of SWNTs from mice via the biliary and renal pathways. No toxic side effect of SWNTs to mice was observed in necropsy, histology, and blood chemistry measurements. ... /Functionalized single-walled carbon nanotubes/

PMID:18230737 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234157 Liu Z et al; Proc Natl Acad Sci U S A.105 (5): 1410-5 (2008)


Single walled carbon nanotubes (SWCNT) have a small size and unique physicalchemical properties which suggest that novel particles may translocate to systemic organs after deposition in the lungs. In this study, gold particles (10 nm) were used to label a highly dispersed preparation of SWCNT with a mean geometric diameter of 1.1 microns. The gold labeled SWCNT were delivered to the lungs by pharyngeal aspiration to C57BL/6 mice. Neutron activation analysis (NAA) of lung, blood and other organs was carried out at various times after aspiration to determine if the gold labeled SWCNT translocated out of the lungs. Six mice per group were studied at 1 hour, 1 day and 3 days after exposure to a single dose of 50 ug of gold labeled SWCNT. A separate group was given gold particles without SWCNT. A phosphate buffered saline (PBS) aspiration group served as the negative control. At sacrifice the lungs, heart, brain, liver, kidneys and a blood sample were taken for analysis of gold content by NAA. Gold content of the PBS aspiration group was negligible. In the gold labeled SWCNT group lung gold content at 1 day was 65 percent of that at 1 hour and not significantly different from the content at 3 days. The heart, brain, liver, kidney and blood samples from the gold labeled SWCNT groups contained less than 1 part in 200 of the total dose and were not statistically different from the PBS aspiration group at 1 hour, 1 day and 3 days. The results indicate that SWCNT do not readily translocate from the lungs. /Single-walled carbon nanotubes/

Mercer RR et al; Toxicologist 102 (1): 286, abstract 1399 (2008)


For more Absorption, Distribution and Excretion (Complete) data for CARBON NANOTUBES (6 total), please visit the HSDB record page.


Small quantities of carbon suspensions in the form of graphite or India ink injected into the anterior chamber of /the eyes of/ rabbits is mostly taken up by the leukocytes and by the corneal endothelium, producing essentially no signs of inflammation.

Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 178


5.2 Metabolism/Metabolites

Activated charcoal is neither absorbed in the GI tract nor metabolized, and it is excreted in feces.

American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 2968


5.3 Biological Half-Life

Individualized, chemically pristine single-walled carbon nanotubes have been intravenously administered to rabbits and monitored through their characteristic near-infrared fluorescence. ... The nanotube concentration in the blood serum decreased exponentially with a half-life of 1.0 +/- 0.1 hr. /Single-walled carbon nanotubes/

PMID:17135351 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665645 Cherukuri P et al; Proc Natl Acad Sci U S A 103 (50): 18882-6 (2006)


5.4 Mechanism of Action

Macrophages were treated with carbon black and carbon black adsorbate complexes to determine whether the presence, identity and coverage of the adsorbate altered the phagocytic ingestion of the carbon black particles. This study was performed to determine the effect of such treatment on the capacity of the macrophages to phagocytize a secondary particle challenge via its Fc membrane receptor. Rat alveolar macrophages were incubated in vitro with two carbon blacks that had 15 fold differences in specific surface areas (ASTM-N339 less than Black-Pearls-2000) sorbed with 0.5 and 1.0 monolayer coverages of a polar and semi polar adsorbate; acrolein and benzofuran. One half monolayer coverages of N339 with either adsorbate significantly suppressed the phagocytosis of the carbon black, whereas one monolayer coverage did not. Neither adsorbate at either coverages affected the phagocytosis of Black-Pearls-2000. It was concluded that these results indicate that the surface properties of the particles, the chemical properties of chemical pollutants, and the interactions between particles and pollutants can play a major role in defining the biological effects of particles that are carried to the distal lung.

PMID:2088744 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567780 Jakab GJ et al; Environmental Health Perspectives 89: 169-74 (1990)


The desorption of adsorbed molecules from amorphous carbon black was investigated. Five oil furnace carbon blacks consisting of pelletized agglomerates of 0.20 to 0.24 nanometer aciniform particles and 13 adsorbates were used. The adsorbates consisted of organic compounds containing functional groups characteristic of organic molecules formed on particles generated by combustion of organic material. The carbon blacks were incorporated into liquid chromatographic columns. n-Hexane, dichloromethane, tetrahydrofuran, methanol, and water were used as mobile phases. Ten microliter sample aliquots were injected into the chromatographs. The data showed that the adsorbates displaced the mobile phase molecules from the surface. The extent of desorption increased with increasing solubility of the adsorbate in the mobile phase. Desorption also depended on the heat of desorption. With the exception of basic adsorbates adsorbed on the least polar carbon black, N765, most of the compounds were adsorbed irreversibly when the mobile phase was water. The adsorption isotherms showed that desorption depended on the extent of surface coverage and increased as the extent of coverage approached one monolayer. It was concluded that adsorbed molecules are desorbed from particulate surfaces to different extents, the amount desorbed depending on the polarity of the physiological fluid that interacts with the surface. Desorption also depends on the extent of adsorbent surface covered.

Risby TH et al; Environ Health Perspectives 77: 141-9 (1988)


Exposure to ambient ultrafine particles induces airway inflammatory reactions and tissue remodeling. In this experiment, to determine whether ultrafine carbon black (ufCB) affects proliferation of airway epithelium and, if so, what the mechanism of action is, ... human primary bronchial epithelial cell cultures /were studied/. Incubation of cells in the serum-free medium with ufCB increased incorporations of [(3)H]thymidine and [(3)H]leucine into cells in a time- and dose-dependent manner. This effect was attenuated by Cu- and Zn-containing superoxide dismutase (Cu/Zn SOD) and apocynin, an inhibitor of NADPH oxidase, and completely inhibited by pretreatment with the epidermal growth factor receptor (EGF-R) tyrosine kinase inhibitors AG-1478 and BIBX-1382, and the mitogen-activated protein kinase kinase inhibitor PD-98059. Transfection of a dominant-negative mutant of H-Ras likewise abolished the effect ufCB. Stimulation with ufCB also induced processing of membrane-anchored proheparin-binding (HB)-EGF, release of soluble HB-EGF into the medium, association of phosphorylated EGF-R and Shc with glutathione-S-transferase-Grb2 fusion protein, and phosphorylation of extracellular signal-regulated kinase (ERK). Pretreatment with AG-1478, [Glu(52)]Diphtheria toxin, a specific inhibitor of HB-EGF, neutralizing HB-EGF antibody, Cu/Zn SOD, and apocynin each inhibited ufCB-induced ERK activation. These results suggest that ufCB causes oxidative stress-mediated proliferation of airway epithelium, involving processing of HB-EGF and the concomitant activation of EGF-R and ERK cascade.

PMID:15298855 Tamaoki J et al; Am J Physiol 287 (6): 1127-33 (2004)


... Ultrafine carbon black (ufCB) does not have its effects via transition metal-mediated mechanisms. However, ufCB and other ultrafines generate free radicals at their surface as measured by a number of chemical assays and are able to cause oxidative stress to cells and this is likely to be a factor in their ability to cause inflammation. Changes in calcium resulting from oxidative stress within cells may be an additional factor leading to transcription of pro-inflammatory genes...

PMID:12762574 MacNee W, Donaldson K; Eur Resp J Suppl 40: 47-51 (2003)


Activated charcoal avidly adsorbs drugs and chemicals on the surfaces of the charcoal particles, thereby preventing absorption and toxicity. ... The effectiveness of charcoal is dependent on the time since the ingestion and on the dose of charcoal; one should attempt to achieve a charcoal:drug ratio of at least 10:1.

Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill, 2006., p. 1748


Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty
Post Enquiry
POST ENQUIRY