Bromhexine Hydrochloride

Synopsis, Chemistry

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Also known as: 611-75-6, Bromhexine hcl, Bisolvon, Auxit, Bromohexine hydrochloride, Bromhexine (hydrochloride)

Molecular Formula

C₁₄H₂₁Br₂ClN₂

Molecular Weight

412.59 g/mol

InChI Key

UCDKONUHZNTQPY-UHFFFAOYSA-N

FDA UNII

YC2ZOM3Z8V

A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)

1 2D Structure

Bromhexine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride

2.1.2 InChI

InChI=1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H

2.1.3 InChI Key

UCDKONUHZNTQPY-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN(CC1=C(C(=CC(=C1)Br)Br)N)C2CCCCC2.Cl

2.2 Other Identifiers

2.2.1 UNII

YC2ZOM3Z8V

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Aparsonin

2. Bc, Bromhexin

3. Bisolvon

4. Bromhexin

5. Bromhexin Bc

6. Bromhexin Berlin Chemie

7. Bromhexin Berlin-chemie

8. Bromhexin Berlinchemie

9. Bromhexin Ratiopharm

10. Bromhexin Von Ct

11. Bromhexin-ratiopharm

12. Bromhexine

13. Bromhexine Monohydrochloride

14. Bromhexine, Famel

15. Bromhexinratiopharm

16. Brotussol

17. Ct, Bromhexin Von

18. Darolan

19. Dur Elix

20. Dur-elix

21. Durelix

22. Famel Bromhexine

23. Flegamin

24. Flubron

25. Hustentabs Ratiopharm

26. Hustentabs-ratiopharm

27. Hustentabsratiopharm

28. Hydrochloride, Bromhexine

29. Monohydrochloride, Bromhexine

30. Mucohexine

31. Na 274

32. Na-274

33. Na274

34. Quentan

35. Tesacof

36. Von Ct, Bromhexin

2.3.2 Depositor-Supplied Synonyms

1. 611-75-6

2. Bromhexine Hcl

3. Bisolvon

4. Auxit

5. Bromohexine Hydrochloride

6. Bromhexine (hydrochloride)

7. Broncokin

8. Viscolyt

9. 2,4-dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline Hydrochloride

10. Bromhexine Chloride

11. Bromohexine Monohydrochloride

12. Na 274

13. Bromehexine Hydrochloride

14. Mfcd00056626

15. Yc2zom3z8v

16. Nsc-758383

17. Chebi:31303

18. N-cyclohexyl-n-methyl-(2-amino-3,5-dibromobenzyl)ammonium Chloride

19. Na-274

20. 611-75-6 (hcl)

21. Ncgc00095005-01

22. 2-amino-3,5-dibromo-n-cyclohexyl-n-methylbenzylamine Hydrochloride

23. 2-amino-n-cyclohexyl-3,5-dibromo-n-methylbenzylamine Hydrochloride

24. N-(2-amino-3,5-dibromobenzyl)-n-methyl-cyclohexylammonium Chloride

25. 2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline Hydrochloride

26. Benzenemethanamine, 2-amino-3,5-dibromo-n-cyclohexyl-n-methyl-, Monohydrochloride

27. Dsstox_cid_25886

28. Dsstox_rid_81200

29. Dsstox_gsid_45886

30. Bromessina

31. Lisomucin

32. Quentan

33. 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride

34. Cas-611-75-6

35. Bromessina [italian]

36. Bromihexine Hydrochloride

37. Unii-yc2zom3z8v

38. Ophtolsol

39. Sr-05000001825

40. Bisolvon (tn)

41. Einecs 210-280-8

42. Bromhexine Hydrochloride [usan:jan]

43. Brombenzonium

44. Schembl99613

45. Bromohexine Hydrochloride,(s)

46. Spectrum1503107

47. Chembl1319139

48. Dtxsid0045886

49. Bromhexine For System Suitability

50. Hy-b0372a

51. Hms1922e19

52. Pharmakon1600-01503107

53. Tox21_111385

54. Bromhexine Hydrochloride [mi]

55. Ccg-39304

56. N-(2-amino-3,5-dibromobenzyl)-n-methylcyclohexylamine Hydrochloride

57. Nsc758383

58. S2060

59. Bromhexine Hydrochloride [jan]

60. Akos015906433

61. Benzylamine, 2-amino-n-cyclohexyl-3,5-dibromo-n-methyl-, Hydrochloride

62. Tox21_111385_1

63. Ac-6857

64. Bromhexine Hydrochloride (jp17/usan)

65. Bromhexine Hydrochloride [usan]

66. Ks-5253

67. Nsc 758383

68. Bromhexine Hydrochloride [mart.]

69. Bromhexine Hydrochloride [who-dd]

70. Ncgc00095005-02

71. Ncgc00178520-03

72. 3,5-dibromo-n(sup Alpha)-cyclohexyl-n(sup Alpha)-methyltoluene-alpha,2-diamine Monohydrochloride

73. Sy046825

74. Bromhexine Hydrochloride, >=98.0% (at)

75. B4054

76. Bromhexine Hydrochloride, Analytical Standard

77. Ft-0603492

78. Sw199599-2

79. Bromhexine Hydrochloride [ep Monograph]

80. D01778

81. D70838

82. 611b756

83. A833075

84. Q-200754

85. Sr-05000001825-2

86. Q27114269

87. Bromhexine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

88. 2,4-dibromo-6-((cyclohexyl(methyl)amino)methyl)anilinehydrochloride

89. N-(2-amino-3,5-dibromobenzyl)-n-methylcyclohexanaminium Chloride

90. Bromhexine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

91. 3,5-dibromo-n(alpha)-cyclohexyl-n(alpha)-methyltoluene-alpha,2-diamine Monohydrochloride

92. Bromhexine For System Suitability, European Pharmacopoeia (ep) Reference Standard

93. Bromhexine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

94. 2-amino-3,5-dibromo-n-cyclohexyl-n-methylbenzylamine Hydrochloride, N-(2-amino-3,5-dibromobenzyl)-n-methylcyclohexylamine Hydrochloride

95. 3,5-dibromo-n(sup .alpha.)-cyclohexyl-n(sup .alpha.)-methyltoluene-.alpha.,2-diamine Monohydrochloride

96. Toluene-alpha,2-diamine, 3,5-dibromo-n(sup Alpha)-cyclohexyl-n-(sup Alpha)-methyl-, Monohydrochloride

2.4 Create Date

2006-03-07

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₂₁Br₂ClN₂
Molecular Weight	412.59 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	411.97395 g/mol
Monoisotopic Mass	409.97600 g/mol
Topological Polar Surface Area	29.3 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	256
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Expectorants

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (See all compounds classified as Expectorants.)