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    Find (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate manufacturers, exporters & distributors on PharmaCompass

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    Chemistry

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    Also known as: Ast-3424, 2097713-69-2, Odafosfamide, Odafosfamide [inn], Schembl20870082, Schembl29392358
    Molecular Formula
    C21H25N4O6P
    Molecular Weight
    460.4  g/mol
    InChI Key
    NWGZZGNICQFUHV-HNNXBMFYSA-N
    FDA UNII
    C2T9S468D3
    (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate
    Odafosfamide is the S-isoform of odafosfamide, a small-molecule nitro-benzene, aldo-keto reductase 1C3 (AKR1C3)-activated prodrug of N,N'-bisethylenephosphoramidate, a DNA bis-alkylating agent, with potential antineoplastic activity. Upon intravenous administration, odafosfamide is converted to its active form by AKR1C3, which is upregulated in certain tumor cell types while not expressed in normal healthy cells. The active metabolite selectively binds to and alkylates DNA in AKR1C3-overexpressing tumor cells, resulting in DNA base pair mismatching, interstrand crosslinking and inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. As the expression of AKR1C3 is restricted to tumors, Odafosfamide is selectively converted to its active metabolite in tumor cells only while its conversion in normal, healthy tissue is absent; this allows for an increased cytotoxic effect of the alkylating agent in tumor cells while decreasing its toxicity.
    1 2D Structure

    (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-[5-[(1S)-1-[bis(aziridin-1-yl)phosphoryloxy]ethyl]-2-nitrophenoxy]-N,N-dimethylbenzamide
    2.1.2 InChI
    InChI=1S/C21H25N4O6P/c1-15(31-32(29,23-9-10-23)24-11-12-24)16-7-8-19(25(27)28)20(14-16)30-18-6-4-5-17(13-18)21(26)22(2)3/h4-8,13-15H,9-12H2,1-3H3/t15-/m0/s1
    2.1.3 InChI Key
    NWGZZGNICQFUHV-HNNXBMFYSA-N
    2.2 Other Identifiers
    2.2.1 UNII
    C2T9S468D3
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. Ast-3424

    2. 2097713-69-2

    3. Odafosfamide

    4. Odafosfamide [inn]

    5. Schembl20870082

    6. Schembl29392358

    7. C2t9s468d3

    8. Ex-a6317

    9. Obi-3424, (s)-

    10. Th-2870, (s)-

    11. (1s)-1-{3-[3-(dimethylcarbamoyl)phenoxy]-4-nitrophenyl}ethyl Bis(aziridin-1-yl)phosphinate

    12. 3-[5-[(1s)-1-[bis(aziridin-1-yl)phosphoryloxy]ethyl]-2-nitrophenoxy]-n,n-dimethylbenzamide

    13. Phosphinic Acid, P,p-bis(1-aziridinyl)-, (1s)-1-[3-[3-[(dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl Ester

    2.4 Create Date
    2018-10-02
    3 Chemical and Physical Properties
    Molecular Weight 460.4 g/mol
    Molecular Formula C21H25N4O6P
    XLogP32.2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count8
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area108
    Heavy Atom Count32
    Formal Charge0
    Complexity737
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1

    ABOUT THIS PAGE

    Looking for 2097713-69-2 / (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate API manufacturers, exporters & distributors?

    (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate manufacturer or (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate manufacturer or (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate supplier.

    API | Excipient name

    (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate

    Synonyms

    Ast-3424, 2097713-69-2, Odafosfamide, Odafosfamide [inn], Schembl20870082, Schembl29392358

    Cas Number

    2097713-69-2

    Unique Ingredient Identifier (UNII)

    C2T9S468D3

    About (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate

    Odafosfamide is the S-isoform of odafosfamide, a small-molecule nitro-benzene, aldo-keto reductase 1C3 (AKR1C3)-activated prodrug of N,N'-bisethylenephosphoramidate, a DNA bis-alkylating agent, with potential antineoplastic activity. Upon intravenous administration, odafosfamide is converted to its active form by AKR1C3, which is upregulated in certain tumor cell types while not expressed in normal healthy cells. The active metabolite selectively binds to and alkylates DNA in AKR1C3-overexpressing tumor cells, resulting in DNA base pair mismatching, interstrand crosslinking and inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. As the expression of AKR1C3 is restricted to tumors, Odafosfamide is selectively converted to its active metabolite in tumor cells only while its conversion in normal, healthy tissue is absent; this allows for an increased cytotoxic effect of the alkylating agent in tumor cells while decreasing its toxicity.

    (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate Manufacturers

    A (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate, including repackagers and relabelers. The FDA regulates (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate Suppliers

    A (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate supplier is an individual or a company that provides (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate active pharmaceutical ingredient (API) or (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate finished formulations upon request. The (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate suppliers may include (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate API manufacturers, exporters, distributors and traders.

    (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate GMP

    (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate GMP manufacturer or (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate GMP API supplier for your needs.

    (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate CoA

    A (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate CoA (Certificate of Analysis) is a formal document that attests to (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate's compliance with (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate specifications and serves as a tool for batch-level quality control.

    (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate CoA mostly includes findings from lab analyses of a specific batch. For each (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate may be tested according to a variety of international standards, such as European Pharmacopoeia ((1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate EP), (1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate JP (Japanese Pharmacopeia) and the US Pharmacopoeia ((1S)-1-[3-[3-[(Dimethylamino)carbonyl]phenoxy]-4-nitrophenyl]ethyl P,P-bis(1-aziridinyl)phosphinate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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