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Details:

Domvanalimab is an Fc-silent investigational monoclonal antibody that is designed to bind to TIGIT, a protein receptor on immune cells that acts as a brake on the immune response.


Lead Product(s): Etrumadenant,Zimberelimab

Therapeutic Area: Oncology Product Name: AB154

Highest Development Status: Phase IIIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Arcus Biosciences

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 19, 2022

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Details:

Domvanalimab is an Fc-silent investigational monoclonal antibody that is designed to bind to TIGIT, a protein receptor on immune cells that acts as a brake on the immune response.


Lead Product(s): Etrumadenant,Zimberelimab

Therapeutic Area: Oncology Product Name: AB154

Highest Development Status: Phase IIIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Arcus Bioscience

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 28, 2022

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ARC-7 and the ongoing ARC-10 Phase 3 registrational study will continue to enroll as planned, and preparations for additional Phase 3 studies are underway for domvanalimab-based combinations across various cancer types.


Lead Product(s): Domvanalimab,Zimberelimab,Etrumadenant

Therapeutic Area: Oncology Product Name: AB154

Highest Development Status: Phase IIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Gilead Sciences

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 24, 2021

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The Phase 1b clinical trial is a global multi-center, open-label trial of CERC-007 that will enroll around 12 subjects with active adult onset Still’s disease with a primal goal of the study will be to determine the safety and tolerability of CERC-007 in AOSD patients.


Lead Product(s): Eganelisib,Etrumadenant

Therapeutic Area: Oncology Product Name: IPI-549

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Arcus Biosciences

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 05, 2021

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Under this agreement, Gilead Gains Broad Access to Arcus’s Clinical and Preclinical Pipeline of Immuno-Oncology Product Candidates that Target Critical Biological Pathways. Arcus to continue to independently conduct research on New Targets.


Lead Product(s): Zimberelimab,Etrumadenant,AB154

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: Phase IIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Gilead Sciences

Deal Size: $2,000.0 million Upfront Cash: $175.0 million

Deal Type: Collaboration May 27, 2020

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Taiho’s in-licensing facilitates global development and commercialization of zimberelimab as a monotherapy and as a combination backbone for Arcus’s and Taiho’s oncology portfolios.


Lead Product(s): Zimberelimab,Etrumadenant,AB154

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: Phase IIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Taiho Pharmaceutical

Deal Size: $275.0 million Upfront Cash: Undisclosed

Deal Type: Licensing Agreement February 26, 2020

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