Find Aprocitentan manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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JDMF

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EU WC

EU WC

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KDMF

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NDC API

NDC API

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VMF

NDC API

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EDQM

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USP

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JP

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Chemistry

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Also known as: 1103522-45-7, Act-132577, Aprocitentan [usan], Macitentan metabolite m6, Mzi81hv01p, 5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine
Molecular Formula
C16H14Br2N6O4S
Molecular Weight
546.2  g/mol
InChI Key
DKULOVKANLVDEA-UHFFFAOYSA-N
FDA UNII
MZI81HV01P

Aprocitentan
Aprocitentan is under investigation in clinical trial NCT03541174 (A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety).
1 2D Structure

Aprocitentan

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine
2.1.2 InChI
InChI=1S/C16H14Br2N6O4S/c17-11-3-1-10(2-4-11)13-14(24-29(19,25)26)22-9-23-15(13)27-5-6-28-16-20-7-12(18)8-21-16/h1-4,7-9H,5-6H2,(H2,19,25,26)(H,22,23,24)
2.1.3 InChI Key
DKULOVKANLVDEA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=CC=C1C2=C(N=CN=C2OCCOC3=NC=C(C=N3)Br)NS(=O)(=O)N)Br
2.2 Other Identifiers
2.2.1 UNII
MZI81HV01P
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Act-132577

2. N-(5-(4-bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfuric Diamide

3. Sulfamide, N-(5-(4-bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-

2.3.2 Depositor-Supplied Synonyms

1. 1103522-45-7

2. Act-132577

3. Aprocitentan [usan]

4. Macitentan Metabolite M6

5. Mzi81hv01p

6. 5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine

7. Chembl2165326

8. Chebi:76609

9. N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]sulfuric Diamide

10. N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]sulfamide

11. Sulfamide, N-(5-(4-bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-

12. Despropyl Macitentan

13. N-despropyl-macitentan

14. Unii-mzi81hv01p

15. N-(5-(4-bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfamide

16. N-(5-(4-bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)sulfuric Diamide

17. Act 132577

18. Aprocitentan (usan/inn)

19. Aprocitentan [inn]

20. Schembl3646065

21. Aprocitentan (act-132577)

22. Gtpl10070

23. Amy39078

24. Bcp28125

25. Ex-a4419

26. Bdbm50395672

27. Who 10552

28. Zinc95553608

29. Db15059

30. Ncgc00378592-01

31. Ac-36529

32. As-82256

33. Hy-15895

34. Db-130379

35. D11441

36. D87138

37. A922313

38. Q27146161

39. Act-132577; Act 132577; Act132577

40. 5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine.

41. N-(5-(4-bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-sulfamide

42. N-(5-(4-bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfuric Diamide

43. N-(5-(4-bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)sulfamide

2.4 Create Date
2008-12-15
3 Chemical and Physical Properties
Molecular Weight 546.2 g/mol
Molecular Formula C16H14Br2N6O4S
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Exact Mass545.91435 g/mol
Monoisotopic Mass543.91640 g/mol
Topological Polar Surface Area151 Ų
Heavy Atom Count29
Formal Charge0
Complexity597
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of hypertension


API SUPPLIERS

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01

HRV Global Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothHRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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HRV Global Life Sciences

02

Lee Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Arvo
Not Confirmed
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Lee Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Arvo
Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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Honour Lab

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Arvo
Not Confirmed
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Honour Lab

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Arvo
Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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04

Apino Pharma

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Arvo
Not Confirmed
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Listed Suppliers

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01

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothHRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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Digital Content Digital Content

Aprocitentan

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.
HRV Global Life Sciences

02

Apino Pharma

China
American Thoracic Society
Not Confirmed
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Apino Pharma

China
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American Thoracic Society
Not Confirmed

Aprocitentan

About the Company : Apino Pharma prides itself on being an innovation-driven company that strives to continuously improve its products and services. Our dedicated innovation team collaborates with the...

Apino Pharma prides itself on being an innovation-driven company that strives to continuously improve its products and services. Our dedicated innovation team collaborates with the world’s leading research institutes and universities to develop cutting-edge formulations and technologies that bring value to our customers. We are committed to exploring new opportunities presented by technology, science and global best practices to provide quality products and services that meet and exceed our customers’ needs.
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03

Honour Lab

India
American Thoracic Society
Not Confirmed
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Honour Lab

India
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American Thoracic Society
Not Confirmed

Aprocitentan

About the Company : Honour is a leading global Contract Development and Manufacturing Organization (CDMO) as well as a manufacturer of specialty chemicals and ingredients, operating six facilities tha...

Honour is a leading global Contract Development and Manufacturing Organization (CDMO) as well as a manufacturer of specialty chemicals and ingredients, operating six facilities that adhere to international standards of safety and quality. Through our offerings, Honour Synthesis and Honour Specialty, we are committed to fostering partnerships and exploring new possibilities. Our team of over 2,000 professionals delivers exceptional service to our pharmaceutical and biotechnology partners by providing practical solutions.
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04

Lee Pharma

India
American Thoracic Society
Not Confirmed
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Lee Pharma

India
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American Thoracic Society
Not Confirmed

Aprocitentan

About the Company : Founded in 1997, Lee Pharma Limited has transformed from a small venture into a global leader in the pharmaceutical industry. Our journey began with a commitment to providing affor...

Founded in 1997, Lee Pharma Limited has transformed from a small venture into a global leader in the pharmaceutical industry. Our journey began with a commitment to providing affordable and high-quality healthcare solutions. Through advanced research, modern manufacturing, and a strong emphasis on quality, we are dedicated to producing medicines that enhance lives. Lee Pharma is a research-focused company that prioritizes the development, synthesis, and commercialization of high-quality Active Pharmaceutical Ingredients (APIs), intermediate chemicals, and finished formulations.
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05

Nifty Labs

India
American Thoracic Society
Not Confirmed
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Nifty Labs

India
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American Thoracic Society
Not Confirmed

Aprocitentan

About the Company : The company was founded by a technocrat Mr. D. Kesava Reddy in the year 2005. The Managing Director Mr. D. Kesava Reddy along with other three Board of Directors involved in contro...

The company was founded by a technocrat Mr. D. Kesava Reddy in the year 2005. The Managing Director Mr. D. Kesava Reddy along with other three Board of Directors involved in controlling the day to day operations of the company. The company has been focused on manufacturing and marketing of Bulk APIs (Bulk Drugs) and key Intermediates for APIs for Domestic and Global markets. About 60% is catered to domestic market and the rest 40% is catered to exports. The company does have a sister company named “Nifty Pharma Pvt. Ltd. located in Hyderabad focused on manufacturing & marketing of Semi-finished dosage forms.
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API Reference Price

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[{"dataSource":"API Import","activeIngredients":"APROCITENTAN","year":"2021","qtr":"Q1","strtotime":1616697000,"product":"(N.C.V) APROCITENTAN JNJ-68212820-AAA R.S,SULFAMIDE,N-[5-(4-BROMOPHENYL)-6-[2-[(5-BROMO-2-PYRIMIDINYL)OXY]ETHOXY]-4-PYRI","address":"30 FORJETT STREETPOST BOX NO 9301","city":"MUMBAI, MAHARASHTRA.","supplier":"JOHNSON & JOHNSON","supplierCountry":"UNITED STATES","foreign_port":"BRUSSELS","customer":"JOHNSON & JOHNSON","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"286","totalValueFC":"1733.4","currency":"EUR","unitRateINR":"25239.5","date":"26-Mar-2021","totalValueINR":"126197.5","totalValueInUsd":"1733.4","indian_port":"BOMBAY AIR","hs_no":"29339990","bill_no":"3310601","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BRUSSELS","supplierAddress":"","customerAddress":"30 FORJETT STREETPOST BOX NO 9301"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1627929000,"product":"(N.C.V)APROCITENTAN (JNJ-68212820-AAA, ACT-132577)REF.STD SULFAMIDE,N-[5-(4-BROMOPHENYL)-6-[2-[(5-BROMO-2-PYRIMIDINYL) O","address":"30 FORJETT STREETPOST BOX NO 9301","city":"MUMBAI, MAHARASHTRA.","supplier":"JOHNSON & JOHNSON","supplierCountry":"UNITED STATES","foreign_port":"BRUSSELS","customer":"JOHNSON & JOHNSON","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"3","unit":"GMS","unitRateFc":"286","totalValueFC":"1038.8","currency":"EUR","unitRateINR":"25682.8","date":"03-Aug-2021","totalValueINR":"77048.4","totalValueInUsd":"1038.8","indian_port":"BOMBAY AIR","hs_no":"29335990","bill_no":"4916657","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BRUSSELS","supplierAddress":"","customerAddress":"30 FORJETT STREETPOST BOX NO 9301"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1628620200,"product":"(N.C.V) INTERMEDIATE OF APROCITENTAN (JNJ-69102462-AAA, ACT-283437) PYRIMIDINE,5-(4-BROMOPHENYL)-4[2[(5-BROMO-2-PYRIMIDI","address":"30 FORJETT STREETPOST BOX NO 9301","city":"MUMBAI, MAHARASHTRA.","supplier":"JOHNSON & JOHNSON","supplierCountry":"SWITZERLAND","foreign_port":"BRUSSELS","customer":"JOHNSON & JOHNSON","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.2","unit":"GMS","unitRateFc":"286","totalValueFC":"69","currency":"EUR","unitRateINR":"25582.7","date":"11-Aug-2021","totalValueINR":"5116.54","totalValueInUsd":"69","indian_port":"BOMBAY AIR","hs_no":"29335990","bill_no":"5012815","productDescription":"Intermediate","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"BRUSSELS","supplierAddress":"","customerAddress":"30 FORJETT STREETPOST BOX NO 9301"}]
26-Mar-2021
11-Aug-2021
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01

IDORSIA

Switzerland
AAPS National Biotech
Not Confirmed
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IDORSIA

Switzerland
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AAPS National Biotech
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APROCITENTAN

Brand Name : TRYVIO

Dosage Form : TABLET;ORAL

Dosage Strength : 12.5MG

Approval Date : 2024-03-19

Application Number : 217686

RX/OTC/DISCN : RX

RLD : Yes

TE Code :

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Patents & EXCLUSIVITIES

Check the patents & exclusivity for this product

US Patents

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01

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Arvo
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IDORSIA

Switzerland
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Arvo
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APROCITENTAN

US Patent Number : 11174247

Drug Substance Claim :

Drug Product Claim :

Application Number : 217686

Patent Use Code : U-3879

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2037-11-06

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02

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Arvo
Not Confirmed

IDORSIA

Switzerland
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Arvo
Not Confirmed

APROCITENTAN

US Patent Number : 8324232

Drug Substance Claim : Y

Drug Product Claim : Y

Application Number : 217686

Patent Use Code : U-3878

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2029-09-21

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03

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Arvo
Not Confirmed

IDORSIA

Switzerland
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Arvo
Not Confirmed

APROCITENTAN

US Patent Number : 10919881

Drug Substance Claim : Y

Drug Product Claim : Y

Application Number : 217686

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2038-02-26

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04

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Arvo
Not Confirmed

IDORSIA

Switzerland
arrow
Arvo
Not Confirmed

APROCITENTAN

US Patent Number : 11787782

Drug Substance Claim :

Drug Product Claim :

Application Number : 217686

Patent Use Code : U-3877

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2038-03-02

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05

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Arvo
Not Confirmed

IDORSIA

Switzerland
arrow
Arvo
Not Confirmed

APROCITENTAN

US Patent Number : 11680058

Drug Substance Claim :

Drug Product Claim :

Application Number : 217686

Patent Use Code : U-3878

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2038-07-26

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ABOUT THIS PAGE

Looking for 1103522-45-7 / Aprocitentan API manufacturers, exporters & distributors?

Aprocitentan manufacturers, exporters & distributors 1

83

PharmaCompass offers a list of Aprocitentan API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Aprocitentan manufacturer or Aprocitentan supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Aprocitentan manufacturer or Aprocitentan supplier.

PharmaCompass also assists you with knowing the Aprocitentan API Price utilized in the formulation of products. Aprocitentan API Price is not always fixed or binding as the Aprocitentan Price is obtained through a variety of data sources. The Aprocitentan Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Aprocitentan

Synonyms

1103522-45-7, Act-132577, Aprocitentan [usan], Macitentan metabolite m6, Mzi81hv01p, 5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine

Cas Number

1103522-45-7

Unique Ingredient Identifier (UNII)

MZI81HV01P

About Aprocitentan

Aprocitentan is under investigation in clinical trial NCT03541174 (A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety).

Aprocitentan Manufacturers

A Aprocitentan manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Aprocitentan, including repackagers and relabelers. The FDA regulates Aprocitentan manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Aprocitentan API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Aprocitentan manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Aprocitentan Suppliers

A Aprocitentan supplier is an individual or a company that provides Aprocitentan active pharmaceutical ingredient (API) or Aprocitentan finished formulations upon request. The Aprocitentan suppliers may include Aprocitentan API manufacturers, exporters, distributors and traders.

click here to find a list of Aprocitentan suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Aprocitentan GMP

Aprocitentan Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Aprocitentan GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Aprocitentan GMP manufacturer or Aprocitentan GMP API supplier for your needs.

Aprocitentan CoA

A Aprocitentan CoA (Certificate of Analysis) is a formal document that attests to Aprocitentan's compliance with Aprocitentan specifications and serves as a tool for batch-level quality control.

Aprocitentan CoA mostly includes findings from lab analyses of a specific batch. For each Aprocitentan CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Aprocitentan may be tested according to a variety of international standards, such as European Pharmacopoeia (Aprocitentan EP), Aprocitentan JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Aprocitentan USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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