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Chemistry

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Also known as: 30392-41-7, Tornalate, Bitolterol mesilate, Bitolterol methanesulfonate, Bitolterol mesilat, Bitolterol (mesylate)
Molecular Formula
C29H35NO8S
Molecular Weight
557.7  g/mol
InChI Key
HODFCFXCOMKRCG-UHFFFAOYSA-N
FDA UNII
4E53T3611U

Bitolterol
Bitolterol Mesylate is the mesylate salt of bitolterol, a diester sympathomimetic amine with bronchodilator activity. As an ester prodrug, bitolterol is hydrolyzed by esterases to its active metabolite colterol (N-t-butylarterenol). Colterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle. This increases air flow and prevents bronchospasms and may eventually lead to an improvement of airway function.
1 2D Structure

Bitolterol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(4-methylbenzoyl)oxyphenyl] 4-methylbenzoate;methanesulfonic acid
2.1.2 InChI
InChI=1S/C28H31NO5.CH4O3S/c1-18-6-10-20(11-7-18)26(31)33-24-15-14-22(23(30)17-29-28(3,4)5)16-25(24)34-27(32)21-12-8-19(2)9-13-21;1-5(2,3)4/h6-16,23,29-30H,17H2,1-5H3;1H3,(H,2,3,4)
2.1.3 InChI Key
HODFCFXCOMKRCG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC=C(C=C1)C(=O)OC2=C(C=C(C=C2)C(CNC(C)(C)C)O)OC(=O)C3=CC=C(C=C3)C.CS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
4E53T3611U
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bitolterol

2. Bitolterol Methanesulfonate

3. S-1540

4. Tornalate

5. Win 32784

2.3.2 Depositor-Supplied Synonyms

1. 30392-41-7

2. Tornalate

3. Bitolterol Mesilate

4. Bitolterol Methanesulfonate

5. Bitolterol Mesilat

6. Bitolterol (mesylate)

7. Bitolterol Mesylate [usan]

8. (tert-butyl)[beta-hydroxy-3,4-bis(p-toluoyloxy)phenethyl]ammonium Methanesulphonate

9. Win 32784

10. Win-32784

11. Win 32,784

12. 4-(2-(tert-butylamino)-1-hydroxyethyl)-o-phenylene Di-p-toluate Methanesulfonate (salt)

13. 4e53t3611u

14. Effectin

15. Bitolterol Mesilate (jan)

16. Bitolterol Mesylate (usan)

17. [4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(4-methylbenzoyl)oxyphenyl] 4-methylbenzoate;methanesulfonic Acid

18. Benzoic Acid, 4-methyl-, 4-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-1,2-phenylene Ester Methanesulfonate (salt)

19. Bitolterol Mesilate [jan]

20. Biterol; Bitoterol Methanesulfonate; Effectin; Tornalate; Win 32784

21. Chebi:3134

22. (tert-butyl)(beta-hydroxy-3,4-bis(p-toluoyloxy)phenethyl)ammonium Methanesulphonate

23. Einecs 250-177-5

24. Asmalene

25. Produrol

26. Unii-4e53t3611u

27. Tornalate (tn)

28. 4-(2-(t-butylamino)-1-hydroxyethyl)-o-phenylene Di-p-toluate Mesilate

29. S-1540

30. Schembl4371

31. Alpha((tert-butylamino)methyl)-3,4-dihydroxybenzyl Alcohol 3,4-di-p-toluate Methanesulfonate (salt)

32. Chembl1200405

33. Dtxsid80952735

34. Bitolterol Mesylate [vandf]

35. Bitolterol Mesilate [mart.]

36. Bitolterol Mesilate [who-dd]

37. Bitolterol Methanesulfonate [mi]

38. Bitolterol Mesylate [orange Book]

39. P-toluic Acid, 4-(2-(tert-butylamino)-1-hydroxyethyl)-o-phenylene Ester, Methanesulfonate(salt)

40. D00684

41. Q27105949

42. .alpha.((tert-butylamino)methyl)-3,4-dihydroxybenzyl Alcohol 3,4-di-p-toluate Methanesulfonate (salt)

43. .alpha.((tert-butylamino)methyl)-3,4-dihydroxybenzyl Alcohol 3,4-di-p-toluate Methanesulphonate (salt)

44. 4-(2-(tert-butylamino)-1-hydroxyethyl)-1,2-phenylene Bis(4-methylbenzoate) Methanesulfonate (salt)

45. 4-(2-(tert-butylamino)-1-hydroxyethyl)-1,2-phenylene Bis(4-methylbenzoate) Methanesulphonate (salt)

46. 4-(2-(tert-butylamino)-1-hydroxyethyl)-o-phenylene Di-p-toluate Methanesulphonate (salt)

47. 4-methyl-benzoic Acid 1,1'-[4-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,2-phenylene] Ester Methanesulfonate

48. Alpha ((t-butylamino)methyl)-3,4-dihydroxybenzyl Alcohol 3,4-di(p-toluate) Methanesulfonate

49. Alpha ((t-butylamino)methyl)-3,4-dihydroxybenzyl Alcohol 3,4-di(p-toluate) Methanesulphonate

50. Benzoic Acid, 4-methyl-, 4-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-1,2-phenylene Ester Methanesulphonate (salt)

51. Benzoic Acid, 4-methyl-, 4-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-1,2-phenylene Ester, Methanesulfonate (1:1)

52. Benzoic Acid, 4-methyl-, 4-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-1,2-phenylene Ester, Methanesulphonate (1:1)

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 557.7 g/mol
Molecular Formula C29H35NO8S
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count10
Exact Mass557.20833825 g/mol
Monoisotopic Mass557.20833825 g/mol
Topological Polar Surface Area148 Ų
Heavy Atom Count39
Formal Charge0
Complexity751
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Adrenergic beta-2 Receptor Agonists

Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS. (See all compounds classified as Adrenergic beta-2 Receptor Agonists.)


Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)


ABOUT THIS PAGE

Looking for 30392-41-7 / Bitolterol API manufacturers, exporters & distributors?

Bitolterol manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Bitolterol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Bitolterol manufacturer or Bitolterol supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Bitolterol manufacturer or Bitolterol supplier.

PharmaCompass also assists you with knowing the Bitolterol API Price utilized in the formulation of products. Bitolterol API Price is not always fixed or binding as the Bitolterol Price is obtained through a variety of data sources. The Bitolterol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Bitolterol

Synonyms

30392-41-7, Tornalate, Bitolterol mesilate, Bitolterol methanesulfonate, Bitolterol mesilat, Bitolterol (mesylate)

Cas Number

30392-41-7

Unique Ingredient Identifier (UNII)

4E53T3611U

About Bitolterol

Bitolterol Mesylate is the mesylate salt of bitolterol, a diester sympathomimetic amine with bronchodilator activity. As an ester prodrug, bitolterol is hydrolyzed by esterases to its active metabolite colterol (N-t-butylarterenol). Colterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle. This increases air flow and prevents bronchospasms and may eventually lead to an improvement of airway function.

Bitolterol Manufacturers

A Bitolterol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Bitolterol, including repackagers and relabelers. The FDA regulates Bitolterol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Bitolterol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Bitolterol Suppliers

A Bitolterol supplier is an individual or a company that provides Bitolterol active pharmaceutical ingredient (API) or Bitolterol finished formulations upon request. The Bitolterol suppliers may include Bitolterol API manufacturers, exporters, distributors and traders.

Bitolterol GMP

Bitolterol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Bitolterol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Bitolterol GMP manufacturer or Bitolterol GMP API supplier for your needs.

Bitolterol CoA

A Bitolterol CoA (Certificate of Analysis) is a formal document that attests to Bitolterol's compliance with Bitolterol specifications and serves as a tool for batch-level quality control.

Bitolterol CoA mostly includes findings from lab analyses of a specific batch. For each Bitolterol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Bitolterol may be tested according to a variety of international standards, such as European Pharmacopoeia (Bitolterol EP), Bitolterol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Bitolterol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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