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Also known as: 2321-07-5, Solvent yellow 94, Resorcinolphthalein, Yellow fluorescein, Fluoresceine, 3',6'-dihydroxy-3h-spiro[isobenzofuran-1,9'-xanthen]-3-one
Molecular Formula
C20H12O5
Molecular Weight
332.3  g/mol
InChI Key
GNBHRKFJIUUOQI-UHFFFAOYSA-N
FDA UNII
TPY09G7XIR

Fluorescein
A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.
Fluorescein is a Diagnostic Dye. The mechanism of action of fluorescein is as a Dye.
1 2D Structure

Fluorescein

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
2.1.2 InChI
InChI=1S/C20H12O5/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,21-22H
2.1.3 InChI Key
GNBHRKFJIUUOQI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C2C(=C1)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O
2.2 Other Identifiers
2.2.1 UNII
TPY09G7XIR
2.3 Synonyms
2.3.1 MeSH Synonyms

1. C.i. 45350

2. Colircusi Fluoresceina

3. D And C Yellow No. 7

4. D And C Yellow No. 8

5. Diofluor

6. Dipotassium Salt, Fluorescein

7. Disodium Fluorescein

8. Disodium Salt, Fluorescein

9. Fluor I Strip A.t.

10. Fluor-i-strip A.t.

11. Fluorescine Sodique Faure

12. Fluorescein Dipotassium Salt

13. Fluorescein Disodium Salt

14. Fluorescein Monosodium Salt

15. Fluorescein Sodium, Minims

16. Fluorescein, Disodium

17. Fluorescein, Sodium

18. Fluoresceina, Colircusi

19. Fluoresceine, Minims

20. Fluorescite

21. Fluorets

22. Ful Glo

23. Ful-glo

24. Funduscein

25. Minims Fluorescein Sodium

26. Minims Fluoresceine

27. Minims Stains

28. Monosodium Salt, Fluorescein

29. Optifluor Diba

30. Sodium Fluorescein

31. Sodium, Fluorescein

32. Uranine

2.3.2 Depositor-Supplied Synonyms

1. 2321-07-5

2. Solvent Yellow 94

3. Resorcinolphthalein

4. Yellow Fluorescein

5. Fluoresceine

6. 3',6'-dihydroxy-3h-spiro[isobenzofuran-1,9'-xanthen]-3-one

7. 3,6-fluorandiol

8. D&c Yellow No. 7

9. Japan Yellow 201

10. D And C Yellow No. 7

11. C.i. Solvent Yellow 94

12. 3',6'-dihydroxyfluoran

13. Fluorescein Acid

14. Fluoreszein

15. Soap Yellow F

16. Hidacid Fluorescein

17. Resorcinol Phthalein

18. D & C Yellow No. 7

19. D+c Yellow No. 7

20. 9-(o-carboxyphenyl)-6-hydroxy-3-isoxanthenone

21. Fluorescein (free Acid)

22. 11712 Yellow

23. Chebi:31624

24. 9-(o-carboxyphenyl)-6-hydroxy-3h-xanthen-3-one

25. Japan Yellow No. 201

26. Zlut Kysela 73

27. 3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one

28. Fluoran, 3',6'-dihydroxy-

29. Nsc 667256

30. 3',6'-fluorandiol

31. C.i. 45350:1

32. Mfcd00005050

33. Tpy09g7xir

34. Spiro[isobenzofuran-1(3h),9'-[9h]xanthen]-3-one, 3',6'-dihydroxy-

35. Chembl1057

36. Ci 45350:1

37. 3h-xanthen-3-one, 9-(o-carboxyphenyl)-6-hydroxy-

38. Nsc667256

39. Benzoic Acid, O-(6-hydroxy-3-oxo-3h-xanthen-9-yl)-

40. Nsc-667256

41. Nsc-759114

42. Benzoic Acid, 2-(6-hydroxy-3-oxo-3h-xanthen-9-yl)-

43. Ncgc00161643-03

44. 3',6'-dihydroxyspiro(isobenzofuran-1(3h),9'(9h)-xanthen)-3-one

45. 3',6'-dihydroxyspiro(isobenzofuran-1(3h),9'-(9h)xanthen)-3-one

46. Spiro(isobenzofuran-1(3h),9'-(9h)xanthen)-3-one, 3',6'-dihydroxy-

47. 3,6-dihydroxyspiro(xanthene-9,3'-phthalide)

48. Dsstox_cid_18887

49. Dsstox_rid_79416

50. Dsstox_gsid_38887

51. 3',6'-dihydroxy-3h-spiro[2-benzofuran-1,9'-xanthen]-3-one

52. Fluorescein Red

53. Cas-2321-07-5

54. 3,6-dihydroxyspiro[xanthene-9,3'-phthalide]

55. Zlut Kysela 73 [czech]

56. Fluorecein

57. Diofluor

58. Ccris 7076

59. Hsdb 2128

60. Fluorescite (tn)

61. Diresorcinolphthalein

62. Einecs 219-031-8

63. Brn 0094324

64. Fluorescite (salt/mix)

65. 3',6' Dihydroxyfluoran

66. Fluorescein (jan/usp)

67. Fluorescein [ii]

68. Fluorescein [mi]

69. Unii-tpy09g7xir

70. Fluorescein [jan]

71. Fluorescein [hsdb]

72. Epitope Id:137337

73. Upcmld-dp087

74. Yellow 7 [inci]

75. Fluorescein [vandf]

76. Fluorescein [mart.]

77. Schembl16533

78. Fluorescein [usp-rs]

79. Fluorescein [who-dd]

80. Fluorescein [usp:ban:jan]

81. Ki201 [inci]

82. Dtxsid0038887

83. Upcmld-dp087:001

84. Acid Yellow 73 [inci]

85. Gnbhrkfjiuuoqi-uhfffaoysa-

86. Fluorescein (solvent Yellow 94)

87. C.i. 45350 (salt/mix)

88. Fluorescein [ep Monograph]

89. Hms2093f21

90. Hms3744c17

91. Moli001003

92. Pharmakon1600-01505396

93. Fluorescein [usp Monograph]

94. Amy22388

95. Hy-d0251

96. Zinc3860453

97. Tox21_113500

98. Tox21_303508

99. Bdbm50237588

100. C.i. Acid Yellow 73 (salt/mix)

101. Nsc759114

102. S5488

103. Spiro(isobenzofuran-1(3h),9'-(9h)xanthen)-3-one,3'6'-dihydroxy-

104. Akos015903296

105. Ccg-213417

106. Cs-7537

107. Db00693

108. C.i. 45350a

109. Fluorescein, For Fluorescence, Free Acid

110. Ncgc00161643-01

111. Ncgc00161643-02

112. Ncgc00257491-01

113. D & C Yellow No. 7 K7133

114. Sy012645

115. Sbi-0206827.p001

116. F0095

117. Fluorescein (free Acid), Dye Content 95 %

118. Ft-0668579

119. D01261

120. D70685

121. Ec 219-031-8

122. Ab00643381_02

123. 5-19-06-00456 (beilstein Handbook Reference)

124. Q410922

125. Sr-05000001696

126. Sr-05000001696-1

127. W-107417

128. Brd-k21913543-001-01-6

129. 3',6'-dihydroxyspiro[isobenzofuran-3,9'-xanthene]-1-one

130. E89fa0b4-4844-46a2-af9b-29eca50e5599

131. Fluorescein, European Pharmacopoeia (ep) Reference Standard

132. 3',6'-dihydroxy-3h-spiro[isobenzo[b]furan-1,9'-xanthen]-3-one

133. Fluorescein, United States Pharmacopeia (usp) Reference Standard

134. Fluorescein Low Range Dna Standard, Fluorescein-labeled Marker For Dna Electrophoresis

135. Spiro[isobenzofuran-1(3h),9'-[9h]xanthene]-ar-carboxylicacid, 3',6'-dihydroxy-3-oxo-

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 332.3 g/mol
Molecular Formula C20H12O5
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Exact Mass332.06847348 g/mol
Monoisotopic Mass332.06847348 g/mol
Topological Polar Surface Area76 Ų
Heavy Atom Count25
Formal Charge0
Complexity522
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameFluorescite
PubMed HealthFluorescein (Injection)
Drug ClassesDisclosing Agent
Drug LabelFLUORESCITE (fluorescein injection, USP) 10% contains fluorescein sodium (equivalent to fluorescein 10% w/v). It is a sterile solution for use intravenously as a diagnostic aid. Its chemical name is spiro[isobenzofuran-1(3H), 9'-[9H]xanthene]-3-one..
Active IngredientFluorescein sodium
Dosage FormInjectable
RouteIntravenous
Strengtheq 500mg base/5ml (eq 100mg base/ml)
Market StatusPrescription
CompanyAlcon Pharms

2 of 2  
Drug NameFluorescite
PubMed HealthFluorescein (Injection)
Drug ClassesDisclosing Agent
Drug LabelFLUORESCITE (fluorescein injection, USP) 10% contains fluorescein sodium (equivalent to fluorescein 10% w/v). It is a sterile solution for use intravenously as a diagnostic aid. Its chemical name is spiro[isobenzofuran-1(3H), 9'-[9H]xanthene]-3-one..
Active IngredientFluorescein sodium
Dosage FormInjectable
RouteIntravenous
Strengtheq 500mg base/5ml (eq 100mg base/ml)
Market StatusPrescription
CompanyAlcon Pharms

4.2 Therapeutic Uses

Contrast Medium

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


VET: Deep corneal ulcers, descemetocele, and iris prolapse are seen with some frequency in dogs, cats, and horses. ... Important diagnostic aids are the Schirmer tear test to measure aqueous tear production and topical fluorescein to examine the corneal ulcer. ...

Kahn, C.M. (Ed.); The Merck Veterinary Manual 9th ed. Merck & Co. Whitehouse Station, NJ. 2005, p. 1416


Fluorescein is now sometimes used for determination of circulation time, adequacy of blood supply, and viability of tissue.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1004


In determination of circulation time, ... by rapid iv ... appearance of fluorescence in lips, eyes, or intact skin or in wheals (histamine or scratch) ... is taken as end point.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1004


Measurement of arm-to-retina circulation time is employed for diagnosis of carotid artery occlusion.

American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 985


4.3 Drug Warning

Adverse effects following topical administration to the eye may include irritation and rash. Fluorescein may cause yellow discoloration of skin or eyes. urine may attain a bright yellow color. Adverse effects following intravenous administration include nausea, vomiting, headache, dizziness, fainting, and low blood pressure.

United States Pharmacopeial Convention, Inc (USP); MSDS Database Online; Material Safety Data Sheet: Fluorescein; Catalog Number: 1277004; (Revision Date: January 31, 2005)


4.4 Drug Indication

For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Contrast Media

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)


Fluorescent Dyes

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)


5.2 FDA Pharmacological Classification
5.2.1 Active Moiety
FLUORESCEIN
5.2.2 FDA UNII
TPY09G7XIR
5.2.3 Pharmacological Classes
Dyes [MoA]; Diagnostic Dye [EPC]
5.3 ATC Code

S01JA01

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


S - Sensory organs

S01 - Ophthalmologicals

S01J - Diagnostic agents

S01JA - Colouring agents

S01JA01 - Fluorescein


5.4 Absorption, Distribution and Excretion

Absorption

Rapidly distributed


Route of Elimination

Fluorescein and its metabolites are mainly eliminated via renal excretion.


Volume of Distribution

0.5 L/kg


Clearance

renal cl=1.75 mL/min/kg [After IV administration]

hepatic cl=1.50 mL/min/kg [After IV administration]


Fluorescence of skin persists for several hr, and dye appears in urine for as long as 30 hr.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1004


Within 7 to 14 seconds after IV administration into antecubital vein, fluorescein usually appears in the central artery of the eye. Within a few minutes of IV administration of fluorescein sodium, a yellowish discoloration of the skin occurs, which begins to fade after 6 to 12 hours of dosing. Various estimates of volume of distribution indicate that fluorescein distributes well into interstitial space (0.5 L/ kg).

US Natl Inst Health; DailyMed. Current Medication Information for Fluorescite (fluorescein sodium) injection, solution (2009). Available from, as of October 19, 2009: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Fluorescein+sodium


Fluorescein and its metabolites are mainly eliminated via renal excretion. After IV administration, the urine remains slightly fluorescent for 24 to 36 hours. A renal clearance of 1.75 mL/min/kg and a hepatic clearance (due to conjugation) of 1.50 mL/min/kg have been estimated. The systemic clearance of fluorescein was essentially complete by 48 to 72 hours after administration of 500 mg fluorescein.

US Natl Inst Health; DailyMed. Current Medication Information for Fluorescite (fluorescein sodium) injection, solution (2009). Available from, as of October 19, 2009: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Fluorescein+sodium


Fluorescein sodium has been demonstrated to be excreted in human milk.

US Natl Inst Health; DailyMed. Current Medication Information for Fluorescite (fluorescein sodium) injection, solution (2009). Available from, as of October 19, 2009: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Fluorescein+sodium


The permeability of the blood-retinal and blood-aqueous barriers to fluorescein and the rate of aqueous flow can be estimated by measurements of fluorescein in the vitreous, aqueous, and plasma after systemic administration. Fluorescein is commonly measured by fluorescence, but fluorescein glucuronide, a metabolite of fluorescein, also fluoresces. To assess the influence of fluorescein glucuronide on the quantitation of fluorescein by fluorescence, we studied the pharmacokinetics of fluorescein and fluorescein glucuronide for 38 hr in the plasma of five normal subjects given 14 mg/kg of sodium fluorescein intravenously. The plasma and the plasma ultrafiltrate were measured by fluorescence and by high performance liquid chromatography. In our fluorophotometer, fluorescein glucuronide was 0.124 times as fluorescent as fluorescein. Fluorescein was rapidly converted to fluorescein glucuronide, and within 10 min the concentration of unbound fluorescein glucuronide exceeded that of unbound fluorescein. The terminal half-lives of fluorescein and fluorescein glucuronide in the plasma ultrafiltrate were 23.5 and 264 min, respectively, so that fluorescein glucuronide contributed almost all of the plasma fluorescence after 4-5 hr. Because fluorescein glucuronide was less bound in the plasma than fluorescein, the ratio of the fluorescence of the plasma ultrafiltrate to that of the plasma increased with time. The greatest proportion of the total fluorescein available to penetrate into the ocular compartments occurred shortly after injection. ...

PMID:3721789 Blair NP et al; Invest Ophthalmol Vis Sci 27 (7): 1107-14 (1986).


5.5 Metabolism/Metabolites

The permeability of the blood-retinal and blood-aqueous barriers to fluorescein and the rate of aqueous flow can be estimated by measurements of fluorescein in the vitreous, aqueous, and plasma after systemic administration. Fluorescein is commonly measured by fluorescence, but fluorescein glucuronide, a metabolite of fluorescein, also fluoresces. To assess the influence of fluorescein glucuronide on the quantitation of fluorescein by fluorescence, we studied the pharmacokinetics of fluorescein and fluorescein glucuronide for 38 hr in the plasma of five normal subjects given 14 mg/kg of sodium fluorescein intravenously. The plasma and the plasma ultrafiltrate were measured by fluorescence and by high performance liquid chromatography. In our fluorophotometer, fluorescein glucuronide was 0.124 times as fluorescent as fluorescein. Fluorescein was rapidly converted to fluorescein glucuronide, and within 10 min the concentration of unbound fluorescein glucuronide exceeded that of unbound fluorescein. The terminal half-lives of fluorescein and fluorescein glucuronide in the plasma ultrafiltrate were 23.5 and 264 min, respectively, so that fluorescein glucuronide contributed almost all of the plasma fluorescence after 4-5 hr. Because fluorescein glucuronide was less bound in the plasma than fluorescein, the ratio of the fluorescence of the plasma ultrafiltrate to that of the plasma increased with time. The greatest proportion of the total fluorescein available to penetrate into the ocular compartments occurred shortly after injection. ...

PMID:3721789 Blair NP et al; Invest Ophthalmol Vis Sci 27 (7): 1107-14 (1986).


Fluorescein undergoes rapid metabolism to fluorescein monoglucuronide. After IV administration of fluorescein sodium (14 mg/kg) to 7 healthy subjects, approximately 80% of fluorescein in plasma was converted to glucuronide conjugate after a period of 1 hour post dose, indicating relatively rapid conjugation.

US Natl Inst Health; DailyMed. Current Medication Information for Fluorescite (fluorescein sodium) injection, solution (2009). Available from, as of October 19, 2009: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Fluorescein+sodium


Fluorescein is a known human metabolite of zinc15020070.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


5.6 Biological Half-Life

... The pharmacokinetics of fluorescein and fluorescein glucuronide /were studied/ for 38 hr in the plasma of five normal subjects given 14 mg/kg of sodium fluorescein intravenously. ... The terminal half-lives of fluorescein and fluorescein glucuronide in the plasma ultrafiltrate were 23.5 and 264 min, respectively, ... .

PMID:3721789 Blair NP et al; Invest Ophthalmol Vis Sci 27 (7): 1107-14 (1986).


5.7 Mechanism of Action

Fluorescein sodium is used extensively as a diagnostic tool in the field of ophthalmology. Fluorescein is a fluorescent compound or fluorophore having a maximum absorbance of 494 m and an emission maximum of 521 nm. The yellowish-green fluorescence of the compound can be used to demarcate the vascular area under observation, distinguishing it from adjacent areas. It is applied topically in the form of a drop or it can be injected intravenously to produce a fluorescein angiogram. Topical fluorescein is a useful tool in the diagnosis of corneal abrasions, corneal ulcers, herpetic corneal infections, and dry eye. Fluorescein angiography is used to diagnose and categorize macular degeneration, diabetic retinopathy, inflammatory intraocular conditions, and intraocular tumors.


Fluorescein sodium responds to electromagnetic radiation and light between the wavelengths of 465-490 nm and fluoresces, i.e., emits light at wavelengths of 520-530 nm. Thus, the hydrocarbon is excited by blue light and emits light that appears yellowish-green. Following intravenous injection of fluorescein sodium in an aqueous solution, the unbound fraction of the fluorescein can be excited with a blue light flash from a fundus camera as it circulates through the ocular vasculature, and the yellowish green fluorescence of the dye is captured by the camera. In the fundus, the fluorescence of the dye demarcates the retinal and/or choroidal vasculature under observation, distinguishing it from adjacent areas/structures. /Fluorescein sodium/

US Natl Inst Health; DailyMed. Current Medication Information for Fluorescite (fluorescein sodium) injection, solution (2009). Available from, as of October 19, 2009: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Fluorescein+sodium


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08

Icrom

Italy
SCI Medicinal Chemistry
Not Confirmed
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Icrom

Italy
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SCI Medicinal Chemistry
Not Confirmed

Fluorescein

About the Company : ICROM is specialized in the manufacturing and contract manufacturing of Active Pharmaceutical Ingredients (APIs) and GMP intermediates. ICROM is the partner of choice for pharmaceu...

ICROM is specialized in the manufacturing and contract manufacturing of Active Pharmaceutical Ingredients (APIs) and GMP intermediates. ICROM is the partner of choice for pharmaceutical outsourcing. Since 1969, ICROM is specialized in the manufacturing and contract manufacturing of Active Pharmaceutical Ingredients (APIs) and GMP intermediates. Thanks to the extensive experience and strong know-how, ICROM is the ideal partner for designing and tailoring projects upon customers’ needs.
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09

Unipex

France
SCI Medicinal Chemistry
Not Confirmed
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Unipex

France
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SCI Medicinal Chemistry
Not Confirmed

Fluorescein

About the Company : Our work in the distribution sector starts and ends with the quality of human relations; first and foremost, it is trust that we want to build with you. The connections we build ar...

Our work in the distribution sector starts and ends with the quality of human relations; first and foremost, it is trust that we want to build with you. The connections we build are made to last. They are built on professionalism, respect and transparency. This is how we work, and how we have been working for a long time now, with our client partners and constituents. Unipex has been operational for 50 years, and has always remained true to its core business: the distribution of specialities. This is also why we are independent and we intend to stay that way. Our structure is simple, our commitment is absolute: we work directly with you.
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API Reference Price

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[{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1649442600,"product":"5-CARBOXYFLUORESCEIN","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2& 3,BOMMASANDRA INDUSTRIAL AREA,IVPHA","city":"BANGALORE,KARNATAKA","supplier":"COMBI BLOCKS INC","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"SYNGENE INTERNATIONAL LTD","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"1","unit":"GMS","unitRateFc":"60","totalValueFC":"74","currency":"USD","unitRateINR":"5581.4","date":"09-Apr-2022","totalValueINR":"5581.44","totalValueInUsd":"74","indian_port":"BANGALORE AIR","hs_no":"29339990","bill_no":"8210194","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2& 3,BOMMASANDRA INDUSTRIAL AREA,IVPHA"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1656441000,"product":"5-CARBOXYFLUORESCEIN","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2& 3,BOMMASANDRA INDUSTRIAL AREA,IVPHA","city":"BANGALORE,KARNATAKA","supplier":"COMBI BLOCKS INC","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"SYNGENE INTERNATIONAL LTD","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"1","unit":"GMS","unitRateFc":"60","totalValueFC":"73.5","currency":"USD","unitRateINR":"5737.7","date":"29-Jun-2022","totalValueINR":"5737.69","totalValueInUsd":"73.5","indian_port":"BANGALORE AIR","hs_no":"29339990","bill_no":"9337112","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2& 3,BOMMASANDRA INDUSTRIAL AREA,IVPHA"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1660847400,"product":"DIACETYLFLUORESCEIN (QTY: 1 X 200 MG, PRICE: USD 257)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNDISCLOSED","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIAINDIA PRIVATE LTD","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0002","unit":"KGS","unitRateFc":"1285000","totalValueFC":"290.5","currency":"USD","unitRateINR":"115571000","date":"19-Aug-2022","totalValueINR":"23114.2","totalValueInUsd":"290.5","indian_port":"HYDERABAD AIR","hs_no":"29329990","bill_no":"2074879","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1661452200,"product":"FLUORESCEIN 6-ISOTHIOCYANATE","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"ASTATECHINC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LTD UNIT II BLOCK S 11","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"1","unit":"GMS","unitRateFc":"338.2","totalValueFC":"342.2","currency":"USD","unitRateINR":"27228","date":"26-Aug-2022","totalValueINR":"27228","totalValueInUsd":"342.2","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1012839","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1665513000,"product":"FLUORESCEIN 6-ISOTHIOCYANATE-VALUE FOR CUSTOM PURPOSE(FOC)","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"ASTATECHINC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LTD UNIT II BLOCK S 11","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"1","unit":"GMS","unitRateFc":"355.4","totalValueFC":"356.1","currency":"USD","unitRateINR":"29304","date":"12-Oct-2022","totalValueINR":"29304","totalValueInUsd":"356.1","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1015344","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1666290600,"product":"FLUORESCEINYL 5-ISOTHIOCYANATE","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"ESSEN SCIENTIFIC LLC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LTD UNIT IX","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"1","unit":"GMS","unitRateFc":"298","totalValueFC":"303.8","currency":"USD","unitRateINR":"25002","date":"21-Oct-2022","totalValueINR":"25002","totalValueInUsd":"303.8","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1015893","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"5321 W BRIARSTONE DR, PEORIA IL New York,New York US","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1668969000,"product":"5-AMINOFLUORESCEIN","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"COMBI BLOCKS INC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LTD UNIT XI","customerCountry":"INDIA","quantity":"0.02","actualQuantity":"20","unit":"GMS","unitRateFc":"37.2","totalValueFC":"752.1","currency":"USD","unitRateINR":"3069","date":"21-Nov-2022","totalValueINR":"61380","totalValueInUsd":"752.1","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1017574","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715020200,"product":"FLUORESCEIN ISOTHIOCYANATE ISOMER I, TECH GRADE(COO-CHINA)-VALUE FOR CUSTOM PURPOSES ONLY","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"COMBIBLOCKS INC","supplierCountry":"UNITED STATES","foreign_port":"SAN DIEGO","customer":"SYNGENE INTERNATIONAL LTD UNIT II BLOCK S 11","customerCountry":"INDIA","quantity":"0.49","actualQuantity":"488","unit":"GMS","unitRateFc":"4.9","totalValueFC":"2396.8","currency":"USD","unitRateINR":"409.4","date":"07-May-2024","totalValueINR":"199780","totalValueInUsd":"2396.8","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1005576","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"SAN DIEGO","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717353000,"product":"6-CARBOXYFLUORESCEIN","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"SUZHOU SIBIAN CHEMICAL TECHNOLOGY CO LTD","supplierCountry":"CHINA","foreign_port":"HONG KONG","customer":"SYNGENE INTERNATIONAL LTD UNIT IX","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"23.5","totalValueFC":"237.4","currency":"USD","unitRateINR":"1982.2","date":"03-Jun-2024","totalValueINR":"19822","totalValueInUsd":"237.4","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1006853","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734460200,"product":"FLUORESCEIN RELATED COMPOUND C (QTY: 1 X 0.05 G, VALUE: USD43.25)(FOC)SAMPLES FOR IN HOUSE R&D\/TESTING PURPOSE","address":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"UNITED STATES PHARMACOPEIAL CONVENTION","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIAINDIA PRIVATE LTD","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00005","unit":"KGS","unitRateFc":"895940","totalValueFC":"45.2","currency":"USD","unitRateINR":"76737600","date":"18-Dec-2024","totalValueINR":"3836.88","totalValueInUsd":"45.2","indian_port":"Hyderabad Air","hs_no":"29189990","bill_no":"7317190","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK, MD, US 21704, UNITED STATES OF AMER ICA United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734460200,"product":"FLUORESCEIN RELATED COMPOUND C (QTY: 2 X 25 MG, VALUE: USD 838\/EACH)(FOC)SAMPLES FOR IN HOUSE R&D\/TESTING PURPOSE","address":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"UNITED STATES PHARMACOPEIAL CONVENTION","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIAINDIA PRIVATE LTD","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00005","unit":"KGS","unitRateFc":"34719140","totalValueFC":"1749.9","currency":"USD","unitRateINR":"2973694200","date":"18-Dec-2024","totalValueINR":"148684.71","totalValueInUsd":"1749.9","indian_port":"Hyderabad Air","hs_no":"29189990","bill_no":"7317190","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK, MD, US 21704, UNITED STATES OF AMER ICA United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735583400,"product":"5-AMINOFLUORESCEIN - CS-3856 - 3326-34-9 NA","address":"102\/12 KRISHNA GREENLAND PARK,KASA","city":"THANE,MAHARASHTRA","supplier":"SHANGHAI KAIXIN PHARMACEUTICALS CO","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"JINAY PHARMACEUTICALS PRIVATE LTD","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"12.6","totalValueFC":"127.5","currency":"USD","unitRateINR":"1083","date":"31-Dec-2024","totalValueINR":"10829.7","totalValueInUsd":"127.5","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"7554282","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":",LTD ROOM 502,5\/F NO.2 BUILDING 720 CAIL ZHANGJIANG HIGH-TECH PARK SHANGHAI CHINA","customerAddress":"102\/12 KRISHNA GREENLAND PARK,KASA"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1746988200,"product":"AMIDITE 5-HEXACHLORO - FLUORESCEIN CE PHOSPHORAMIDITE (6-HEX AMIDITE) (FOR RESEARCH USE ONLY)AMIDITE 5-HEXACHLORO - FLUORESCEIN CE PHOSPHORAMIDITE (6-HE","address":"135\/139, Muktanand Marg","city":"Vapi","supplier":"HUNAN HONYA BIOTECH COLTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"MICRO CRISPR PRIVATE LTD","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"1","unit":"GMS","unitRateFc":"575.3","totalValueFC":"577.7","currency":"USD","unitRateINR":"49216.3","date":"12-May-2025","totalValueINR":"49216.25","totalValueInUsd":"577.7","indian_port":"Bombay Air","hs_no":"29349990","bill_no":"2011096","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"NO.246 SHIDAIYANGGUANG BLVD, YUHUA DISTRICT, CHANGSHA CITY, HUNAN, SDNF CHINA","customerAddress":"135\/139, Muktanand Marg"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1749407400,"product":"FLUORESCEIN ISOTHIOCYANATE ISOMER I, TECH GRADE FLUORESCEIN ISOTHIOCYANATE ISOMER I, TECH GRADE","address":"NO.4-1-10\/1, TILAK ROAD,","city":"HYDERABAD, TELANGANA.","supplier":"COMBI BLOCKS INC","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK","customer":"PRINCE SCIENTIFIC","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"1","unit":"GMS","unitRateFc":"60","totalValueFC":"60.6","currency":"USD","unitRateINR":"5205","date":"09-Jun-2025","totalValueINR":"5205","totalValueInUsd":"60.6","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"2555083","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"7949 SILVERTON AVE SUITE 915 SAN DIEGO, CA 92126 SDNF US","customerAddress":"NO.4-1-10\/1, TILAK ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1750617000,"product":"2-CHLOROPYRIMIDINE-5-CARBALDEHYDE CAS:933702-55-7 P\/N:AG0036X0 - AGN2025-730265FLUORESCEIN ISOTHIOCYANATE ISOMER 1 CAS3326-32-7 P\/NAG000E31","address":"PLOT NO. 148-150, IDA,","city":"HYDERABAD,TELANGANA","supplier":"ANGENE INTERNATIONAL LTD","supplierCountry":"HONG KONG","foreign_port":"HONG KONG","customer":"AZOLE CHEM PRIVATE LTD","customerCountry":"INDIA","quantity":"0.15","actualQuantity":"0.15","unit":"KGS","unitRateFc":"4800","totalValueFC":"734.5","currency":"USD","unitRateINR":"420720","date":"23-Jun-2025","totalValueINR":"63108","totalValueInUsd":"734.5","indian_port":"Hyderabad Air","hs_no":"29334990","bill_no":"2818479","productDescription":"API","marketType":"","country":"HONG KONG","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"WORKSHOP 27 ON 8\/F THRIVING INDUSTRIAL CENTRE NOS. 26 38 SHATSU I ROAD TSUEN WAN NT HONGKONG CN","customerAddress":"PLOT NO. 148-150, IDA,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1750617000,"product":"FLUORESCEIN ISOTHIOCYANATE ISOMER 1 CAS:3326-32-7 P\/N:AG000E31 - AGN2025-730264FLUORESCEIN ISOTHIOCYANATE ISOMER 1 CAS3326-32-7 P\/NAG000E31","address":"PLOT NO. 148-150, IDA,","city":"HYDERABAD,TELANGANA","supplier":"ANGENE INTERNATIONAL LTD","supplierCountry":"HONG KONG","foreign_port":"HONG KONG","customer":"AZOLE CHEM PRIVATE LTD","customerCountry":"INDIA","quantity":"0.04","actualQuantity":"0.035","unit":"KGS","unitRateFc":"22000","totalValueFC":"785.5","currency":"USD","unitRateINR":"1928300","date":"23-Jun-2025","totalValueINR":"67490.5","totalValueInUsd":"785.5","indian_port":"Hyderabad Air","hs_no":"29334990","bill_no":"2818479","productDescription":"API","marketType":"","country":"HONG KONG","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"WORKSHOP 27 ON 8\/F THRIVING INDUSTRIAL CENTRE NOS. 26 38 SHATSU I ROAD TSUEN WAN NT HONGKONG CN","customerAddress":"PLOT NO. 148-150, IDA,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1751826600,"product":"5-AMINOFLUORESCEIN - PRODUCT ID : CS-3856, CAS NO: 3326-34-9 LABORATORY CHEMICALS","address":"102\/12 KRISHNA GREENLAND PARK,KASA","city":"THANE,MAHARASHTRA","supplier":"SHANGHAI KAIXIN PHARMACEUTICALS CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"JINAY PHARMACEUTICALS PRIVATE LTD","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"12.6","totalValueFC":"63.1","currency":"USD","unitRateINR":"1086.1","date":"07-Jul-2025","totalValueINR":"5430.6","totalValueInUsd":"63.1","indian_port":"Hyderabad Air","hs_no":"29329990","bill_no":"3112461","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ROOM 502.5\/F.NO ROAD ZHANGIJANG HIGH-TECH PARK SDNF CN","customerAddress":"102\/12 KRISHNA GREENLAND PARK,KASA"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1751913000,"product":"5-AMINOFLUORESCEIN - PRODUCT ID : CS-3856, CAS NO: 3326-34-9 LABORATORY CHEMICALS","address":"102\/12 KRISHNA GREENLAND PARK,KASA","city":"THANE,MAHARASHTRA","supplier":"SHANGHAI KAIXIN PHARMACEUTICALS CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"JINAY PHARMACEUTICALS PRIVATE LTD","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"12.6","totalValueFC":"63.1","currency":"USD","unitRateINR":"1086.1","date":"08-Jul-2025","totalValueINR":"5430.6","totalValueInUsd":"63.1","indian_port":"Hyderabad Air","hs_no":"29329990","bill_no":"3136316","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ROOM 502.5\/F.NO ROAD ZHANGIJANG HIGH-TECH PARK SDNF CN","customerAddress":"102\/12 KRISHNA GREENLAND PARK,KASA"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1753295400,"product":"FLUORESCEIN ISOTHIOCYANATE ISOMER 1 FLUORESCEIN ISOTHIOCYANATE ISOMER 1","address":"FLAT NO 710,7TH FLOOR,,ADITYA TRAD","city":"HYDERABAD,TELANGANA","supplier":"APPCHEM LIMITED","supplierCountry":"HONG KONG","foreign_port":"HONG KONG","customer":"ANGENE CHEMICAL PRIVATE LTD","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"50","unit":"GMS","unitRateFc":"22.2","totalValueFC":"1117.3","currency":"USD","unitRateINR":"1923.2","date":"24-Jul-2025","totalValueINR":"96162.25","totalValueInUsd":"1117.3","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"3455965","productDescription":"API","marketType":"","country":"HONG KONG","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"ROOM 511, 5\/F, MING SANG INDUSTRIALBUILDING, 19-21 HING YIP STREET, KWUN TONG,KOWLOON,HONG KONG HK","customerAddress":"FLAT NO 710,7TH FLOOR,,ADITYA TRAD"}]
09-Apr-2022
24-Jul-2025
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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South Africa

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01

NASP
Not Confirmed
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NASP
Not Confirmed

Fluorescein

Brand Name : Fluorescite 10%

Dosage Form : INJ

Dosage Strength : 500mg/5ml

Packaging : 5X12mg/5ml

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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02

NASP
Not Confirmed
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NASP
Not Confirmed

Fluorescein

Brand Name : Fluorescite 25% 5Ml

Dosage Form : INJ

Dosage Strength : 25%

Packaging : 12X1%

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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Listed Dossiers

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01

Aurolab

India
SCI Medicinal Chemistry
Not Confirmed
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Aurolab

India
arrow
SCI Medicinal Chemistry
Not Confirmed

Fluorescein

Brand Name : Flures

Dosage Form : Injection

Dosage Strength : 20%/W/V

Packaging : 10 Ampules / Box

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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01

Aurolab

India
SCI Medicinal Chemistry
Not Confirmed
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Aurolab

India
arrow
SCI Medicinal Chemistry
Not Confirmed

Fluorescein

Dosage : Injection

Dosage Strength : 20%/W/V

Brand Name : Flures

Approval Date :

Application Number :

Registration Country : India

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02

Laboratorios Poen

Argentina
SCI Medicinal Chemistry
Not Confirmed
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Laboratorios Poen

Argentina
arrow
SCI Medicinal Chemistry
Not Confirmed

Fluorescein

Brand Name :

Dosage Form : Ophthalmic Solution

Dosage Strength : 0.25%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Argentina

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02

Laboratorios Poen

Argentina
SCI Medicinal Chemistry
Not Confirmed
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Laboratorios Poen

Argentina
arrow
SCI Medicinal Chemistry
Not Confirmed

Fluorescein

Dosage : Ophthalmic Solution

Dosage Strength : 0.25%

Brand Name :

Approval Date :

Application Number :

Registration Country : Argentina

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03

Laboratorios Poen

Argentina
SCI Medicinal Chemistry
Not Confirmed
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Laboratorios Poen

Argentina
arrow
SCI Medicinal Chemistry
Not Confirmed

Proximetacainum; Fluorescein

Brand Name : Fotoptic

Dosage Form : Ophthalmic Solution

Dosage Strength : 0.5%; 0.25%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Argentina

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03

Laboratorios Poen

Argentina
SCI Medicinal Chemistry
Not Confirmed
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Laboratorios Poen

Argentina
arrow
SCI Medicinal Chemistry
Not Confirmed

Proximetacainum; Fluorescein

Dosage : Ophthalmic Solution

Dosage Strength : 0.5%; 0.25%

Brand Name : Fotoptic

Approval Date :

Application Number :

Registration Country : Argentina

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04

Polifarma

Turkey
SCI Medicinal Chemistry
Not Confirmed
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Polifarma

Turkey
arrow
SCI Medicinal Chemistry
Not Confirmed

Fluorescein

Brand Name :

Dosage Form : IV Injection Solution

Dosage Strength : 500MG/5ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Turkey

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04

Polifarma

Turkey
SCI Medicinal Chemistry
Not Confirmed
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Polifarma

Turkey
arrow
SCI Medicinal Chemistry
Not Confirmed

Fluorescein

Dosage : IV Injection Solution

Dosage Strength : 500MG/5ML

Brand Name :

Approval Date :

Application Number :

Registration Country : Turkey

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.2...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.25%

USFDA APPLICATION NUMBER - 208582

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DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.3...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.3%

USFDA APPLICATION NUMBER - 211039

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ABOUT THIS PAGE

Looking for 2321-07-5 / Fluorescein API manufacturers, exporters & distributors?

Fluorescein manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Fluorescein API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Fluorescein manufacturer or Fluorescein supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Fluorescein manufacturer or Fluorescein supplier.

PharmaCompass also assists you with knowing the Fluorescein API Price utilized in the formulation of products. Fluorescein API Price is not always fixed or binding as the Fluorescein Price is obtained through a variety of data sources. The Fluorescein Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Fluorescein

Synonyms

2321-07-5, Solvent yellow 94, Resorcinolphthalein, Yellow fluorescein, Fluoresceine, 3',6'-dihydroxy-3h-spiro[isobenzofuran-1,9'-xanthen]-3-one

Cas Number

2321-07-5

Unique Ingredient Identifier (UNII)

TPY09G7XIR

About Fluorescein

A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.

AK-FLUOR 25% Manufacturers

A AK-FLUOR 25% manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of AK-FLUOR 25%, including repackagers and relabelers. The FDA regulates AK-FLUOR 25% manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. AK-FLUOR 25% API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of AK-FLUOR 25% manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

AK-FLUOR 25% Suppliers

A AK-FLUOR 25% supplier is an individual or a company that provides AK-FLUOR 25% active pharmaceutical ingredient (API) or AK-FLUOR 25% finished formulations upon request. The AK-FLUOR 25% suppliers may include AK-FLUOR 25% API manufacturers, exporters, distributors and traders.

click here to find a list of AK-FLUOR 25% suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

AK-FLUOR 25% USDMF

A AK-FLUOR 25% DMF (Drug Master File) is a document detailing the whole manufacturing process of AK-FLUOR 25% active pharmaceutical ingredient (API) in detail. Different forms of AK-FLUOR 25% DMFs exist exist since differing nations have different regulations, such as AK-FLUOR 25% USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A AK-FLUOR 25% DMF submitted to regulatory agencies in the US is known as a USDMF. AK-FLUOR 25% USDMF includes data on AK-FLUOR 25%'s chemical properties, information on the facilities and procedures used, and details about packaging and storage. The AK-FLUOR 25% USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of AK-FLUOR 25% suppliers with USDMF on PharmaCompass.

AK-FLUOR 25% CEP

A AK-FLUOR 25% CEP of the European Pharmacopoeia monograph is often referred to as a AK-FLUOR 25% Certificate of Suitability (COS). The purpose of a AK-FLUOR 25% CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of AK-FLUOR 25% EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of AK-FLUOR 25% to their clients by showing that a AK-FLUOR 25% CEP has been issued for it. The manufacturer submits a AK-FLUOR 25% CEP (COS) as part of the market authorization procedure, and it takes on the role of a AK-FLUOR 25% CEP holder for the record. Additionally, the data presented in the AK-FLUOR 25% CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the AK-FLUOR 25% DMF.

A AK-FLUOR 25% CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. AK-FLUOR 25% CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of AK-FLUOR 25% suppliers with CEP (COS) on PharmaCompass.

AK-FLUOR 25% NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing AK-FLUOR 25% as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for AK-FLUOR 25% API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture AK-FLUOR 25% as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain AK-FLUOR 25% and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a AK-FLUOR 25% NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of AK-FLUOR 25% suppliers with NDC on PharmaCompass.

AK-FLUOR 25% GMP

AK-FLUOR 25% Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of AK-FLUOR 25% GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right AK-FLUOR 25% GMP manufacturer or AK-FLUOR 25% GMP API supplier for your needs.

AK-FLUOR 25% CoA

A AK-FLUOR 25% CoA (Certificate of Analysis) is a formal document that attests to AK-FLUOR 25%'s compliance with AK-FLUOR 25% specifications and serves as a tool for batch-level quality control.

AK-FLUOR 25% CoA mostly includes findings from lab analyses of a specific batch. For each AK-FLUOR 25% CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

AK-FLUOR 25% may be tested according to a variety of international standards, such as European Pharmacopoeia (AK-FLUOR 25% EP), AK-FLUOR 25% JP (Japanese Pharmacopeia) and the US Pharmacopoeia (AK-FLUOR 25% USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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