Find Zunsemetinib manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

0

USDMF

0

CEP/COS

0

JDMF

0

EU WC

0

KDMF

0

NDC API

0

VMF

0

Listed Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

0

FDA Orange Book

0

Europe

0

Canada

0

Australia

0

South Africa

0

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

API/FDF Prices: Book a Demo

API REF. PRICE (USD/KG)

$
$ 0

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Regulatory FDF Prices

NA

MARKET PLACE

0

API

0

FDF

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Ati-450, Zunsemetinib [inn], Ati450, Cdd450, Zunsemetinib [usan], Cdd-450
Molecular Formula
C25H22ClF2N5O3
Molecular Weight
513.9  g/mol
InChI Key
FQPQMJULRZINPV-UHFFFAOYSA-N
FDA UNII
AX2VWG0ZCR

Zunsemetinib
Zunsemetinib is an orally bioavailable, small molecule inhibitor of mitogen-activated protein (MAP) kinase-activated protein kinase 2 (MAPKAPK2; MK2), with potential anti-inflammatory activity. Upon oral administration, zunsemetinib targets and binds to the p38MAPK-MK2 complex, thereby inhibiting the p38MAPK phosphorylation and activation of MK2. This inhibits p38MAPK/MK2-mediated inflammatory signaling pathway. This may result in the inhibition of the production of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1-alpha, IL-1-beta and IL-6.
1 2D Structure

Zunsemetinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-chloro-4-[(3,5-difluoropyridin-2-yl)methoxy]-1-[2-[2-(2-hydroxypropan-2-yl)pyrimidin-4-yl]-5-methylpyridin-4-yl]-6-methylpyridin-2-one
2.1.2 InChI
InChI=1S/C25H22ClF2N5O3/c1-13-10-30-18(17-5-6-29-24(32-17)25(3,4)35)9-20(13)33-14(2)7-21(22(26)23(33)34)36-12-19-16(28)8-15(27)11-31-19/h5-11,35H,12H2,1-4H3
2.1.3 InChI Key
FQPQMJULRZINPV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC(=C(C(=O)N1C2=CC(=NC=C2C)C3=NC(=NC=C3)C(C)(C)O)Cl)OCC4=C(C=C(C=N4)F)F
2.2 Other Identifiers
2.2.1 UNII
AX2VWG0ZCR
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Ati-450

2. Zunsemetinib [inn]

3. Ati450

4. Cdd450

5. Zunsemetinib [usan]

6. Cdd-450

7. Ax2vwg0zcr

8. (1(2h),4'-bipyridin)-2-one, 3-chloro-4-((3,5-difluoro-2-pyridinyl)methoxy)-2'-(2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl)-5',6-dimethyl-, (-)-

9. (p)-3-chloro-4-((3,5-difluoropyridin-2-yl)methoxy)-2'-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5',6-dimethyl-2h-(1,4'-bipyridin)-2-one

10. 1640282-42-3

11. Unii-ax2vwg0zcr

12. Zunsemetinib [usan:inn]

13. Ati 450

14. Ati 450 [who-dd]

15. Chembl3704901

16. Schembl16279876

17. Gtpl11681

18. Bdbm175242

19. Ex-a6292

20. Who 11983

21. Hy-139553

22. Cs-0204147

23. Us9115089, 49

24. 1639791-42-6

25. 3-chloro-4-[(3,5-difluoropyridin-2-yl)methoxy]-1-[2-[2-(2-hydroxypropan-2-yl)pyrimidin-4-yl]-5-methylpyridin-4-yl]-6-methylpyridin-2-one

2.4 Create Date
2014-12-22
3 Chemical and Physical Properties
Molecular Weight 513.9 g/mol
Molecular Formula C25H22ClF2N5O3
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area101
Heavy Atom Count36
Formal Charge0
Complexity888
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Looking for 1639791-42-6 / Zunsemetinib API manufacturers, exporters & distributors?

Zunsemetinib manufacturers, exporters & distributors 1

27

PharmaCompass offers a list of Zunsemetinib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Zunsemetinib manufacturer or Zunsemetinib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Zunsemetinib manufacturer or Zunsemetinib supplier.

PharmaCompass also assists you with knowing the Zunsemetinib API Price utilized in the formulation of products. Zunsemetinib API Price is not always fixed or binding as the Zunsemetinib Price is obtained through a variety of data sources. The Zunsemetinib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Zunsemetinib

Synonyms

Ati-450, Zunsemetinib [inn], Ati450, Cdd450, Zunsemetinib [usan], Cdd-450

Cas Number

1639791-42-6

Unique Ingredient Identifier (UNII)

AX2VWG0ZCR

About Zunsemetinib

Zunsemetinib is an orally bioavailable, small molecule inhibitor of mitogen-activated protein (MAP) kinase-activated protein kinase 2 (MAPKAPK2; MK2), with potential anti-inflammatory activity. Upon oral administration, zunsemetinib targets and binds to the p38MAPK-MK2 complex, thereby inhibiting the p38MAPK phosphorylation and activation of MK2. This inhibits p38MAPK/MK2-mediated inflammatory signaling pathway. This may result in the inhibition of the production of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1-alpha, IL-1-beta and IL-6.

Ati 450 Manufacturers

A Ati 450 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ati 450, including repackagers and relabelers. The FDA regulates Ati 450 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ati 450 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ati 450 Suppliers

A Ati 450 supplier is an individual or a company that provides Ati 450 active pharmaceutical ingredient (API) or Ati 450 finished formulations upon request. The Ati 450 suppliers may include Ati 450 API manufacturers, exporters, distributors and traders.

Ati 450 GMP

Ati 450 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ati 450 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ati 450 GMP manufacturer or Ati 450 GMP API supplier for your needs.

Ati 450 CoA

A Ati 450 CoA (Certificate of Analysis) is a formal document that attests to Ati 450's compliance with Ati 450 specifications and serves as a tool for batch-level quality control.

Ati 450 CoA mostly includes findings from lab analyses of a specific batch. For each Ati 450 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ati 450 may be tested according to a variety of international standards, such as European Pharmacopoeia (Ati 450 EP), Ati 450 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ati 450 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty