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Chemistry

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Also known as: Crn04894, 2392970-97-5, Chembl5414447, N-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-6-(2-ethoxyphenyl)-3-[(2r)-2-ethyl-4-[1-(trifluoromethyl)cyclobutanecarbonyl]piperazin-1-yl]pyridine-2-carboxamide, Atumelnant [inn], Nr57fh6u1n
Molecular Formula
C33H42F3N5O3
Molecular Weight
613.7  g/mol
InChI Key
QJRFBKYETDVAJQ-ZEQKJWHPSA-N
FDA UNII
NR57FH6U1N

Atumelnant
Atumelnant is an orally bioavailable nonpeptide antagonist of the adrenocorticotropic hormone (ACTH) receptor (ACTHR; melanocortin receptor 2; MC2R), with potential steroid hormone production inhibitory activity. Upon oral administration, atumelnant competes with ACTH for receptor binding to MC2R in the adrenal cortex and inhibits ACTH signaling. This may inhibit the synthesis and secretion of steroid hormones. MC2R, a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors, plays a key role in adrenal steroidogenesis.
1 2D Structure

Atumelnant

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-6-(2-ethoxyphenyl)-3-[(2R)-2-ethyl-4-[1-(trifluoromethyl)cyclobutanecarbonyl]piperazin-1-yl]pyridine-2-carboxamide
2.1.2 InChI
InChI=1S/C33H42F3N5O3/c1-3-23-20-40(31(43)32(14-7-15-32)33(34,35)36)18-19-41(23)27-11-10-25(24-8-5-6-9-28(24)44-4-2)37-29(27)30(42)38-26-21-39-16-12-22(26)13-17-39/h5-6,8-11,22-23,26H,3-4,7,12-21H2,1-2H3,(H,38,42)/t23-,26-/m1/s1
2.1.3 InChI Key
QJRFBKYETDVAJQ-ZEQKJWHPSA-N
2.2 Other Identifiers
2.2.1 UNII
NR57FH6U1N
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Crn04894

2. 2392970-97-5

3. Chembl5414447

4. N-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-6-(2-ethoxyphenyl)-3-[(2r)-2-ethyl-4-[1-(trifluoromethyl)cyclobutanecarbonyl]piperazin-1-yl]pyridine-2-carboxamide

5. Atumelnant [inn]

6. Nr57fh6u1n

7. Schembl21700563

8. Gtpl13339

9. Qjrfbkyetdvajq-zeqkjwhpsa-n

10. Crn-0489

11. Bdbm50623115

12. Crn04894?

13. Ex-a10367

14. At43038

15. Compound 17h [pmid: 38628803]

16. Hy-158081

17. Cs-1038003

18. 2-pyridinecarboxamide, N-(3s)-1-azabicyclo[2.2.2]oct-3-yl-6-(2-ethoxyphenyl)-3-[(2r)-2-ethyl-4-[[1-(trifluoromethyl)cyclobutyl]carbonyl]-1-piperazinyl]-

19. N-(3s)-1-azabicyclo[2.2.2]oct-3-yl-6-(2-ethoxyphenyl)-3-[(2r)-2-ethyl-4-[[1-(trifluoromethyl)cyclobutyl]carbonyl]-1-piperazinyl]-2-pyridinecarboxamide

20. N-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-6-(2-ethoxyphenyl)-3-{(2r)-2-ethyl-4-[1-(trifluoromethyl)cyclobutane-1-carbonyl]piperazin-1-yl}pyridine-2-carboxamide

2.4 Create Date
2020-06-27
3 Chemical and Physical Properties
Molecular Weight 613.7 g/mol
Molecular Formula C33H42F3N5O3
XLogP35.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area78
Heavy Atom Count44
Formal Charge0
Complexity1020
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 2392970-97-5 / Atumelnant API manufacturers, exporters & distributors?

Atumelnant manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Atumelnant API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Atumelnant manufacturer or Atumelnant supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Atumelnant manufacturer or Atumelnant supplier.

PharmaCompass also assists you with knowing the Atumelnant API Price utilized in the formulation of products. Atumelnant API Price is not always fixed or binding as the Atumelnant Price is obtained through a variety of data sources. The Atumelnant Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Atumelnant

Synonyms

Crn04894, 2392970-97-5, Chembl5414447, N-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-6-(2-ethoxyphenyl)-3-[(2r)-2-ethyl-4-[1-(trifluoromethyl)cyclobutanecarbonyl]piperazin-1-yl]pyridine-2-carboxamide, Atumelnant [inn], Nr57fh6u1n

Cas Number

2392970-97-5

Unique Ingredient Identifier (UNII)

NR57FH6U1N

About Atumelnant

Atumelnant is an orally bioavailable nonpeptide antagonist of the adrenocorticotropic hormone (ACTH) receptor (ACTHR; melanocortin receptor 2; MC2R), with potential steroid hormone production inhibitory activity. Upon oral administration, atumelnant competes with ACTH for receptor binding to MC2R in the adrenal cortex and inhibits ACTH signaling. This may inhibit the synthesis and secretion of steroid hormones. MC2R, a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors, plays a key role in adrenal steroidogenesis.

Atumelnant Manufacturers

A Atumelnant manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Atumelnant, including repackagers and relabelers. The FDA regulates Atumelnant manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Atumelnant API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Atumelnant Suppliers

A Atumelnant supplier is an individual or a company that provides Atumelnant active pharmaceutical ingredient (API) or Atumelnant finished formulations upon request. The Atumelnant suppliers may include Atumelnant API manufacturers, exporters, distributors and traders.

Atumelnant GMP

Atumelnant Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Atumelnant GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Atumelnant GMP manufacturer or Atumelnant GMP API supplier for your needs.

Atumelnant CoA

A Atumelnant CoA (Certificate of Analysis) is a formal document that attests to Atumelnant's compliance with Atumelnant specifications and serves as a tool for batch-level quality control.

Atumelnant CoA mostly includes findings from lab analyses of a specific batch. For each Atumelnant CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Atumelnant may be tested according to a variety of international standards, such as European Pharmacopoeia (Atumelnant EP), Atumelnant JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Atumelnant USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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