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Chemistry

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Also known as: 7241-98-7, Dihydroaflatoxin g1, 2ms0d8wa29, (7ar-cis)-3,4,7a,9,10,10a-hexahydro-5-methoxy-1h,12h-furo[3',2':4,5]furo[2,3-h]pyrano[3,4-c][1]benzopyran-1,12-dione, Aflatoxin g2 0.5 microg/ml in acetonitrile, 1h,12h-furo[3',2':4,5]furo[2,3-h]pyrano[3,4-c][1]benzopyran-1,12-dione, 3,4,7a,9,10,10a-hexahydro-5-methoxy-, (7ar,10as)-
Molecular Formula
C17H14O7
Molecular Weight
330.29  g/mol
InChI Key
WPCVRWVBBXIRMA-WNWIJWBNSA-N
FDA UNII
2MS0D8WA29

Aflatoxin G2
aflatoxin g2 is a natural product found in Aspergillus nomiae, Aspergillus flavus, and Aspergillus parasiticus with data available.
1 2D Structure

Aflatoxin G2

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(3S,7R)-11-methoxy-6,8,16,20-tetraoxapentacyclo[10.8.0.02,9.03,7.013,18]icosa-1,9,11,13(18)-tetraene-17,19-dione
2.1.2 InChI
InChI=1S/C17H14O7/c1-20-9-6-10-12(8-3-5-22-17(8)23-10)14-11(9)7-2-4-21-15(18)13(7)16(19)24-14/h6,8,17H,2-5H2,1H3/t8-,17+/m0/s1
2.1.3 InChI Key
WPCVRWVBBXIRMA-WNWIJWBNSA-N
2.1.4 Canonical SMILES
COC1=C2C3=C(C(=O)OCC3)C(=O)OC2=C4C5CCOC5OC4=C1
2.1.5 Isomeric SMILES
COC1=C2C3=C(C(=O)OCC3)C(=O)OC2=C4[C@@H]5CCO[C@@H]5OC4=C1
2.2 Other Identifiers
2.2.1 UNII
2MS0D8WA29
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 7241-98-7

2. Dihydroaflatoxin G1

3. 2ms0d8wa29

4. (7ar-cis)-3,4,7a,9,10,10a-hexahydro-5-methoxy-1h,12h-furo[3',2':4,5]furo[2,3-h]pyrano[3,4-c][1]benzopyran-1,12-dione

5. Aflatoxin G2 0.5 Microg/ml In Acetonitrile

6. 1h,12h-furo[3',2':4,5]furo[2,3-h]pyrano[3,4-c][1]benzopyran-1,12-dione, 3,4,7a,9,10,10a-hexahydro-5-methoxy-, (7ar,10as)-

7. Aflatoxing2

8. Unii-2ms0d8wa29

9. Ccris 4936

10. Hsdb 3456

11. 1h,12h-furo(3',2':4,5)furo(2,3-h)pyrano(3,4-c)(1)benzopyran-1,12-dione, 3,4,7a,9,10,10a-hexahydro-5-methoxy-, (7ar,10as)-

12. Einecs 230-643-4

13. Aflatoxin G2 [mi]

14. Aflatoxin G2 [hsdb]

15. Aflatoxin G2 In Acetonitrile

16. Chebi:80705

17. Aflatoxin G2, Reference Material

18. Dtxsid80891796

19. Ex-a4123

20. Hy-n6698

21. Zinc2029390

22. Mfcd00078141

23. 1h,12h-furo(3',2':4,5)furo(2,3-h)pyrano(3,4-c)(1)benzopyran-1,12-dione,3,4,7aalpha,9,10,10aalpha-hexahydro-5-methoxy-

24. 1h,12h-furo[3',2':4,5]furo[2,3-h]pyrano[3,4-c][1]benzopyran-1,12-dione, 3,4,7a,9,10,10a-hexahydro-5-

25. 3,4,7aalpha,9,10,10aalpha-hexahydro-5-methoxy-1h,12h-furo(3',2':4,5)furo(2,3-h)pyrano(3,4-c)(1)-benzopyran-1,12-dione

26. Cs-0099736

27. C16754

28. Q26841280

29. Aflatoxin G2, From Aspergillus Flavus, >=98.0% (hplc/tlc)

30. Aflatoxin G2 Solution, 0.5 Mug/ml In Acetonitrile, Analytical Standard

31. Aflatoxin G2 Solution, 3.80 Mug/g In Acetonitrile, Erm(r) Certified Reference Material

32. (3s,7r)-11-methoxy-6,8,16,20-tetraoxapentacyclo[10.8.0.02,9.03,7.013,18]icosa-1,9,11,13(18)-tetraene-17,19-dione

33. (7ar,cis)3,4,7a,9,10,10a-hexahydro-5-methoxy-1h,12h- Furo(3',2':4,5)furo(2,3-h)pyrano(3,4-c)chromene-1,12-dione

34. (7ar,cis)3,4,7a,9,10,10a-hexahydro-5-methoxy-1h,12h-furo(3',2':4,5)furo(2,3-h)pyrano(3,4-c)chromene-1,12-dione

35. 1h,12h-furo(3',2':4,5)furo(2,3-h)pyrano(3,4-c)(1)benzopyran- 1,12-dione, 3,4,7a,9,10,10a-hexahydro-5-methoxy-, (7ar,10as)-

36. 1h,12h-furo(3',2':4,5)furo(2,3-h)pyrano(3,4-c)(1)benzopyran-1,12-dione, 3,4,7a-alpha,9,10,10a-alpha-hexahydro-5-methoxy-

37. Aflatoxin G2 Solution, Certified Reference Material, 3 Mug/ml In Benzene:acetonitrile (98:2), Ampule Of 1 Ml

2.4 Create Date
2005-07-19
3 Chemical and Physical Properties
Molecular Weight 330.29 g/mol
Molecular Formula C17H14O7
XLogP31.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Exact Mass330.07395278 g/mol
Monoisotopic Mass330.07395278 g/mol
Topological Polar Surface Area80.3 Ų
Heavy Atom Count24
Formal Charge0
Complexity626
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Absorption, Distribution and Excretion

To evaluate the rate at which the four main aflatoxins (aflatoxins B1, B2, G1 and G2) are able to cross the luminal membrane of the rat small intestine, a study about intestinal absorption kinetics of these mycotoxins has been made. In situ results obtained showed that the absorption of aflatoxins in rat small intestine is a very fast process that follows first-order kinetics, with an absorption rate constant (ka) of 5.84 +/- 0.05 (aflatoxin B1), 4.06 +/- 0.09 (aflatoxin B2), 2.09 +/- 0.03 (aflatoxin G1) and 1.58 +/- 0.04 (aflatoxin G2) h-1, respectively.

Ramos A et al; Mycopathologia 134(1): p.27-30 (1996)


4.2 Metabolism/Metabolites

Aflatoxin G2 ... /is/ the 9,10-dihydro derivative of aflatoxin G1.

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 35


4.3 Mechanism of Action

With the 4 principal Aflatoxins tested, the order of inhibitory effect on RNA polymerase II was: B1 greater than G1 greater than B1, G2.

Yu FL et al; Carcinogenesis (London) 3 (9): 1005 (1982)


Phagocytosis, intracellular killing of Candida albicans, and superoxide production by rat peritoneal macrophages exposed to aflatoxins B1, B2, G1, G2, B2a, and M1 at several times and concentration were analyzed to evaluate the intensity of a depressive effect for each mycotoxin. All aflatoxins used at very low concn had a depressive effect on the functions of macrophages. The biggest impairment of phagocytosis, intracellular killing, and spontaneous superoxide production was observed in macrophages exposed to aflatoxins B1 and M1.

PMID:2176448 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC184993 Cusumano V et al; Appl Environ Microbiol 56 (11): 3482-4 (1990)


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ABOUT THIS PAGE

Looking for 7241-98-7 / Aflatoxin G2 API manufacturers, exporters & distributors?

Aflatoxin G2 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Aflatoxin G2 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Aflatoxin G2 manufacturer or Aflatoxin G2 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Aflatoxin G2 manufacturer or Aflatoxin G2 supplier.

PharmaCompass also assists you with knowing the Aflatoxin G2 API Price utilized in the formulation of products. Aflatoxin G2 API Price is not always fixed or binding as the Aflatoxin G2 Price is obtained through a variety of data sources. The Aflatoxin G2 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Aflatoxin G2

Synonyms

7241-98-7, Dihydroaflatoxin g1, 2ms0d8wa29, (7ar-cis)-3,4,7a,9,10,10a-hexahydro-5-methoxy-1h,12h-furo[3',2':4,5]furo[2,3-h]pyrano[3,4-c][1]benzopyran-1,12-dione, Aflatoxin g2 0.5 microg/ml in acetonitrile, 1h,12h-furo[3',2':4,5]furo[2,3-h]pyrano[3,4-c][1]benzopyran-1,12-dione, 3,4,7a,9,10,10a-hexahydro-5-methoxy-, (7ar,10as)-

Cas Number

7241-98-7

Unique Ingredient Identifier (UNII)

2MS0D8WA29

About Aflatoxin G2

aflatoxin g2 is a natural product found in Aspergillus nomiae, Aspergillus flavus, and Aspergillus parasiticus with data available.

Aflatoxin G2 Manufacturers

A Aflatoxin G2 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Aflatoxin G2, including repackagers and relabelers. The FDA regulates Aflatoxin G2 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Aflatoxin G2 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Aflatoxin G2 Suppliers

A Aflatoxin G2 supplier is an individual or a company that provides Aflatoxin G2 active pharmaceutical ingredient (API) or Aflatoxin G2 finished formulations upon request. The Aflatoxin G2 suppliers may include Aflatoxin G2 API manufacturers, exporters, distributors and traders.

Aflatoxin G2 GMP

Aflatoxin G2 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Aflatoxin G2 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Aflatoxin G2 GMP manufacturer or Aflatoxin G2 GMP API supplier for your needs.

Aflatoxin G2 CoA

A Aflatoxin G2 CoA (Certificate of Analysis) is a formal document that attests to Aflatoxin G2's compliance with Aflatoxin G2 specifications and serves as a tool for batch-level quality control.

Aflatoxin G2 CoA mostly includes findings from lab analyses of a specific batch. For each Aflatoxin G2 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Aflatoxin G2 may be tested according to a variety of international standards, such as European Pharmacopoeia (Aflatoxin G2 EP), Aflatoxin G2 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Aflatoxin G2 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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