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    Also known as: 138890-62-7, Azopt, Al-4862, Al 4862, (4r)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide, (4r)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2h-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
    Molecular Formula
    C12H21N3O5S3
    Molecular Weight
    383.5  g/mol
    InChI Key
    HCRKCZRJWPKOAR-JTQLQIEISA-N
    FDA UNII
    9451Z89515
    Brinzolamide
    Brinzolamide is a sulfonamide and carbonic anhydrase inhibitor with specific affinity for carbonic anhydrase II. Following topical ocular administration, brinzolamide inhibits carbonic anhydrase II, an enzyme that is responsible for the movement of sodium and fluid transport in the eye. This inhibition leads to a decrease in aqueous humor secretion, probably by slowing the formation of bicarbonate ions, and results in a reduction in intraocular pressure. Brinzolamide is used to treat increased pressure in the eye caused by open-angle glaucoma.
    Brinzolamide is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.
    1 2D Structure

    Brinzolamide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
    2.1.2 InChI
    InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
    2.1.3 InChI Key
    HCRKCZRJWPKOAR-JTQLQIEISA-N
    2.1.4 Canonical SMILES
    CCNC1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC
    2.1.5 Isomeric SMILES
    CCN[C@H]1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC
    2.2 Other Identifiers
    2.2.1 UNII
    9451Z89515
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (r)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2h-thieno(3,2-e)-1,2-thiazine-6-sulfonamide 1,1-dioxide

    2. Azopt

    2.3.2 Depositor-Supplied Synonyms

    1. 138890-62-7

    2. Azopt

    3. Al-4862

    4. Al 4862

    5. (4r)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

    6. (4r)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2h-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide

    7. 138890-50-3

    8. Chebi:3176

    9. (r)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2h-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide

    10. Nsc-760050

    11. (+)-4-ethylamino-3,4-dihydro-2-(methoxy)propyl-2h-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide

    12. (r)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2h-thieno(3,2-e)-1,2-thiazine-6-sulfonamide 1,1-dioxide

    13. (r)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2h-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

    14. 2h-thieno(3,2-e)-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (r)-

    15. Brinzolamide [usan]

    16. Mfcd08067749

    17. Dsstox_cid_25531

    18. Dsstox_rid_80934

    19. Dsstox_gsid_45531

    20. 2h-thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (4r)-

    21. Bz1

    22. 9451z89515

    23. (4r)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2h-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

    24. Brinzolamide (brz)

    25. Azopt (tn)

    26. Brinzolamide (jan/usp/inn)

    27. 3znc

    28. Ncgc00016979-01

    29. Brinzolamide [usan:usp:inn:ban]

    30. Unii-9451z89515

    31. Brinzolamide- Bio-x

    32. Cas-138890-62-7

    33. Prestwick0_000365

    34. Prestwick1_000365

    35. Prestwick2_000365

    36. Prestwick3_000365

    37. Brinzolamide [mi]

    38. Brinzolamide [inn]

    39. Brinzolamide [jan]

    40. Brinzolamide [vandf]

    41. Schembl24636

    42. Brinzolamide [mart.]

    43. Bspbio_000489

    44. Mls002153787

    45. Bidd:gt0039

    46. Brinzolamide [usp-rs]

    47. Brinzolamide [who-dd]

    48. Spbio_002410

    49. Amy372

    50. Bpbio1_000539

    51. Chembl220491

    52. Gtpl6797

    53. Brinzolamide [ema Epar]

    54. Dtxsid6045531

    55. Bdbm10885

    56. Brinzolamide, >=98% (hplc)

    57. Brinzolamide [orange Book]

    58. Hms1569i11

    59. Hms2096i11

    60. Hms2234k06

    61. Hms3713i11

    62. Hms3885i11

    63. Brinzolamide [usp Impurity]

    64. Azarga Component Brinzolamide

    65. Bcp22330

    66. Hy-b0588

    67. Zinc3953037

    68. Brinzolamide [usp Monograph]

    69. Tox21_110722

    70. S3178

    71. Akos005145708

    72. Simbrinza Component Brinzolamide

    73. Tox21_110722_1

    74. Ac-5277

    75. Brinzolamide Component Of Azarga

    76. Ccg-220365

    77. Ccg-222516

    78. Db01194

    79. Nsc 760050

    80. Ncgc00179542-03

    81. Ncgc00179542-09

    82. Ncgc00179542-10

    83. As-35084

    84. Bb164262

    85. Brinzolamide Component Of Simbrinza

    86. Smr001233169

    87. Ab00513824

    88. B4258

    89. Sw197152-3

    90. Al4862;al 4862;al-4862

    91. C07760

    92. D00652

    93. Ab00513824_06

    94. Q411517

    95. Sr-01000838832

    96. Q-200751

    97. Sr-01000838832-2

    98. Brd-k74913225-001-03-3

    99. Brinzolamide, United States Pharmacopeia (usp) Reference Standard

    100. (4r)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2h,3h,4h-1$l^{6},7,2-thieno[3,2-e][1$l^{6},2]thiazine-6-sulfonamide

    101. (4r)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2h,3h,4h-1$l^{6},7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide

    102. (4r)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2h-thieno[3,2-e][1,2]thiazine-6-sulfonamide-1,1-dioxide

    103. (4r)-4-ethylamino-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[4,5-e]thiazine-6-sulfonamide

    104. (5r)-5-ethylamino-3-(3-methoxypropyl)-2,2-dioxo-2,9-dithia-3-azabicyclo[4.3.0]nona-1(6)7-diene-8-sulfonamide

    105. (r)-3,4-dihydro-4-ethylamino-2-(3-methoxypropyl)-2h-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 383.5 g/mol
    Molecular Formula C12H21N3O5S3
    XLogP3-0.3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count7
    Exact Mass383.06433430 g/mol
    Monoisotopic Mass383.06433430 g/mol
    Topological Polar Surface Area164 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity598
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameAzopt
    PubMed HealthBrinzolamide (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelAZOPT (brinzolamide ophthalmic suspension) 1% contains a carbonic anhydrase inhibitor formulated for multidose topical ophthalmic use. Brinzolamide is described chemically as: (R)-(+)-4-Ethylamino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno [3,2-e]-1...
    Active IngredientBrinzolamide
    Dosage FormSuspension/drops
    RouteOphthalmic
    Strength1%
    Market StatusPrescription
    CompanyAlcon Pharms

    2 of 2  
    Drug NameAzopt
    PubMed HealthBrinzolamide (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelAZOPT (brinzolamide ophthalmic suspension) 1% contains a carbonic anhydrase inhibitor formulated for multidose topical ophthalmic use. Brinzolamide is described chemically as: (R)-(+)-4-Ethylamino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno [3,2-e]-1...
    Active IngredientBrinzolamide
    Dosage FormSuspension/drops
    RouteOphthalmic
    Strength1%
    Market StatusPrescription
    CompanyAlcon Pharms

    4.2 Drug Indication

    For the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

    FDA Label

    Azopt is indicated to decrease elevated intraocular pressure in:

    - ocular hypertension;

    - open-angle glaucomaas monotherapy in adult patients unresponsive to beta-blockers or in adult patients in whom beta-blockers are contraindicated, or as adjunctive therapy to beta-blockers or prostaglandin analogues.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Used in the treatment of glaucoma, brinzolamide inhibits aqueous humor formation and reduces elevated intraocular pressure. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss. Brinzolamide can decrease intraocular pressure by approximately 16-19% in patients with elevated intraocular pressure.

    5.2 MeSH Pharmacological Classification

    Carbonic Anhydrase Inhibitors

    A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES. (See all compounds classified as Carbonic Anhydrase Inhibitors.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    BRINZOLAMIDE
    5.3.2 FDA UNII
    9451Z89515
    5.3.3 Pharmacological Classes
    Carbonic Anhydrase Inhibitors [MoA]; Carbonic Anhydrase Inhibitor [EPC]
    5.4 ATC Code

    S01EC04

    S01EC04

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    S - Sensory organs

    S01 - Ophthalmologicals

    S01E - Antiglaucoma preparations and miotics

    S01EC - Carbonic anhydrase inhibitors

    S01EC04 - Brinzolamide

    5.5 Absorption, Distribution and Excretion

    Absorption

    Absorbed into systemic circulation following topical ocular application

    5.6 Metabolism/Metabolites

    Ophthalmic

    5.7 Biological Half-Life

    111 days

    5.8 Mechanism of Action

    Brinzolamide is a highly specific inhibitor of CA-II, which is the main CA isoenzyme involved in the secretion of aqueous humor. Inhibition of CA in the ciliary process of the eye slows the formation of bicarbonate, and reduces sodium and fluid transport. This results in a reduction in the rate of aqueous humor secretion and the intraocular pressure. Brinzolamide is absorbed systemically following topical ocular administration. Since it has a high affinity for CA-II, brinzolamide binds extensively to red blood cells, where CA-II is primarily found. As sufficient CA-II activity remains, adverse effects resulting from the systemic inhibition of CA by brinzolamide are not observed. The metabolite N-desethyl brinzolamide is also formed. This metabolite binds to CA and accumulates in red blood cells as well. In the presence of brinzolamide, the metabolite binds mainly to carbonic anhydrase I (CA-I).

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    Registrant Name : Novartis Korea Co., Ltd.

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    Registrant Name : Novartis Korea Co., Ltd.

    Registration Date : 2023-10-10

    Registration Number : 20231010-209-J-1549

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    Registration Number : 20230104-209-J-1431

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    Brinzolamide

    About the Company : SCI Pharmtech Inc. offers APIs, advanced intermediates, and custom products with a focus on rapid development and cost-effective production. Its fully equipped research labs, pilot...

    SCI Pharmtech Inc. offers APIs, advanced intermediates, and custom products with a focus on rapid development and cost-effective production. Its fully equipped research labs, pilot plants, and production facilities ensure high-quality results. Collaborating globally, SCI Pharmtech creates key intermediates and APIs, meeting FDA, EDQM, and Taiwan TFDA standards for reliable, compliant, large-scale manufacturing. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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    03

    Transo-Pharm USA LLC

    U.S.A
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    DCAT Week
    Lotte New York Palace
    • fda
    • EDQM
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    Virtual BoothTransoPharm USA works in the Sourcing and Management of Active Pharmaceutical Ingredients.

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    Brinzolamide

    About the Company : Transo-Pharm is a licensed distributor of pharmaceutical components for human and veterinary markets. The company supports the full API life cycle, from development to sales, and a...

    Transo-Pharm is a licensed distributor of pharmaceutical components for human and veterinary markets. The company supports the full API life cycle, from development to sales, and acts as a sourcing and regulatory marketing agent for API manufacturers. Transo-Pharm assists with DMF setup, GMP consulting, and regulatory activities, supported by a regulatory team, warehouse facilities, proprietary API process IPs, and laboratory partnerships, with offices in Shanghai, Hong Kong, Singapore, and the US. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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    04

    LGM Pharma

    U.S.A
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    DCAT Week
    The Lexington Hotel
    • fda
    • EDQM
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    Virtual BoothLGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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    Brinzolamide

    About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for pharmaceutical and biotech industries. LGM also operates as a full-service CDMO, offering formulat...

    LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for pharmaceutical and biotech industries. LGM also operates as a full-service CDMO, offering formulation, analytical method development and testing, custom API synthesis, regulatory support, and commercial manufacturing. Supported by a network of over 300 accredited cGMP manufacturing partners and more than 100,000 sq. ft. of FDA-inspected cGMP manufacturing and warehouse space, LGM delivers secure, end-to-end solutions across multiple dosage forms. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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    05

    Jai Radhe Sales

    India
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    SCOPE Summit
    Not Confirmed
    • fda
    • EDQM
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    Virtual BoothJai Radhe Sales is your partner for all your sourcing needs.

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    Brinzolamide

    About the Company : Jai Radhe Sales, founded in 1999, is a global distributor specializing in high-quality pharmaceutical ingredients from India. It offers complete sourcing solutions, technical and r...

    Jai Radhe Sales, founded in 1999, is a global distributor specializing in high-quality pharmaceutical ingredients from India. It offers complete sourcing solutions, technical and regulatory support, and strives for global standards. Known for quality and affordability, it has established a niche through innovative methods and exports to nearly every continent. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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    06

    Bhavna Laboratories

    India
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    SCOPE Summit
    Not Confirmed
    • fda
    • EDQM
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    Virtual BoothBhavna Laboratories is an API & Intermediate manufacturer focusing on the muscle relaxant & ophthalmic segments.

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    Brinzolamide

    About the Company : Bhavna Laboratories Pvt. Ltd., founded in 1986, is an Indian manufacturer of APIs and intermediates. The company is approved by the FDA of India and holds cGMP certification for it...

    Bhavna Laboratories Pvt. Ltd., founded in 1986, is an Indian manufacturer of APIs and intermediates. The company is approved by the FDA of India and holds cGMP certification for its products, while also complying with WHO GMP standards. Bhavna focuses on muscle relaxants and ophthalmic products and provides custom manufacturing services. Its cGMP-compliant facility near Mumbai has a production capacity exceeding 500 tonnes per year, with exports across Southeast Asia, the Middle East, and Europe. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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    07

    Century Pharmaceuticals

    India
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    Asia Pharma Expo
    Booth #2309
    • fda
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    Virtual BoothCentury has been an API manufacturer for over 40 years & is the partner of choice for multipurpose custom manufacturing projects.

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    Brinzolamide

    About the Company : Century Pharmaceuticals, established in 1982, has 40 years of experience manufacturing APIs for major pharma companies in India and abroad. Its products are made in compliance with...

    Century Pharmaceuticals, established in 1982, has 40 years of experience manufacturing APIs for major pharma companies in India and abroad. Its products are made in compliance with cGMP, 21 CFR, and ICH guidelines, and it also produces intermediates and develops new APIs as per client requirements. The company conducts biotechnological research on human therapeutic proteins, including treatments for asthma, mastocytosis, and basophilic leukemia, and supplies research-grade biotech and animal health products. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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    08

    Neuland Laboratories

    India
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    DCAT Week
    InterContinental New York Barclay
    • fda
    • EDQM
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    Virtual BoothNeuland Laboratories- A dedicated 100% API provider.

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    Brinzolamide

    About the Company : Neuland Laboratories, established in 1984 and headquartered in Hyderabad, is a publicly listed company offering solutions for pharmaceutical chemistry needs—from library compound...

    Neuland Laboratories, established in 1984 and headquartered in Hyderabad, is a publicly listed company offering solutions for pharmaceutical chemistry needs—from library compounds to NCEs and advanced intermediates. It manufactures APIs and intermediates in USFDA-approved facilities, applying advanced process chemistry in a regulatory-compliant environment for clinical and commercial stages. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
    Neuland

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    09

    Pharmathen SA

    Greece
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    Lotte New York Palace
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

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    Brinzolamide

    About the Company : Pharmathen, established in 1969, has emerged as a leading in-house development partner in Europe. It specializes in the development, registration, manufacturing & life-cycle manage...

    Pharmathen, established in 1969, has emerged as a leading in-house development partner in Europe. It specializes in the development, registration, manufacturing & life-cycle management of complex pharmaceutical technologies & generic formulations. With a portfolio of over 100 products, Pharmathen serves over 250 clients across 80 countries. It’s pipeline includes advanced long-acting injectables, sustained-release formulations & preservative-free ophthalmics manufactured in USFDA & EU-approved facilities. Pharmathen’s core technology platforms, including microspheres, nanosuspensions & nanogels, are used to develop long-acting therapies.
    Pharmathen

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    10

    Capital Farma

    Spain
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    CDMO Live Europe 2026
    Attending
    • fda
    • EDQM
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    Virtual BoothCapital Farma, a leading European pharmaceutical company focusing on the development & distribution of niche APIs & Pharma Services.

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    Brinzolamide

    About the Company : Capital Farma provides integrated pharmaceutical solutions with a focus on high-quality Active Pharmaceutical Ingredients (APIs) sourced from leading European manufacturers. The co...

    Capital Farma provides integrated pharmaceutical solutions with a focus on high-quality Active Pharmaceutical Ingredients (APIs) sourced from leading European manufacturers. The company co-develops proprietary APIs with established European Contract Manufacturing Organizations (CMOs) and offers complete product packages by combining APIs with Finished Dosage Form (FDF) dossiers. Capital Farma also supports market expansion through FDF licensing services, enabling partners to access new regions efficiently. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
    Capital Farma

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    API Reference Price

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LTD","customerCountry":"INDIA","quantity":"4.99","actualQuantity":"4.987","unit":"KGS","unitRateFc":"14350","totalValueFC":"80653.8","currency":"EURO","unitRateINR":"1358945","date":"03-Oct-2024","totalValueINR":"6777058.72","totalValueInUsd":"80653.8","indian_port":"Delhi Air","hs_no":"29379090","bill_no":"5934235","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN","supplierAddress":"VIA DELLE ARTI, 33 - 20863 CONCOREZ ZO (MB) SDNF Italy","customerAddress":"212 ASHIRWAD COMMERCIAL COMPLEX"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730831400,"product":"I-PF-0092 BRINZOLAMIDE MICRONIZED STERILE ( TEST LICENCE NUMBER TL\/NZ\/23\/000450 DATED 11.07.2023) ( R & D PURPOSE)","address":"208, OKHLA INDUSTRIAL ESTATE,,PHAS","city":"NEW DELHI,DELHI","supplier":"ICROM SRL","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"MANKIND PHARMA LTD","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"40000","totalValueFC":"80532.6","currency":"USD","unitRateINR":"3398000","date":"06-Nov-2024","totalValueINR":"6796000","totalValueInUsd":"80532.6","indian_port":"Delhi Air","hs_no":"29359090","bill_no":"6519971","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN - MALPENSA","supplierAddress":"VIA DELLE ARTI 33 20863 CONCOREZZO (MS) ITALY . SDNF","customerAddress":"208, OKHLA INDUSTRIAL ESTATE,,PHAS"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1751567400,"product":"BRINZOLAMIDE MICRONIZED STERILE USP BRINZOLAMIDE MICRONIZED STERILE USP","address":"SPARC, TANDALJA,,VADODARA, GUJARAT","city":"VADODARA,GUJARAT","supplier":"ICROM SRL","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"SUN PHARMACEUTICAL MEDICARE LTD","customerCountry":"INDIA","quantity":"2.08","actualQuantity":"2080","unit":"GMS","unitRateFc":"38.5","totalValueFC":"80204.7","currency":"USD","unitRateINR":"3318.7","date":"04-Jul-2025","totalValueINR":"6902896","totalValueInUsd":"80204.7","indian_port":"Bombay Air","hs_no":"29359090","bill_no":"3068668","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN","supplierAddress":"VIA DELLA ARTI 33 20863 CONCOREZZO ITALY IT","customerAddress":"SPARC, TANDALJA,,VADODARA, GUJARAT"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1751740200,"product":"BRINZOLAMIDE MICRONIZED STERILE USP FOR MANUFACTURING EYE DROPS","address":"212 ASHIRWAD COMMERCIAL COMPLEX","city":"NEW DELHI","supplier":"ICROM SRL","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"SENTISS PHARMA PRIVATE LTD","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25.003","unit":"KGS","unitRateFc":"17080.2","totalValueFC":"427720.6","currency":"EURO","unitRateINR":"1472310","date":"06-Jul-2025","totalValueINR":"36812166.93","totalValueInUsd":"427720.6","indian_port":"Delhi Air","hs_no":"29379090","bill_no":"3096983","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN","supplierAddress":"VIA DELLE ARTI, 33 - 20863 CONCOREZ ZO (MB) SDNF Italy","customerAddress":"212 ASHIRWAD COMMERCIAL COMPLEX"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1752863400,"product":"BRINZOLAMIDE MICRONIZED STERILE USP (QTY 0.40 KGS X UNIT PRICE 38500.00 USD) (INV NO. FE-C55_25000123 DT. 16.07.2025)BRINZOLAMIDE MICRONIZED STERILE USP (QTY 0.40 KGS X UNIT PRI","address":"ACME PLAZA, ANDHERI KURLA ROAD,","city":"MUMBAI, MAHARASHTRA.","supplier":"ICROM SRL","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"SUN PHARMACEUTICAL INDUSTRIES LTD","customerCountry":"INDIA","quantity":"0.40","actualQuantity":"400","unit":"GMS","unitRateFc":"38.5","totalValueFC":"15531.3","currency":"USD","unitRateINR":"3341.8","date":"19-Jul-2025","totalValueINR":"1336720","totalValueInUsd":"15531.3","indian_port":"Bombay Air","hs_no":"29359090","bill_no":"3365787","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN - MALPENSA","supplierAddress":"VIA DELLA ARTI 33 20863 CONCOREZZO ITALY IT","customerAddress":"ACME PLAZA, ANDHERI KURLA ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1753381800,"product":"BRINZOLAMIDE STERILIZED (RE-IMPORT) (EXPORT VIDE SB NO.2789246\/17.06.2025)BRINZOLAMIDE STERILIZED (RE-IMPORT)","address":"20TH K M, HOSUR ROAD,,ELECTRONIC C","city":"BANGALORE,KARNATAKA","supplier":"VEM ILAC-URETIM TESISLERI","supplierCountry":"INDIA","foreign_port":"ISTANBUL","customer":"BIOCON LTD","customerCountry":"INDIA","quantity":"1.95","actualQuantity":"1.948","unit":"KGS","unitRateFc":"14259","totalValueFC":"28013.4","currency":"USD","unitRateINR":"1237679.3","date":"25-Jul-2025","totalValueINR":"2410999.33","totalValueInUsd":"28013.4","indian_port":"Hyderabad Air","hs_no":"29359090","bill_no":"3486059","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Sterile","supplierPort":"ISTANBUL","supplierAddress":"NO 38C O.S.B KARAA#AC MAH FATIH BUL VARIKAPAKLI-TEK#RDA# SDNF Turkey","customerAddress":"20TH K M, HOSUR ROAD,,ELECTRONIC C"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q4","strtotime":1762453800,"product":"BRINZOLAMIDE MICRONIZED STERILE USP BRINZOLAMIDE MICRONIZED STERILE USP","address":"ACME PLAZA, ANDHERI KURLA ROAD,","city":"MUMBAI, MAHARASHTRA.","supplier":"ICROM SRL","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"SUN PHARMACEUTICAL INDUSTRIES LTD","customerCountry":"INDIA","quantity":"0.69","actualQuantity":"690","unit":"GMS","unitRateFc":"38.5","totalValueFC":"26750","currency":"USD","unitRateINR":"3445.8","date":"07-Nov-2025","totalValueINR":"2377567.5","totalValueInUsd":"26750","indian_port":"Bombay Air","hs_no":"29359090","bill_no":"93896186","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN","supplierAddress":"VIA DELLA ARTI 33 20863 CONCOREZZO ITALY IT","customerAddress":"ACME PLAZA, ANDHERI KURLA ROAD,"}]
    01-Feb-2022
    30-Dec-2025
    KGS
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    Drugs in Development

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    Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost

    Details:

    Brinzolamide is a Other Small Molecule drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Glaucoma, Open-Angle.


    Lead Product(s): Brinzolamide,Brimonidine Tartrate,Netarsudil,Latanoprost

    Therapeutic Area: Ophthalmology Brand Name: Undisclosed

    Study Phase: Phase IVProduct Type: Miscellaneous

    Sponsor: Sengi

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable March 19, 2025

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    01

    Prairie Eye Center

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    Prairie Eye Center

    Country
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    Not Confirmed
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    Lead Product(s) : Brinzolamide,Brimonidine Tartrate,Netarsudil,Latanoprost

    Therapeutic Area : Ophthalmology

    Highest Development Status : Phase IV

    Partner/Sponsor/Collaborator : Sengi

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost

    Details : Brinzolamide is a Other Small Molecule drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Glaucoma, Open-Angle.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    March 19, 2025

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    Padagis Announces the Launch of Brinzolamide Ophthalmic Suspension with CGT Exclusivity

    Details:

    Brinzolamide, generic equivalent to the Reference Listed Drug Azopt Ophthalmic Suspension, is indicated to decrease elevated intraocular pressure (IOP) in adult patients with ocular hypertension or open-angle glaucoma.


    Lead Product(s): Brinzolamide,Inapplicable

    Therapeutic Area: Ophthalmology Brand Name: Azopt-Generic

    Study Phase: Approved FDFProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable October 13, 2023

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    02

    Padagis

    Israel
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    Not Confirmed

    Padagis

    Israel
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    Not Confirmed
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    Lead Product(s) : Brinzolamide,Inapplicable

    Therapeutic Area : Ophthalmology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Padagis Announces the Launch of Brinzolamide Ophthalmic Suspension with CGT Exclusivity

    Details : Brinzolamide, generic equivalent to the Reference Listed Drug Azopt Ophthalmic Suspension, is indicated to decrease elevated intraocular pressure (IOP) in adult patients with ocular hypertension or open-angle glaucoma.

    Product Name : Azopt-Generic

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    October 13, 2023

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    A Therapeutic Equivalence Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension

    Details:

    Brinzolamide is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Glaucoma, Open-Angle.


    Lead Product(s): Brinzolamide,Inapplicable

    Therapeutic Area: Ophthalmology Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable August 26, 2021

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    03

    Sun Pharmaceutical Industries Limited

    India
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    Not Confirmed

    Sun Pharmaceutical Industries Limited

    India
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    Not Confirmed
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    Lead Product(s) : Brinzolamide,Inapplicable

    Therapeutic Area : Ophthalmology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    A Therapeutic Equivalence Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertensio...

    Details : Brinzolamide is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Glaucoma, Open-Angle.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    August 26, 2021

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    To Compare the Efficacy and Safety of Perrigo's Product to an FDA Approved Product for the Treatment of Glaucoma or Ocular Hypertension in Both Eyes

    Details:

    Brinzolamide is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Glaucoma, Open-Angle.


    Lead Product(s): Brinzolamide,Brimonidine Tartrate

    Therapeutic Area: Ophthalmology Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable June 29, 2021

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    04

    Padagis

    Israel
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    Padagis

    Israel
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    Lead Product(s) : Brinzolamide,Brimonidine Tartrate

    Therapeutic Area : Ophthalmology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    To Compare the Efficacy and Safety of Perrigo's Product to an FDA Approved Product for the Treatme...

    Details : Brinzolamide is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Glaucoma, Open-Angle.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    June 29, 2021

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    Alcon to Acquire U.S. Commercialization Rights to Ophthalmic Eye Drop Simbrinza

    Details:

    Simbrinza is a fixed combination of a carbonic anhydrase inhibitor and an alpha-2 adrenergic receptor agonist indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.


    Lead Product(s): Brinzolamide,Brimonidine Tartrate

    Therapeutic Area: Ophthalmology Brand Name: Simbrinza

    Study Phase: Approved FDFProduct Type: Miscellaneous

    Sponsor: Alcon Inc

    Deal Size: $355.0 million Upfront Cash: Undisclosed

    Deal Type: Acquisition April 28, 2021

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    05

    Novartis Pharmaceuticals Corporation

    Switzerland
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    Novartis Pharmaceuticals Corporation

    Switzerland
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    Not Confirmed
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    Lead Product(s) : Brinzolamide,Brimonidine Tartrate

    Therapeutic Area : Ophthalmology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Alcon Inc

    Deal Size : $355.0 million

    Deal Type : Acquisition

    DEALS_DEV arrow-down

    Alcon to Acquire U.S. Commercialization Rights to Ophthalmic Eye Drop Simbrinza

    Details : Simbrinza is a fixed combination of a carbonic anhydrase inhibitor and an alpha-2 adrenergic receptor agonist indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

    Product Name : Simbrinza

    Product Type : Miscellaneous

    Upfront Cash : Undisclosed

    April 28, 2021

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    Teva Announces Launch of First Generic Version of AZOPT 1%, used to Treat High Pressure Inside the Eye, in the United States

    Details:

    Teva announced launch of the first available generic version of AZOPT® (brinzolamide ophthalmic suspension) 1%, approved by the US Food and Drug Administration to treat high pressure inside the eye due to ocular hypertension and open-angle glaucoma.


    Lead Product(s): Brinzolamide,Inapplicable

    Therapeutic Area: Ophthalmology Brand Name: Undisclosed

    Study Phase: Approved FDFProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable March 09, 2021

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    06

    Teva Pharmaceutical Industries

    Israel
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    Not Confirmed

    Teva Pharmaceutical Industries

    Israel
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    Not Confirmed
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    Lead Product(s) : Brinzolamide,Inapplicable

    Therapeutic Area : Ophthalmology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Teva Announces Launch of First Generic Version of AZOPT 1%, used to Treat High Pressure Inside the...

    Details : Teva announced launch of the first available generic version of AZOPT® (brinzolamide ophthalmic suspension) 1%, approved by the US Food and Drug Administration to treat high pressure inside the eye due to ocular hypertension and open-angle glaucoma.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    March 09, 2021

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    Senju Pharmaceutical Launches New Combination Ophthalmic Solution for the Treatment of Glaucoma and Ocular Hypertension

    Details:

    New combination ophthalmic solution for the treatment of glaucoma and ocular hypertension, AILAMIDE® Combination Ophthalmic Suspension has been launched in Japan on June 16, 2020.


    Lead Product(s): Brimonidine Tartrate,Brinzolamide

    Therapeutic Area: Ophthalmology Brand Name: Ailamide

    Study Phase: Approved FDFProduct Type: Miscellaneous

    Sponsor: Otsuka Pharmaceutical

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable June 16, 2020

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    07

    SENJU PHARMACEUTICAL CO LTD

    Japan
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    SCOPE Summit
    Not Confirmed

    SENJU PHARMACEUTICAL CO LTD

    Japan
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    Not Confirmed
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    Lead Product(s) : Brimonidine Tartrate,Brinzolamide

    Therapeutic Area : Ophthalmology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Otsuka Pharmaceutical

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Senju Pharmaceutical Launches New Combination Ophthalmic Solution for the Treatment of Glaucoma an...

    Details : New combination ophthalmic solution for the treatment of glaucoma and ocular hypertension, AILAMIDE® Combination Ophthalmic Suspension has been launched in Japan on June 16, 2020.

    Product Name : Ailamide

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    June 16, 2020

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    To Compare the Safety and Efficacy of Perrigo's Product to an FDA Approved Product for the Treatment of Glaucoma or Ocular Hypertension in Both Eyes

    Details:

    Brinzolamide is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Glaucoma, Open-Angle.


    Lead Product(s): Brinzolamide,Inapplicable

    Therapeutic Area: Ophthalmology Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable July 18, 2019

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    08

    Padagis

    Israel
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    Not Confirmed

    Padagis

    Israel
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    Lead Product(s) : Brinzolamide,Inapplicable

    Therapeutic Area : Ophthalmology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    To Compare the Safety and Efficacy of Perrigo's Product to an FDA Approved Product for the Treatme...

    Details : Brinzolamide is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Glaucoma, Open-Angle.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    July 18, 2019

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    Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt

    Details:

    Brinzolamide is a Other Small Molecule drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Glaucoma.


    Lead Product(s): Brinzolamide,Inapplicable

    Therapeutic Area: Ophthalmology Brand Name: Undisclosed

    Study Phase: Phase I/ Phase IIProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable April 01, 2019

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    09

    Bausch & Lomb Incorporated

    Canada
    arrow
    SCOPE Summit
    Not Confirmed

    Bausch & Lomb Incorporated

    Canada
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    Not Confirmed
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    Lead Product(s) : Brinzolamide,Inapplicable

    Therapeutic Area : Ophthalmology

    Highest Development Status : Phase I/ Phase II

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt

    Details : Brinzolamide is a Other Small Molecule drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Glaucoma.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    April 01, 2019

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    Additive Effect of Twice-daily Brinzolamide 1%/Brimonidine 0.2%Combination as an Adjunctive Therapy to Travoprost in Patients With Normal Tension Glauco...

    Details:

    Brinzolamide is a Other Small Molecule drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Glaucoma.


    Lead Product(s): Brinzolamide,Brimonidine Tartrate,Travoprost

    Therapeutic Area: Ophthalmology Brand Name: Undisclosed

    Study Phase: Phase IVProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable May 12, 2017

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    10

    Novartis Pharmaceuticals Corporation

    Switzerland
    arrow
    SCOPE Summit
    Not Confirmed

    Novartis Pharmaceuticals Corporation

    Switzerland
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    Not Confirmed
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    Lead Product(s) : Brinzolamide,Brimonidine Tartrate,Travoprost

    Therapeutic Area : Ophthalmology

    Highest Development Status : Phase IV

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Additive Effect of Twice-daily Brinzolamide 1%/Brimonidine 0.2%Combination as an Adjunctive Therap...

    Details : Brinzolamide is a Other Small Molecule drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Glaucoma.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    May 12, 2017

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    INTERMEDIATE SUPPLIERS

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    01

    Shandong Chenghui Shuangda Pharmace...

    China
    CPhI Japan
    Booth #1C-08
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    Virtual BoothChina’s top API & intermediate manufacturer, delivering advanced CMO/CDMO solutions to 60+ countries, empowering global health progress

    (S)-3,4-dihydro-6-chloro-4- hydroxy-2H-thieno[3,2-...

    CAS Number : 160982-16-1

    End Use API : Brinzolamide

    About The Company : Shandong Chenghui Shuangda Pharmaceutical Co., Ltd. specializes in API and advanced intermediate R&D and manufacturing, delivering comprehensive CDMO/CRO/OEM se...

    Shandong Chenghui Shuangda Pharmaceutical

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    02

    Shandong Chenghui Shuangda Pharmace...

    China
    CPhI Japan
    Booth #1C-08
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    Virtual BoothChina’s top API & intermediate manufacturer, delivering advanced CMO/CDMO solutions to 60+ countries, empowering global health progress

    (S)-3,4-Dihydro-4-hydroxy-2-(3- methoxypropyl)-2H-...

    CAS Number : 154127-42-1

    End Use API : Brinzolamide

    About The Company : Shandong Chenghui Shuangda Pharmaceutical Co., Ltd. specializes in API and advanced intermediate R&D and manufacturing, delivering comprehensive CDMO/CRO/OEM se...

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    03

    Indian Drugs And Chemicals

    India
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    Virtual BoothIndian Drugs & Chemicals – delivering trusted APIs, intermediates & fine chemicals worldwide with 40+ years of quality expertise.

    2,5-dichloro-3-acetyl thiophene

    CAS Number : 36157-40-1

    End Use API : Brinzolamide

    About The Company : Indian Drugs And Chemicals supplies quality products using modern technologies, supported by strong industry expertise. The company serves global markets with a...

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    04

    Bakul Group

    India
    SCOPE Summit
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    Bakul Group

    India
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    3-Acetyl-5-chloro-2-thiophenesulfonamide

    CAS Number : 160982-10-5

    End Use API : Brinzolamide

    About The Company : The Bakul Group of companies headquartered in Mumbai, India are engaged in the development and manufacture of high-quality Active Pharmaceutical Ingredients (AP...

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    05

    Bakul Group

    India
    SCOPE Summit
    Not Confirmed
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    Bakul Group

    India
    SCOPE Summit
    Not Confirmed
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    • EDQM
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    3-Bromoacetyl-5-chloro-2-thiophene sulfonamide

    CAS Number : 160982-11-6

    End Use API : Brinzolamide

    About The Company : The Bakul Group of companies headquartered in Mumbai, India are engaged in the development and manufacture of high-quality Active Pharmaceutical Ingredients (AP...

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    06

    Bakul Group

    India
    SCOPE Summit
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    Bakul Group

    India
    SCOPE Summit
    Not Confirmed
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    6-Chloro-2,3-dihydro-4H-thieno[3,2-e]-1,2-thiazin-...

    CAS Number : 174139-69-6

    End Use API : Brinzolamide

    About The Company : The Bakul Group of companies headquartered in Mumbai, India are engaged in the development and manufacture of high-quality Active Pharmaceutical Ingredients (AP...

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    07

    Bakul Group

    India
    SCOPE Summit
    Not Confirmed
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    Bakul Group

    India
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    Not Confirmed
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    (S)-6-Chloro-4-hydroxy-3,4-dihydro-2H-thieno[3,2-e...

    CAS Number : 160982-16-1

    End Use API : Brinzolamide

    About The Company : The Bakul Group of companies headquartered in Mumbai, India are engaged in the development and manufacture of high-quality Active Pharmaceutical Ingredients (AP...

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    08

    Berr Chemical Company Ltd

    China
    SCOPE Summit
    Not Confirmed
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    Berr Chemical Company Ltd

    China
    SCOPE Summit
    Not Confirmed
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    1-bromo-3-methoxyproane

    CAS Number : 36865-41-5

    End Use API : Brinzolamide

    About The Company : Berr Chemical Company Ltd is a high-tech enterprise engaged in Pharmaceuctials; azepan products;Pyrimidine products;Piperazines products;Pyridine products;Piper...

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    09

    Green Stone Swiss Co ., Ltd

    China
    SCOPE Summit
    Not Confirmed
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    Green Stone Swiss Co ., Ltd

    China
    SCOPE Summit
    Not Confirmed
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    3-Acetyl-5-chloro-2-thiophenesulfonamide

    CAS Number : 160982-10-5

    End Use API : Brinzolamide

    About The Company : Green Stone Swiss Co ., ltd.is a high-tech enterprise of pharmaceuticals and health ingredients, and provide customized products/OEM/ODM. We signed technical co...

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    10

    Green Stone Swiss Co ., Ltd

    China
    SCOPE Summit
    Not Confirmed
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    Green Stone Swiss Co ., Ltd

    China
    SCOPE Summit
    Not Confirmed
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    3-(2-Bromoacetyl)-5-chloro-2-thiophenesulfonami de

    CAS Number : 160982-11-6

    End Use API : Brinzolamide

    About The Company : Green Stone Swiss Co ., ltd.is a high-tech enterprise of pharmaceuticals and health ingredients, and provide customized products/OEM/ODM. We signed technical co...

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    Listed Dossiers

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    01

    Octavius Pharma Pvt. Ltd

    India
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    Virtual BoothOctavius Pharma has been empowering lives since 1980 by providing quality products like DC granules, APIs and FDFs.

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    Regulatory Info :

    Registration Country : India

    Brinzolamide

    Brand Name : Brinzolamide

    Dosage Form : Nano particles

    Dosage Strength : 1%

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : India

    Octavius Pharma

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    01

    Octavius Pharma Pvt. Ltd

    India
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    Virtual BoothOctavius Pharma has been empowering lives since 1980 by providing quality products like DC granules, APIs and FDFs.

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    Packaging :

    Regulatory Info :

    Brinzolamide

    Dosage : Nano particles

    Dosage Strength : 1%

    Brand Name : Brinzolamide

    Approval Date :

    Application Number :

    Registration Country : India

    Octavius Pharma

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    02

    Pharmathen SA

    Greece
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    DCAT Week
    Lotte New York Palace
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    Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

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    Regulatory Info :

    Registration Country : Greece

    Brinzolamide; Brimonidine Tartrate

    Brand Name :

    Dosage Form : Eye Drops Suspension

    Dosage Strength : 2MG/ML; 10MG/ML

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Greece

    Pharmathen

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    02

    Pharmathen SA

    Greece
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    Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

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    Packaging :

    Regulatory Info :

    Brinzolamide; Brimonidine Tartrate

    Dosage : Eye Drops Suspension

    Dosage Strength : 2MG/ML; 10MG/ML

    Brand Name :

    Approval Date :

    Application Number :

    Registration Country : Greece

    Pharmathen

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    03

    Pharmathen SA

    Greece
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    Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

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    Flag Greece
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    Regulatory Info :

    Registration Country : Greece

    Brinzolamide; Timolol Maleate

    Brand Name :

    Dosage Form : Eye Drops Suspension

    Dosage Strength : 5MG/ML; 10MG/ML

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Greece

    Pharmathen

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    03

    Pharmathen SA

    Greece
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    Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

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    Flag Greece
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    Packaging :

    Regulatory Info :

    Brinzolamide; Timolol Maleate

    Dosage : Eye Drops Suspension

    Dosage Strength : 5MG/ML; 10MG/ML

    Brand Name :

    Approval Date :

    Application Number :

    Registration Country : Greece

    Pharmathen

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    04

    Pharmathen SA

    Greece
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    Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

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    Flag Greece
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    Regulatory Info : EU Approved

    Registration Country : Greece

    Brinzolamide

    Brand Name :

    Dosage Form : Eye Drops Suspension

    Dosage Strength : 10MG/ML

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : EU Approved

    Registration Country : Greece

    Pharmathen

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    04

    Pharmathen SA

    Greece
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    Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

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    Flag Greece
    Virtual Booth Virtual Booth
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    Packaging :

    Regulatory Info : EU Approved

    Brinzolamide

    Dosage : Eye Drops Suspension

    Dosage Strength : 10MG/ML

    Brand Name :

    Approval Date :

    Application Number :

    Registration Country : Greece

    Pharmathen

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    05

    Pharmathen SA

    Greece
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    Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

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    Flag Greece
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    Regulatory Info : USA

    Registration Country : Greece

    Brinzolamide

    Brand Name :

    Dosage Form : Eye Drops Suspension

    Dosage Strength : 10MG/ML

    Packaging : Multi Dose Container

    Approval Date :

    Application Number :

    Regulatory Info : USA

    Registration Country : Greece

    Pharmathen

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    05

    Pharmathen SA

    Greece
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    Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

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    Packaging : Multi Dose Container

    Regulatory Info : USA

    Brinzolamide

    Dosage : Eye Drops Suspension

    Dosage Strength : 10MG/ML

    Brand Name :

    Approval Date :

    Application Number :

    Registration Country : Greece

    Pharmathen

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    06

    Indiana Ophthalmics

    India
    SCOPE Summit
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    Indiana Ophthalmics

    India
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    Regulatory Info :

    Registration Country : India

    Brinzolamide

    Brand Name :

    Dosage Form : Ophthalmic Suspension

    Dosage Strength : 1.0%/W/V

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : India

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    Indiana Ophthalmics

    India
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    India
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    Packaging :

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    Brinzolamide

    Dosage : Ophthalmic Suspension

    Dosage Strength : 1.0%/W/V

    Brand Name :

    Approval Date :

    Application Number :

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    Brinzolamide

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    Packaging : 5/10/15ml

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    Brimonidine Tartrate; Brinzolamide

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    Brimonidine Tartrate; Brinzolamide

    Dosage : Ophthalmic Solution

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    Murli Krishna Pharma

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    Brinzolamide

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    UNIDO Pharmaceutical

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    Brinzolamide

    Brand Name : BNZ

    Dosage Form : Eye Drop

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    india-flag.png
    IP Grade Brinzolamide (100 g) API needed in India [ENA19039]
    A CDMO that focuses on the research, development & manufacturing of tablets, capsules, creams, gels and sprays is looking for suppliers of IP Grade Brinzolamide (100 g) API for development purposes. The suppliers must support this enquiry with CoA.
    13 Feb 2024

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    13 Feb 2024

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    13 Feb 2024

    Bangladesh.png
    Brinzolamide (6 kg) API needed in Bangladesh [ENA16304]
    A company that deals in the distribution of various pharmaceutical products is looking for suppliers of Brinzolamide (6 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.
    06 Feb 2023

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    06 Feb 2023

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    06 Feb 2023

    Russia-big.png
    Brinzolamide API needed in Russia [ENA16086]
    A company that focuses on the research, development and manufacturing of vasodilators, platelet aggregation inhibitors & other heart medications is looking for suppliers of Brinzolamide API. The required quantity is 300 g for development and 2.5 kg for commercial purposes. The suppliers must support this enquiry with CoA.
    13 Jan 2023

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    13 Jan 2023

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    Reply Comment (18)

    13 Jan 2023

    Bangladesh.png
    Micronized/ USP/ Sterile Grade Brinzolamide API needed in Bangladesh [ENA13461]
    An indenting company that deals in distribution of various pharmaceutical products is looking for suppliers of Micronized/ USP/ Sterile Grade Brinzolamide API for ophthalmic formulation. The required quantity is 250 g for development & 12 kg - 15 kg/ annum for commercial purpose.
    28 Apr 2022

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    28 Apr 2022

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    28 Apr 2022

    Bangladesh.png
    Brinzolamide (4 kg) API needed in Bangladesh [ENA12817]
    A company based in India that deals in the research, development, manufacturing & marketing of various pharmaceutical products for human & veterinary use is looking for suppliers of Brinzolamide (4 kg) API for commercial purpose. The suppliers must support this enquiry with CoA.
    25 Feb 2022

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    25 Feb 2022

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    25 Feb 2022

    india-flag.png
    Brinzolamide API needed in India [ENA12584]
    A leading pharmaceutical company that deals in the development, manufacturing & marketing of generic products is looking for suppliers of Brinzolamide API for development purpose. The suppliers must support this enquiry with CoA.
    02 Feb 2022

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    02 Feb 2022

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    02 Feb 2022

    Bangladesh.png
    Various Ophthalmic Grade APIs needed in Bangladesh [ENA12364]
    A company based in Bangladesh that provides world-class solutions to the local pharmaceutical industry & deals in active pharmaceutical ingredients and excipients is looking for suppliers of Various Ophthalmic Grade APIs for development purpose. The suppliers must support this enquiry with CoA. 1. Moxifloxacin HCl API 2. Levofloxacin Hemihydrate API 3. Travoprost API 4. Brinzolamide API 5. Brimonidine Tartrate API 6. Nepafenac API 7. Olopatadine HCl API 8. Dorzolamide HCl API 9. Tobramycin API 10. Ganciclovir API
    10 Jan 2022

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    10 Jan 2022

    india-flag.png
    Micronized & Sterile Brinzolamide (10 g) API needed in India [ENA12024]
    A world-class oral solid dosage form manufacturing company that deals in pellets, micro-pellets and granules is looking for suppliers of Micronized & Sterile Brinzolamide (10 g) API for development purpose.
    06 Dec 2021

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    06 Dec 2021

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    06 Dec 2021

    Bangladesh.png
    Sterile & USP Grade Brinzolamide API needed in Bangladesh [ENA12021]
    A company based in Bangladesh that provides world-class solutions to the local pharmaceutical industry & deals in active pharmaceutical ingredients and excipients is looking for suppliers of Sterile & USP Grade Brinzolamide API for commercial purpose.
    06 Dec 2021

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    06 Dec 2021

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    06 Dec 2021

    india-flag.png
    Various APIs needed in India [ENA10641]
    A company specializing in analytical testing of a range of drug delivery systems is looking for Various APIs for development purposes. The required quantity is 50 g for each. The suppliers must support this enquiry with USDMF. The final market is the US. 1. USP Grade Brimonidine Tartrate API 2. Travoprost API 3. Timolol Maleate API 4. Budesonide (Sterile) API 5. Varenicline Tartrate API 6. Formoterol Fumarate API 7. Arformoterol Tartrate API 8. USP Grade Brinzolamide (Micronized) API 9. Loteprednol Etabonate API 10. Lifitegrast API 11. Naloxone Hydrochloride API
    15 Jun 2021

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    15 Jun 2021

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    15 Jun 2021

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    ABOUT THIS PAGE

    Looking for 138890-62-7 / Brinzolamide API manufacturers, exporters & distributors?

    Brinzolamide manufacturers, exporters & distributors 1

    21

    PharmaCompass offers a list of Brinzolamide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Brinzolamide manufacturer or Brinzolamide supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Brinzolamide manufacturer or Brinzolamide supplier.

    PharmaCompass also assists you with knowing the Brinzolamide API Price utilized in the formulation of products. Brinzolamide API Price is not always fixed or binding as the Brinzolamide Price is obtained through a variety of data sources. The Brinzolamide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Brinzolamide

    Synonyms

    138890-62-7, Azopt, Al-4862, Al 4862, (4r)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide, (4r)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2h-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide

    Cas Number

    138890-62-7

    Unique Ingredient Identifier (UNII)

    9451Z89515

    About Brinzolamide

    Brinzolamide is a sulfonamide and carbonic anhydrase inhibitor with specific affinity for carbonic anhydrase II. Following topical ocular administration, brinzolamide inhibits carbonic anhydrase II, an enzyme that is responsible for the movement of sodium and fluid transport in the eye. This inhibition leads to a decrease in aqueous humor secretion, probably by slowing the formation of bicarbonate ions, and results in a reduction in intraocular pressure. Brinzolamide is used to treat increased pressure in the eye caused by open-angle glaucoma.

    Brinzolamide (BRZ) Manufacturers

    A Brinzolamide (BRZ) manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Brinzolamide (BRZ), including repackagers and relabelers. The FDA regulates Brinzolamide (BRZ) manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Brinzolamide (BRZ) API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Brinzolamide (BRZ) manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Brinzolamide (BRZ) Suppliers

    A Brinzolamide (BRZ) supplier is an individual or a company that provides Brinzolamide (BRZ) active pharmaceutical ingredient (API) or Brinzolamide (BRZ) finished formulations upon request. The Brinzolamide (BRZ) suppliers may include Brinzolamide (BRZ) API manufacturers, exporters, distributors and traders.

    click here to find a list of Brinzolamide (BRZ) suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Brinzolamide (BRZ) USDMF

    A Brinzolamide (BRZ) DMF (Drug Master File) is a document detailing the whole manufacturing process of Brinzolamide (BRZ) active pharmaceutical ingredient (API) in detail. Different forms of Brinzolamide (BRZ) DMFs exist exist since differing nations have different regulations, such as Brinzolamide (BRZ) USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Brinzolamide (BRZ) DMF submitted to regulatory agencies in the US is known as a USDMF. Brinzolamide (BRZ) USDMF includes data on Brinzolamide (BRZ)'s chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Brinzolamide (BRZ) USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Brinzolamide (BRZ) suppliers with USDMF on PharmaCompass.

    Brinzolamide (BRZ) JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Brinzolamide (BRZ) Drug Master File in Japan (Brinzolamide (BRZ) JDMF) empowers Brinzolamide (BRZ) API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Brinzolamide (BRZ) JDMF during the approval evaluation for pharmaceutical products. At the time of Brinzolamide (BRZ) JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Brinzolamide (BRZ) suppliers with JDMF on PharmaCompass.

    Brinzolamide (BRZ) KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Brinzolamide (BRZ) Drug Master File in Korea (Brinzolamide (BRZ) KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Brinzolamide (BRZ). The MFDS reviews the Brinzolamide (BRZ) KDMF as part of the drug registration process and uses the information provided in the Brinzolamide (BRZ) KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Brinzolamide (BRZ) KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Brinzolamide (BRZ) API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Brinzolamide (BRZ) suppliers with KDMF on PharmaCompass.

    Brinzolamide (BRZ) WC

    A Brinzolamide (BRZ) written confirmation (Brinzolamide (BRZ) WC) is an official document issued by a regulatory agency to a Brinzolamide (BRZ) manufacturer, verifying that the manufacturing facility of a Brinzolamide (BRZ) active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Brinzolamide (BRZ) APIs or Brinzolamide (BRZ) finished pharmaceutical products to another nation, regulatory agencies frequently require a Brinzolamide (BRZ) WC (written confirmation) as part of the regulatory process.

    click here to find a list of Brinzolamide (BRZ) suppliers with Written Confirmation (WC) on PharmaCompass.

    Brinzolamide (BRZ) NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Brinzolamide (BRZ) as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Brinzolamide (BRZ) API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Brinzolamide (BRZ) as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Brinzolamide (BRZ) and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Brinzolamide (BRZ) NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Brinzolamide (BRZ) suppliers with NDC on PharmaCompass.

    Brinzolamide (BRZ) GMP

    Brinzolamide (BRZ) Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Brinzolamide (BRZ) GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Brinzolamide (BRZ) GMP manufacturer or Brinzolamide (BRZ) GMP API supplier for your needs.

    Brinzolamide (BRZ) CoA

    A Brinzolamide (BRZ) CoA (Certificate of Analysis) is a formal document that attests to Brinzolamide (BRZ)'s compliance with Brinzolamide (BRZ) specifications and serves as a tool for batch-level quality control.

    Brinzolamide (BRZ) CoA mostly includes findings from lab analyses of a specific batch. For each Brinzolamide (BRZ) CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Brinzolamide (BRZ) may be tested according to a variety of international standards, such as European Pharmacopoeia (Brinzolamide (BRZ) EP), Brinzolamide (BRZ) JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Brinzolamide (BRZ) USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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