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    Chemistry

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    Also known as: Bendrofluazide, 73-48-3, Naturetin, Aprinox, Benzhydroflumethiazide, Benzylrodiuran
    Molecular Formula
    C15H14F3N3O4S2
    Molecular Weight
    421.4  g/mol
    InChI Key
    HDWIHXWEUNVBIY-UHFFFAOYSA-N
    FDA UNII
    5Q52X6ICJI
    Bendroflumethiazide
    A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
    Bendroflumethiazide is a Thiazide Diuretic. The physiologic effect of bendroflumethiazide is by means of Increased Diuresis.
    1 2D Structure

    Bendroflumethiazide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-16,2,4-benzothiadiazine-7-sulfonamide
    2.1.2 InChI
    InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)
    2.1.3 InChI Key
    HDWIHXWEUNVBIY-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC=C(C=C1)CC2NC3=C(C=C(C(=C3)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N2
    2.2 Other Identifiers
    2.2.1 UNII
    5Q52X6ICJI
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aprinox

    2. Bendrofluazide

    3. Benzide

    4. Benzide M

    5. Benzide-m

    6. Berkozide

    7. Centyl

    8. Esberizid

    9. Naturetin

    10. Naturine

    11. Neo Naclex

    12. Neo-naclex

    13. Pluryl

    14. Urizid

    2.3.2 Depositor-Supplied Synonyms

    1. Bendrofluazide

    2. 73-48-3

    3. Naturetin

    4. Aprinox

    5. Benzhydroflumethiazide

    6. Benzylrodiuran

    7. Berkozide

    8. Centyl

    9. Pluryl

    10. Neo-naclex

    11. Bentride

    12. Bristuric

    13. Bristuron

    14. Flumesil

    15. Niagaril

    16. Plusuril

    17. Poliuron

    18. Sinesalin

    19. Sodiuretic

    20. Thiazidico

    21. Benuron

    22. Intolex

    23. Livesan

    24. Nikion

    25. Orsile

    26. Pluryle

    27. Repicin

    28. Salural

    29. Salures

    30. Urlea

    31. Benzylhydroflumethiazide

    32. Neo-rontyl

    33. Relan Beta

    34. Bhft

    35. Rauzide

    36. Benzydroflumethiazide

    37. Bendrofumethiazide

    38. Rautrax N

    39. Bendroflumethiazidum

    40. Bendroflumethazide

    41. Bendroflumetiazida

    42. Bendroflumethiazidum [inn-latin]

    43. Bendroflumetiazida [inn-spanish]

    44. Be 724-a

    45. Bl H368

    46. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide

    47. Nsc-758229

    48. 5q52x6icji

    49. 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    50. 6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide

    51. Mls000028558

    52. Chebi:3013

    53. Naturetin-2.5

    54. Naturine

    55. Flumersil

    56. Naigaril

    57. Nateretin

    58. Smr000058802

    59. Bendroflumethiazide-d5

    60. Benzy-rodiuran

    61. Dsstox_cid_2647

    62. Bendroflumetiazide

    63. Naturetin-5

    64. Naturetin-10

    65. 6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

    66. Dsstox_rid_76673

    67. Dsstox_gsid_22647

    68. 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2h-1lambda6,2,4-benzothiadiazine-7-sulfonamide

    69. Bendroflumetiazide [dcit]

    70. Ft 81

    71. 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2h-1,2,4- Benzothiadiazine-7-sulfonamide

    72. Naturetin (tn)

    73. Hsdb 3293

    74. Sr-01000000103

    75. Einecs 200-800-1

    76. Bendroflumethiazide [inn]

    77. Unii-5q52x6icji

    78. Brn 0373316

    79. Neonaclex

    80. Cas-73-48-3

    81. Relan .beta.

    82. Ncgc00016312-01

    83. 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2h-1?^{6},2,4-benzothiadiazine-7-sulfonamide

    84. Bendroflumethiazide (jan/usp/inn)

    85. Prestwick_992

    86. Behenic Fatty Acids

    87. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

    88. 3-benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide

    89. Bendroflumethiazide [usp:inn:ban:jan]

    90. Spectrum_001386

    91. Opera_id_1043

    92. Prestwick0_000784

    93. Prestwick1_000784

    94. Prestwick2_000784

    95. Prestwick3_000784

    96. Spectrum2_001524

    97. Spectrum3_001558

    98. Spectrum4_000774

    99. Spectrum5_001016

    100. 3-benzyl-6-(trifluoromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    101. Chembl1684

    102. Schembl26016

    103. Bspbio_000888

    104. Bspbio_003036

    105. Kbiogr_001188

    106. Kbioss_001866

    107. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-,1,1-dioxide

    108. 4-27-00-08041 (beilstein Handbook Reference)

    109. Mls001076062

    110. Mls002548857

    111. Divk1c_000274

    112. Spectrum1503104

    113. Spbio_001308

    114. Spbio_002827

    115. (.+/-.)-bendroflumethiazide

    116. Bpbio1_000978

    117. Gtpl7122

    118. Bendroflumethiazide [mi]

    119. Dtxsid5022647

    120. Bendroflumethiazide [jan]

    121. Hms500n16

    122. Kbio1_000274

    123. Kbio2_001866

    124. Kbio2_004434

    125. Kbio2_007002

    126. Kbio3_002536

    127. Bendroflumethiazide [hsdb]

    128. Ninds_000274

    129. Bendroflumethiazide [vandf]

    130. Hms1570m10

    131. Hms1922e15

    132. Hms2092j16

    133. Hms2097m10

    134. Hms2230g10

    135. Hms3259d17

    136. Hms3370i20

    137. Hms3714m10

    138. Pharmakon1600-01503104

    139. Bendroflumethiazide [mart.]

    140. Bcp24525

    141. Hy-b1363

    142. Bendroflumethiazide [usp-rs]

    143. Bendroflumethiazide [who-dd]

    144. Tox21_110365

    145. Ccg-39302

    146. Mfcd00078963

    147. Nsc758229

    148. Akos024255718

    149. Tox21_110365_1

    150. Bendroflumethiazide, Analytical Standard

    151. Db00436

    152. Hs-0095

    153. Nc00664

    154. Nsc 758229

    155. 3-benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxide

    156. Idi1_000274

    157. Bendroflumethiazide [ep Impurity]

    158. Bendroflumethiazide [orange Book]

    159. Ncgc00018194-02

    160. Ncgc00018194-03

    161. Ncgc00018194-04

    162. Ncgc00018194-08

    163. Ncgc00089729-02

    164. Ncgc00089729-03

    165. (+-)-3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    166. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide, (+-)-

    167. 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    168. 3-(phenylmethyl)-6-(trifluoromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    169. 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

    170. Bendroflumethiazide [ep Monograph]

    171. Bendroflumethiazide [usp Monograph]

    172. Sbi-0051772.p002

    173. Corzide Component Bendroflumethiazide

    174. Ab00052315

    175. Cs-0013104

    176. Eu-0009291

    177. Ft-0662518

    178. Ft-0662519

    179. Ft-0662520

    180. Sw028069-4

    181. Unm000000601501

    182. Bendroflumethiazide Component Of Corzide

    183. C07758

    184. D00650

    185. Ab00052315_15

    186. Ab00052315_16

    187. 073b483

    188. A851258

    189. Q1169164

    190. Sr-01000000103-2

    191. Sr-01000000103-4

    192. Brd-a80017228-001-05-9

    193. Brd-a80017228-001-15-8

    194. Z2786051551

    195. Bendroflumethiazide, British Pharmacopoeia (bp) Reference Standard

    196. Bendroflumethiazide, European Pharmacopoeia (ep) Reference Standard

    197. Bendroflumethiazide, United States Pharmacopeia (usp) Reference Standard

    198. 3-benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

    199. (+/-)-3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    200. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide, (+/-)-

    201. 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide

    202. 3-benzyl-6-(trifluoromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide #

    203. 3-benzyl-6-(trifluoromethyl)-3,4-dihydro-2h-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 421.4 g/mol
    Molecular Formula C15H14F3N3O4S2
    XLogP31.2
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count3
    Exact Mass421.03778277 g/mol
    Monoisotopic Mass421.03778277 g/mol
    Topological Polar Surface Area135 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity740
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameCorzide
    PubMed HealthNadolol/Bendroflumethiazide (By mouth)
    Drug ClassesBeta-Adrenergic Blocker, Nonselective/Thiazide Combination
    Active Ingredientnadolol; Bendroflumethiazide
    Dosage FormTablet
    RouteOral
    Strength5mg; 80mg; 40mg
    Market StatusPrescription
    CompanyKing Pharms

    2 of 2  
    Drug NameCorzide
    PubMed HealthNadolol/Bendroflumethiazide (By mouth)
    Drug ClassesBeta-Adrenergic Blocker, Nonselective/Thiazide Combination
    Active Ingredientnadolol; Bendroflumethiazide
    Dosage FormTablet
    RouteOral
    Strength5mg; 80mg; 40mg
    Market StatusPrescription
    CompanyKing Pharms

    4.2 Therapeutic Uses

    Antihypertensive Agents; Diuretics, Thiazide

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    IT IS INDICATED IN CONTROL OF EDEMA, CONGESTIVE HEART FAILURE, NEPHROSIS & NEPHRITIS, CIRRHOSIS & ASCITES, & OTHER EDEMATOUS STATES. ... IT IS ALSO OF VALUE IN HYPERTENSION ALONE OR WHEN COMBINED WITH OTHER ANTIHYPERTENSIVES.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 868

    THIAZIDE DRUGS...USUALLY FIRST DRUG TO BE EMPLOYED IN TREATMENT OF HYPERTENSION. SINCE THIAZIDES INDUCE ONLY LIMITED (10%) REDN IN BLOOD PRESSURE THEY ARE USEFUL EITHER IN MILD CASES OF HYPERTENSION OR AS ADJUNCTIVE THERAPY TO OTHER DRUGS. /THIAZIDE DIURETICS/

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 868

    THIAZIDE DIURETICS ARE EFFECTIVE AS ADJUNCTIVE THERAPY IN EDEMA ASSOC WITH CONGESTIVE HEART FAILURE, HEPATIC CIRRHOSIS, & CORTICOSTEROID & ESTROGEN THERAPY, AS WELL AS EDEMA DUE TO VARIOUS FORMS OF RENAL DYSFUNCTION...& SEVERE EDEMA DUE TO PREGNANCY. /THIAZIDE DIURETICS/

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 868

    For more Therapeutic Uses (Complete) data for BENDROFLUMETHIAZIDE (10 total), please visit the HSDB record page.

    4.3 Drug Warning

    PERIODIC SERUM ELECTROLYTE DETERMINATION SHOULD BE DONE ON ALL PT IN ORDER TO DETECT ELECTROLYTE IMBALANCE SUCH AS HYPONATREMIA, HYPOCHLOREMIC ALKALOSIS, & HYPOKALEMIA. /THIAZIDE DIURETICS/

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 868

    THIAZIDE DIURETICS ARE CONTRAINDICATED IN ANURIA, PATIENTS HYPERSENSITIVE TO THESE & OTHER SULFONAMIDE DRUGS, & IN OTHERWISE HEALTHY PREGNANT WOMEN WITH OR WITHOUT MILD EDEMA. ...SHOULD BE USED WITH CAUTION IN PATIENTS WITH RENAL DISEASE, SINCE THEY MAY PPT AZOTEMIA. /THIAZIDE DIURETICS/

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 868

    PLASMA POTASSIUM CONCN SHOULD BE DETERMINED PERIODICALLY IN PT WHO RECEIVE THIAZIDE DIURETICS FOR EXTENDED PERIODS. /THIAZIDE DIURETICS/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 832

    Maternal Medication usually Compatible with Breast-Feeding: Bendroflumethiazide: Reported Sign or Symptom in Infant or Effect on Lactation: Suppresses lactation. /From Table 6/

    Report of the American Academy of Pediatrics Committee on Drugs in Pediatrics 93 (1): 140 (1994)

    For more Drug Warnings (Complete) data for BENDROFLUMETHIAZIDE (20 total), please visit the HSDB record page.

    4.4 Minimum/Potential Fatal Human Dose

    3. 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT FOR 70 KG PERSON (150 LB). /BENZOTHIADIAZIDE DIURETICS/

    Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-239

    4.5 Drug Indication

    For the treatment of high blood pressure and management of edema related to heart failure.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

    5.2 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Diuretics

    Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

    Sodium Chloride Symporter Inhibitors

    Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA. (See all compounds classified as Sodium Chloride Symporter Inhibitors.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    BENDROFLUMETHIAZIDE
    5.3.2 FDA UNII
    5Q52X6ICJI
    5.3.3 Pharmacological Classes
    Chemical Structure [CS] - Thiazides
    5.4 ATC Code

    C - Cardiovascular system

    C03 - Diuretics

    C03A - Low-ceiling diuretics, thiazides

    C03AA - Thiazides, plain

    C03AA01 - Bendroflumethiazide

    5.5 Absorption, Distribution and Excretion

    Absorption

    Absorbed relatively rapidly after oral administration

    MOST CMPD ARE RAPIDLY EXCRETED WITHIN 3-6 HR. BENDROFLUMETHIAZIDE...LONGER DURATION OF ACTION THAT IS CORRELATED WITH...SLOWER EXCRETION.

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 902

    THIAZIDES ARE ABSORBED FROM GI TRACT & OWE THEIR USEFULNESS LARGELY TO THEIR EFFECTIVENESS BY ORAL ROUTE. ABSORPTION IS RELATIVELY RAPID. MOST AGENTS SHOW DEMONSTRABLE DIURETIC EFFECT WITHIN HR AFTER ORAL ADMIN. /BENZOTHIADIAZIDES/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 831

    IN GENERAL, THIAZIDES WITH RELATIVELY LONG DURATIONS OF ACTION SHOW PROPORTIONATELY HIGH DEGREE OF BINDING TO PLASMA PROTEINS & ARE REABSORBED... BY RENAL TUBULES. ... DRUG PASSES READILY THROUGH PLACENTAL BARRIER TO FETUS. ALL THIAZIDES PROBABLY UNDERGO ACTIVE SECRETION IN PROXIMAL TUBULE. /THIAZIDE DIURETICS/

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 902

    BENDROFLUMETHIAZIDE WAS ADMIN ORALLY TO 9 HEALTHY VOLUNTEERS. PEAK PLASMA LEVELS REACHED @ 1 + OR - 0.4 HR. CONCN DECLINED WITH MEAN T/2 OF 3 HR. APPARENT VOL OF DISTRIBUTION AVG 1.48 L/KG. MAJOR PART ELIMINATED VIA NONRENAL MECHANISMS. URINARY RECOVERY AVG 30%.

    BEERMANN B ET AL; CLIN PHARMACOL THER 22(OCT) 385 (1977)

    Bendroflumethiazide appears to be well absorbed from the GI tract. The drug is excreted unchanged in urine, and excretion is essentially complete within 24 hours.

    McEvoy, G.K. (ed.). American Hospital Formulary Service-Drug Information 19 98. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 1998 (Plus Supplements)., p. 2166

    5.6 Biological Half-Life

    8.5 hours

    Halflife is 3-3.9 hrs. /From table/

    Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 703

    5.7 Mechanism of Action

    As a diuretic, bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of bendroflumethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.

    ...BENZOTHIADIAZIDES HAVE DIRECT EFFECT ON RENAL TUBULAR TRANSPORT OF SODIUM & CHLORIDE...INDEPENDENT OF ANY EFFECT ON CARBONIC ANHYDRASE. /THIAZIDE DIURETICS/

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 899

    NATURE OF CHEM INTERACTION BETWEEN THIAZIDES & SPECIFIC RENAL RECEPTORS RESPONSIBLE FOR CHLORURETIC EFFECT IS NOT KNOWN; NO CRITICAL ENZYMATIC REACTIONS HAVE BEEN IDENTIFIED. /THIAZIDE DIURETICS/

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 901

    ...MAY DECR EXCRETION OF URIC ACID IN MAN, THUS INCR ITS CONCN IN PLASMA. HYPERURICEMIC EFFECT RESULTS PRIMARILY FROM INHIBITION OF TUBULAR SECRETION OF URATE. ... UNLIKE MOST OTHER NATRIURETIC AGENTS...DECR RENAL EXCRETION OF CALCIUM RELATIVE TO THAT OF SODIUM... /ENHANCE/ EXCRETION OF MAGNESIUM... /THIAZIDE DIURETICS/

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 901

    THIAZIDES INHIBIT REABSORPTION OF SODIUM &...CHLORIDE IN DISTAL SEGMENT. ... AS CLASS...HAVE IMPORTANT ACTION ON EXCRETION OF POTASSIUM THAT RESULTS FROM INCR SECRETION OF CATION BY DISTAL TUBULE. ... GLOMERULAR FILTRATION RATE MAY BE REDUCED BY THIAZIDES, PARTICULARLY WITH IV ADMIN FOR EXPTL PURPOSES. /THIAZIDE DIURETICS/

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 901

    For more Mechanism of Action (Complete) data for BENDROFLUMETHIAZIDE (11 total), please visit the HSDB record page.

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    26-Feb-2021
    25-Mar-2025
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    DOSAGE - TABLET;ORAL - 5MG;40MG **Federal Reg...DOSAGE - TABLET;ORAL - 5MG;40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 18647

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    DOSAGE - TABLET;ORAL - 5MG;80MG **Federal Reg...DOSAGE - TABLET;ORAL - 5MG;80MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 18647

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    ABOUT THIS PAGE

    Looking for 73-48-3 / Bendroflumethiazide API manufacturers, exporters & distributors?

    Bendroflumethiazide manufacturers, exporters & distributors 1

    80

    PharmaCompass offers a list of Bendroflumethiazide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Bendroflumethiazide manufacturer or Bendroflumethiazide supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Bendroflumethiazide manufacturer or Bendroflumethiazide supplier.

    PharmaCompass also assists you with knowing the Bendroflumethiazide API Price utilized in the formulation of products. Bendroflumethiazide API Price is not always fixed or binding as the Bendroflumethiazide Price is obtained through a variety of data sources. The Bendroflumethiazide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Bendroflumethiazide

    Synonyms

    Bendrofluazide, 73-48-3, Naturetin, Aprinox, Benzhydroflumethiazide, Benzylrodiuran

    Cas Number

    73-48-3

    Unique Ingredient Identifier (UNII)

    5Q52X6ICJI

    About Bendroflumethiazide

    A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)

    Bendroflumethiazide Manufacturers

    A Bendroflumethiazide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Bendroflumethiazide, including repackagers and relabelers. The FDA regulates Bendroflumethiazide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Bendroflumethiazide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Bendroflumethiazide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Bendroflumethiazide Suppliers

    A Bendroflumethiazide supplier is an individual or a company that provides Bendroflumethiazide active pharmaceutical ingredient (API) or Bendroflumethiazide finished formulations upon request. The Bendroflumethiazide suppliers may include Bendroflumethiazide API manufacturers, exporters, distributors and traders.

    click here to find a list of Bendroflumethiazide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Bendroflumethiazide USDMF

    A Bendroflumethiazide DMF (Drug Master File) is a document detailing the whole manufacturing process of Bendroflumethiazide active pharmaceutical ingredient (API) in detail. Different forms of Bendroflumethiazide DMFs exist exist since differing nations have different regulations, such as Bendroflumethiazide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Bendroflumethiazide DMF submitted to regulatory agencies in the US is known as a USDMF. Bendroflumethiazide USDMF includes data on Bendroflumethiazide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Bendroflumethiazide USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Bendroflumethiazide suppliers with USDMF on PharmaCompass.

    Bendroflumethiazide CEP

    A Bendroflumethiazide CEP of the European Pharmacopoeia monograph is often referred to as a Bendroflumethiazide Certificate of Suitability (COS). The purpose of a Bendroflumethiazide CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Bendroflumethiazide EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Bendroflumethiazide to their clients by showing that a Bendroflumethiazide CEP has been issued for it. The manufacturer submits a Bendroflumethiazide CEP (COS) as part of the market authorization procedure, and it takes on the role of a Bendroflumethiazide CEP holder for the record. Additionally, the data presented in the Bendroflumethiazide CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Bendroflumethiazide DMF.

    A Bendroflumethiazide CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Bendroflumethiazide CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Bendroflumethiazide suppliers with CEP (COS) on PharmaCompass.

    Bendroflumethiazide WC

    A Bendroflumethiazide written confirmation (Bendroflumethiazide WC) is an official document issued by a regulatory agency to a Bendroflumethiazide manufacturer, verifying that the manufacturing facility of a Bendroflumethiazide active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Bendroflumethiazide APIs or Bendroflumethiazide finished pharmaceutical products to another nation, regulatory agencies frequently require a Bendroflumethiazide WC (written confirmation) as part of the regulatory process.

    click here to find a list of Bendroflumethiazide suppliers with Written Confirmation (WC) on PharmaCompass.

    Bendroflumethiazide NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Bendroflumethiazide as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Bendroflumethiazide API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Bendroflumethiazide as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Bendroflumethiazide and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Bendroflumethiazide NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Bendroflumethiazide suppliers with NDC on PharmaCompass.

    Bendroflumethiazide GMP

    Bendroflumethiazide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Bendroflumethiazide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Bendroflumethiazide GMP manufacturer or Bendroflumethiazide GMP API supplier for your needs.

    Bendroflumethiazide CoA

    A Bendroflumethiazide CoA (Certificate of Analysis) is a formal document that attests to Bendroflumethiazide's compliance with Bendroflumethiazide specifications and serves as a tool for batch-level quality control.

    Bendroflumethiazide CoA mostly includes findings from lab analyses of a specific batch. For each Bendroflumethiazide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Bendroflumethiazide may be tested according to a variety of international standards, such as European Pharmacopoeia (Bendroflumethiazide EP), Bendroflumethiazide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Bendroflumethiazide USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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