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Treatment-Na\u00efve Metastatic Pancreatic Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I"}]
Find Clinical Drug Pipeline Developments & Deals by Arcus Biosciences
The collaboration aims to focus on advancing and potentially accelerating the development of domvanalimab for the treatment of Metastatic Non-Small Cell Lung Cancer.
Lead Product(s):
Zimberelimab,Domvanalimab,Carboplatin
AB680 (quemliclustat) is an investigational small molecule CD73 inhibitor. It is being evaluated in phase 1 clinical trials in combination with zimberelimab and chemotherapy for the treatment of metastatic pancreatic cancer.
AB680 (quemliclustat) is an investigational small molecule CD73 inhibitor. It is under phase 1 clinical development for the treatment of in combination with chemotherapy with or without zimberelimab for treatment-naïve metastatic pancreatic cancer.
The companies will enter into a clinical trial collaboration evaluating XL092 (zanzalintinib), a tyrosine kinase inhibitor, in combination with AB521 in patients with advanced solid tumors including clear cell renal cell carcinoma.
Under the terms of the expanded collaboration, Arcus will initiate research programs against up to four targets jointly selected by the parties that are applicable to inflammatory diseases.
Domvanalimab is an Fc-silent investigational monoclonal antibody that is designed to bind to TIGIT, a protein receptor on immune cells that acts as a brake on the immune response.
Initial pharmacokinetic /pharmacodynamic data for AB521, a Clinical-Stage, Potent, and Selective Hypoxia-Inducible Factor (HIF)-2α Inhibitor, in healthy volunteers, confirm its potential to have an improved clinical profile compared to that of only approved HIF-2a inhibitor.
Preclinical research related to therapeutic opportunities to enhance anti-tumor immunity and new insights into the benet of dual A2a/A2b adenosine receptor antagonism, CD39 inhibition and HPK1 inhibition will be presented at the American Association for Cancer Research.
Gilead exercised its options to anti-TIGIT molecules domvanalimab and AB308, as well as clinical candidates etrumadenant (dual adenosine A2a/A2b receptor antagonist) and quemliclustat (small molecule CD73 inhibitor).
Taiho exercised its option for anti-TIGIT antibodies domvanalimab (development code: AB154) and AB308 from Arcus Biosciences (“Arcus”), in Japan and certain other territories in Asia (excluding China).
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