Find AVA6000 manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Ava6000, Ava-6000, Unii-7xpb9b6mua, 1841402-73-0, Schembl17345374
Molecular Formula
C41H44N4O14
Molecular Weight
816.8  g/mol
InChI Key
CNGRCGLLHXRRTQ-SXSFFGRISA-N
FDA UNII
7XPB9B6MUA

AVA6000
Fibroblast Activation Protein Alpha-activated Doxorubicin Prodrug AVA6000 is a prodrug of the anthracycline antineoplastic antibiotic doxorubicin composed of doxorubicin covalently bonded to the dipeptide N-(pyridine-4-carbonyl)-D-Ala-L-Pro, with potential antineoplastic activity. Upon administration, fibroblast activation protein alpha (FAP)-activated doxorubicin prodrug AVA6000 is hydrolyzed by FAP, which is overexpressed on cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME). Doxorubicin is released in the TME, and intercalates into DNA and interacts with topoisomerase II. This leads to an inhibition of DNA replication and repair, and prevents RNA and protein synthesis. By targeting the delivery of doxorubicin directly to the tumor, AVA6000 may result in less systemic toxicities. FAP, a membrane-bound protease, is overexpressed on CAFs in various tumors but minimally expressed on normal, healthy cells.
1 2D Structure

AVA6000

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(2R)-1-[(2S)-2-[[(2S,3S,4S,6R)-3-hydroxy-2-methyl-6-[[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]oxan-4-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]pyridine-4-carboxamide
2.1.2 InChI
InChI=1S/C41H44N4O14/c1-18(43-38(53)20-9-11-42-12-10-20)40(55)45-13-5-7-24(45)39(54)44-23-14-28(58-19(2)33(23)48)59-26-16-41(56,27(47)17-46)15-22-30(26)37(52)32-31(35(22)50)34(49)21-6-4-8-25(57-3)29(21)36(32)51/h4,6,8-12,18-19,23-24,26,28,33,46,48,50,52,56H,5,7,13-17H2,1-3H3,(H,43,53)(H,44,54)/t18-,19+,23+,24+,26+,28+,33-,41+/m1/s1
2.1.3 InChI Key
CNGRCGLLHXRRTQ-SXSFFGRISA-N
2.2 Other Identifiers
2.2.1 UNII
7XPB9B6MUA
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Ava6000

2. Ava-6000

3. Unii-7xpb9b6mua

4. 1841402-73-0

5. Schembl17345374

2.4 Create Date
2016-02-23
3 Chemical and Physical Properties
Molecular Weight 816.8 g/mol
Molecular Formula C41H44N4O14
XLogP31.9
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count15
Rotatable Bond Count10
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area271
Heavy Atom Count59
Formal Charge0
Complexity1630
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1841402-73-0 / AVA6000 API manufacturers, exporters & distributors?

AVA6000 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of AVA6000 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right AVA6000 manufacturer or AVA6000 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred AVA6000 manufacturer or AVA6000 supplier.

PharmaCompass also assists you with knowing the AVA6000 API Price utilized in the formulation of products. AVA6000 API Price is not always fixed or binding as the AVA6000 Price is obtained through a variety of data sources. The AVA6000 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

AVA6000

Synonyms

Ava-6000, Unii-7xpb9b6mua, 1841402-73-0, Schembl17345374

Cas Number

1841402-73-0

Unique Ingredient Identifier (UNII)

7XPB9B6MUA

About AVA6000

Fibroblast Activation Protein Alpha-activated Doxorubicin Prodrug AVA6000 is a prodrug of the anthracycline antineoplastic antibiotic doxorubicin composed of doxorubicin covalently bonded to the dipeptide N-(pyridine-4-carbonyl)-D-Ala-L-Pro, with potential antineoplastic activity. Upon administration, fibroblast activation protein alpha (FAP)-activated doxorubicin prodrug AVA6000 is hydrolyzed by FAP, which is overexpressed on cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME). Doxorubicin is released in the TME, and intercalates into DNA and interacts with topoisomerase II. This leads to an inhibition of DNA replication and repair, and prevents RNA and protein synthesis. By targeting the delivery of doxorubicin directly to the tumor, AVA6000 may result in less systemic toxicities. FAP, a membrane-bound protease, is overexpressed on CAFs in various tumors but minimally expressed on normal, healthy cells.

AVA6000 Manufacturers

A AVA6000 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of AVA6000, including repackagers and relabelers. The FDA regulates AVA6000 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. AVA6000 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

AVA6000 Suppliers

A AVA6000 supplier is an individual or a company that provides AVA6000 active pharmaceutical ingredient (API) or AVA6000 finished formulations upon request. The AVA6000 suppliers may include AVA6000 API manufacturers, exporters, distributors and traders.

AVA6000 GMP

AVA6000 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of AVA6000 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right AVA6000 GMP manufacturer or AVA6000 GMP API supplier for your needs.

AVA6000 CoA

A AVA6000 CoA (Certificate of Analysis) is a formal document that attests to AVA6000's compliance with AVA6000 specifications and serves as a tool for batch-level quality control.

AVA6000 CoA mostly includes findings from lab analyses of a specific batch. For each AVA6000 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

AVA6000 may be tested according to a variety of international standards, such as European Pharmacopoeia (AVA6000 EP), AVA6000 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (AVA6000 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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